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Cornified Envelope Proline-Rich Proteins (0):
Recent article
Cornified Envelope Proline-Rich Proteins
Abstract
We investigated a possible association between LCE3C_LCE3B-del and AD. Evaluation of four different cohorts of European ancestry, containing a total of 1075 AD patients and 1658 controls, did not provide evidence for such an association. Subgroup analysis did not reveal an association with concomita...
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PMID: 20376060
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PDF is available here.
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Abstract
SPRR1B is upregulated by the proinflammatory cytokines IL-1beta and IFN-gamma via p38 MAPK-mediated signaling pathways that lead to the activation of transcription factors CREB and ZEB1, respectively. These results identify key intracellular signaling intermediates involved in the pathogenesis of im...
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PMID: 20042643
PDF is available here.
PDF is available here.
Abstract
We hypothesize that the deregulated increase in SPRR1A expression in chronic atopic skin lesions reflects an insufficient rise in SPRR transcripts, unable to compensate for the lack of LOR and thus contributing to the persistence of chronic AD skin lesions. Turning off the stress response in the ski...
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PMID: 19672094
PDF is available here.
PDF is available here.
Abstract
We know, psoriasis is a disease of interfollicular epidermis and rapid keratinocyte proliferation may cause the production of parakeratotic keratinocytes in psoriatic skin and, thus, the formation of poorly adherent stratum corneum, which in turn results in the characteristic scale or flakes of psor...
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PMID: 19693967
PDF is available here.
PDF is available here.
Abstract
We have previously shown that CO suppresses fibrosis in a murine bleomycin model. To investigate the mechanisms by which CO opposes fibrogenesis, we performed gene expression profiling of fibroblasts treated with transforming growth factor-beta(1) and CO. The most highly differentially expressed cat...
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PMID: 19097987
PDF is available here.
PDF is available here.
Abstract
We identified two novel SCP markers, 1700106J16Rik and Sprr2d, whose expression is ovary-biased during early gonad development, and altered in Wnt4, Sf1, Wt1, and Fog2 mutant gonads. In XX and XY gonads, both genes were up-regulated at approximately E11 in a center-to-poles wave, and then rapidly do...
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PMID: 19301398
PDF is available here.
PDF is available here.
Nature Genetics (41)2 2009
Abstract
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ances...
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PMID: 19169255
PDF is available here.
PDF is available here.
Nature Genetics (41)2 2009
Abstract
We have identified a deletion comprising LCE3B and LCE3C, members of the late cornified envelope (LCE) gene cluster. The absence of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated (P = 1.38E-08) with risk of psoriasis in 2,831 samples from Spain, The Netherlands, Italy and the United S...
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PMID: 19169253
PDF is available here.
PDF is available here.
Abstract
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from th...
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PMID: 19582408
PDF is available here.
PDF is available here.
Abstract
Medical-surgical nurses in inpatient settings may encounter dying patients who exhibit a number of symptoms during the end of life. One symptom, the death rattle, refers to the noise of excessive secretions present during the inspiratory and expiratory phases of respiration. Symptom improvement can...
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PMID: 19331295
PDF is available here.
PDF is available here.
Molecular Vision (15) 2009
Abstract
Aire-deficient mice represent a useful model to study Sjögren-like autoimmune-mediated ocular surface disease. Results of the current study suggest that squamous cell precursor protein, SPRR1B, provides an important readout to evaluate ocular surface damage and specific events related to immune-m...
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PMID: 19365590
PDF is available here.
PDF is available here.
Journal of Hepatology (48)2 2008
Abstract
These observations suggest that SPRR2A-related BEC barrier modifications represent a novel, but widely utilized and evolutionarily conserved, response to stress that is worthy of further study....
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PMID: 18155796
PDF is available here.
PDF is available here.
Abstract
Osmotic stress promotes production of certain CE proteins and cross-linking membrane-associated TG1 and decreases cell viability via JNK MAPK-mediated pathways. Strategies that inhibit JNK production downregulate the cornification response of PCHCE cells to osmotic stress. These findings have potent...
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PMID: 18234997
PDF is available here.
PDF is available here.
BMC Genomics (9)1 2008
Abstract
Enterocyte suspensions of high purity (98-99%) were isolated from intestinal biopsies. Of the 3,800 genes investigated, 102 genes were found to have significantly altered expression between coeliac disease patients and controls (p < 0.05). Analysis of these altered genes revealed a number of biologi...
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PMID: 18691394
PDF is available here.
PDF is available here.
Abstract
We demonstrated for the first time that 1,25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium consistent with the cornifin beta expression and 1,25-dihydroxyvitamin D3 up-regulated 1,25-dihydroxyvitamin D3 receptor expression in vaginal epithelium....
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PMID: 18591157
PDF is available here.
PDF is available here.
Abstract
SPRR1B is a valid biomarker for the study of the molecular mechanisms of squamous metaplasia. There is a definitive link between inflammation and squamous metaplasia in autoimmune-mediated dry eye disease, with IL1beta and IFNgamma likely acting as key participants....
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PMID: 18172072
PDF is available here.
PDF is available here.
Abstract
E2 controls a plethora of cellular pathways that are concordant with its profound effect on vaginal physiology. The data presented here are a useful step toward understanding the role of E2 in vaginal tissue and the development of novel therapeutics for the treatment of VA....
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PMID: 17997058
PDF is available here.
PDF is available here.
Experimental Dermatology (16)11 2007
Abstract
The outermost protein layer of wool cuticle cells is known as the exocuticle a-layer. This layer is a resistant barrier to the degradation of the fibre and, as a result, little is known of its proteinaceous composition. Merino wool fibres were subjected to both proteolytic and chemical digestion and...
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PMID: 17927579
PDF is available here.
PDF is available here.
Laryngoscope (117)10 2007
Abstract
We suggest that autologous cultured nasal squamous epithelium, which differentiates into mucociliary epithelium after in vivo grafting, can be used as a clinically relevant substitute for skin graft in airway luminal reconstruction....
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PMID: 17713448
PDF is available here.
PDF is available here.
Abstract
Conjunctival epithelial response to experimental dryness is related to the degree of CD4+ T-cell infiltration and the level of IFN-gamma production. These findings suggest that IFN-gamma plays a pivotal role in promoting conjunctival squamous metaplasia in dry eye, and they provide insight into the...
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PMID: 17525184
PDF is available here.
PDF is available here.
Abstract
Various envelope precursors are expressed in human corneal epithelium and in HCECs, acute UVB stress differentially alters their expression in HCECs. The expression of envelope precursors and their rapid modulation by UVB supports the role of these proteins in the regulation of ocular surface stress...
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PMID: 16639001
PDF is available here.
PDF is available here.
Experimental Neurology (197)1 2006
Abstract
We evaluated the acute expression of Nogo-A, the Nogo-66 receptor (NgR) and the novel small proline-rich repeat protein 1A (SPRR1A, previously undetected in brain), following experimental lateral fluid percussion (FP) brain injury in rats. Immunofluorescence with antibodies against Nogo-A, NgR and S...
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PMID: 16321384
PDF is available here.
PDF is available here.
Abstract
Small proline-rich proteins (SPRR) are known to construct the cornified cell envelope (CE) in the stratified squamous epithelial cell. Their functions in the simple epithelium such as the uterine epithelium are not clear hitherto. In the present study, the mRNA expression patterns of sprr2 family me...
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PMID: 17169311
PDF is available here.
PDF is available here.
Abstract
We developed a novel method of isolating TEB and ducts free of stroma, and compared the gene expression profiles of these two isolates using oligonucleotide microarrays. Ninety one genes were upregulated in TEB compared to ducts. Three of these genes, Sprr1A, Sema3B, and BASP1, are associated with a...
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PMID: 15920758
PDF is available here.
PDF is available here.
Abstract
We aimed to elucidate novel pathways involved in the pathogenesis of asthma. Employing asthma models induced by different allergens (ovalbumin and Aspergillus fumigatus), we uncovered the involvement of two members of the small proline-rich protein (SPRR) family, SPRR2a and SPRR2b, known to be invol...
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PMID: 15731505
PDF is available here.
PDF is available here.
Cancer Research (65)8 2005
Abstract
We did expressional profiling on 24 paired samples of normal esophageal epithelium, Barrett's metaplasia, and esophageal adenocarcinomas. Matching tissue samples representing the three different histologic types were obtained from each patient undergoing esophagectomy for adenocarcinoma. Our analysi...
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PMID: 15833844
PDF is available here.
PDF is available here.
Journal of Immunology (174)8 2005
Abstract
These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma....
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PMID: 15814686
PDF is available here.
PDF is available here.
Genome Research (14)12 2004
Abstract
We utilized bioinformatic tools and classical biochemical dissection. Long-range comparative sequence analysis identified conserved noncoding sequences (CNSs). Clusters of epidermal-specific DNaseI-hypersensitive sites (HSs) mapped to specific CNSs. Increased prevalence of these HSs in barrier-defic...
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PMID: 15574822
PDF is available here.
PDF is available here.
Abstract
We conclude that low-risk and high-risk HPVs share the ability to alter expression of CCE proteins, although the exact mechanisms may differ. Expression of individual SPRs differed between these types and these alterations may play a role in fragility of CCEs in HPV infection.
Copyright 2004 Wiley-L...
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PMID: 14748073
PDF is available here.
PDF is available here.
Acta Oto-Laryngologica (124)1 2004
Abstract
Using an ALI technique, we were able to differentiate HCE cells into a keratinizing squamous epithelium. When we treated the keratinizing HCE cells with RA, the morphological phenotype progressively changed into mucociliary epithelium. In addition, the expression of cornifin-alpha mRNA was suppresse...
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PMID: 14977075
PDF is available here.
PDF is available here.
Abstract
We reported that expression of SPRR1B in Chinese hamster ovary (CHO) cells is increased as they enter the G0 phase of the cell cycle. The purpose of this study was to further investigate the SPRR1B expression pattern in nonsquamous tumors and to study its role in these cells. Expression of SPRR1B wa...
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PMID: 12832281
PDF is available here.
PDF is available here.
Experimental Dermatology (12)4 2003
Abstract
We have characterized two overlapping genes, SEEK1 and SPR1. SEEK1 encodes two putative protein isoforms: the first being one of 152 amino acids from the full-length splice-isoform (exon 1-6), and the second being one of 100 amino acids from an alternate splice-isoform (exon 1 and 6). SPR1 encodes a...
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PMID: 12930300
PDF is available here.
PDF is available here.
Abstract
The up-regulated expression of keratin 6 and -16, small proline-rich protein 2A, and kallikrein 7 in the conjunctival epithelium of SS patients suggests an anomalous keratinization pattern. Epithelial thickening may be due to amphiregulin and/or c-fos-stimulated cell cycle progression. The up-regula...
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PMID: 12823984
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)24 2003
Abstract
We have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers. Here, we show that a region be...
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PMID: 12682075
PDF is available here.
PDF is available here.
Experimental Dermatology (12)3 2003
Abstract
We investigated the SPR1 gene for disease association by direct sequencing of the SPR1 gene in 116 Chinese patients with PV and 116 normal subjects. Genotyping for HLA-Cw6 was also carried out using polymerase chain reaction/restriction fragment length polymorphism. Significant increase of the HLA-C...
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PMID: 12823445
PDF is available here.
PDF is available here.
Journal of Neuroscience (23)10 2003
Abstract
We consider whether this approach can be adapted to systemic therapy in a postinjury therapeutic time window. Subcutaneous treatment with the NgR antagonist peptide NEP1-40 (Nogo extracellular peptide, residues 1-40) results in extensive growth of corticospinal axons, sprouting of serotonergic fiber...
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PMID: 12764110
PDF is available here.
PDF is available here.
Acta Oto-Laryngologica (123)4 2003
Abstract
This study shows that RA depletion induces keratinizing squamous differentiation in NHMEE cell cultures. This finding supports the hypothesis that middle ear cholesteatoma originates from metaplastic middle ear mucosa....
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PMID: 12797579
PDF is available here.
PDF is available here.
Abstract
The altered expression of SPR2, SPR3 and loricrin reflects the possible adaptation of epidermal keratinocytes in the new environment of the oral cavity....
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PMID: 12786819
PDF is available here.
PDF is available here.
Abstract
We examined gastric killing of gavaged E. coli in gastrin-deficient mice, which have decreased gastric acid production. Additionally, the expression of intestinal genes involved in epithelial protection were analyzed: the mucus layer glycoprotein muclin, the polymeric Ig receptor, trefoil factor 3,...
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PMID: 12772799
PDF is available here.
PDF is available here.
Mammalian Genome (14)2 2003
Abstract
We identified a novel member of the family, the murine ortholog of SPRR4. We present a sequence-verified physical map of the region and identify the complete coding sequence of the Sprr2 genes. Highly specific RNase protection assays based on the 3' untranslated sequences were used to query the expr...
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PMID: 12584609
PDF is available here.
PDF is available here.
Abstract
Molecular Endocrinology (16)12 2002
Abstract
Targeted deletion of the bZIP transcription factor, CCAAT/enhancer binding protein-beta (C/EBPbeta), was shown previously to result in aberrant ductal morphogenesis and decreased lobuloalveolar development, accompanied by an altered pattern of progesterone receptor (PR) expression. Here, similar cha...
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PMID: 12456789
PDF is available here.
PDF is available here.
Genes & Development (16)20 2002
Abstract
We report the molecular identity of two spr genes, spr-1 and spr-5. Our genetic analysis indicates that loss of spr-1 elevates lin-12/Notch gene activity in many different cell fate decisions, suggesting that spr-1 is a negative regulator of LIN-12/Notch signaling. Sequence analysis revealed that sp...
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PMID: 12381669
PDF is available here.
PDF is available here.
BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells.
Abstract
We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1). Though mitogen-activated protein kinase (MAPK) kinase (MEK)-1/2 pathway inhibitors strongl...
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PMID: 12091247
PDF is available here.
PDF is available here.
Journal of Neuroscience (22)4 2002
Abstract
We have used cDNA microarrays to survey those genes induced during successful sciatic nerve regeneration. The small proline-rich repeat protein 1A (SPRR1A) is not detectable in uninjured neurons but is induced by >60-fold after peripheral axonal damage. The protein is localized to injured neurons an...
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PMID: 11850458
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time phorbol 13-myristate 12-acetate (PMA)-inducible expression of SCD markers, SPRRs, in Clara-like H441 cells. The transcriptional stimulation of human SPRR1B expression is mainly mediated by a -150- to -84-bp region that harbors two critical activator protein (AP)-1 s...
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PMID: 11792626
PDF is available here.
PDF is available here.
Abstract
We have investigated the epidermis and forestomach epithelium of these mice by electron microscopy. In both tissues, corneocytes have normal-looking cell envelopes, despite the absence of loricrin, which was confirmed by immunolabeling, and the absence of the distinctive loricrin-containing keratohy...
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PMID: 11851882
PDF is available here.
PDF is available here.
Journal of Cell Science (114)Pt 21 2001
Abstract
Our results show for the first time that UV-induced cornification is accompanied by qualitative changes in CE precursor assembly. SPRR4 is part of an adaptive tissue response to environmental stress, which is likely to compensate for UV induced impairment of the epidermal barrier function....
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PMID: 11719550
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (276)22 2001
Abstract
The protective barrier provided by stratified squamous epithelia relies on the cornified cell envelope (CE), a structure synthesized at late stages of keratinocyte differentiation. It is composed of structural proteins, including involucrin, loricrin, and the small proline-rich (SPRR) proteins, all...
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PMID: 11279051
PDF is available here.
PDF is available here.
Abstract
The transcription factor E2F1 is an important regulator of cell proliferation, apoptosis, and differentiation. A novel mouse gene (Eig3) was originally identified as up-regulated in E2F1-overexpressing keratinocytes by the rapid analysis of gene expression technique. An apparently full-length cDNA a...
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PMID: 11350120
PDF is available here.
PDF is available here.
Genome Research (11)3 2001
Abstract
We report on the identification of 10 additional EDC genes by a powerful subtractive hybridization method using entire YACs (950_e_2 and 986_e_10) to screen a gridded human keratinocyte cDNA library. Localization of the detected cDNA clones has been established on a long-range restriction map coveri...
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PMID: 11230159
PDF is available here.
PDF is available here.
Abstract
We colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the normal mouse and human intestinal microflora. Global intestinal transcriptional responses to colonization were observed with DNA microarrays, and the cellular origins of selected responses were established by...
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PMID: 11157169
PDF is available here.
PDF is available here.
Abstract
We have used a model system consisting of normal and malignant bronchial epithelial (BE) cells to elucidate the differential transcriptional control of SPRR1B. SPRR1B expression is either detectable or PMA (phorbol 13-myristate 12-acetate) -inducible in several malignant BE cells including squamous,...
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PMID: 11313996
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (275)41 2000
Abstract
We have analyzed the signaling pathways that mediate the induction in tracheobronchial epithelial cells. PKC inhibitor ablated PMA-stimulated expression of endogenous SPRR1B and reporter gene expression driven by SPRR1B promoter. PKC activator promoted the transcription. The dominant negative protei...
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PMID: 10918063
PDF is available here.
PDF is available here.
Journal of Cell Biology (151)2 2000
Abstract
We have generated mice that are deficient for this protein. These mice showed a delay in the formation of the skin barrier in embryonic development. At birth, homozygous mutant mice weighed less than control littermates and showed skin abnormalities, such as congenital erythroderma with a shiny, tra...
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PMID: 11038185
PDF is available here.
PDF is available here.
Abstract
As SPRRs were originally cloned on the basis of their expression in ultraviolet light-irradiated keratinocytes, the expression of SPRR3 in actinic lesions is of interest, and might serve as a diagnostic tool....
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PMID: 11069449
PDF is available here.
PDF is available here.
Abstract
To investigate whether ESE-1 gene abnormalities are involved in alterations of epithelial cell differentiation in squamous anal cancer ESE-1 expression and structure were screened in six patients by reverse transcriptase-polymerase chain reaction (RT-PCR) and automated sequence analysis. The complet...
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PMID: 10891534
PDF is available here.
PDF is available here.
Abstract
Involucrin, loricrin and the small proline-rich proteins (SPRRs) are precursors of the cornified envelope of terminally differentiated keratinocytes. The genes for these proteins are closely linked on mouse chromosome 3. Each of the proteins is encoded by a single exon and is largely composed of a s...
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PMID: 10903451
PDF is available here.
PDF is available here.
Abstract
We recently developed wholemount assays that demonstrate epidermal barrier function during late gestation and showed that epidermal barrier forms at specific sites (epidermal initiation sites), and then spreads around the body as apparent moving fronts. We now ask if this is a fundamental and widesp...
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PMID: 10771479
PDF is available here.
PDF is available here.
Abstract
These results suggest a PKC-dependent signaling pathway for both gene induction and enhanced cell cornification by PMA. However, a mitogen-activated protein kinase-specific inhibitor, PD98059, could only block the gene induction event but failed to prevent cell cornification induced by PMA. These re...
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PMID: 10783132
PDF is available here.
PDF is available here.