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Ephrins (8):
Recent article
Ephrins
Developmental Cell (19)2 2010
Abstract
We report that the metalloproteinase activity of ADAM13 is required for early induction of CNC in Xenopus. In both cultured cells and X. tropicalis embryos, membrane-bound Ephrins (Efns) B1 and B2 were identified as substrates for ADAM13. ADAM13 upregulates canonical Wnt signaling and early expressi...
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PMID: 20708595
PDF is available here.
PDF is available here.
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Abstract
We have recently reported that members of the Eph family of receptor tyrosine kinases, namely EphA2 and one of its ligands, ephrin-A4 (EFNA4) can mediate in the traffic of chronic lymphocytic leukemia (CLL) cells and presumably of normal B cells between the blood and the tissues. The importance of E...
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PMID: 20400865
PDF is available here.
PDF is available here.
Abstract
The vertebrate intestine is a complex and highly specialized organ comprising tissues derived from all three germ layers. While a description of the morphological events underlying the consolidation and organization of the endoderm, mesoderm, and ectoderm-derived cells into a multi-layered, continuo...
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PMID: 20691849
PDF is available here.
PDF is available here.
Abstract
All information about the visual world is conveyed to the brain by a single type of neurons at the back of the eye called retinal ganglion cells (RGCs). Understanding how RGC axons locate and wire up with their targets is therefore critical to understanding visual development. In recent years, sever...
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PMID: 20959168
PDF is available here.
PDF is available here.
Brain Research Bulletin (79)5 2009
Abstract
We discuss the roles of the Eph/ephrin system in the establishment of retinotopic projections onto the tectum/colliculus, the most detailed studied model of topographic mapping. The expression patterns of Ephs and ephrins in opposing gradients both in the retina and the tectum/colliculus, label the...
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PMID: 19480983
PDF is available here.
PDF is available here.
Abstract
We demonstrate that Phr1, an evolutionarily conserved regulator of synapse formation and axon guidance, defines a novel molecular pathway required for proper localization of retinogeniculate projections. Following conditional excision of Phr1 in the retina, eye-specific domains within the dLGN are s...
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PMID: 19371781
PDF is available here.
PDF is available here.
Abstract
Bone remodeling is composed of bone formation and resorption. Structural integrity and strength of bone is maintained by the balance between bone formation and resorption.
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PMID: 19432103
PDF is available here.
PDF is available here.
Abstract
We reported that the response of cancellous bone to intermittent PTH is reduced in beta-arrestin2(-/-) mice and suggested that beta-arrestins could influence the bone mineral balance by controlling RANKL and osteoprotegerin (OPG) gene expression. Here, we study the role of beta-arrestin2 on the in v...
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PMID: 19113915
PDF is available here.
PDF is available here.
Abstract
We have mapped the retinotectal projection and the spatiotemporal progression of tectal cellular development onto Eph/ephrin expression patterns in the tectum of larval Rana pipiens, as studied by means of in situ affinity analysis with fusion proteins. EphA expression is maximal in anterior tectum...
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PMID: 19260054
PDF is available here.
PDF is available here.
Abstract
We examined the expression and possible role of Eph/ephrins in the biology of the thymus gland. We reviewed numerous in vivo and in vitro results that confirm a role for Eph and ephrins in the maturation of the thymic epithelial cell (TEC) network and T cell differentiation. Their possible involveme...
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PMID: 19236323
PDF is available here.
PDF is available here.
Postepy biochemii (55)2 2009
Abstract
We summarize recent reports concerning mechanisms of Eph/ephrin signaling and its role in tumour cell migration. Ephrins can regulate cell migration directly, by activation of cytoskeleton rearrangement, or indirectly by changes in cell-cell or cell-ECM adhesion. The relevance of these processes in...
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PMID: 19824471
PDF is available here.
PDF is available here.
EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.
Abstract
We demonstrate that ephrinsA1, A3 and A4, as well as several EphA receptors, are expressed in the closing mouse spinal neural tube. Most ephrinAs and EphA receptors were found to be expressed in multiple tissues in the caudal region, whereas EphA2 receptor was expressed specifically at the apices of...
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PMID: 19247962
PDF is available here.
PDF is available here.
Abstract
Venous and arterial identity is predetermined in the embryo, with embryonic vessels expressing Eph-B4 differentiating into veins and vessels expressing ephrin-B2 differentiating into arteries. The specialized membrane organelles lipid rafts and caveolae serve as localized domains for proteins to int...
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PMID: 19426603
PDF is available here.
PDF is available here.
Abstract
We show that the expression of EphB receptors by motor axons, and ephrin-B ligands by limb mesenchymal cells, directs the ventral trajectory of motor axons. Our findings reveal symmetry in the molecular strategies that establish this aspect of nerve-muscle connectivity. The involvement of ephrin:Eph...
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PMID: 19109910
PDF is available here.
PDF is available here.
Developmental Dynamics (237)11 2008
Abstract
We demonstrate that the receptor Neuropilin-2 is expressed in an increasing nasal-temporal gradient in RGCs, whereas one of its ligands, Semaphorin3F, but not other Sema3 molecules, presents a graded low-rostral to high-caudal expression in the SC when mapping is underway. Neuropilin-2 and its corec...
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PMID: 18942144
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)43 2008
Abstract
We characterize the functional retinocollicular maps in mice lacking the guidance molecules ephrin-A2, -A3, and -A5 and in mice deficient in both ephrin-As and structured spontaneous retinal activity, using a method of Fourier imaging of intrinsic signals. We find that the SC of ephrin-A2/A3/A5 trip...
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PMID: 18945909
PDF is available here.
PDF is available here.
Abstract
Overexpression of EphA4 mRNA expression was observed in 8 (73%) of 11 gastric cancer cell lines and 10 (42%) of 24 gastric cancer tissues. Overexpression of EphA4, analyzed by immunohistochemistry, was observed in 62 (48%) of 129 gastric cancer tissues. EphA4 overexpression, at the protein level, wa...
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PMID: 18837080
PDF is available here.
PDF is available here.
Abstract
We established a novel technique for microdissecting the spontaneously formed vascular-like networks and the randomly arranged cells (nests) from living 3D cultures of melanoma and performed microgenomics analysis. For the first time we show that despite the shared genotype, transcription was differ...
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PMID: 18655191
PDF is available here.
PDF is available here.
Abstract
We show expression of ephrin-A ligands on CD4+ T cells cultured in medium with human serum and the T cell line Jurkat TAg and on cells isolated from patients with T cell lymphomas and T cell leukemias. Functional role and identification of proteins involved in ephrin-A signaling were investigated he...
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PMID: 18593733
PDF is available here.
PDF is available here.
Abstract
The dynamic nature of the skeleton is achieved by a process called "remodeling" which involves the co-ordinated actions of osteoclasts, osteoblasts, osteocytes within the bone matrix and osteoblast-derived lining cells that cover the surface of bone. Remodeling commences with signals that initiate o...
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PMID: 18718546
PDF is available here.
PDF is available here.
Abstract
We show that the p75 neurotrophin receptor (NTR) serves this role in retinal axons. p75(NTR) and ephrin-A colocalize within caveolae along retinal axons and form a complex required for Fyn phosphorylation upon binding EphAs, activating a signaling pathway leading to cytoskeletal changes. In vitro, r...
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PMID: 18786358
PDF is available here.
PDF is available here.
Immunology (125)1 2008
Abstract
We have analysed the phenotype of EphB2 and/or EphB3 deficient thymocytes confirming and extending previous studies on the role of this family of molecules in T-cell differentiation. In all mutant thymuses statistically significant reduced cell contents were observed. This reduction of thymic cellul...
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PMID: 18397270
PDF is available here.
PDF is available here.
Abstract
We have examined cell-biologic mechanisms underlying this switch by analyzing ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells. Their exposure to ephrin-A5 surfaces leads to a rapid conversion from a suspended/nonpolarized to an adherent/pola...
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PMID: 18385452
PDF is available here.
PDF is available here.
Abstract
Abstract
We will discuss the latest advances in the functions of ErbBs and Ephs at the synapse, including dendritic spine morphogenesis, synapse formation and maturation, and synaptic transmission and plasticity. In addition to signaling at interneuronal synapses, communication between neuron and glia is inc...
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PMID: 19785921
PDF is available here.
PDF is available here.
Abstract
Abstract
EPH receptors and their ephrin ligands constitute the largest sub-family of receptor tyrosine kinases (RTKs) and are components of cell signaling pathways involved in animal development. The ability of the EPH/ephrin guidance system to position cells and modulate cell morphology underlies their vari...
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PMID: 18498077
PDF is available here.
PDF is available here.
Abstract
We report that astrocytes in areas outside of the SGZ and SVZ of adult mice express high levels of ephrin-A2 and -A3, which present an inhibitory niche, negatively regulating neural progenitor cell growth. Adult mice lacking both ephrin-A2 and -A3 display active ongoing neurogenesis throughout the C...
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PMID: 18562299
PDF is available here.
PDF is available here.
Neuroscience Letters (438)2 2008
Abstract
Genetic inhibition of the ephrin receptor (EphA6) in mice produced behavioral deficits specifically in tests of learning and memory. Using a fear conditioning training paradigm, mice deficient in EphA6 did not acquire the task as strongly as did wild type (WT) mice. When tested in the same context 2...
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PMID: 18450376
PDF is available here.
PDF is available here.
Journal of Cell Biology (181)6 2008
Abstract
We report that the ephrin-B-PDZ-RGS3 signaling pathway functions to regulate this balance in the developing mammalian cerebral cortex. During cortical neurogenesis, expression of ephrin-B1 and PDZ-RGS3 is specifically seen in progenitor cells and is turned off at the onset of neuronal differentiatio...
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PMID: 18541704
PDF is available here.
PDF is available here.
Development Growth & Differentiation (50 Suppl 1) 2008
Abstract
We here overview the inductive events that have recently been shown to play important roles in the formation of the intersomitic fissures. We then discuss molecular mechanisms underlying these inductive actions, and also discuss how the fissure formation is interpreted by the subsequent morphogenesi...
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PMID: 18482400
PDF is available here.
PDF is available here.
Abstract
We describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling....
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PMID: 18406338
PDF is available here.
PDF is available here.
Developmental Biology (317)2 2008
Abstract
We show that bus-8, which encodes a predicted glycosyltransferase, is essential for embryonic enclosure and acts in or with ephrin signalling to mediate neuroblast organisation and to permit epidermal migration. BUS-8 acts non-cell-autonomously in this process, and likely modifies an extracellular r...
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PMID: 18395708
PDF is available here.
PDF is available here.
Physiological Genomics (33)2 2008
Abstract
We hypothesize that differential growth may be due to differences in hormonal responsiveness that is partially mediated by differences in expression of genes involved in signal transduction. We used the bovine dominant follicle model, microarrays, quantitative real-time PCR and RNA interference to e...
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PMID: 18285519
PDF is available here.
PDF is available here.
Abstract
We report that, within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections. These heterotypic axon-axon interactions require motor axonal EphA3/EphA4 receptor tyrosine kinases activated by cognate se...
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PMID: 18403711
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)15 2008
Abstract
We have investigated whether reverse signaling via a glycosyl-phosphatidylinositol (GPI)-linked ephrin controls the behavior of migratory neurons in vivo. During the formation of the enteric nervous system (ENS) in the moth Manduca, approximately 300 neurons [enteric plexus (EP) cells] migrate onto...
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PMID: 18400884
PDF is available here.
PDF is available here.
Abstract
Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on neighboring cells. The ensuing bidirectional signals have emerged as a major form of contact-dependent communication between cells. New findings reveal that Eph receptors and ephrins coordinate not only dev...
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PMID: 18394988
PDF is available here.
PDF is available here.
Abstract
We will review recent advances on the role of Eph-ephrin signalling in the intestine and other organs....
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PMID: 18353626
PDF is available here.
PDF is available here.
Abstract
We will summarize the published data on the "non-APP" functions of all three ADAMs, the further evaluation of which may be crucial when attempting to treat Alzheimer s Disease by increasing their expression and/or activity. As the knockouts of ADAM10 and ADAM17 are only informative for their roles i...
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PMID: 18393804
PDF is available here.
PDF is available here.
Abstract
We performed a large-scale screening and successfully identified a variety of molecules with various asymmetrical expression patterns along both axes in the developing retina. Included were many novel molecules with unknown functions, together with known molecules. Through analyses of these molecule...
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PMID: 18421984
PDF is available here.
PDF is available here.
Abstract
During development, neurons migrate from their birthplace to their appropriate positions and extend their axons toward their proper targets. These events are crucial for the establishment of CNS cytoarchitectures and neural cuircuits essential for brain functions. Recent genetic and biochemical stud...
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PMID: 18421982
PDF is available here.
PDF is available here.
Abstract
Abstract
We have previously shown that precise mapping of thalamocortical projections requires both molecular cues and structured retinal activity. To probe the interaction between these two mechanisms, we studied mice deficient in both ephrin-As and retinal waves. Functional and anatomical cortical maps in...
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PMID: 18304481
PDF is available here.
PDF is available here.
Abstract
We verified thus the possibility that GGT-mediated metabolism of glutathione may favour the supply of ascorbic acid to bronchial cells. Using human BEAS-2B cells transfected with GGT cDNA, as well as WT cells exposed to ELF-like GGT concentrations, we observed that indeed much higher (5-10 fold) lev...
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PMID: 18234566
PDF is available here.
PDF is available here.
Abstract
We tested the response of chick retinal ganglion cell (RGC) axons, which are guided in vivo by ephrin gradients, to these in vitro gradients. Temporal, but not nasal axons stop at a distinct zone in the gradient, which is covered with a certain surface density of substrate-bound ephrinA5. Within the...
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PMID: 17557153
PDF is available here.
PDF is available here.
Nature Neuroscience (11)2 2008
Abstract
We report that the activation of ephrin-B reverse signaling in the developing Xenopus laevis optic tectum promotes morphological and functional maturation of retinotectal synapses. Elevation of ephrin-B signaling increased the number of retinotectal synapses and stabilized the axon arbors of retinal...
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PMID: 18193042
PDF is available here.
PDF is available here.
Anticancer Research (28)2A 2008
Abstract
A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r = 0.97, p < 0.01) and EphB3 (r = 0.94, p < 0.05); overexpression of ephrin-B2 correlated with overexpression of EphB1 (r = 0.94, p <...
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PMID: 18507018
PDF is available here.
PDF is available here.
Abstract
Eph receptor tyrosine kinases (Ephs) and their membrane-anchored ligands (ephrins) form a vital cell communication system capable of bi-directional signaling. This Eph receptor/ephrin system has classically been demonstrated to play a role in development. However, emerging evidence has revealed diff...
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PMID: 18525107
PDF is available here.
PDF is available here.
BMC Cell Biology (9)1 2008
Abstract
Our findings indicate that Eph receptors form three major clades: one comprised of non-chordate and cephalochordate Eph receptors, a second comprised of urochordate Eph receptors, and a third comprised of vertebrate Eph receptors. Ephrins, on the other hand, fall into either a clade made up of the n...
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PMID: 18495034
PDF is available here.
PDF is available here.
Abstract
The maintenance of bone homeostasis is tightly controlled, and largely dependent upon cellular communication between osteoclasts and osteoblasts, and the coupling of bone resorption to bone formation. This tight coupling is essential for the correct function and maintenance of the skeletal system, r...
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PMID: 18797510
PDF is available here.
PDF is available here.
Abstract
Successful axonal outgrowth in the adult central nervous system (CNS) is central to the process of nerve regeneration and brain repair. To date, much of the knowledge on axonal guidance and outgrowth comes from studies on neuritogenesis and patterning during development where distal...
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PMID: 18544498
PDF is available here.
PDF is available here.
Brain Research (1184) 2007
Abstract
We will focus on recent findings highlighting the functions of ephrin/Eph signaling in dendritic spine morphogenesis, synapse formation and synaptic plasticity....
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PMID: 17166489
PDF is available here.
PDF is available here.
Experimental Cell Research (313)20 2007
Abstract
We show that soluble ephrin A5 is subject to oligomerization. Ephrins A1 and A5 are substrates for a cross-linking enzyme, tissue transglutaminase, which mediates the formation of oligomeric ephrin. Transglutaminase-cross-linked ephrin binds to A-type Eph receptors, stimulates Eph kinase activity, a...
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PMID: 17707797
PDF is available here.
PDF is available here.
Abstract
We have studied the biological characteristics of ovarian carcinoma, breast carcinoma, and malignant mesothelioma cells in effusions and compared it to their counterparts in primary tumors and solid metastases. Our data show that a large number of cancer-associated molecules, including cell adhesion...
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PMID: 18298385
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We reported that prior treatment of primary chronic lymphocytic leukaemia (CLL) cells with histone deacetylase inhibitors was required to sensitize CLL cells to TRAIL and, using various receptor-selective TRAIL mutant ligands, we demonstrated that CLL cells signalled to apoptosis primarily through T...
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PMID: 17922877
PDF is available here.
PDF is available here.
Schizophrenia Research (96)1-3 2007
Abstract
We have used two contrasting methodologies to determine the validity of the findings reported above which if true would have major implications for the pathogenesis of schizophrenia. Samples from a UK population were tested using a method of allele quantification by DNA pooling and samples from Belg...
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PMID: 17826036
PDF is available here.
PDF is available here.
Developmental Dynamics (236)10 2007
Abstract
We provide one mechanistic basis for the requirement for FoxC1 in vertebrate development. We find that, in Xenopus laevis embryos, FoxC1 expression is regulated by the maternal T-box transcription factor VegT, via the nodal sub-family of TGFbeta signaling transducers. We show that at the late neurul...
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PMID: 17705306
PDF is available here.
PDF is available here.
Abstract
We demonstrate that SYT-SSX2 is a unique oncogene. Rather than confer enhanced proliferation on its target cells, SYT-SSX2 instead causes a profound alteration of their architecture. This aberrant morphology included elongation of the cell body and formation of neurite-like extensions. We also obser...
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PMID: 17686994
PDF is available here.
PDF is available here.