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Heterotrimeric GTP-Binding Proteins (2):
Recent article
Heterotrimeric GTP-Binding Proteins
Abstract
We evaluate the expression and activation of rat diaphragm or cultured skeletal muscle G-proteins using [(35)S]GTPγS. Total membrane Gα subunit content was 4-7 times higher in rat primary cultured myotubes and L6 cell line than in diaphragm (32.6±1.2fmol/mg protein) and 7-27% of them were in the...
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PMID: 21084061
PDF is available here.
PDF is available here.
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Abstract
G protein-coupled receptors (GPCRs) are expressed throughout the nervous system where they regulate multiple physiological processes, participate in neurological diseases, and are major targets for therapy. Given that many GPCRs respond to neurotransmitters and hormones that are pres...
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PMID: 20632972
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We hypothesize that lyso-PC activation of G2A causes the increases in cytosolic Ca²(+) via release of G(α) and G(βγ) subunits, kinase activation, and the recruitment of clathrin, β-arrestin-1 and GRK6 (G-protein receptor kinase 6) to G2A for signal transduction. PMNs were isolated by standard t...
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PMID: 20799926
PDF is available here.
PDF is available here.
Neuroscience (169)3 2010
Abstract
We find that chickens homozygous for the RGE allele completely lack GNB3 protein. We find that the pattern of expression of GNB3 in the retina is highly conserved across vertebrate species, including teleost fish (Carassius auratus), frogs (Xenopus laevis), chickens (Gallus domesticus), mice (Mus mu...
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PMID: 20538044
PDF is available here.
PDF is available here.
Human Genetics (128)2 2010
Abstract
A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) gen...
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PMID: 20473689
PDF is available here.
PDF is available here.
Cellular Signalling (22)9 2010
Abstract
Regulators of G protein signalling (RGS) proteins are united into a family by the presence of the RGS domain which serves as a GTPase-activating protein (GAP) for various Galpha subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins regulate signalling of numerous G protein-coup...
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PMID: 20363320
PDF is available here.
PDF is available here.
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
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PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
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PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
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PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)1 2010
Abstract
Heterotrimeric G proteins, consisting of the guanine nucleotide-binding Galpha subunits with GTPase activity and the closely associated Gbeta and Ggamma subunits, are important signaling components for receptors with seven transmembrane domains (7TMRs). These receptors, also termed G...
|
PMID: 20404072
PDF is available here.
PDF is available here.
Abstract
We generate and analyze microarray data from guard cells and leaves of G-protein subunit mutants of the model plant Arabidopsis thaliana, with or without treatment with the stress hormone, abscisic acid. Although G-protein control of the transcriptome has received little attention to date in any sys...
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PMID: 20531402
PDF is available here.
PDF is available here.
Abstract
We present the results of combining design and selection to remodel a protein-peptide binding interface, using the peptide PTIEEVD and the TPR1 module interaction as our test case. We initially used the program Rosetta to interrogate possible TPR1 sequences compatible with binding the peptide PTIEEV...
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PMID: 20304973
PDF is available here.
PDF is available here.
Pharmacological Reviews (62)2 2010
Abstract
Heptahelical G protein-coupled receptors are the most diverse and therapeutically important family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins that transmit intracellular signals by regulating effector enzymes or ion channels. G protein signaling is terminate...
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PMID: 20427692
PDF is available here.
PDF is available here.
Cancer Investigation (28)5 2010
Abstract
GNB3 825C>T SNP may be a novel independent prognostic marker for patients suffering from extrahepatic CCA with the CC genotype to be associated with a favorable clinical outcome. Further prospective studies are needed to confirm these results and reveal additional functional SNP effects....
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PMID: 19968497
PDF is available here.
PDF is available here.
Abstract
The prevalence of Gly972Arg genotype in PCOS women was 22.64% and was not significantly higher than in control group with the prevalence 9.52%. The frequency of T alleles was 28% in PCOS group that was similar to control group (29%). We did not find the significant differences in the frequency of TC...
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PMID: 20170352
PDF is available here.
PDF is available here.
Abstract
We test this extended scheme for rhodopsin in a membrane bilayer environment by investigating lipid perturbation of the activation mechanism. We found that symmetric membrane lipids having two unsaturated acyl chains, such as 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), selectively stabilize the...
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PMID: 20230054
PDF is available here.
PDF is available here.
Abstract
We developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gbetagamma dimer to repress transcription of the glucose-regulated fbp1(+) gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues, with all but one conf...
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PMID: 20139237
PDF is available here.
PDF is available here.
Abstract
Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear. The number of genetic association studies investigating varian...
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PMID: 20425202
PDF is available here.
PDF is available here.
Eukaryotic Cell (9)4 2010
Abstract
We developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gbetagamma dimer to repress transcription of the glucose-regulated fbp1(+) gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues, with all but one conf...
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PMID: 20139237
PDF is available here.
PDF is available here.
Eukaryotic Cell (9)4 2010
Abstract
We developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gbetagamma dimer to repress transcription of the glucose-regulated fbp1(+) gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues, with all but one conf...
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PMID: 20139237
PDF is available here.
PDF is available here.
Eukaryotic Cell (9)4 2010
Abstract
We developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gbetagamma dimer to repress transcription of the glucose-regulated fbp1(+) gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues, with all but one conf...
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PMID: 20139237
PDF is available here.
PDF is available here.
Eukaryotic Cell (9)4 2010
Abstract
We developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gbetagamma dimer to repress transcription of the glucose-regulated fbp1(+) gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues, with all but one conf...
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PMID: 20139237
PDF is available here.
PDF is available here.
Pharmacogenomics (11)3 2010
Abstract
No SNPs or haplotypes were associated with essential hypertension. In females only, GNB3 SNPs and haplotypes were associated with the blood pressure response (p < 0.05). CONCLUSION: Our study confirmed the sex-specific association of GNB3 with the blood pressure response to atenolol with no substant...
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PMID: 20235788
PDF is available here.
PDF is available here.
Abstract
Taste dysfunction that develops after radiotherapy for head and neck cancer impairs patients' quality of life. Although taste cells have been shown to degenerate after exposure to X-ray irradiation, the alteration in taste cell population is unclear. This study investigated the histo...
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PMID: 19702869
PDF is available here.
PDF is available here.
Kardiologiia (50)1 2010
Abstract
We examined 177 patients - 83 (46.9%) men and 94 (53.1%) women. Mean age was 60.6 +/- 0.76 years. In the studied group there were 19 patients (10.9%) with I degree arterial hypertension (AH), 57 patients (32.8%) with II degree AH, and 101 patients (56.3%) with III degree AH. Structural peculiarities...
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PMID: 20144152
PDF is available here.
PDF is available here.
Science Signaling (3)141 2010
Abstract
We directly measured the mobilities of cyclic adenosine monophosphate (cAMP) receptor 1 (cAR1), a chemoattractant receptor, and a G protein βγ subunit in live cells. We found that cAR1 diffused more slowly in the plasma membrane than did Gβγ. Upon binding of ligand to the receptor, the mobility...
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PMID: 20876874
PDF is available here.
PDF is available here.
Abstract
I have described a general mechanism of signal transduction through GPCR/G proteins, structure of GPCRs, family of GPCRs and plant GPCR and its role....
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PMID: 19826234
PDF is available here.
PDF is available here.
médecine/sciences (25)10 2009
Abstract
Extracellular signals received by G protein-coupled receptors (GPCRs) are transduced into intracellular responses following the activation of heterotrimeric G proteins. As their names suggests, they are composed of three subunits, Galpha and Gbetagamma, the latter being effectively treated as a sing...
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PMID: 19849984
PDF is available here.
PDF is available here.
Abstract
These results indicate that Galphas augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 lung cancer cells, suggesting that the efficacy of radiotherapy of lung cancer may be improved by modulating Gs signaling pathway....
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PMID: 19381065
PDF is available here.
PDF is available here.
Abstract
We examined the effect of HIMF on intracellular Ca(2+) in human pulmonary artery smooth muscle cells (SMC). Ca(2+) imaging in fluo 4-loaded human pulmonary artery SMC revealed that recombinant murine HIMF increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in a sustained and oscillatory manne...
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PMID: 19429774
PDF is available here.
PDF is available here.
Journal of Cell Science (122)Pt 15 2009
Abstract
We now report the kinetics of G-protein activation as a loss of FRET prior to and after cAMP addition by using total internal reflection fluorescence microscopy (TIRFM). We also performed photobleaching experiments to measure G-protein recovery times. Our data show that inactive and active G-protein...
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PMID: 19584094
PDF is available here.
PDF is available here.
Eukaryotic Cell (8)7 2009
Abstract
We identified and functionally characterized genes encoding three Galpha proteins and one Gbeta protein in the dimorphic fungal wheat pathogen Mycosphaerella graminicola, which we designated MgGpa1, MgGpa2, MgGpa3, and MgGpb1, respectively. Sequence comparisons and phylogenetic analyses showed that...
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PMID: 19411619
PDF is available here.
PDF is available here.
Abstract
We genotyped 383 RA patients and 432 controls. GNB3 C825T was identified using real-time polymerase chain reaction (PCR) and melting curve analysis. There were no differences in the frequencies of the GNB3 C825T genotype and alleles between RA and controls. Within RA patients, prevalence of hyperten...
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PMID: 19811352
PDF is available here.
PDF is available here.
Neuroreport (20)10 2009
Abstract
We investigated the expression patterns of transduction components and the contribution of intracellular Ca2+ stores. Of 64 cells responding to bitter compounds, 63% of the cells expressed the taste tissue-specific G-protein alpha-gustducin. Of the alpha-gustducin immunoreactive cells, 78% expressed...
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PMID: 19562832
PDF is available here.
PDF is available here.
Abstract
We review the literature and summarize apoptotic signaling through each of the four heterotrimeric G protein families (and the relevant G protein coupled receptors), and discuss limitations and future directions for research on regulating apoptosis through G protein coupled mechanisms. Continued inv...
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PMID: 19601805
PDF is available here.
PDF is available here.