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Phospholipid Transfer Proteins (0):
Recent article
Phospholipid Transfer Proteins
Journal of Urology (186)3 2011
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine.
Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute...
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PMID: 21784463
PDF is available here.
PDF is available here.
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Journal of Urology (186)3 2011
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine.
Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute...
|
PMID: 21784463
PDF is available here.
PDF is available here.
Journal of Urology (186)3 2011
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine.
Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute...
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PMID: 21784463
PDF is available here.
PDF is available here.
Abstract
Journal of Clinical Oncology (28)28 2010
Abstract
We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes. We defined stromal metagenes and tested their prognostic values in 684 node-negative patients who received no systemic adjuvant thera...
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PMID: 20805453
PDF is available here.
PDF is available here.
FEBS Letters (584)13 2010
Abstract
The best understood consequence of the collapse of lipid asymmetry is exposure of phosphatidylserine (PS) in the external leaflet of the plasma membrane bilayer, where it is known to serve at least two major functions: providing a platform for development of the blood coagulation cascade and present...
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PMID: 20302864
PDF is available here.
PDF is available here.
Abstract
We show that MPD-flippase activity can be reconstituted in large unilamellar proteoliposomes prepared from phosphatidylcholine and Triton X-100-solubilized rat liver ER-membrane proteins. Using carboxy-2,2,6,6-tetramethylpiperidine 1-oxyl NO(+) as a topological probe to selectively oxidize MPD molec...
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PMID: 20534553
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of PLTP region tagging single nucleotide polymorphisms (SNPs) on the prediction of both carotid artery disease (CAAD) and PLTP activity. CAAD effects were evaluated in 442 Caucasian male subjects with severe CAAD and 497 vascular disease-free controls. SNP prediction of PLTP...
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PMID: 19965587
PDF is available here.
PDF is available here.
Abstract
We show that these differences allow the enzymes to control regioselectivity of posttranslational modifications, helping to control product chemistry in this hypervariable family of marine natural products....
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PMID: 20210311
PDF is available here.
PDF is available here.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (41)2 2010
Abstract
To investigate the proteomics change in injured lung tissues of adult rats subjected to acrolein inhalation for 6 weeks.
Two-dimensional electrophoresis was used to define the change of proteomic expresses and mass spectrometry was applied to identify the amino acid s...
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PMID: 20506650
PDF is available here.
PDF is available here.
Abstract
To determine whether hyperalphalipoproteinemia modifies carotid intima-media thickness (cIMT) and/or influences the relationship of clinical and biochemical parameters with cIMT. This study was conducted on 169 asymptomatic individuals, classified as hyperalphalipoproteinemic (Hyper-A) (Hyper-A, n =...
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PMID: 19876761
PDF is available here.
PDF is available here.
Abstract
Abstract
These findings point to acquired LCAT and Apo A-1 deficiencies and tend to exclude dysregulation of PLTP or CETP in the pathogenesis of HDL abnormalities in haemodialysis patients....
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PMID: 19297356
PDF is available here.
PDF is available here.
Mammalian Genome (20)8 2009
Abstract
These results identify SH3PXD2B as a podosomal-adaptor protein required for postnatal growth and development, particularly within physiologic contexts involving extracellular matrix regulation....
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PMID: 19669234
PDF is available here.
PDF is available here.
Abstract
PLT (%) was higher in the T2DM group than in the control group (25.2 +/- 3.2 and 19.7 +/- 3.2 respectively; p < 0.001), as was free cholesterol (% FC): 9.1 +/- 2.7 and 6.3 +/- 1.5 respectively; p < 0.001. The diagnosis of microalbuminuria (MA) was not associated with changes in lipid transfers. Insu...
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PMID: 19360241
PDF is available here.
PDF is available here.
Abstract
We analyzed the role of the Caenorhabditis elegans Drs2p homologue transbilayer amphipath transporter (TAT)-1 in intracellular trafficking. tat-1 is expressed in many tissues including the intestine, the epidermis and the nervous system. In intestinal cells, tat-1 loss-of-function mutants accumulate...
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PMID: 18939953
PDF is available here.
PDF is available here.
Abstract
A series of 16 synthetic scramblase candidates were prepared from a tris(aminoethyl)amine (TREN) scaffold and evaluated for ability to facilitate translocation of fluorescent phospholipid probes across vesicle membranes and endogenous phosphatidylserine across the plasma membrane of nucleated cells....
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PMID: 19028426
PDF is available here.
PDF is available here.
Abstract
Lipids are actively involved in many cellular processes. Their roles pivot toward determining membrane structure, compartment targeting, and membrane fusion but also regulation of cell signaling via their interactions with proteins and the production of second messengers. As they play a key role in...
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PMID: 19160679
PDF is available here.
PDF is available here.
Abstract
Mammalian cells have evolved proteins that can extract single lipids from membranes and sequester them in their hydrophobic cavity. These proteins, collectively known as lipid transport proteins, play essential roles in many aspects of lipid metabolism, lipid signaling, and membrane traffic. Phospha...
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PMID: 19160681
PDF is available here.
PDF is available here.
Biotechnology Letters (30)12 2008
Abstract
Human phospholipid scramblase 1 (hPLSCR1) scrambles plasma membrane phospholipids during cell activation, blood coagulation and apoptosis. It was over-expressed in E. coli with a histidine tag and purified from the inclusion bodies (*30 mg/l culture broth) under denaturing conditions using 8 M urea....
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PMID: 18629440
PDF is available here.
PDF is available here.
Metabolism (57)12 2008
Abstract
We previously demonstrated the role of a phospholipid transfer protein (PLTP) gene variation (rs2294213) in determining levels of high-density lipoprotein cholesterol (HDL-C) in hypoalphalipoproteinemia (HypoA). We have now explored the role of PLTP in hyperalphalipoproteinemia (HyperA). The human P...
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PMID: 19013296
PDF is available here.
PDF is available here.
Abstract
We will attempt to highlight some of the recent studies of the roles of this class of lipids in plant membrane trafficking, particularly on their important roles in polarized membrane trafficking in plants....
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PMID: 19028349
PDF is available here.
PDF is available here.
Abstract
We previously isolated 102 genes expressed early in mouse 3T3-L1 preadipocyte cells using a PCR subtraction system. About half of the genes isolated appeared to be unknown. After isolating full-length cDNAs of the unknown genes, one of them, named factor for adipocyte differentiation 49 (fad49), app...
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PMID: 18959745
PDF is available here.
PDF is available here.
Abstract
We assessed cerebrospinal fluid (CSF) levels of apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, cholesterol, secreted amyloid-beta protein precursor alpha and beta (sAbetaPPalpha, sAbetaPPbeta), amyloid-beta peptides 1-40 (Abeta_{40}) and 1-42 (Abeta_{42}), total tau and tau...
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PMID: 18997294
PDF is available here.
PDF is available here.
Abstract
We suggest combinatorial Sec14/Tlg2 dysfunction evokes inappropriate turnover of complex sphingolipids in endosomes. One result of this turnover is potentiation of ceramide-activated phosphatase-mediated down-regulation of the UPR. These results provide new insight into Sec14 function, and they emph...
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PMID: 18753406
PDF is available here.
PDF is available here.
Abstract
We have known the enzymes required for the biosynthesis of peptidoglycan; what was missing was the flippase that translocates the lipid-anchored precursors across the cytoplasmic membrane before their polymerization into mature peptidoglycan. Using a reductionist bioinformatics approach, I have iden...
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PMID: 18832143
PDF is available here.
PDF is available here.
Abstract
Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. M...
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PMID: 18791845
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1783)10 2008
Abstract
The conditioned medium (CM) from mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein alpha (PI-TPalpha; SPIalpha cells) demonstrates an increased anti-apoptotic activity compared with CM from wild type NIH3T3 (wtNIH3T3) cells. As previously shown, the anti-apoptotic ac...
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PMID: 18501717
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)37 2008
Abstract
We previously reported the phosphorylation on tyrosine of phospholipid scramblase 1 (PLSCR1) after FcepsilonRI aggregation. Here, PLSCR1 expression was knocked down in the RBL-2H3 mast cell line using short hairpin RNA. Knocking down PLSCR1 expression resulted in significantly impaired degranulation...
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PMID: 18579528
PDF is available here.
PDF is available here.
Abstract
We chemically targeted their C95 residue that, although non-essential for lipid transfer, is buried within the phospholipid-binding cavity, and so, its chemical modification prevents PtdIns binding because of steric hindrance. This treatment resulted in entrapment of open conformation PITPs at the m...
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PMID: 18636990
PDF is available here.
PDF is available here.
Oral Diseases (14)6 2008
Abstract
Full-mouth tooth extraction significantly reduces SAA, a marker of inflammation, while it does not affect plasma PLTP activity. However, the inverse correlation between PLTP activity and average PPD suggests that increased PLTP activity may limit periodontal tissue damage....
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PMID: 18826383
PDF is available here.
PDF is available here.
Abstract
We now show that a specific ER protein(s), but not Rft1, is required to flip Man(5)GlcNAc(2)-PP-Dol in reconstituted vesicles. Rft1 may have a critical accessory role in translocating Man(5)GlcNAc(2)-PP-Dol in vivo, but the Man(5)GlcNAc(2)-PP-Dol flippase itself remains to be identified....
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PMID: 18668045
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)30 2008
Abstract
We report the reconstitution of M5-DLO flipping in proteoliposomes generated from Triton X-100-extracted Saccharomyces cerevisiae microsomal proteins. Flipping was assayed by using the lectin Concanavalin A to capture M5-DLOs that had been translocated from the inner to the outer leaflet of the vesi...
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PMID: 18597486
PDF is available here.
PDF is available here.
FASEB Journal (22)7 2008
Abstract
We show that decreased plasma concentrations of glucose and free fatty acids in fasting PC-TP-deficient (Pctp(-/-)) mice are attributable to increased hepatic insulin sensitivity. In hyperinsulinemic-euglycemic clamp studies, Pctp(-/-) mice exhibited profound reductions in hepatic glucose production...
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PMID: 18347010
PDF is available here.
PDF is available here.
Abstract
We report that exogenous-expression of PLS3 enhances apoptotic death induced by TRAIL. This is acheived by potentiating the mitochondrial arm of the death pathway. Thereby, PLS3 expression facilitates changes in mitochondrial membrane lipids that promote the release of apoptogenic factors and conseq...
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PMID: 18491232
PDF is available here.
PDF is available here.
Abstract
In conclusion, acute elevation of PLTP activity destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis....
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PMID: 18421000
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)27 2008
Abstract
We show that the intravascular redistribution of LPS from the plasma lipoprotein-free fraction toward circulating lipoproteins is delayed in PLTP-deficient mice. In agreement with earlier in vitro studies, which predicted the neutralization of the endotoxic properties of LPS when associated with lip...
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PMID: 18458077
PDF is available here.
PDF is available here.
Atherosclerosis (199)1 2008
Abstract
We found a positive correlation between apoA-I and levels of CD4+ cells (r(2)=0.3, p<0.001). Plasma level of phospholipid transfer protein was reduced in the group on antiretroviral therapy. Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directi...
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PMID: 18054941
PDF is available here.
PDF is available here.
Abstract
The increased cholesterol efflux potential of HDL(2) is most likely an anti-atherogenic feature linked to heavy alcohol consumption. The cholesterol efflux and HDL phospholipids also associated strongly within the whole study group (r(s) = 0.910, p
PDF is available here.
PDF is available here.
Abstract
While it was previously known that phosphatidylcholine biosynthesis was required for normal hepatic VLDL secretion, recent studies have shown that both phosphatidylcholine biosynthetic pathways (the cytidine 5'-diphosphocholine and the phosphatidylethanolamine methylation pathways) are required. In...
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PMID: 18460912
PDF is available here.
PDF is available here.
Abstract
We have developed VisGrid algorithm that uses the visibility criterion to characterize local geometric features of protein surfaces. Unlike existing methods, which only concerns identifying pockets that could be potential ligand-binding sites in proteins, VisGrid is also aimed to identify large prot...
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PMID: 17975834
PDF is available here.
PDF is available here.
Abstract
Proteomic and molecular evidence supports the presence of a small number of lipid transporters that control the distribution of phospholipids across the erythrocyte membrane. These include members of the ATP-binding cassette and P-type ATPase transporter families. Recent data indicate that these pro...
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PMID: 18391783
PDF is available here.
PDF is available here.
Abstract
Abstract
We report that the Caenorhabditis elegans P-type adenosine triphosphatase homolog, TAT-1, is critical for maintaining cell surface asymmetry of phosphatidylserine (PS). In animals deficient in tat-1, PS is abnormally exposed on the cell surface, and normally living cells are randomly lost through a...
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PMID: 18436785
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)17 2008
Abstract
We examined the ability of synthetic peptides corresponding to helices in PLTP to remove cellular cholesterol by the ABCA1 pathway. Of the seven helices tested, only one containing PLTP residues 144-163 (p144), located at the tip of the N-terminal barrel, promoted ABCA1-dependent cholesterol efflux...
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PMID: 18287097
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)15 2008
Abstract
We investigated the regulation of tBid-induced cytochrome c release and apoptosis by phospholipid scramblase 3 (PLS3). Overexpression of PLS3 enhanced, whereas downregulation of PLS3 delayed, TNF-alpha-induced apoptosis and targeting of tBid to mitochondria. On the basis of the theory that tBid targ...
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PMID: 18358005
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)16 2008
Abstract
We show that nonapoptotic PS externalization induced through the high affinity IgE receptor (FcepsilonRI) or the glycosylphosphatidylinositol-anchored protein Thy-1 does not correlate with enhanced tyrosine phosphorylation of PLSCR1. In addition, PS externalization in FcepsilonRI- or Thy-1-activated...
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PMID: 18281686
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)15 2008
Abstract
We found that ALG-2 interacts with PLSCR3 expressed in HEK293 cells in a Ca(2+)-dependent manner by co-immunoprecipitation, pulldown with glutathione S-transferase (GST) fused ALG-2 and an overlay assay using biotin-labeled ALG-2. The GST fusion protein of an alternatively spliced isoform of ALG-2,...
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PMID: 18256029
PDF is available here.
PDF is available here.
Cancer Science (99)4 2008
Abstract
We investigate the potential role of wogonin in the proliferation and differentiation of NB4, a human promyelocytic leukemia cell line derived from a patient with acute promyelocytic leukemia. Our results indicated that wogonin significantly suppressed the proliferation and efficiently induced the d...
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PMID: 18377421
PDF is available here.
PDF is available here.
Abstract
We report that chronic high-fat, high-cholesterol diet feeding markedly increased plasma cholesterol levels in C57BL/6 mice. PLTP deficiency attenuated diet-induced hypercholesterolemia by dramatically reducing apolipoprotein E-rich lipoproteins (-88%) and, to a lesser extent, LDL (-40%) and HDL (-3...
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PMID: 18198166
PDF is available here.
PDF is available here.
Clinical Endocrinology (68)3 2008
Abstract
Plasma PLTP activity is determined by MetS and by diabetes per se. Serum transaminases are independently associated with PLTP activity. We suggest that this lipid transfer protein may be a marker for NAFLD....
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PMID: 17877759
PDF is available here.
PDF is available here.
Molecular Cell (29)2 2008
Abstract
We report that Sec14 binds PtdIns and PtdCho at distinct (but overlapping) sites, and both PtdIns- and PtdCho-binding activities are essential Sec14 activities. We further show both activities must reside within the same molecule to reconstitute a functional Sec14 and for effective Sec14-mediated re...
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PMID: 18243114
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)3 2008
Abstract
We performed a comparative analysis in Drosophila models of the two diseases. We show that while some modifier genes function similarly in SCA1 and HD Drosophila models, others have model-specific effects. Surprisingly, certain modifier genes modify SCA1 and HD models in opposite directions, i.e. th...
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PMID: 17984172
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1778)2 2008
Abstract
We report evidences against a role of endocytosis in perifosine uptake by human KB carcinoma cells. We have generated a KB cell line resistant to perifosine (KB PER(R) clone10), which shows cross-resistance to the ALPs miltefosine and edelfosine, a marked impairment in the uptake of (14)C-perifosine...
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PMID: 18005660
PDF is available here.
PDF is available here.
Atherosclerosis (196)2 2008
Abstract
We tested whether hypertriglyceridemia associated with type 2 diabetes mellitus is accompanied by alterations in pre beta-HDL, which are considered to be initial acceptors of cell-derived cholesterol, and by changes in the ability of plasma to promote cellular cholesterol efflux. In 28 hypertriglyce...
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PMID: 17275009
PDF is available here.
PDF is available here.
Abstract
We conclude that PLTP expression by bone marrow derived cells results in atherogenic effects on plasma lipids, increased PLTP activity, high local PLTP protein levels in the atherosclerotic lesions and increased atherosclerotic lesion size....
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PMID: 18509527
PDF is available here.
PDF is available here.
Abstract
The ability of plasma from MetS subjects to promote fibroblast cholesterol efflux is not defective, although HDL cholesterol is decreased. Higher cholesterol esterification, PLTP activity, and apo E levels may contribute to the maintenance of cholesterol efflux in MetS....
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PMID: 18166817
PDF is available here.
PDF is available here.
Biochemical Journal (409)1 2008
Abstract
We focus on the role of SFH2/CSR1, a hypoxic gene related to SEC14 and its involvement in lipid metabolism upon haem depletion in the absence of oleic acid supplementation. We observed that inactivation of SFH2 results in enhanced accumulation of SFA and phospholipid metabolism alterations. It resul...
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PMID: 17803462
PDF is available here.
PDF is available here.
Abstract
We have synthesized a novel photoactive sphingolipid precursor that, together with a precursor for phosphoglycerolipids and with photo-cholesterol, was investigated in vivo with regard to specific protein transmembrane span-lipid interactions. As a proof of principle, we show specific labeling of th...
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PMID: 17906222
PDF is available here.
PDF is available here.
Abstract
Phospholipid transfer protein (PLTP) transfers phospholipids between HDL and other lipoproteins in plasma. It also remodels spherical, apolipoprotein A-I (apoA-I)-containing HDL into large and small particles in a process involving the dissociation of lipid-free/lipid-poor apoA-I. ApoE is another ap...
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PMID: 17921435
PDF is available here.
PDF is available here.