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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptor-Like Protein Tyrosine Phosphatases (7):
- Receptor-Like Protein Tyrosine Phosphatases, Class 8
- Receptor-Like Protein Tyrosine Phosphatases, Class 7
- Receptor-Like Protein Tyrosine Phosphatases, Class 5
- Receptor-Like Protein Tyrosine Phosphatases, Class 4
- Receptor-Like Protein Tyrosine Phosphatases, Class 3
- Receptor-Like Protein Tyrosine Phosphatases, Class 2
- Receptor-Like Protein Tyrosine Phosphatases, Class 1
Recent article
Receptor-Like Protein Tyrosine Phosphatases
Journal of Neuroscience (28)44 2008
Abstract
We identified diaphanous in a screen for genes that are necessary for the normal growth and stabilization of the Drosophila neuromuscular junction (NMJ). Here, we demonstrate that diaphanous mutations perturb synaptic growth at the NMJ. Diaphanous protein is present both presynaptically and postsyna...
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PMID: 18971454
PDF is available here.
PDF is available here.
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Abstract
Abstract
We examine the roles of four RPTPs during development of the larval mushroom body (MB). MB neurons extend axons into parallel tracts known as the peduncle and lobes. The temporal order of neuronal birth is reflected in the organization of axons within these tracts. Axons of the youngest neurons, kno...
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PMID: 18356078
PDF is available here.
PDF is available here.
Neuroscience (152)3 2008
Abstract
We investigated potential roles of RPTPs in the developing mouse retina. Using a degenerate oligonucleotide-based reverse transcription polymerase chain reaction approach, we identified 11 different RPTPs in the retina at embryonic stage 13 (E13). Subsequently, the expression patterns of RPTPkappa,...
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PMID: 18308476
PDF is available here.
PDF is available here.
Mechanisms of Development (125)3-4 2008
Abstract
We provide evidence that PTP69D modulates signaling by Abl and its antagonist, Ena. An Abl loss-of function mutation dominantly suppresses most Ptp69D mutant phenotypes including larval/pupal lethality and CNS and motor axon defects, while increased Abl and decreased Ena expression dramatically incr...
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PMID: 18160268
PDF is available here.
PDF is available here.
Nippon Saikingaku Zasshi (62)4 2007
Abstract
Abstract
We utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The Ets-2 gene was not expressed in v-Myb-ER transformed cells in the presence of estradiol, but was expressed within 4 h after estradiol withdrawal. The expression of Ets-2 also increased d...
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PMID: 16909100
PDF is available here.
PDF is available here.
Abstract
We expressed full-length wild-type and mutant PTP69D protein in Schneider 2 cells, and assessed phosphatase activity using the fluorogenic substrate 6,8-difluoro-4-methylumbelliferone phosphate (DiFMUP). Detailed biochemical characterization of wild-type PTP69D, including an examination of sensitivi...
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PMID: 16514605
PDF is available here.
PDF is available here.
Developmental Biology (288)2 2005
Abstract
We show here that Bif and PP1-87B as well as their ability to interact with each other are required for photoreceptor growth cone targeting in the larval visual system. Single mutants for bif or PP1-87B show defects in axonal projections in which the axons of the outer photoreceptors bypass the lami...
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PMID: 16280124
PDF is available here.
PDF is available here.
Abstract
We show here that loss-of-function mutations in clr-1 enhance netrin-dependent attraction, suppressing ventral guidance defects in slt-1 mutants. clr-1 encodes a transmembrane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through the DCC family receptor UNC-...
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PMID: 15232111
PDF is available here.
PDF is available here.
Development (131)11 2004
Abstract
We identified an enhancer element (e15) within the egl-15 promoter, which is both necessary for the promoter activity and sufficient when duplicated to drive either egl-15 or clr-1 rescue activity. This enhancer drives GFP expression in hypodermal cells. Consistent with this finding, immunofluoresce...
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PMID: 15115754
PDF is available here.
PDF is available here.
Abstract
These results indicate multiple roles for PTP-D2, perhaps by acting as a docking domain for downstream elements and as a regulator of PTP-D1....
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PMID: 12972609
PDF is available here.
PDF is available here.
Abstract
We have isolated and characterized a series of 18 chemically induced alleles of Ptp69D ranging in strength from viable to worse than null, which represent unique tools for probing the structure, function, and signaling pathway of DPTP69D. Three alleles are strongly temperature sensitive and were use...
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PMID: 12807778
PDF is available here.
PDF is available here.
Developmental Biology (256)1 2003
Abstract
We propose that UNC-52 serves dual roles in C. elegans larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways....
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PMID: 12654300
PDF is available here.
PDF is available here.
Journal of Neuroscience (22)12 2002
Abstract
We have shown previously that cPTPsigma plays a role in supporting the retinal phase of axon outgrowth. Here we have now addressed the role of cPTPsigma within retinal axons as they undergo growth and topographic targeting in the optic tectum. With the use of retroviruses, a secretable cPTPsigma ect...
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PMID: 12077198
PDF is available here.
PDF is available here.
Abstract
We examine the synaptic function of the receptor protein tyrosine phosphatase (RPTP), Dlar, and an associated intracellular protein, Dliprin-alpha, at the Drosophila larval neuromuscular junction. We show that Dliprin-alpha and Dlar are required for normal synaptic morphology. We also find that syna...
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PMID: 11931739
PDF is available here.
PDF is available here.
Abstract
We demonstrate here that cPTPsigma is a heparin-binding protein and that its basal lamina ligands include the heparan sulfate proteoglycans (HSPGs) agrin and collagen XVIII. These molecules interact with high affinity with cPTPsigma in vitro, and this binding is totally dependent upon their heparan...
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PMID: 11865065
PDF is available here.
PDF is available here.
Journal of Neurobiology (49)2 2001
Abstract
Receptor protein tyrosine phosphatases (RPTPs) are regulators of axon outgrowth and guidance in a variety of different vertebrate and invertebrate systems. Three RPTPs, CRYP-alpha, PTP-delta, and LAR, are expressed in overlapping but distinct patterns in the developing Xenopus retina, including expr...
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PMID: 11598918
PDF is available here.
PDF is available here.
Development (128)21 2001
Abstract
We describe DPTP52F, the sixth RPTP to be discovered in Drosophila. Our genomic analysis indicates that there are likely to be no additional RPTPs encoded in the fly genome. Five of the six Drosophila RPTPs have C. elegans counterparts, and three of the six are also orthologous to human RPTP subfami...
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PMID: 11684671
PDF is available here.
PDF is available here.
Current Biology (11)17 2001
Abstract
Dlar cooperates with integrins to coordinate actin filaments at the basal surface of the follicular epithelium. To our knowledge, this is the first direct demonstration of an RPTP's influence on the actin cytoskeleton....
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PMID: 11553324
PDF is available here.
PDF is available here.
Abstract
We focus here on their role within the embryonic avian spinal cord, in particular the development and outgrowth of motorneurons. We have used in situ mRNA hybridization to examine the spatiotemporal expression of eight receptor-like protein tyrosine phosphatases and find that it is both dynamic and...
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PMID: 11085882
PDF is available here.
PDF is available here.
Journal of Neurobiology (44)2 2000
Abstract
These results suggest that CRYPalpha and its ligand act as growth-promoting molecules during intraretinal axon growth.
Copyright 2000 John Wiley & Sons, Inc....
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PMID: 10934323
PDF is available here.
PDF is available here.
Abstract
Abstract
We have cloned a variety of Xenopus RPTPs, including four RPTPs expressed in the developing visual system (LAR, PTP-delta, CRYP-alpha and PTP-rho). These four RPTPs are transcribed in the developing optic vesicle during differentiation and in overlapping but distinct patterns in the developing retin...
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PMID: 10727868
PDF is available here.
PDF is available here.
Abstract
The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins....
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PMID: 10679439
PDF is available here.
PDF is available here.
Journal of Cell Biology (147)2 1999
Abstract
We disrupted ligand- receptor interactions on the retinal basal membrane in culture. Antibodies against CRYPalpha strongly reduced retinal axon growth on the basal membrane, and induced a dramatic change in morphology of retinal growth cones, reducing the size of growth cone lamellipodia. A similar...
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PMID: 10525542
PDF is available here.
PDF is available here.
Abstract
We present evidence that two isoforms of this type IIa phosphatase, CRYPalpha1 and CRYPalpha2, have extracellular ligands along the developing retinotectal pathway. Using alkaline phosphatase fusion proteins containing the CRYPalpha1 ectodomain, we detect a prominent ligand on basement membranes of...
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PMID: 10493824
PDF is available here.
PDF is available here.
Abstract
We now demonstrate that the Drosophila Abl tyrosine kinase functions in the intersegmental nerve b (ISNb) motor choice point pathway as an antagonist of the RPTP Dlar. The function of Abl in this pathway is dependent on an intact catalytic domain. We also show that the Abl phosphoprotein substrate E...
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PMID: 10069336
PDF is available here.
PDF is available here.
Current Biology (8)20 1998
Abstract
Recent work on the Caenorhabditis elegans clr-1 gene shows that the receptor tyrosine phosphatase that it encodes negatively regulates a receptor tyrosine kinase related to mammalian fibroblast growth factor receptors. This opens up a promising system for investigating receptor tyrosine phosphatase...
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PMID: 9778517
PDF is available here.
PDF is available here.
Genes & Development (12)10 1998
Abstract
We show that the Caenorhabditis elegans protein CLR-1 (CLeaR) is a receptor tyrosine phosphatase (RTP) with a complex extracellular region and two intracellular phosphatase domains. Mutations in clr-1 result in a dramatic Clr phenotype that we have used to study the physiological requirements for th...
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PMID: 9585503
PDF is available here.
PDF is available here.
Developmental Brain Research (90)1-2 1995
Abstract
The avian CRYP alpha gene is expressed in the embryonic nervous system and encodes a receptor-like protein tyrosine phosphatase with structural similarity to neural cell adhesion molecules. To gain further insight into the role of the CRYP alpha phosphatase in neural development, this study addresse...
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PMID: 8719336
PDF is available here.
PDF is available here.
Development (121)6 1995
Abstract
We present the first evidence that vertebrate cell adhesion molecule-like protein tyrosine phosphatases are likely to be components of this signalling system. CRYP alpha, the gene for an avian cell adhesion molecule-like phosphatase, is strongly expressed in the embryonic nervous system. In this stu...
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PMID: 7600997
PDF is available here.
PDF is available here.