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Receptors, Serotonin, 5-HT2 (3):
Recent article
Receptors, Serotonin, 5-HT2
Abstract
The airway and ventilatory responses in mice elicited by the inhalation of hypercapnic or hypoxic gas mixtures were investigated by a microdialysis technique, 5-HT release analysis and double-chamber plethysmography with or without 5-HT2 receptor activity in the dorsomedial medulla oblongata (DMM)....
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PMID: 20217357
PDF is available here.
PDF is available here.
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European journal of medical research (14 Suppl 4) 2009
Abstract
Biphasic respiratory response to hypoxia in anesthetized animals is accompanied by changes in the EEG mostly in the low EEG frequency bands. Serotonin is a potent modulator of cortical and respiratory activity through 5-HT(2) receptors. Present study investigated whether 5-HT(2) receptors might be i...
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PMID: 20156721
PDF is available here.
PDF is available here.
Abstract
The overall outcome in schizophrenia is generally poor, despite the undisputed efficacy of antipsychotics in treating the acute symptoms of psychosis. There remains a subset of patients who are refractory to treatment. Also, for most patients treatment is not effective against the full spectrum of s...
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PMID: 19589093
PDF is available here.
PDF is available here.
Neuroscience Research (64)3 2009
Abstract
We show that some antipsychotic drugs produce significant functional changes in serotonergic neurons that directly impact feeding behavior in the model organism, Caenorhabditis elegans. In particular, antipsychotic drugs acutely suppress pharyngeal pumping, which is regulated by serotonin from the N...
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PMID: 19447297
PDF is available here.
PDF is available here.
Abstract
Abstract
We have cloned and fully sequenced two serotonin receptors, 5-HT(1Mac) and 5-HT(2Mac), from the CNS of the freshwater prawn Macrobrachium rosenbergii and have mapped their CNS immunohistochemical distribution. 5-HT(1Mac) was found primarily on the membranes of subsets of cells in all CNS ganglia, in...
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PMID: 19184976
PDF is available here.
PDF is available here.
Abstract
We analyzed the expression of 5-HT(2) receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT(2A) receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured osteoblasts. The mRNA for the 5-HT(2B) receptor...
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PMID: 19212095
PDF is available here.
PDF is available here.
Abstract
The effect of human and bovine beta-casomorphins-7 on the behavior of mice under conditions of 5-hydroxytryptophan (5-HT) induced hyperactivation of the serotoninergic system (head twitch test) has been studied. Intraperitoneal administration of each peptide in a dose of 1 mg/kg was shown to suppres...
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PMID: 19441718
PDF is available here.
PDF is available here.
Abstract
We administered parathion to newborn rats on postnatal days (PN) 1-4 at doses spanning the threshold for detectable cholinesterase inhibition (0.1 mg/kg/day) and the first signs of loss of viability (0.2 mg/kg/day). In adolescence (PN30), young adulthood (PN60) and full adulthood (PN100), we measure...
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PMID: 18773955
PDF is available here.
PDF is available here.
Abstract
The beneficial effects of serotonin S(2)-receptor blockers on healing skin and muscle ulcers and refractory lesions such as leprosy and diabetic and ischemic ulcers have been reported previously, but their mechanisms of actions are not clear. The present study sought to elucidate the action of an S(...
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PMID: 19842899
PDF is available here.
PDF is available here.
Abstract
Abstract
Serotonin (5-HT) has been implicated in the regulation of the stress response. Two experiments were conducted to investigate the possibility that the 5-HT(2A), 2C agonist DOI would reduce behavioral responsiveness to stress, and that selective blockade of one or both of these receptor subtypes would...
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PMID: 18572227
PDF is available here.
PDF is available here.
Abstract
We found that short-term exposure to the antipsychotic drugs altered the frequency of turns/reversals off food. This response was mediated through dopamine and serotonin receptors and was abolished in serotonin-deficient mutants (tph-1) and strains lacking the SER-1 and MOD-1 serotonin receptors. Co...
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PMID: 18438926
PDF is available here.
PDF is available here.
Neuropharmacology (55)2 2008
Abstract
We investigated the ability of serotonergic agents to reverse the inhibition of the induction of hippocampal long-term potentiation (LTP) caused by prior exposure to inescapable stress. Elevated platform stress prevented the induction of LTP in the CA1 area of anaesthetized rats. An agent that incre...
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PMID: 18538800
PDF is available here.
PDF is available here.
Abstract
Pyloric stenosis and pancreatitis were simulated before and after administration of serotonin and spiperone (5-HT2 receptor blocker). Activation of the serotoninergic system prevented the development of pancreatitis, but led to more severe course of pyloric stenosis.
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PMID: 19145332
PDF is available here.
PDF is available here.
Abstract
We aimed to examine the role of central 5-HT on normoxic and acute hypoxic ventilatory depression (AHVD) in peripheral chemoreceptors denervated rabbits. All experiments were performed in peripherally chemodenervated rabbits anesthetized with intravenous injection of urethane (400 mg/kg) and alpha-c...
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PMID: 18935908
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)25 2008
Abstract
We examine whether activation of 5-HT(2)Rs can regulate synapses through such a mechanism by studying excitatory synapses onto cells in the inferior olive (IO). These cells express 5-HT(2)Rs on their soma and dendrites, and the IO receives extensive serotonergic input. We find that the excitatory sy...
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PMID: 18562622
PDF is available here.
PDF is available here.
Neuropharmacology (54)7 2008
Abstract
Parasympathetic preganglionic cardiac vagal neurons (CVNs) which dominate the control of heart rate are located within the nucleus ambiguus (NA). Serotonin (5HT), and in particular 5HT2 receptors, play an important role in cardiovascular function in the brainstem. However, there is a lack of informa...
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PMID: 18396300
PDF is available here.
PDF is available here.
Abstract
The effect of serotonin 5-HT2 receptor blockade on nitric oxide production in rats with myocardial infarction was evaluated by the method of electron paramagnetic resonance. The spectra were recorded in samples of the heart tissue (left and right chambers), liver, and blood. 5-HT2 receptor blockade...
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PMID: 19110557
PDF is available here.
PDF is available here.
Hormones and Behavior (54)1 2008
Abstract
We investigated serotonergic regulation of electrocommunication signals in the weakly electric fish Apteronotus leptorhynchus. During social interactions, these fish modulate their electric organ discharges (EODs) to produce signals known as chirps. Males chirp more than females and produce two chir...
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PMID: 18336816
PDF is available here.
PDF is available here.
Abstract
We examine flexibility in the serotonin (5-HT) response system that modulates the cycle frequency (cf) of a rhythmic motor output. We found that depending on the preparation, the same 5-min bath application of 5-HT to the pyloric network of the California spiny lobster, Panulirus interruptus, could...
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PMID: 18400960
PDF is available here.
PDF is available here.
Abstract
We decided to establish whether AM404 may act through opioidergic and serotonergic mechanisms. Thus, we pretreated rats with opioid mu(1) (naloxonazine) and kappa (MR2266) or 5-HT(1A) (NAN-190), 5-HT(2) (ketanserin), and 5-HT(3) (ondansetron) receptor antagonists. We investigated the possible change...
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PMID: 18404260
PDF is available here.
PDF is available here.
Abstract
We have previously shown that increasing 5-HT activity over this period in male or androgenized female rats feminizes their adult behaviour and also feminizes the size of their anteroventral periventricular nucleus (AVPV) and sexually dimorphic nucleus of the preoptic area (SDN-POA). To investigate...
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PMID: 18445234
PDF is available here.
PDF is available here.
Abstract
We studied the changes in inferior cardiac sympathetic nerve discharge (SND) produced by unilateral microinjections of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists into the ventrolateral medulla (VLM) of urethane-anesthetized, baroreceptor-denervated cats. Microinjection of the 5-HT2...
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PMID: 18337315
PDF is available here.
PDF is available here.
Abstract
We demonstrated that the activation of serotonin (5-HT) receptors or blockade of 5-HT2 receptors, given after establishment of the sensitization, attenuates the expression of methamphetamine-induced behavioral sensitization in mice. In addition, we also showed that repeated administration of methamp...
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PMID: 18516987
PDF is available here.
PDF is available here.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence (43)2 2008
Abstract
Predisposition to alcohol dependence is affected by multiple environmental and genetic factors in complicated way. Family and twin studies estimated about 60% of hereditary rate for alcoholism. Many lines of evidence by divergent methods, e.g. gene-manipulated animals, linkage of human genome and ge...
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PMID: 18516948
PDF is available here.
PDF is available here.
Brain Research Bulletin (75)5 2008
Abstract
We exposed neonatal rats to daily doses of diazinon on postnatal days 1-4, using doses (0.5 or 2mg/kg) spanning the threshold for barely-detectable cholinesterase inhibition. We then evaluated the effects on 5HT(1A) and 5HT(2) receptors, and on the 5HT transporter in cerebral cortical regions and th...
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PMID: 18355640
PDF is available here.
PDF is available here.
Hormones and Behavior (53)3 2008
Abstract
We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases...
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PMID: 18206154
PDF is available here.
PDF is available here.
Abstract
We examined a modifying role of 5HT1A and 5HT2A receptors in the relation between childhood difficult temperament and adulthood hostility in 729 subjects derived from a population-based sample. Subjects were 3-12 years when their childhood temperaments consisting of hyperactivity, low sociability an...
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PMID: 17504248
PDF is available here.
PDF is available here.
European Journal of Pharmacology (579)1-3 2008
Abstract
We demonstrated that the 12(S)-HPETE-induced scratching was reduced not by U75302 (BLT(1) receptor antagonist), but by LY255283 (BLT(2) receptor antagonist). In the present study, we tested various compounds to elucidate the mechanism of 12(S)-HPETE-induced scratching relating to transient receptor...
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PMID: 18037400
PDF is available here.
PDF is available here.
Neuroscience Letters (430)3 2008
Abstract
We determined if the blockade of 5-HT reuptake or the activation of 5-HT(1A) or 5-HT(2) receptors modulates capsaicin-evoked hypothermia. The administration of capsaicin (0.2-1mg/kg, i.m.) produced dose-related hypothermia. Fluoxetine (10mg/kg, i.p.), a selective serotonin reuptake inhibitor (SSRI),...
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PMID: 18155835
PDF is available here.
PDF is available here.
Abstract
We review current knowledge regarding the cellular localization of 5-HT(1A), 5-HT(2A) and dopamine D1, D5, and D2, D4 receptors in primate PFC and their possible functions in the neuronal circuits of the PFC....
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PMID: 18772029
PDF is available here.
PDF is available here.
Collegium Antropologicum (32 Suppl 1) 2008
Abstract
Our study shows that 5HTt-LPR and -1438AG 5HT(2Ar) genotypes did not significantly affect PSL. However, significantly higher PSLs were observed in subjects with "cc" genotype of a218c TPH and subjects with "4" genotype of uVNTR MAOA. In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" ge...
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PMID: 18405062
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that osemozotan, a specific 5-HT(1A)-receptor agonist, and ritanserin, a 5-HT(2)-receptor antagonist, inhibited the expression and development of both methamphetamine- and cocaine-induced behavioral sensitization in mice and that these drugs attenuated the maintenance o...
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PMID: 18198473
PDF is available here.
PDF is available here.
Journal of Experimental Biology (211)Pt 1 2008
Abstract
We provide pharmacological profiles for two 5-HT receptors from the swamp crayfish, Procambarus clarkii: 5-HT(2beta) and 5-HT(1alpha). In so doing, we also report the first functional expression of a crustacean 5-HT(1) receptor, and show that it inhibits accumulation of cAMP. The drugs mCPP and quip...
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PMID: 18083737
PDF is available here.
PDF is available here.
Abstract
Methamphetamine (METH) causes the release of serotonin (5-HT), but little is known about how repeated exposure to METH modifies serotonergic receptor function, especially in the ventral pallidum (VP), a brain region highly innervated by serotonin inputs. The current study was designed to ascertain i...
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PMID: 17957734
PDF is available here.
PDF is available here.
Abstract
A series of new tropan derivatives have been synthesized and investigated, which can both weaken and potentiate the serotonin-induced cerebrovascular constrictory reactions. The compound LK-728 produces a pronounced antiserotonin cerebrovascular action comparable to that of tropoxin, but being super...
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PMID: 18365483
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that the HTR2A T102C could be a potential indicator of clinical improvement after risperidone treatment.
(c) 2007 John Wiley & Sons, Ltd....
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PMID: 17924589
PDF is available here.
PDF is available here.
Abstract
The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. It is established that a key mechanism involved in the control of 5-HT neuro...
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PMID: 17996955
PDF is available here.
PDF is available here.
Abstract
Serotonin, the major secretory product of activated platelets, has been widely reported as regulating various constituents of the immune system and immune functions. This modulation is complex and the data available are rather controversial. The aim of the present study was to clarify the mechanisms...
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PMID: 18041649
PDF is available here.
PDF is available here.
Abstract
We further elucidated the involvement of serotonin. We found that high dose of suanzaorentang (4 g/kg/2 ml) significantly increased non-rapid eye movement sleep (NREMS) when comparing to that obtained after administering starch placebo, although placebo at dose of 4 g/kg also enhanced NREMS comparin...
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PMID: 17657585
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that serotonin affects alveolar macrophage (AM) cytokine production, altering the cytokine network in the lung and contributing to asthma pathogenesis. AMs were treated with different concentrations of serotonin (10(-11)-10(-9) M) or 5-HT(1) and 5-HT(2) receptor agonists for...
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PMID: 17822443
PDF is available here.
PDF is available here.
Abstract
A relationship between morphofunctional changes in the heart and predominance of adrenergic or serotoninergic influences on the strength of myocardial contraction in the right atrium was revealed in patients with chronic heart failure. During left ventricular hypertrophy, the strength of myocardial...
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PMID: 18642697
PDF is available here.
PDF is available here.
European Psychiatry (22)7 2007
Abstract
These results suggest that the 5HT2-receptor antagonists trazodone and nefazodone and the SSRIs do not differ with respect to their overall efficacy and tolerability in the treatment of MDD. Although the sample size was relatively large and conveyed sufficient statistical power to test for differenc...
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PMID: 17418537
PDF is available here.
PDF is available here.
Abstract
Abstract
The protective effect of 5-HT(2) receptor blockade with ketanserin or ritanserin against cadmium liver injury was investigated. Male Wistar rats were injected intraperitoneally with a sublethal dose of cadmium (3.5 mg/kg body weight). Rats were treated with normal saline (group I), k...
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PMID: 17420952
PDF is available here.
PDF is available here.
Psychopharmacology (193)2 2007
Abstract
Antidepressants probably exert tandem neurochemical effects by increasing synaptic monoamine concentrations and by producing phosphoinositides used in 5HT(2) receptor signaling. This combination of actions may constitute the mechanism of at least the acute behavioral effects of the drugs and could i...
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PMID: 17435992
PDF is available here.
PDF is available here.
Diabetologia (50)8 2007
Abstract
Serotonin (5-HT) stimulated glycogen synthesis at nanomolar concentrations but inhibited it at micromolar concentrations. The stimulatory effect was mimicked by alpha-methyl-5-HT, a mixed 5-HT1/5-HT2 receptor agonist, whereas the inhibition was counteracted by a 5-HT2B/2C receptor antagonist. alpha-...
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PMID: 17579833
PDF is available here.
PDF is available here.
Abstract
5-HT2 receptor activity in the hypoglossal nucleus and hypercapnia is associated with airway dilation. 5-HT neurons in the medullary raphe and hypercapnia are responsible for tidal volume change. In this study, the effects of 5-HT2 receptors in the dorsomedial medulla oblongata (DMM), which receives...
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PMID: 17537836
PDF is available here.
PDF is available here.
Neuropsychopharmacology (32)8 2007
Abstract
The relationship between clinically effective antipsychotic drug dosage and binding affinity to cloned dopamine (DA) and serotonin receptor subtypes was analyzed in an effort to elucidate the contribution of individual receptor subtypes to medication response. Clinically effective dose and binding af...
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PMID: 17251913
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (112)3 2007
Abstract
We evaluated the ameliorating effects of emodin on cycloheximide (CXM)-induced impairment of passive avoidance response in rats. Secondly, we clarified the role of cholinergic, serotonergic or GABAergic system on the ameliorating effect of emodin by using 5-HT1A receptor partial agonist, 5-HT2 recep...
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PMID: 17572029
PDF is available here.
PDF is available here.
Life Sciences (81)7 2007
Abstract
The present study evaluated the effect of 5-hydroxytryptamine (5-HT) on intestinal Na(+)/H(+) exchanger (NHE) activity and the cellular signaling pathways involved in T84 cells. T84 cells express endogenous NHE1 and NHE2 proteins, detected by immunoblotting, but not NHE3. The rank order for inhibiti...
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PMID: 17663006
PDF is available here.
PDF is available here.
Neuroscience Letters (422)3 2007
Abstract
Psychiatric disorders are common in Parkinson's disease (PD) and hallucinations are observed in nearly 40% of PD patients. The involvement of dopaminergic system in the pathogenesis of psychosis has been sustained by most of the authors even if several evidences indicate that multiple neurochemical...
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PMID: 17614196
PDF is available here.
PDF is available here.
Neuropsychopharmacology (32)7 2007
Abstract
We compared NDMC to a typical (haloperidol), atypical (clozapine), and partial-agonist atypical (aripiprazole) antipsychotic in preclinical models. The comparison was carried out using: brain D(2) and 5-HT(2) receptor occupancy; animal models predictive of antipsychotic efficacy (amphetamine-induced...
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PMID: 17164815
PDF is available here.
PDF is available here.
Neuroscience (146)4 2007
Abstract
The present study investigated the role of several 5-HT receptor subtypes in the lateral parabrachial nucleus (LPBN) in the control of sodium appetite (i.e. NaCl consumption). Male Holtzman rats had cannulas implanted bilaterally into the LPBN for the injection of 5-HT receptor agonists and antagoni...
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PMID: 17434681
PDF is available here.
PDF is available here.
Neuroscience Letters (418)1 2007
Abstract
We investigated the role of 5-HT(2A) and 5-HT(2C) receptors in atypical absence seizures (AAS) induced by trans-1,4-bis[2-chloro-benzylaminomethyl] cyclohexane, dihydrocholoride (AY-9944). The total duration and number and mean duration of the spontaneous bursts of slow spike-and-wave discharges (SS...
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PMID: 17350760
PDF is available here.
PDF is available here.
Psychopharmacology (191)2 2007
Abstract
The present results suggest that past stressful experience can produce changes in the synaptic function of 5-HT(2) receptors within the dPAG with important impact on the expression of defensive behaviors....
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PMID: 17205316
PDF is available here.
PDF is available here.
Inflammation Research (56)4 2007
Abstract
The opioidergic and serotonergic systems are involved in different ways in the induction and maintenance of antinociception after paracetamol or morphine treatment....
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PMID: 17522810
PDF is available here.
PDF is available here.
Developmental Dynamics (236)4 2007
Abstract
We screened for point mutations in the 5-HT(2Dro) receptor gene. We identified one point mutation that generates a gain of serotonin affinity for the receptor and affects germband extension: 5-HT(2Dro) (C1644). Embryos homozygous for this point mutation display a fourfold increase in the maximal spe...
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PMID: 17366631
PDF is available here.
PDF is available here.
Abstract
Ovariectomized Fischer (CDF-344) rats, with bilateral cannulae in the mediobasal hypothalamus (MBH) near the ventromedial nucleus of the hypothalamus (VMN), were used to test the hypothesis that serotonin receptors in the VMN contribute to the lordosis-inhibiting effects of mild restraint. Rats were...
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PMID: 17368527
PDF is available here.
PDF is available here.