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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, Melatonin (2):
Recent article
Receptors, Melatonin
Abstract
Melatonin, the chief secretory product of the pineal gland, has long been known to modulate hair growth, pigmentation and/or molting in many species, presumably as a key neuroendocrine regulator that couples coat phenotype and function to photoperiod-dependent environmental and reproductive changes....
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PMID: 18078443
PDF is available here.
PDF is available here.
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Abstract
Melatonin influences insulin secretion both in vivo and in vitro. (i) The effects are MT(1)-and MT(2)-receptor-mediated. (ii) They are specific, high-affinity, pertussis-toxin-sensitive, G(i)-protein-coupled, leading to inhibition of the cAMP-pathway and decrease of insulin release. [Correction adde...
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PMID: 18078445
PDF is available here.
PDF is available here.
Design, synthesis, and melatoninergic activity of new azido- and isothiocyanato-substituted indoles.
Abstract
We report on the design and synthesis of new melatoninergic azido- and isothiocyanato-substituted indoles. All active compounds were partial agonists or antagonists in the Xenopus melanophore assay, the most potent being the 5-OMe C3-substituted azido 45 and isothiocyanato 46 analogues....
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PMID: 17988084
PDF is available here.
PDF is available here.
Abstract
We examined whether these effects will be affected by the melatonin receptor antagonists luzindole (a competitive MT(1)/MT(2) antagonist), DH 97 (MT(2)), prazosin (MT(3)), and 4-P-PDOT (MT(2)). Lipid peroxidation in the form of malondialdehyde (MDA) was assayed by measuring thiobarbituric acid-react...
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PMID: 18077581
PDF is available here.
PDF is available here.
Abstract
Insomnia affects a large percentage of the population, particularly the elderly. Literature reports varying estimates of prevalence, a variation that relates to the lack of definition and consistency in diagnostic criteria. Primary insomnia (not caused by known physical/mental conditions) responds t...
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PMID: 18041870
PDF is available here.
PDF is available here.
Abstract
The circadian clock modulates timing of sleep and wakefulness. In certain situations, the circadian potentiation of wakefulness may interfere with desired sleep-scheduling, particularly in the elderly and shift workers. Known abnormalities of circadian regulation are defined by their impact on sleep...
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PMID: 18041873
PDF is available here.
PDF is available here.
Abstract
An active cortex is necessary for intact cognitive function. In a sleepy individual, the cerebral cortex is to some extent deactivated; a sleep-deprived person will experience reduced physical and mental activity and productivity, more errors on the job, more risk for motor vehicle accidents, and ps...
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PMID: 18041875
PDF is available here.
PDF is available here.
Abstract
We hypothesize that melatonin is a co-substrate of QR2. We surmise that melatonin binds to a co-substrate binding site (MT3 binding site) donating an electron to the enzyme co-factor, flavin adenine dinucleotide (FAD). FAD can be reduced to either FADH or FADH2 while melatonin is converted to N1-ace...
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PMID: 17910598
PDF is available here.
PDF is available here.
Animal Reproduction Science (101)3-4 2007
Abstract
These results preliminarily showed an association between genotype RR and year-round estrus in goats, and an association between genotype Rr and seasonal estrus in goats....
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PMID: 17046181
PDF is available here.
PDF is available here.
Abstract
Current antidepressants used in major depressive disorder (MDD) are still not efficacious enough for many patients due to high levels of treatment resistance and bothersome side-effects. Using a novel blinding method (interactive voice response system), this flexible-dosing study examined the effect...
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PMID: 17477888
PDF is available here.
PDF is available here.
Cell and Tissue Research (330)1 2007
Abstract
We have performed immunocytochemical analyses for PER1, CRY2, and pCREB in retinae of melatonin-proficient wild type (WT) mice and mice with targeted deletions of the MT1 receptor (MelaaBB) or the MT1 and MT2 receptors (Melaabb) at four different time points. Immunoreactions for PER1, CRY2 and pCREB...
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PMID: 17701055
PDF is available here.
PDF is available here.
The Pennsylvania nurse (62)3 2007
Abstract
Many patients with primary medical or psychiatric disorders may be at risk for the development of comorbid insomnia. Research now suggests that effective treatment and management of the comorbid insomnia may be as important as the primary disorder--especially when the relationship between the two di...
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PMID: 18019308
PDF is available here.
PDF is available here.
Abstract
We provide evidence that on U937 monocytic cells, apoptosis is antagonized by melatonin by receptor interaction rather than by radical scavenging. First, melatonin and a set of synthetic analogues prevented apoptosis in a manner that is proportional to their affinity for plasma membrane receptors bu...
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PMID: 17645693
PDF is available here.
PDF is available here.
Abstract
The antiproliferative and proapoptotic properties of melatonin in human colon cancer cells in culture were recently reported. To address the mechanisms involved in these actions, HT-29 human colon cancer cells were cultured in RPMI 1640 medium supplemented with fetal bovine serum at 37 degrees C. Ce...
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PMID: 17645698
PDF is available here.
PDF is available here.
Abstract
The pars tuberalis (PT) of the adenohypophysis expresses a high density of melatonin receptors and is thought to be a crucial relay for the actions of melatonin on seasonal rhythmicity of prolactin secretion by the pars distalis (PD). In common with the suprachiasmatic nucleus of the hypothalamus an...
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PMID: 17620107
PDF is available here.
PDF is available here.
Abstract
We have identified the existence of melatonin receptors and test the effect of melatonin on hydrogen peroxide-induced endothelial nitric oxide synthase (eNOS) expression in bovine cerebral arteries. The results indicate that mt1A melatonin receptor mRNA is expressed in bovine cerebral arteries. The...
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PMID: 17614833
PDF is available here.
PDF is available here.
Neuropharmacology (53)1 2007
Abstract
We examined the effects of melatonin and its receptor antagonists on various behaviors in Caenorhabditis elegans. Exogenously applied melatonin specifically decreased locomotion rates in 15-min treatments, suggesting that melatonin directly regulates neural activities for locomotion. This melatonin...
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PMID: 17573073
PDF is available here.
PDF is available here.
Journal of Neurochemistry (102)2 2007
Abstract
Melatonin (MT) may work as a neuromodulator through the associated MT receptors in the central nervous system. Previously, our studies have shown that MT increased the I(K) current via a G protein-related pathway. In the present study, patch-clamp whole-cell recording, transwell migration assays and...
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PMID: 17561939
PDF is available here.
PDF is available here.
Abstract
Circadian rhythms of the intensity of 3H-melatonin absorption by organs of the hypothalamic-pituitary-thyroid system were studied in young mature male Wistar rats in summer. The hypothalamus, pituitary, and thyroid gland incorporated 3H-melatonin during the day and night hours, but the intensity of...
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PMID: 18239818
PDF is available here.
PDF is available here.
Abstract
Abstract
The demonstration of melatonergic receptors in these brain areas supports their probable involvement in the behavioural, neuroendocrine and circadian rhythms disturbances observed in the psychosocial stress model of depression in the tree shrew....
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PMID: 17627260
PDF is available here.
PDF is available here.
Abstract
Melatonin synthesis occurs in the retina of most animals as well as in humans. Circadian oscillators that control retinal melatonin synthesis have been identified in the eyes of different animal species. The presence of melatonin receptors is demonstrable by immunocytochemical studies of ocular tiss...
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PMID: 17174303
PDF is available here.
PDF is available here.
Abstract
These results suggest that light exerts certain effects on Mel(1c) mRNA expression directly or indirectly through melatonin actions....
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PMID: 17293145
PDF is available here.
PDF is available here.
Abstract
In older adults with chronic primary insomnia, ramelteon produced significant reductions in latency to persistent sleep and increases in total sleep time and sleep efficacy, and showed no evidence of adverse next-day psychomotor or cognitive effects....
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PMID: 17519067
PDF is available here.
PDF is available here.
Abstract
Melatonin, a chronobiotic that participates in the control of the circadian system, is known for its sleep-promoting effects, which include shortening of sleep latency and lengthening of sleep duration. As a result of its short half-life, melatonin does not exhibit undesirable side effects, and its...
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PMID: 17410109
PDF is available here.
PDF is available here.