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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, G-Protein-Coupled (45):
- Receptors, Muscarinic
- Receptors, Lysophospholipid
- Receptors, FSH
- Receptors, Formyl Peptide
- Receptors, Corticotropin-Releasing Hormone
- Receptors, Calcium-Sensing
- Receptors, Angiotensin
- Receptors, Pheromone
- Receptors, Serotonin
- Receptors, Purinergic
- Receptors, Vasoactive Intestinal Peptide
- Receptors, Somatostatin
- Receptors, Oxytocin
- Receptors, Opioid
- Receptors, Neurotensin
- Receptors, Galanin
- Receptors, Endothelin
- Receptors, Glucagon
- Receptors, Cholecystokinin
- Receptors, Bradykinin
- Receptors, Parathyroid Hormone
- Receptors, Metabotropic Glutamate
- Rhodopsin
- Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
- Receptors, Melatonin
- Receptors, Cannabinoid
- Receptors, Calcitonin Gene-Related Peptide
- Receptors, Bombesin
- Receptors, Vasopressin
- Receptors, Thrombin
- Receptors, Odorant
- Receptors, Ghrelin
- Receptors, Chemokine
- Receptors, Calcitonin
- Receptors, Neuropeptide Y
- Receptors, GABA-B
- Receptors, Melanocortin
- Receptors, LHRH
- Receptors, Eicosanoid
- Receptors, Catecholamine
- Receptors, LH
- Receptors, Histamine H2
- Receptors, Histamine H1
- Receptor, PAR-2
- Receptor, Anaphylatoxin C5a
Recent article
Receptors, G-Protein-Coupled
Abstract
We screened a set of proteins from the G-protein complex using two-hybrid complementation in yeast. After deep and exhaustive interrogation, we detected 544 interactions between 434 proteins, of which 68 highly interconnected proteins form the core G-protein interactome. Within this core, over half...
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PMID: 21952135
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We sought to develop an appropriate method to examine large sets of GPCR ligand information for both screening collection enhancement and hit expansion. To this end, we have implemented a modified version of BDACCS that removes highly correlated descriptors (rBDACCS). To test the hypothesis that a s...
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PMID: 21761904
PDF is available here.
PDF is available here.
Abstract
Traditionally, G protein-coupled receptors (GPCRs) were thought to function as monomeric units activating linear signaling pathways to reach a single functional response. However, it is now recognized that GPCRs can exist as higher order structures, such as homomers or heteromers. Th...
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PMID: 21764024
PDF is available here.
PDF is available here.
Abstract
Cancer Biology & Therapy (12)1 2011
Abstract
We agree with this hypothesis and would like to highlight here some published results supporting this hypothesis and give some details concerning the role of estrogens and xeno-estrogens in testicular carcinogenesis and the effects of GPER antagonist in human seminoma cells. We are sure that this in...
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PMID: 21508670
PDF is available here.
PDF is available here.
Cancer Cell (19)6 2011
Abstract
We explored whether KSHV oncogenes deploy cell type-specific signaling pathways activating mTOR, which could be exploited to halt KS development while minimizing immune suppressive effects. We found that PI3Kγ, a PI3K isoform exhibiting restricted tissue distribution, is strictly required for signa...
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PMID: 21665152
PDF is available here.
PDF is available here.
Chemmedchem (6)6 2011
Abstract
Specifically designed bivalent ligands targeting G protein-coupled receptor (GPCR) dimeric structures have become increasingly popular in recent literature. The advantages of the bivalent approach are numerous, including enhanced potency and receptor subtype specificity. However, t...
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PMID: 21520422
PDF is available here.
PDF is available here.
Chemmedchem (6)6 2011
Abstract
We report the design and discovery of a novel APJ antagonist. By using a bivalent ligand approach, we have designed compounds with two 'affinity' motifs and a short series of linker groups with different conformational and non-bonded interaction properties. One of these, cyclo(1-6)CRPRLC-KH-cyclo(9-...
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PMID: 21560248
PDF is available here.
PDF is available here.
Abstract
Over the past 20 years, naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, mainly in patients with endocrine diseases. The study of loss-of-function or gain-of-function mutations has contributed to our understanding of the pathophysiol...
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PMID: 21301490
PDF is available here.
PDF is available here.
Abstract
We provide a comprehensive review of the actions of BAs on cardiovascular function. In the heart and the systemic circulation, BAs interact with plasma membrane G-protein-coupled receptors, for example, TGR5 and muscarinic receptors, and nuclear receptors, for example, the farnesoid (FXR) and pregna...
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PMID: 21707953
PDF is available here.
PDF is available here.
Abstract
We previously prepared a SREB2-overexpressing transgenic mouse for functional analysis but were unable to confirm SREB2 protein expression level by immunochemical or biochemical methods. In this article, we report mass spectrometric identification and relative quantitative analysis of SREB2 in the f...
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PMID: 21395347
PDF is available here.
PDF is available here.
Abstract
Abstract
GPR40, a G-protein-coupled receptor has been well established to play a crucial role in regulating blood glucose levels. Hence, GPR40 is a potential target for future antidiabetic agents. The present 3D QSAR study is aimed at delineating structural parameters governing GPR40 agonisti...
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PMID: 21352503
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (11)8 2011
Abstract
Abstract
Biochimica et Biophysica Acta (1812)4 2011
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.
Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
PDF is available here.
Abstract
We evaluated immunohistochemical Lgr5 expression in 31 distant metastases and in primary tumor compartments with relevance for metastasizing, comprising 89 colorectal carcinomas. Lgr5 expression was seen in 51.6% of distant metastases. 12.9%, 14.8% and 26.7% of primary tumors with histologically con...
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PMID: 21577318
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Organic Letters (13)5 2011
Abstract
A concise enantioselective synthetic route to a potent GPR40 agonist AMG 837 is described. The crucial catalytic asymmetric conjugate addition of terminal alkyne was promoted by a soft Lewis acid/hard Brønsted base cooperative catalyst, allowing efficient construction of the requisi...
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PMID: 21291204
PDF is available here.
PDF is available here.
Abstract
We undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P =...
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PMID: 21040458
PDF is available here.
PDF is available here.
Abstract
We demonstrate that machine learning of multiple CPIs can not only assess drug polypharmacology but can also efficiently identify novel bioactive scaffold-hopping compounds. Through a machine-learning technique that uses multiple CPIs, we have successfully identified novel lead compounds for two pha...
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PMID: 21364574
PDF is available here.
PDF is available here.
Abstract
We evaluate the expression and activation of rat diaphragm or cultured skeletal muscle G-proteins using [(35)S]GTPγS. Total membrane Gα subunit content was 4-7 times higher in rat primary cultured myotubes and L6 cell line than in diaphragm (32.6±1.2fmol/mg protein) and 7-27% of them were in the...
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PMID: 21084061
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (131)2 2011
Abstract
We established a novel dermatitis model in mice earlobes and analyzed the roles of histamine using specific antagonists for histamine receptors. After sensitization with picryl chloride (PiCl) by painting it on the earlobes of cyclophosphamide-treated mice, 12-O-tetradecanoylphorbol 13-acetate (TPA)...
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PMID: 21297358
PDF is available here.
PDF is available here.
Abstract
We quantified expression of 94 human GPCRs, including 75 orphan GPCRs and 19 chemokine receptors, and 36 chemokine ligands, in 40 melanoma metastases from different individuals and benign nevi. Inter-metastatic site comparison revealed that orphan GPR174 and CCL28 are statistically significantly ove...
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PMID: 20880198
PDF is available here.
PDF is available here.
Abstract
Understanding the role of G protein-coupled receptor (GPCR; also known as a 7 transmembrane receptor) heteromerization in the physiology and pathophysiology of cellular function has now become a major research focus. However, there is currently a lack of cell-based assays capable of...
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PMID: 21133678
PDF is available here.
PDF is available here.
Abstract
We describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis. We do so in the context of whether the histamine H4 receptor offers a novel ta...
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PMID: 21104170
PDF is available here.
PDF is available here.
Abstract
We have established an optimised RNA isolation workflow specifically designed to yield maximal RNA from minimal cell numbers. This procedure obtained RNA yield sufficient for carrying out global transcriptional profiling from vascular endothelial cell biopsies, clinical material not previously amena...
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PMID: 21445340
PDF is available here.
PDF is available here.
Abstract
We report that the cell membrane-localized Zn transporter SLC39A14 controls G-protein coupled receptor (GPCR)-mediated signaling. Mice lacking Slc39a14 (Slc39a14-KO mice) exhibit growth retardation and impaired gluconeogenesis, which are attributable to disrupted GPCR signaling in the growth plate,...
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PMID: 21445361
PDF is available here.
PDF is available here.
Science Signaling (4)181 2011
Abstract
We show that Mrgprs (Mas-related G protein-coupled receptors), particularly MrgprC11, rather than PAR2 (protease-activated receptor 2) as previously thought, mediate this type of itch. A shorter peptide, SLIGR, which specifically activates PAR2 but not MrgprC11, induced thermal pain hypersensitivity...
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PMID: 21775281
PDF is available here.
PDF is available here.
Science Signaling (4)159 2011
Abstract
We determined its crystal structure. AtGPA1 is structurally similar to animal G protein α subunits, but our crystallographic and biophysical studies revealed that it had distinct properties. Notably, the helical domain of AtGPA1 displayed pronounced intrinsic disorder and a tendency to disengage fr...
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PMID: 21304159
PDF is available here.
PDF is available here.
Science Signaling (4)155 2011
Abstract
We show that the interaction of ORs with the type 3 muscarinic acetylcholine receptor (M3-R), which is found in olfactory sensory neurons (OSNs), modulated OR responses to cognate odorants. In human embryonic kidney-293T cells, ORs and the M3-R physically interacted, and the M3-R increased the poten...
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PMID: 21224444
PDF is available here.
PDF is available here.
Acta Physiologica (201)1 2011
Abstract
We have investigated the effects of apelin peptides on duodenal bicarbonate secretion in vivo and the release of cholecystokinin (CCK) from acutely isolated mucosal cells and the neuroendocrine cell line STC-1.
Lewis × Dark Agouti rats had free access to water and, unless fasted ove...
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PMID: 20726845
PDF is available here.
PDF is available here.
Acta Physiologica (201)1 2011
Abstract
Acidosis in the gastrointestinal tract can be both a physiological and pathological condition. While gastric acid serves digestion and protection from pathogens, pathological acidosis is associated with defective acid containment, inflammation and ischaemia. The pH in the oesophagus,...
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PMID: 20456281
PDF is available here.
PDF is available here.
Acta Physiologica (201)1 2011
Abstract
Acidosis in the gastrointestinal tract can be both a physiological and pathological condition. While gastric acid serves digestion and protection from pathogens, pathological acidosis is associated with defective acid containment, inflammation and ischaemia. The pH in the oesophagus,...
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PMID: 20456281
PDF is available here.
PDF is available here.
Abstract
We sought the molecules involved in [Ca(2+)](c) regulation using a single-taste-cell transcriptome approach. We found that Serca3, a member of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) family that sequesters cytosolic Ca(2+) into endoplasmic reticulum, is exclusively expressed in sweet/u...
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PMID: 21829714
PDF is available here.
PDF is available here.
Abstract
Hypospadias is a common congenital anomalies, yet its molecular basis remains unknown. Recent studies have linked perturbations in the Hedgehog signaling pathway to hypospadias. However, the expression of Sonic hedgehog (Shh) has not been reported during genital development. Immunohi...
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PMID: 21434830
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We have isolated ANKRD13C, a protein of unknown function, as an interacting partner for the DP receptor for prostaglandin D(2). In the present study we report the characterization of this novel protein as a regulator of DP biogenesis and trafficking in the biosynthetic pathway. Co-localization by co...
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PMID: 20959461
PDF is available here.
PDF is available here.
Abstract
We have enhanced and validated the ligand-steered homology method through cross-modeling and investigated the performance of the thus generated models in docking-based screening. The ligand-steered modeling method uses information about existing ligands to optimize the binding site by accounting for...
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PMID: 21080692
PDF is available here.
PDF is available here.
Abstract
These results indicate that GPR40 mediates the short-term effects of FFAs on GSIS, but does not mediate the chronic lipotoxicity on β-cells. The reverse role of pioglitazone on lipotoxicity of β-cells may be related to GPR40.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 21036144
PDF is available here.
PDF is available here.
Chemmedchem (5)12 2010
Abstract
Journal of Endocrinology (207)3 2010
Abstract
Pancreatic β cells adapt to pregnancy-induced insulin resistance by unclear mechanisms. This study sought to identify genes involved in β cell adaptation during pregnancy. To examine changes in global RNA expression during pregnancy, murine islets were isolated at a time point of increased β cell...
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PMID: 20847227
PDF is available here.
PDF is available here.
Abstract
We evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 20971062
PDF is available here.
PDF is available here.
Abstract
We used calcium imaging analysis of human embryonic kidney 293T cells that heterologously expressed human taste receptors to demonstrate that gentiobiose activated hTAS2R16, a bitter taste receptor, but not hT1R2/hT1R3, a sweet taste receptor. In contrast, isomaltose activated hT1R2/hT1R3. As a resu...
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PMID: 20965151
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
We have generated a T1R2-LacZ reporter knock-in mouse to investigate tissue distribution of T1R2 at a single-cell level. We found that the LacZ gene expression in these mice was faithful to the expression of T1R2 in the taste tissue and in the gastrointestinal tract where T1R3 expression has been re...
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PMID: 20965149
PDF is available here.
PDF is available here.
Abstract
We evaluated the therapeutic potential of a novel small molecule GPR119 agonist, AS1535907, which was modified from the previously identified 2,4,6-tri-substituted pyrimidine core agonist AS1269574. AS1535907 displayed an EC50 value of 4.8 μM in HEK293 cells stably expressing human GPR119 and stimu...
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PMID: 20937249
PDF is available here.
PDF is available here.
Abstract
During development, microvessels acquire specialized functions to meet the requirements of different tissues and organs. The vasculature of the brain constitutes one of the best examples of an organ-specific and highly specialized microvasculature, in which the endothelial cells that...
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PMID: 21084718
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
We will present here a general classification of the main pathways of cell signalling and some of the recurrent mechanisms used for the transmission of information between cells and inside cells....
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PMID: 21047720
PDF is available here.
PDF is available here.
Journal of Endocrinology (207)2 2010
Abstract
We characterised the expression pattern and cellular localisation of both RLN and its own receptor LGR7 (RXFP1) in boar testes during postnatal development by molecular and immunological approaches. Testes were collected from Duroc boars, and partial cDNA sequences of the boar homologue of human RXF...
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PMID: 20807724
PDF is available here.
PDF is available here.
Abstract
A number of G-protein-coupled receptors (GPCRs) are currently under consideration as potential therapeutic targets for drugs acting in the central nervous system (CNS). Attempts to discover new medications have operated under the assumption that GPCRs are monomers and that a specific...
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PMID: 20632968
PDF is available here.
PDF is available here.
Abstract
G protein-coupled receptors (GPCRs) are expressed throughout the nervous system where they regulate multiple physiological processes, participate in neurological diseases, and are major targets for therapy. Given that many GPCRs respond to neurotransmitters and hormones that are pres...
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PMID: 20632972
PDF is available here.
PDF is available here.
Abstract
Dopamine modulation of excitatory neurotransmission is critical in the control of movement, emotion and reward. In the striatum, medium size spiny neurons (MSNs) are responsible for the integration of cortical and thalamic information that flows through parallel, partly overlapping,...
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PMID: 20632967
PDF is available here.
PDF is available here.
Abstract
Because G protein-coupled receptors (GPCRs) are numerous, widely expressed and involved in major physiological responses, they represent a relevant therapeutic target for drug discovery, particularly regarding pharmacological treatments of neurological disorders. Among the biological...
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PMID: 20632964
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (432)1 2010
Abstract
We hypothesize that lyso-PC activation of G2A causes the increases in cytosolic Ca²(+) via release of G(α) and G(βγ) subunits, kinase activation, and the recruitment of clathrin, β-arrestin-1 and GRK6 (G-protein receptor kinase 6) to G2A for signal transduction. PMNs were isolated by standard t...
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PMID: 20799926
PDF is available here.
PDF is available here.
Abstract
We show accurate measurement of the internalization and endosomal trafficking of single groups of serotonin (5-hydroxytryptamine, 5-HT) receptors using single quantum dot (QD) probes and quantitative colocalization. We demonstrate that the presence of a QD tag does not interfere with 5-HT receptor i...
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PMID: 20940319
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
These results suggested that Dvl2 is involved in mitotic progression by regulating the dynamics of MT plus-ends and the SAC in Plk1-dependent and -independent manners....
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PMID: 20823832
PDF is available here.
PDF is available here.
Abstract
We have engineered an expression vector, p1D4-hrGFP II, in order to efficiently express visual pigments in mammalian cell culture. This expression vector is based on pIRES-hrGFP II (Stratagene), with the addition of a C-terminal 1D4 epitope tag for immunoblotting and immunoaffinity purification. Thi...
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PMID: 20627111
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
Human medulloblastomas exhibit diverse molecular pathology. Aberrant hedgehog signalling is found in 20-30% of human medulloblastomas with largely unknown metabolic consequences.
Transgenic mice over-expressing smoothened (SMO) receptor in granule cell precursors with high incidence of exophytic med...
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PMID: 20842126
PDF is available here.
PDF is available here.