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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, Cell Surface (27):
- Receptors, Transferrin
- Receptors, Pheromone
- Receptors, Lipoprotein
- Receptors, Death Domain
- Receptors, Neurotransmitter
- Receptors, G-Protein-Coupled
- Receptors, Peptide
- Receptors, Notch
- Neuropilins
- Receptors, N-Acetylglucosamine
- Receptors, Eicosanoid
- Autoreceptors
- Receptors, Purinergic
- Receptors, Biogenic Amine
- Receptors, Adipokine
- Receptor Protein-Tyrosine Kinases
- Antigens, CD36
- Receptors, Proteinase-Activated
- Receptors, Guanylate Cyclase-Coupled
- Receptors, Collagen
- Frizzled Receptors
- Asialoglycoprotein Receptor
- Receptors, Phospholipase A2
- Receptors, Odorant
- Receptors, Immunologic
- Receptors, Virus
- Receptors, Urokinase Plasminogen Activator
Recent article
Receptors, Cell Surface
Journal of Biological Chemistry (286)40 2011
Abstract
We analyzed early activation of murine CD4+ and CD8+ T-lymphocytes at 24 h. We observed a striking and selective up-regulation in the binding of a recombinant soluble form of siglec-E, an inhibitory siglec, which is expressed on several myeloid cell types including antigen-presenting dendritic cells...
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PMID: 21835922
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We investigated the effect of MSCs on immunophenotype of macrophages in the presence of an HA-hydrogel scaffold using a unique 3D coculture system. MSCs were encapsulated in the hydrogel and peripheral blood CD14+ monocyte-derived macrophages plated in direct contact with the MSC-gel construct. To d...
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PMID: 21554192
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)10 2011
Abstract
We will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal c...
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PMID: 20932898
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)10 2011
Abstract
We will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal c...
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PMID: 20932898
PDF is available here.
PDF is available here.
Abstract
Loss of pulp due to caries and pulpitis leads to loss of teeth and reduced quality of life. Thus, there is an unmet need for regeneration of pulp. A promising approach is stem cell therapy. Autologous pulp stem/progenitor (CD105(+)) cells were transplanted into a root canal with stro...
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PMID: 21417716
PDF is available here.
PDF is available here.
Current Oncology Reports (13)3 2011
Abstract
We focus on prognostic and predictive markers in CRC that have a substantial body of data in support of their potential role in routine clinical practice....
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PMID: 21373987
PDF is available here.
PDF is available here.
Abstract
We analyzed how Hb exposure could modulate the macrophage phenotype on a proteome level. We identified and relatively quantified 3691 macrophage proteins, representing the largest human macrophage proteome published to date. The Hb polarized macrophage phenotype was characterized by an induced Hb:Hp...
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PMID: 21405025
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Many biosensors depend on molecular recognition reagents to achieve highly sensitive and specific detection levels of an analyte of interest. Although new and improved detection platforms continue to be developed, improvements in the affinity and specificity of the molecular recognition reagents oft...
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PMID: 19159106
PDF is available here.
PDF is available here.
Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
PDF is available here.
Abstract
We previously examined the functional roles of adipokinetic hormone in Manduca sexta L. (Lepidoptera: Sphingidae). Here we report the cloning of the full-length cDNA encoding the putative adipokinetic hormone receptor from the fat body of M. sexta. The sequence analysis shows that the deduced amino...
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PMID: 21529255
PDF is available here.
PDF is available here.
Abstract
Review of actual trends in early prediction of preeclampsia.
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PMID: 21649998
PDF is available here.
PDF is available here.
Physiological Reviews (91)2 2011
Abstract
We focus on four key mechanistic elements: the molecular basis for adhesion through cadherin ectodomains, the regulation of cadherin expression at the cell surface, cooperation between cadherins and the actin cytoskeleton, and regulation by cell signaling. We discuss current progress and outline iss...
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PMID: 21527735
PDF is available here.
PDF is available here.
Abstract
Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immun...
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PMID: 21350578
PDF is available here.
PDF is available here.
Abstract
We have shown that oligomannose-coated liposomes (OMLs) have a strong adjuvant effect in inducing T-helper 1 (Th1) immune responses and cytotoxic T cells specific for the encased antigen. In the present study, we demonstrate that preferential uptake of OMLs by DCs and subsequent DC maturation and sp...
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PMID: 21112331
PDF is available here.
PDF is available here.
Developmental Cell (20)1 2011
Abstract
We performed a protein-protein interaction screen with the Robo4 extracellular domain. We find that Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors. We show that Robo4 maintains vessel integrity by activating...
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PMID: 21238923
PDF is available here.
PDF is available here.
Abstract
We have used the Mammalian Glycan Array to determine the specific affinities of these proteins. This was correlated with binding protein expression induced by different prebiotics including HMO. Half of the F1SBPs in B. infantis were determined to bind mammalian oligosaccharides. Their affinities in...
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PMID: 21423604
PDF is available here.
PDF is available here.
Abstract
Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1....
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PMID: 21386960
PDF is available here.
PDF is available here.
Abstract
We report that L56A, a PA-binding-affinity-elevated mutant of sTEM8, could inhibit anthrax intoxication as effectively as sCMG2 in Fisher 344 rats. Additionally, pharmacokinetics showed that L56A and sTEM8 exhibit advantages over sCMG2 with better lung-targeting and longer plasma retention time, whi...
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PMID: 21674060
PDF is available here.
PDF is available here.
Acta Crystallographica Section F (67)Pt 1 2011
Abstract
The Gram-positive spore-forming bacterium Bacillus anthracis causes anthrax by secreting anthrax toxin, which consists of protective antigen (PA), lethal factor and oedema factor. Binding of PA to receptors triggers the multi-step process of anthrax toxin entry into target cells. Two...
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PMID: 21206026
PDF is available here.
PDF is available here.
Abstract
We identified the chicken chorioallantoic membrane (CAM) as a model system to study the endogenous function of TEM8 in blood vessels as we found that TEM8 expression was induced transiently between day 10 and 12 of embryonic development, when the vascular tree is undergoing final development and gro...
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PMID: 21829615
PDF is available here.
PDF is available here.
Abstract
Hypospadias is a common congenital anomalies, yet its molecular basis remains unknown. Recent studies have linked perturbations in the Hedgehog signaling pathway to hypospadias. However, the expression of Sonic hedgehog (Shh) has not been reported during genital development. Immunohi...
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PMID: 21434830
PDF is available here.
PDF is available here.
Abstract
We show that porcine sialoadhesin-specific antibodies and F(ab')₂ fragments trigger sialoadhesin internalization, both in primary porcine macrophages and in cells expressing recombinant porcine sialoadhesin. Using chemical inhibitors, double immunofluorescence stainings and dominant-negative const...
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PMID: 21359217
PDF is available here.
PDF is available here.
Abstract
We explored which mechanism could be involved in renal clearance of rFVIIa.
Immunohistochemistry was used for examination of the renal distribution in detail after injection of rFVIIa to mice and rats. Surface plasmon resonance evaluated specific binding of rFVIIa to megalin and cubi...
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PMID: 20861656
PDF is available here.
PDF is available here.
Abstract
We explored which mechanism could be involved in renal clearance of rFVIIa.
Immunohistochemistry was used for examination of the renal distribution in detail after injection of rFVIIa to mice and rats. Surface plasmon resonance evaluated specific binding of rFVIIa to megalin and cubi...
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PMID: 20861656
PDF is available here.
PDF is available here.
Abstract
We explored which mechanism could be involved in renal clearance of rFVIIa.
Immunohistochemistry was used for examination of the renal distribution in detail after injection of rFVIIa to mice and rats. Surface plasmon resonance evaluated specific binding of rFVIIa to megalin and cubi...
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PMID: 20861656
PDF is available here.
PDF is available here.
Abstract
Goeckerman's therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Disturbances in angiogenic activity are characteristic for the immunopathogenesis of psoriasis. The aim of study was to evaluate the influence of GT o...
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PMID: 21842718
PDF is available here.
PDF is available here.
Abstract
T-cell activation depends upon two types of signals: a T-cell-receptor-mediated antigen-specific signal and several non-antigen-specific ones provided by the engagement of costimulatory and/or inhibitory T-cell surface molecules. In clinical transplantation, T-cell costimulatory/inhibitory molecules...
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PMID: 20941624
PDF is available here.
PDF is available here.
Abstract
Mesenchymal stem cells (MSCs) have been isolated from many tissues including differentiating human embryonic stem cells (hESCs). Derivation of MSCs from hESCs consists of two major steps: differentiation and isolation. In our hands, differentiation of hESCs towards MSC-enriched culture can be induce...
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PMID: 21042993
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We demonstrate a physical association of RTE1 and ETR1 using in vivo and in vitro methods. Interaction of RTE1 and ETR1 was revealed in vivo by bimolecular fluorescence complementation (BiFC) in a tobacco cell transient assay and in stably transformed Arabidopsis. The association was also observed u...
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PMID: 20952388
PDF is available here.
PDF is available here.
Abstract
We have now examined the expression of Sema3A and its receptor components Npn1 and PlxA during development of the mouse cornea. Sema3A and Npn1 showed similar patterns of expression by immunohistofluorescence analysis, with such expression being prominent in the corneal epithelium during both embryo...
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PMID: 21075075
PDF is available here.
PDF is available here.
Experimental oncology (32)4 2010
Abstract
The hallmark of Hodgkin's lymphoma (HL) are mononucleated Hodgkin's cells and multinucleated Reed-Sternberg (HRS) cells, which usually account for only about 1% of cells in the tumor tissue. The majority of HRS cells in classical HL are derived from germinal centre B cells that have...
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PMID: 21270747
PDF is available here.
PDF is available here.
Nature Methods (7)12 2010
Abstract
We used an array of self-assembled monolayers to identify peptide surfaces that sustain pluripotent stem cell self-renewal. The effective substrates displayed heparin-binding peptides, which can interact with cell-surface glycosaminoglycans and could be used with a defined medium to culture hES cell...
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PMID: 21076418
PDF is available here.
PDF is available here.
Microbial Pathogenesis (49)6 2010
Abstract
We confirmed that invasion into two lung epithelial cell lines (16HBE14o- and CFBE41o-) which have a non-CF and CF phenotype, respectively, is receptor mediated and showed that pre-treatment of these epithelial cell lines with α- or β-galactosidase reduced invasion of isolates of two species of Bc...
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PMID: 20826205
PDF is available here.
PDF is available here.
Bulletin du cancer (97)12 2010
Abstract
It has long been known that the hedgehog signaling pathway is crucial for embryonic development, in both Drosophila and vertebrate systems. During the past few years its implication in carcinogenesis has become clear and today it is acknowledged that this pathway plays a role in the malignant transf...
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PMID: 21220225
PDF is available here.
PDF is available here.
Journal of Endocrinology (207)3 2010
Abstract
Pancreatic β cells adapt to pregnancy-induced insulin resistance by unclear mechanisms. This study sought to identify genes involved in β cell adaptation during pregnancy. To examine changes in global RNA expression during pregnancy, murine islets were isolated at a time point of increased β cell...
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PMID: 20847227
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We recently demonstrated that the Gla domain-dependent interaction of protein C with endothelial protein C receptor (EPCR) leads to dissociation of the receptor from caveolin-1 and recruitment of PAR-1 to a protective signaling pathway. Thus, the activation of PAR-1 by either thrombin or PAR-1 agoni...
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PMID: 20826780
PDF is available here.
PDF is available here.
Abstract
We summarize recent evidence of receptor- and transporter-mediated Aβ clearance across the BBB. Furthermore, we discuss the models used to identify and characterize Aβ transport across the BBB in regard to barrier properties and suitability of the models for the experimental investigation of trans...
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PMID: 20704558
PDF is available here.
PDF is available here.
Abstract
We sought to evaluate the association between soluble fms-like tyrosine kinase 1 (sFlt1) and endoglin (ENG) and preeclampsia in an urban population, to develop a discriminatory model, and evaluate the association of these biomarkers with small for gestational age (SGA).
Cases are prospectively ident...
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PMID: 20482287
PDF is available here.
PDF is available here.
Abstract
Myometrial invasion is an independent prognostic parameter of the endometrioid carcinomas which correlates with the risk of metastasis to pelvic and/or paraaortic lymph nodes. Recognition of myometrial invasion is sometimes difficult. In fact, myoinvasion is overdiagnosed in routine practice in as m...
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PMID: 20962622
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)10 2010
Abstract
The present review explores the interactions between sweeteners and enteroendocrine cells, and consequences for glucose absorption and insulin release. A combination of in vitro, in situ, molecular biology and clinical studies has formed the basis of our knowledge about the taste receptor proteins i...
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PMID: 20619074
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
We will present here a general classification of the main pathways of cell signalling and some of the recurrent mechanisms used for the transmission of information between cells and inside cells....
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PMID: 21047720
PDF is available here.
PDF is available here.
Abstract
We present crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto). These structures, together with biop...
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PMID: 20877282
PDF is available here.
PDF is available here.
Abstract
We report the crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states. Before binding, the Sema6A ectodomain was in the expecte...
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PMID: 20881961
PDF is available here.
PDF is available here.
Abstract
We previously showed that neurotoxin-induced dopaminergic (DA) cell loss is decreased by inhibition of angiotensin receptors, but the location and functional effects of prorenin receptor (PRR) in the brain, including the DA system, are unknown. In the substantia nigra of Macaca fascicularis and in r...
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PMID: 20940627
PDF is available here.
PDF is available here.
Cancer Treatment Reviews (36 Suppl 3) 2010
Abstract
Metastatic colorectal cancer (mCRC) patients carrying KRAS mutated tumors do not benefit from epidermal growth factor receptor (EGFR)-targeted cetuximab- or panitumumab-based therapies. Indeed, the mutational status of KRAS is currently a validated predictive biomarker employed to select mCRC patien...
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PMID: 21129603
PDF is available here.
PDF is available here.
Abstract
We studied 5 individuals who had survived EBV infection and found CD8(+) T-cell responses numerically comparable with healthy donors. However, further investigation of in vitro-derived CD8(+) T-cell clones established from 2 of these donors showed they efficiently recognized SLAM ligand-negative tar...
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PMID: 20644117
PDF is available here.
PDF is available here.
Abstract
We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation and are tumor specific. Unexpectedly, added glycans terminate at high mannose, suggesting a potentially important interaction of F...
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PMID: 20937880
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We show that the A chain of ricin, the well-known plant RIP (ribosome-inactivating protein), interacts with PMN (Kd=10⁻⁹ M; 2×10⁵ binding sites) competing for the same receptor that recognizes Stx, whereas diphtheria toxin and several agonists of TLRs (Toll-like receptors) or the mannose rece...
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PMID: 20809900
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We have previously identified the PKC (protein kinase C)-anchoring protein RACK1 (receptor for activated C-kinase 1), as a specific binding partner for the cAMP-specific phosphodiesterase PDE4D5, suggesting a potential site for cross-talk between the PKC and cAMP signalling pathways. In the present...
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PMID: 20819076
PDF is available here.
PDF is available here.
Abstract
Sex steroids play a key role in maintaining skeletal integrity lifelong, through a complex variety of endocrine, but also paracrine and possibly autocrine actions. The current knowledge that androgens may act as pro-hormones for estrogens has seriously challenged many traditional views, so that, at...
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PMID: 20627086
PDF is available here.
PDF is available here.
Abstract
We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over calvariae of BALB/c mice for 3 days, after which the soft tissues and...
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PMID: 20883221
PDF is available here.
PDF is available here.
Abstract
This protocol presents methods for the specific detection of neuronal cell-surface receptors and secreted factors. These techniques allow visualization of surface pools of receptor proteins and also reveal the surface distribution of secreted cues. Live dissection of embryos to expose the ventral ne...
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PMID: 20889701
PDF is available here.
PDF is available here.
Abstract
Analyses of microvascular networks with traditional tracer filling techniques suggest that the blood and lymphatic systems are distinct without direct communications, yet involvement of common growth factors during angiogenesis and lymphangiogenesis suggest that interactions at the c...
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PMID: 20648570
PDF is available here.
PDF is available here.
Clinical Immunology (137)1 2010
Abstract
We analyzed the M2 marker expression and intracellular signal transduction in the course of cytokine-driven differentiation. We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. S...
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PMID: 20674506
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (26)10 2010
Abstract
to detect the expression of Hedgehog pathway components PTCH-1 and SMO mRNA in nasopharyngeal carcinoma (NPC), and discuss its biological significance.
expression of PTCH-1 and SMO mRNA was evaluated by real-time fluorescence quantitative PCR in 32 cases of NPC and 32 cases of nasopharyngitis. Accor...
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PMID: 20937227
PDF is available here.
PDF is available here.
Abstract
We sequenced multiple alleles of the eater gene from an African and a North American population of D. melanogaster and found signatures of a partial selective sweep in North America that is localized around the second intron. This pattern is consistent with local adaptation to novel selective pressu...
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PMID: 20444883
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)28 2010
Abstract
We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes. We defined stromal metagenes and tested their prognostic values in 684 node-negative patients who received no systemic adjuvant thera...
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PMID: 20805453
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
We investigated endothelial cell marker CD31 (PECAM-1) and angiogenesis associated marker CD105 (endoglin) by immunohistochemistry.
Thirty-two cases of surgically resected IPMN were chosen retrospectively and clinical data were obtained. Specimens were stained for proliferation marker (Ki-67), CD31...
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PMID: 20712008
PDF is available here.
PDF is available here.