Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Utrophin (0):
Recent article
Utrophin
Abstract
We show that the extracellular matrix protein biglycan regulates utrophin expression in immature muscle and that recombinant human biglycan (rhBGN) increases utrophin expression in cultured myotubes. Systemically delivered rhBGN up-regulates utrophin at the sarcolemma and reduces muscle pathology in...
|
PMID: 21187385
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Brain Pathology (20)2 2010
Abstract
We generated Utrn-A and -B promoter-specific antibodies, Taqman Polymerase chain reaction (PCR)-based absolute copy number assays, and luciferase-reporter constructs to study CNS of normal and dystrophic mdx mice. Differential expression of Utrn-A and -B was noted in microdissected and capillary-enr...
|
PMID: 19486009
PDF is available here.
PDF is available here.
Abstract
We demonstrated that a cell polarity-regulating kinase, PAR-1b, interacts with the utrophin-DG complex, and positively regulates the interaction between utrophin and DG. In this study, we demonstrate that the 8th and 9th spectrin-like repeats (R8 and R9) of utrophin cooperatively form a PAR-1b-inter...
|
PMID: 19945424
PDF is available here.
PDF is available here.
Abstract
This work provides, for the first time, evidences about miRNAs misexpression in DM1 muscle tissues, adding a new element in the pathogenesis of this complex genetic disease....
|
PMID: 20487562
PDF is available here.
PDF is available here.
Abstract
We engineered and selected a new family of artificial transcription factors, whose DNA-binding domain consists in a three zinc finger peptide called "Jazz." Jazz protein binds specifically the 9 bp DNA sequence (5(')-GCT-GCT-GCG-3(')) present in the promoter region of both the human and mouse utroph...
|
PMID: 20680835
PDF is available here.
PDF is available here.
Abstract
We show that both synaptic and extrasynaptic forms of laminin and agrin have increased binding to the CT carbohydrate compared to sialyl-N-acetyllactosamine, its extrasynaptically expressed precursor. Muscle laminins also show increased binding to CT-glycosylated muscle alpha dystroglycan relative t...
|
PMID: 19442736
PDF is available here.
PDF is available here.
Abstract
To investigate the differentiation of rat bone marrow mesenchymal stem cells (MSCs) into myocytes and their expression of dystrophin/utrophin after transplantation in mdx mice.
BrdU-labeled fifth-passage rat MSCs were transplanted in mdx mice with previous total body...
|
PMID: 19460724
PDF is available here.
PDF is available here.
Abstract
Present study demonstrates a novel localization of beta-dystroglycan in rat brain. Beside the meningeal surface and the cerebral vessels where beta-dystroglycan immunopositivity has been described, now immunopositive solid bodies were found at the basis of ependymocytes. Since they proved to be roun...
|
PMID: 18985737
PDF is available here.
PDF is available here.
Biotechnology Letters (30)12 2008
Abstract
We describe here the application of mRNA-display technology with a cDNA library for the isolation of cross-reacting antigens using a monoclonal antibody against human tumor protein p53 (hTP53) as a model. A mixed cDNA library constructed from mRNAs prepared from several human tissues and cell-lines...
|
PMID: 18633578
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)3 2008
Abstract
We show that sarcospan (SSPN), a unique tetraspanin-like component of the DGC, ameliorates muscular dystrophy in dystrophin-deficient mdx mice. SSPN stabilizes the sarcolemma by increasing levels of the utrophin-glycoprotein complex (UGC) at the extrasynaptic membrane to compensate for the loss of d...
|
PMID: 18981229
PDF is available here.
PDF is available here.
Brain Research (1218) 2008
Abstract
We examined dystrophin and utrophin expression and localization in the avian parasympathetic ciliary ganglion (CG) to determine whether these proteins play a general role at neuronal nicotinic synapses. We have determined that full-length utrophin and dystrophin and the short dystrophin isoform Dp11...
|
PMID: 18533135
PDF is available here.
PDF is available here.
Journal of Gene Medicine (10)6 2008
Abstract
Our results showed that DUE is indispensable for utrophin expression in skeletal muscle and heart, and primary myogenic cells from this Tg mice provide a high through-put screening system for drugs that up-regulate utrophin expression....
|
PMID: 18338831
PDF is available here.
PDF is available here.
Circulation (117)19 2008
Abstract
Selective vacuolar degeneration of Purkinje fibers was found in the early stages of dystrophin deficiency. Dislocation of utrophin besides upregulation of Dp71 can be involved with this pathology. The degeneration of Purkinje fibers can be associated with the distinct deep Q waves in ECG and fatal a...
|
PMID: 18458171
PDF is available here.
PDF is available here.
Abstract
We compared muscle force and pathology in mdx3cv and mdx4cv mice. Dystrophin was eliminated in mdx4cv mouse muscle but was expressed in mdx3cv mice as a near full-length protein at approximately 5% of normal levels. Consistent with previous reports, we found dystrophic muscle pathology in both mouse...
|
PMID: 18385524
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of Dp71 deletion on the composition, anchoring, and membrane localization of the DAPs-Kir4.1 and/or -AQP4 complex. Two distinct complexes were identified in the end-feet fraction associated either with Dp71 or with utrophin. Upon Dp71 deletion, the corresponding DAPs compl...
|
PMID: 18286645
PDF is available here.
PDF is available here.
Abstract
We have investigated whether administration of an antioxidant, epigallocatechin-3-gallate (EGCG), a component of green tea, reduces their oxidative stress and pathophysiology in mdx mice, a mild phenotype model of human Duchenne-type muscular dystrophy. EGCG (5 mg/kg body weight in saline) was injec...
|
PMID: 18264714
PDF is available here.
PDF is available here.
Neuromuscular Disorders (18)3 2008
Abstract
We thus examined the gene expression profile of mdx mouse muscle compared to wild-type mouse muscle and compared the data with that obtained from the transgenic line overexpressing utrophin. The data confirm that the expression of utrophin in the mdx mouse muscle results in a global gene expression...
|
PMID: 18343112
PDF is available here.
PDF is available here.
Abstract
We report the generation of mice with an intact and functional copy of the 2.3-megabase human dystrophin gene (hDMD), the largest functional stretch of human DNA thus far integrated into a mouse chromosome. Yeast spheroplasts containing an artificial chromosome with the full-length hDMD gene were fu...
|
PMID: 18083704
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)3 2008
Abstract
We examined the role of post-transcriptional mechanisms in controlling utrophin A mRNA expression in slow versus fast skeletal muscles. First, we determined that the half-life of utrophin A mRNA is significantly shorter in the presence of proteins isolated from fast muscles. Direct plasmid injection...
|
PMID: 18084024
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (264)1-2 2008
Abstract
We performed qualitative and quantitative analysis of skeletal muscle inflammation and fibrosis in mdx and mdx/utrn+/- littermates. Inflammation was significantly worse in mdx/utrn+/- quadriceps at age 3 and 6 months and in mdx/utrn+/- diaphragm at age 3 but not 6 months. Fibrosis was more severe in...
|
PMID: 17889902
PDF is available here.
PDF is available here.
Circulation Research (102)1 2008
Abstract
We have shown recently that mosaic dystrophin expression prevents stress-induced heart damage in young carrier mice. Although an interesting finding, the clinical relevance remains to be established because young dystrophin-null mdx mice do not have heart disease. On the other hand, heart failure ha...
|
PMID: 17967782
PDF is available here.
PDF is available here.
Abstract
We show that treatment of myotubes with 6alpha-methylprednisolone-21 sodium succinate (PDN) results in enhanced expression of utrophin A without concomitant increases in mRNA levels thereby suggesting that translational regulation contributes to the increase. In agreement with this, we show that PDN...
|
PMID: 18545658
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated the presence of Dp71 isoforms, utrophins, and various dystrophin-associated proteins and their participation in cytoskeleton re-organization, filopodia and lamellipodia extension, and in centralizing cytoplasmic granules during the adhesion process of human platelets. To e...
|
PMID: 18180614
PDF is available here.
PDF is available here.
Abstract
We therefore evaluated the long-term effect of ADAM12 overexpression in muscle. Surprisingly, we observed loss of skeletal muscle and accelerated fibrosis and adipogenesis in 1-year-old mdx mice transgenically overexpressing ADAM12 (ADAM12(+)/mdx mice), even though their utrophin levels were mildly...
|
PMID: 17982130
PDF is available here.
PDF is available here.
Abstract
We describe fluorescent F-actin probes based on the calponin homology domain of utrophin (Utr-CH), which binds F-actin without stabilizing it in vitro. We show that these probes faithfully report the distribution of F-actin in living and fixed cells, distinguish between stable and dynamic F-actin, a...
|
PMID: 17685442
PDF is available here.
PDF is available here.
Neuroreport (18)16 2007
Abstract
We established a coculture model using PC12 cells and L6 myotubes and analyzed expression and localization of Dp71 and related proteins, utrophin and beta-dystroglycan, in PC12 cells. Confocal microscopy showed Dp71d isoform in PC12 nuclei, golgi-complex-like and endoplasmic reticulum-like structure...
|
PMID: 17921863
PDF is available here.
PDF is available here.
Abstract
We have also recently shown the expression of utrophin A, a cytoskeletal protein that accumulates at the neuromuscular junction and plays a role in maturation of the postsynaptic apparatus, to be regulated by CnA-NFAT and Ca2+/CaM signalling. This regulation is fibre-type specific and potentiated by...
|
PMID: 18059617
PDF is available here.
PDF is available here.
Abstract
We found that UTRN (which encodes utrophin, a dystrophin-related protein) at 6q24, when expressed in an antisense orientation, induced cellular transformation, consistent with a tumor suppressor role. Northern blot analysis, semiquantitative reverse transcription-polymerase chain reaction (RT-PCR),...
|
PMID: 17384672
PDF is available here.
PDF is available here.
FEBS Letters (581)22 2007
Abstract
We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed heregulin-mediated utrophin-A activation. MSK1 over-expression potentiated heregulin-mediated utrophin-A activation and c...
|
PMID: 17692845
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the Ets-2 repressor factor (ERF) represses extrasynaptic utrophin-A in muscle. Gel shift and chromatin immunoprecipitation studies demonstrated physical association of ERF with the utrophin-A promoter N-box/EBS site. ERF overexpression repressed utrophin-A promoter activity; conv...
|
PMID: 17507653
PDF is available here.
PDF is available here.
Abstract
We show that overexpression of the cytotoxic T cell (CT) GalNAc transferase (Galgt2) is effective in inhibiting the development of muscle pathology in the dy(W) mouse model of MDC1A, much as we had previously shown in mdx animals. Embryonic overexpression of Galgt2 in skeletal muscles using transgen...
|
PMID: 17591965
PDF is available here.
PDF is available here.
Abstract
These results are the first to report alterations in expression of muscle-enriched microRNAs in skeletal muscle of the mdx mouse, suggesting microRNAs may have a role in the pathophysiology of muscular dystrophy....
|
PMID: 17459947
PDF is available here.
PDF is available here.
Abstract
We designed and engineered synthetic zinc-finger based transcription factors. We have previously shown that the artificial 3-zinc-finger protein Jazz, fused with the appropriate effector domain, is able to drive the transcription of a test gene from utrophin promoter A. Here we report a novel artifi...
|
PMID: 17612630
PDF is available here.
PDF is available here.
Human Pathology (38)5 2007
Abstract
Pancreatic endocrine tumors (PETs), both functioning and nonfunctioning, are usually well differentiated and progress slowly. The 2004 World Health Organization (WHO) criteria classify PETs according to clinicopathologic features and Ki-67 proliferative index. A tumor associated with poorer prognost...
|
PMID: 17306326
PDF is available here.
PDF is available here.
Nature Medicine (13)5 2007
Abstract
Journal of Cell Biology (176)7 2007
Abstract
We show the differential regulation of plectin isoforms during myotube differentiation and their localization to different compartments of muscle fibers, identifying plectins 1 and 1f as sarcolemma-associated isoforms, whereas plectin 1d localizes exclusively to Z-disks. Coimmunoprecipitation and in...
|
PMID: 17389230
PDF is available here.
PDF is available here.
Neuromuscular Disorders (17)3 2007
Abstract
We use adeno-associated virus (AAV) to show that overexpression of Galgt2 in skeletal myofibers in the early postnatal period is equally effective in inhibiting muscular dystrophy, but that it does so without altering muscle growth or neuromuscular structure. Unlike embryonic overexpression, postnat...
|
PMID: 17300937
PDF is available here.
PDF is available here.
Abstract
We used transgenic technology to enhance integrin expression in mice lacking delta-sarcoglycan (delta sgc), a mouse model for human limb girdle muscular dystrophy type 2F. Unlike alpha7 transgenic mdx/utr-/- mice, enhanced alpha7beta1 integrin expression in the delta sgc-null mouse did not alleviate...
|
PMID: 17255329
PDF is available here.
PDF is available here.
Biochemical Journal (401)3 2007
Abstract
We demonstrate a conformational effect of zinc binding to the ZZ domain, and identify two zinc-binding regions within the ZZ domain by SPOTs overlay assays. Epitope mapping of the dystrophin ZZ domain was carried out with new monoclonal antibodies by ELISA, overlay assay and immunohistochemistry. On...
|
PMID: 17009962
PDF is available here.
PDF is available here.
Abstract
We postulated the presence of an utrophin associated protein complex (UAPC) in endothelium from umbilical cord vessels. In the present work, we demonstrate that utrophin (UTR) indeed forms a complex, with beta-dystroglycan (DG), epsilon-sarcoglycan (SG), caveolin-1 (cav-1), and endothelial nitric ox...
|
PMID: 17127434
PDF is available here.
PDF is available here.
Abstract
Our results indicate that LOX inhibitors, similarly to corticosteroids, can be beneficial in the treatment of muscular dystrophies....
|
PMID: 17997295
PDF is available here.
PDF is available here.
Human Molecular Genetics (15 Spec No 2) 2006
Abstract
We need to address whether all or only some of the recently developed mini- and microgenes are protective in the heart, whether partial correction can lead to whole heart function improvement, whether over-expression is hazardous and whether correcting skeletal muscle disease can slow down or stop t...
|
PMID: 16987891
PDF is available here.
PDF is available here.
Journal of Cell Biology (175)1 2006
Abstract
We investigated two genes that are suppressed in fibroblasts converted to skeletal muscle by MyoD, follistatin-like 1 (Fstl1) and Utrn. MyoD directly activates the expression of a muscle-specific microRNA (miRNA), miR-206, which targets sequences in the Fstl1 and Utrn RNA, and these sequences are su...
|
PMID: 17030984
PDF is available here.
PDF is available here.
Abstract
Chinese Medical Journal (119)16 2006
Abstract
Further understanding of pathophysiological mechanisms at molecular levels and regenerative properties of myogenic precursor/stem cells will promote the development of multiple therapeutic strategies. The combined use of multiple strategies may represent the major challenge as well as the greatest h...
|
PMID: 16934185
PDF is available here.
PDF is available here.
Neuroscience (141)2 2006
Abstract
We asked if the processing of the beta-dystroglycan could influence the anchorage of Dp116 and/or utrophin in normal and mdx Schwann cell membrane. We showed that metalloproteinase-9 was more activated in mdx nerve than in wild-type ones. This activation leads to an accumulation of the 30 kDa beta-d...
|
PMID: 16735092
PDF is available here.
PDF is available here.
Abstract
We show herein that tissue-purified avian synemin directly interacts with both dystrophin and utrophin, and that specific expressed regions of both of the mammalian (human) synemin isoforms (alpha-synemin and beta-synemin) directly interact with specific expressed domains/regions of the dystrophin a...
|
PMID: 16777071
PDF is available here.
PDF is available here.
Abstract
We demonstrated the presence of dystrophin-associated protein complex corresponding to short dystrophin isoforms (Dp71d and Dp71) and the uthophin gene family (Up400 and Up71), which promote shape change, adhesion, aggregation, and granule centralisation. To elucidate participation of both complexes...
|
PMID: 16803572
PDF is available here.
PDF is available here.
Muscle & Nerve (34)1 2006
Abstract
The purpose of this study was to determine whether contractile protein alterations are responsible for force deficits in young dystrophic muscle. Contractility of intact extensor digitorum longus muscles and permeabilized fibers from wild-type (wt), dystrophin-deficient (mdx), and dystrophin/utrophin...
|
PMID: 16634063
PDF is available here.
PDF is available here.
Abstract
We focus on recent studies of the DGC in brain, blood-brain barrier and choroid plexus, retina, and kidney and discuss the role of dystrophin isoforms and utrophin for assembly of the complex in these tissues....
|
PMID: 16710609
PDF is available here.
PDF is available here.
Journal of Cell Science (119)Pt 13 2006
Abstract
We analyzed muscles of mdx mice in which degeneration and regeneration were inhibited by the expression of micro-dystrophins or utrophin transgenes. Postnatal RF expansion was diminished in direct correlation to the protective effect of the transgene expression. Similarly, expansion of RFs was inhib...
|
PMID: 16757519
PDF is available here.
PDF is available here.
Muscle & Nerve (33)6 2006
Abstract
We investigated the susceptibility of utrophin to cleavage by calpain in vitro and in muscle cells. We found that utrophin is a direct in vitro substrate of purified calpain I and II. Cleavage of utrophin by calpain I or II generates specific degradation products that are also found in cultured cont...
|
PMID: 16598790
PDF is available here.
PDF is available here.
Human Molecular Genetics (15)10 2006
Abstract
We investigated in diagnostic muscle biopsies from 16 patients with Duchenne muscular dystrophy (DMD) the level of utrophin expression using quantitative immunoblot analysis. In 13 of 16 patients, in whom there was adequate follow-up data, utrophin expression was correlated to two clinical endpoints...
|
PMID: 16595608
PDF is available here.
PDF is available here.
Neurogenetics (7)2 2006
Abstract
We derived mdx and dko primary myogenic cultures and analyzed the expression of Myh7 and Myl2. Real-time reverse transcriptase-polymerase chain reaction analysis demonstrates that transcription of these slow genes is also upregulated in dko vs mdx myotubes. This data suggests that at least part of t...
|
PMID: 16525850
PDF is available here.
PDF is available here.