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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Membrane Proteins (28):
- Pulmonary Surfactant-Associated Protein C
- Pulmonary Surfactant-Associated Protein B
- Phospholipid Transfer Proteins
- Protoporphyrinogen Oxidase
- Membrane Fusion Proteins
- Heterotrimeric GTP-Binding Proteins
- Dystrophin-Associated Proteins
- Vesicular Transport Proteins
- Spectrin
- Neurofibromin 2
- Ephrins
- Arrestins
- Membrane Transport Proteins
- Dystrophin
- Utrophin
- Receptor-Like Protein Tyrosine Phosphatases
- Membrane Glycoproteins
- Chemokine CX3CL1
- Calnexin
- Myelin Proteins
- Pore Forming Cytotoxic Proteins
- Matrix Metalloproteinases, Membrane-Associated
- Presenilins
- Cornified Envelope Proline-Rich Proteins
- Ankyrins
- Receptors, Cell Surface
- LDL-Receptor Related Protein-Associated Protein
- Bacterial Outer Membrane Proteins
Recent article
Membrane Proteins
BMC Genomics (12) 2011
Abstract
We have manually curated the rif and stevor gene repertoires of two Plasmodium falciparum genomes, isolates DD2 and HB3. We have identified 25% of mis-annotated and ~30 missing rif and stevor genes. Using these data sets, as well as sequences from the well curated reference genome (isolate 3D7) and...
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PMID: 21332983
PDF is available here.
PDF is available here.
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Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Journal of Cell Science (124)Pt 6 2011
Abstract
We report here that kindlin-2 interacts with multiple phosphoinositides, preferentially with phosphatidylinositol 3,4,5-trisphosphate. Although integrin-binding is essential for focal adhesion localization of kindlin-2, phosphoinositide-binding is not required for this process. Using biologically an...
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PMID: 21325030
PDF is available here.
PDF is available here.
Abstract
We show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific fashion. This response requires olfactory receptor activity and the Notch ligand Delta. We present evidence that Notch activation depends on synaptic transmission by the ORNs in which the receptors are...
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PMID: 21315258
PDF is available here.
PDF is available here.
Abstract
We have established a tethering system, in which the Gal4 DNA binding domain (DBD) of the Flag:Gal4 DBD:Ote▵LEM fusion protein physically interacts with the Gal4 binding sites upstream of bamP-gfp to artificially recruit the reporter gene gfp to the nuclear membrane. Our data demonstrated that the...
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PMID: 21356524
PDF is available here.
PDF is available here.
Abstract
We mapped 2 differential transcriptome data of MSCs compared, one to mononuclear cells and the other to fibroblasts, onto the membrane proteome data, the analysis of which led to an identification of transmembrane 4 L6 family member 1 (TM4SF1) as a surface protein marker candidate that could discrim...
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PMID: 20486778
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We mapped the surface-attached proteome of S. Typhimurium SL1344 grown in vitro under SPI-2-inducing conditions and identified 108 proteins; using secretion signal prediction software, 43% of proteins identified contained a signal sequence. Of these proteins, 13 were known secreted effector proteins...
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PMID: 21268266
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
Cell surface physicochemical characterization techniques were combined with quantitative changes in protein expression, to investigate the biological and biophysical changes of Escherichia coli MG1655 cells when grown as a biofilm (BIO). The overall surface charge of BIO cells was fo...
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PMID: 21268264
PDF is available here.
PDF is available here.
Journal of Proteomics (74)2 2011
Abstract
Lipid rafts are microdomains of the phospholipid bilayer, proposed to form semi-stable "islands" that act as a platform for several important cellular processes; major classes of raft-resident proteins include signalling proteins and glycosylphosphatidylinositol (GPI)-anchored protei...
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PMID: 21070894
PDF is available here.
PDF is available here.
Abstract
Dynamic plasma membrane rearrangements occur during many cellular processes including endocytosis, morphogenesis, and migration. Actin polymerization together with proteins that directly deform membranes, such as the BAR superfamily proteins, is essential for generation of membrane i...
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PMID: 21093245
PDF is available here.
PDF is available here.
BMC Cancer (11) 2011
Abstract
We have investigated the role of additional apoptotic players, the pro-apoptotic protein Bim as well as the anti-apoptotic protein Mcl-1.
Pharmacological inhibition of JAK2/STAT5 signaling in JAK2V617F mutant SET-2 and MB-02 cells was used to study effects on signaling, cell prolifer...
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PMID: 21247487
PDF is available here.
PDF is available here.
Abstract
We report evidence that ALKBH5 is probably unique amongst the ALKBH genes in being a direct transcriptional target of hypoxia inducible factor-1 (HIF-1) and is induced by hypoxia in a range of cell types. We show that purified recombinant ALKBH5 is a bona fide 2OG oxygenase that catalyses the decarb...
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PMID: 21264265
PDF is available here.
PDF is available here.
Abstract
Congenital nephrotic syndrome of the Finnish type is a serious renal disease belonging to the Finnish disease heritage. It appears as substantial proteinuria, hypoproteinemia and edema in a newborn. Kidney transplantation is the only effective treatment. The cause of the disease is a mutation in the...
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PMID: 21696001
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Abstract
Our results showed that T. stromaticum spores prevented the expression and production of inflammatory mediators in macrophages stimulated with interferon (IFN)-γ plus lipopolysaccharide (LPS) and neutrophils stimulated with phorbol myristate 13-acetate (PMA). Quantitative polymerase chain reaction...
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PMID: 21623538
PDF is available here.
PDF is available here.
Acta Crystallographica Section F (67)Pt 1 2011
Abstract
The Gram-positive spore-forming bacterium Bacillus anthracis causes anthrax by secreting anthrax toxin, which consists of protective antigen (PA), lethal factor and oedema factor. Binding of PA to receptors triggers the multi-step process of anthrax toxin entry into target cells. Two...
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PMID: 21206026
PDF is available here.
PDF is available here.
Abstract
We investigated the role of Spry1 in the development of the endothelial and hematopoietic lineages during development.
Quantitative RT-PCR analysis demonstrates that Spry1, Spry2, and Spry4 are expressed in Flk1(+) hemangioblasts in vivo, and decline significantly in c-Kit(+) and CD4...
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PMID: 21483770
PDF is available here.
PDF is available here.
Abstract
We show that SDF-1 and VEGF, which are produced by tumors, increase Dll4 expression on recruited BM-VPC. Mechanistically, BM-VPC activated, in a Dll4-dependent manner, a transcriptional program on mature EC suggestive of EC activation and stabilization. BM-VPC induced ICAM-2 and Fibronectin expressi...
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PMID: 21483741
PDF is available here.
PDF is available here.
Vascular Pharmacology (55)1-3 2011
Abstract
We reported the unexpected proteomic identification in endothelial cells (EC) of Myoferlin, a member of the Ferlin family of transmembrane proteins. Ferlins are well known to regulate the fusion of lipid vesicles at the plasma membrane in muscle cells, and we showed that Myoferlin gene knockdown not...
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PMID: 21586340
PDF is available here.
PDF is available here.
Abstract
We examined piebald, a pigmentation phenotype in both human and Merino sheep, by analysing multiple data types using a systems approach. First, a case control analysis of 49,034 ovine SNP was performed which confirmed a multigenic basis for the condition. We combined these results with gene expressi...
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PMID: 21701676
PDF is available here.
PDF is available here.
Abstract
We found expression of CD43 induced cell rounding, inhibition of cell re-attachment, augmentation of microvilli, and phosphorylation of ERM in HEK293T cells. Mutant studies revealed the ectodomain of CD43, but not the intracellular domain, essential and sufficient for all these phenomena. We also fo...
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PMID: 21045567
PDF is available here.
PDF is available here.
Abstract
We have created a conditional mouse mutant with brain-restricted deficiency of PEX13 that exhibits cerebellar morphological defects. PEX13 brain mutants survive into the postnatal period, with the majority dying by 35 days, and with survival inversely related to litter size and weaning body weight....
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PMID: 20959636
PDF is available here.
PDF is available here.
Abstract
We found a 2.27-fold (p<0.001) enhanced expression of PINCH, 4 fold for α-parvin, and 10.5 fold (p<0.001) for ILK as compared to non-failing (NF) counterparts. No significant enhancements were found for the PINCH isoform PINCH-2 and parvin isoform β-parvin. Using a co-immunoprecipitation method, w...
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PMID: 21625516
PDF is available here.
PDF is available here.