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Metalloproteins (7):
Recent article
Metalloproteins
Abstract
Although the proteome and genome of bacteriophages are well developed, there is little knowledge about metals and their interactions with the phages, even though metals have been observed in stabilizing phage particles. With expanding studies of phage display and its promising applic...
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PMID: 21423961
PDF is available here.
PDF is available here.
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Metallomics (3)1 2011
Abstract
We treat the changes in copper proteins in historically the same increasingly oxidising environmental conditions. The study is a bioinformatic analysis of the types and the numbers of copper domains of proteins from 435 DNA sequences of a wide range of organisms available in NCBI, using the method d...
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PMID: 21085721
PDF is available here.
PDF is available here.
Abstract
We show that Ldb1 controls gene expression at multiple levels. Ldb1 stabilizes its erythroid complex partners on β-globin chromatin, even though it is not one of the DNA-binding components. In addition, Ldb1 is necessary for enrichment of key transcriptional components in the locus, including P-TEF...
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PMID: 20570862
PDF is available here.
PDF is available here.
Abstract
We here demonstrate that cell lines and a primary sample of t(17;19)-ALL expressed LMO2 at significantly higher levels than other B-precursor ALLs did. Transfection of E2A-HLF into a non-t(17;19) B-precursor ALL cell line induced LMO2 gene expression that was dependent on the DNA-binding and transac...
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PMID: 20519628
PDF is available here.
PDF is available here.
Abstract
We elucidate several major influences this chemistry has had upon biology. All of life exhibits the same proteome size-dependent scaling for the number of metal-binding proteins within a proteome. This fundamental evolutionary constant shows that the selection of one element occurs at the exclusion...
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PMID: 20498051
PDF is available here.
PDF is available here.
Abstract
Abstract
We review the techniques themselves for qualitative and quantitative metalloproteomics, and provide evidence in the form of several example of different kinds of expertise working together to produce coherent and effective results in the area....
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PMID: 20536316
PDF is available here.
PDF is available here.
Natural Product Reports (27)5 2010
Abstract
The actinobacteria of the genus Streptomyces are of immense importance to both ecological and human welfare. They produce a large number of enzymes and compounds such as antibiotics that have attracted the interest of industry over recent decades, resulting in their commercial manufacture and applic...
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PMID: 20372697
PDF is available here.
PDF is available here.
Abstract
Two large gene and protein superfamilies, SDR and MDR (short- and medium-chain dehydrogenases/reductases), were originally defined from analysis of alcohol and polyol dehydrogenases. The superfamilies contain minimally 82 and 25 genes, respectively, in humans, minimally 324 and 86 enzyme families wh...
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PMID: 20494124
PDF is available here.
PDF is available here.
Abstract
We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H (RNase H) from three different organisms. We show that the enzyme can differentiate between different Mg(2+)-binding modes that are nearly equally stable by cr...
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PMID: 20397692
PDF is available here.
PDF is available here.
Pediatrics (125)5 2010
Abstract
We report here the case of a patient who was diagnosed with MoCD at the age of 6 days. Substitution therapy with purified cyclic pyranopterin monophosphate (cPMP) was started on day 36 by daily intravenous administration of 80 to 160 microg of cPMP/kg of body weight. Within 1 to 2 weeks, all urinary...
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PMID: 20385644
PDF is available here.
PDF is available here.
Inorganic Chemistry (49)8 2010
Abstract
We now know that the secondary coordination sphere impacts nearly all aspects of transition-metal chemistry, including the reactivity and selectivity in metal-mediated processes. These features are highlighted in the binding and activation of dioxygen by transition-metal complexes. There are clear c...
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PMID: 20380466
PDF is available here.
PDF is available here.
Abstract
Paramagnetic metal ions offer outstanding opportunities for protein studies by nuclear magnetic resonance (NMR) spectroscopy. The paramagnetic effects manifested in the NMR spectra provide powerful restraints for the determination of the three-dimensional structure of proteins, open new possibilitie...
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PMID: 20462377
PDF is available here.
PDF is available here.
Postepy biochemii (56)1 2010
Abstract
Both the physical and chemical test results indicate that the DNA under different conditions can act as a narrow band semiconductor. The charge transfer along the DNA double strand molecule depends both on the nucleotide sequence and the distance, and is possible only in the case of an ideal paring...
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PMID: 20499678
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (82)11 2010
Abstract
To evaluate the tolerance and therapeutic effectiveness of 1.5% reamberine (RB) solution infusions in complex therapy for pneumonia-complicated pneumonia and acute respiratory diseases (ARD).
133 patients aged 18 to 60 years with pneumonia-complicated influenza and AR...
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PMID: 21381343
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)1-2 2010
Abstract
The use of cytoflavin solution in complex therapy of patients with neuroinfection was studied. It showed a favourable effect on the disease clinical process, evident from less pronounced intoxication and meningeal signs by the 11th day of the treatment and improvement of the liquorological picture....
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PMID: 20583556
PDF is available here.
PDF is available here.
Acta Crystallographica Section F (65)Pt 12 2009
Abstract
The structure of a probable Mo-cofactor biosynthesis protein B from Sulfolobus tokodaii, belonging to space group P6(4)22 with unit-cell parameters a = b = 136.68, c = 210.52 A, was solved by molecular replacement to a resolution of 1.9 A and refined to an R factor and R(free) of 16.8% and 18.5%, re...
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PMID: 20054111
PDF is available here.
PDF is available here.
Abstract
We show here that pretreatment with dipyridyl (1 mM) prior to challenge with high H(2)O(2) concentrations (>or=15 mM) induced mainly G:C-->A:T transitions (more than 100X with 15 mM and more than 250X with 20 mM over the spontaneous mutagenesis rate) in E. coli. In contrast, high H(2)O(2) concentrat...
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PMID: 19838456
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)40 2009
Abstract
We have determined the high-resolution X-ray crystal structure of an Atx1-like copper chaperone protein from Bacillus subtilis containing a novel tetranuclear Cu(I) cluster. The identities and oxidation states of the cluster ions were established unambiguously by refinement of X-ray energy-dependent...
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PMID: 19746989
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)39 2009
Abstract
The effects of replacing the axial methionine ligand of the type 1 copper site with leucine on the structure and function of amicyanin have been characterized. The crystal structures of the oxidized and reduced forms of the protein reveal that the copper site is now tricoordinate with no axial ligan...
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PMID: 19715303
PDF is available here.
PDF is available here.
Abstract
The interaction of cytochrome C and a number of its components such as the apo protein, heme and a coordinated iron with gold nanospheres, has been investigated. The role of the heme group and its effect on the observed spectroscopic properties following binding of cytochrome C to the gold surface h...
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PMID: 19601561
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (113)30 2009
Abstract
In this study an attempt has been made to investigate the effect of metal ion substitution on the structure and spectra of azurin using two-layer ONIOM (our own N-layered integrated molecular orbital + molecular mechanics) approach. It is evident from the results that the overall structure of the pr...
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PMID: 19572691
PDF is available here.
PDF is available here.
Hematology (14)4 2009
Abstract
We examined whether LMO2 protein expression can predict outcome CML patients undergoing tyrosine kinase inhibitor therapy, imatinib mesylate (IM). Immunohistochemistry on bone marrow biopsy material for LMO2 protein was performed in 47 CML patients. We report that the LMO2 protein expression is corr...
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PMID: 19635185
PDF is available here.
PDF is available here.
Abstract
These findings suggest that GSNOR is an important regulator of airway SNO content and airways hyperresponsiveness in human asthma....
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PMID: 19395503
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
|
PMID: 19477421
PDF is available here.
PDF is available here.
Chemistry & Biology (16)5 2009
Abstract
Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis....
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PMID: 19477421
PDF is available here.
PDF is available here.
Abstract
Although blood plasma inherently contains protein biomarkers for human disease diagnosis, their determination is difficult since more than 3700 proteins are commonly present. The associated protein-separation problem can, however, be dramatically simplified by analyzing plasma for a subproteome, suc...
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PMID: 19489698
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)13 2009
Abstract
The MNCs of 51.1% of the patients with acute myeloblastic leukemia (AML) without remission expressed higher levels of LMO2, the MNCs of 62.2% of the AML patients expressed higher levels of LYL1, and the MNCs of 31.1% of those expressed both. The K562 cells transfected with pcDNA3-LMO2 showed higher...
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PMID: 19671288
PDF is available here.
PDF is available here.
Chemical Society Reviews (38)4 2009
Abstract
The emerging field of metallomics refers to the entirety of research activities aimed at the understanding of the molecular mechanisms of metal-dependent life processes. This critical review discusses the concept of metallomics with a focus on analytical techniques and methods for the probing of int...
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PMID: 19421584
PDF is available here.
PDF is available here.
Abstract
Auracyanins A and B are two closely similar "blue" copper proteins produced by the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. Both proteins have a water-soluble 140-residue globular domain, which is preceded in the sequence by an N-terminal tail. The globular domains of...
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PMID: 19190939
PDF is available here.
PDF is available here.
Protein Science (18)3 2009
Abstract
We conclude that the Contryphan motif represents a natural robust scaffold which can be engineered to perform different functions, providing additional means for the design of catalytically active mini metalloproteins....
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PMID: 19241383
PDF is available here.
PDF is available here.
Abstract
In fluorophore-cored dendrimers with peripheral binding functionalities, the effect of generation upon protein binding-induced fluorescence quenching can be unpredictable; this is because the increase in fluorophore-binding functionality distance with generation is also accompanied by an increase in...
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PMID: 19322448
PDF is available here.
PDF is available here.
ChemBioChem (10)3 2009
Abstract
We have found that the polarity of the protein environment is crucial for selectivity and that a synergy between both partners of the hybrid results in the novel activity....
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PMID: 19137535
PDF is available here.
PDF is available here.
Abstract
A recombinant protein overproduction system was developed in Methanosarcina acetivorans to facilitate biochemical characterization of oxygen-sensitive metalloenzymes from strictly anaerobic species in the Archaea domain. The system was used to overproduce the archetype of the independently evolved g...
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PMID: 19187031
PDF is available here.
PDF is available here.
Abstract
The characterization of a novel Mo-Fe protein (MorP) associated with a system that responds to Mo in Desulfovibrio alaskensis is reported. Biochemical characterization shows that MorP is a periplasmic homomultimer of high molecular weight (260 +/- 13 kDa) consisting of 16-18 monomers of 15321.1 +/-...
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PMID: 19138103
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that LMO2 is expressed nearly ubiquitously in native and neoplastic vasculature, including lymphatics. LMO2 reactivity is otherwise virtually absent in nonhematolymphoid tissues except in breast myoepithelium, prostatic basal cells, and secretory phase endometrial glands. Vascul...
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PMID: 19141387
PDF is available here.
PDF is available here.
Abstract
We had developed a CTPOL PEF for protein simulations of Zn(2+) bound to Cys(-) and/or His(0) that includes charge transfer and local polarization effects as well as metal van der Waals parameters that reproduce the structural and thermodynamical properties of 22 dications. Here, we evaluate if the C...
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PMID: 18566982
PDF is available here.
PDF is available here.
Metallomics (1)3 2009
Abstract
Metal chelates with biomolecules are increasingly used in animal supplementation to increase the bioavailability of essential trace elements. However, the transfer of the chelates is not well understood and speciation studies may bring a comprehensive insight to further investigate t...
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PMID: 21305120
PDF is available here.
PDF is available here.
Metallomics (1)6 2009
Abstract
Metals bound to proteins play essential roles in living systems. Elements such as phosphorus, selenium and iodine are commonly covalently linked to proteins while others are non-covalently complexed. Thus, the identification and characterization of the metal-protein complexes require...
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PMID: 21305158
PDF is available here.
PDF is available here.
Metallomics (1)5 2009
Abstract
The tungsten metallome of the hyperthermophilic archaeon Pyrococcus furiosus has been investigated using electroanalytical metal analysis and native-native 2D-PAGE with the radioactive tungsten isotope (187)W (t(1/2) = 23.9 h). P. furiosus cells have an intracellular tungsten concent...
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PMID: 21305143
PDF is available here.
PDF is available here.
Metallomics (1)5 2009
Abstract
Based on explicit definitions of biomolecular EPR spectroscopy and of the metallome, this tutorial review positions EPR in the field of metallomics as a unique method to study native, integrated systems of metallobiomolecular coordination complexes subject to external stimuli. The sp...
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PMID: 21305141
PDF is available here.
PDF is available here.
Abstract
Protein metal-coordination sites are richly varied and exquisitely attuned to their inorganic partners, yet many metalloproteins still select the wrong metals when presented with mixtures of elements. Cells have evolved elaborate mechanisms to scavenge for sufficient metal atoms to meet their needs...
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PMID: 19079350
PDF is available here.
PDF is available here.
Abstract
I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis....
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PMID: 19527627
PDF is available here.
PDF is available here.
Electrophoresis (30)2 2009
Abstract
We present the results of our studies of basic conditions for the effective application of GE-LA-ICP-MS for the separation of metal-binding proteins, focusing on their stability during GE and post-separation gel treatment. The stability of metal-protein complexes (haemoglobin, myoglobin, superoxide...
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PMID: 19204947
PDF is available here.
PDF is available here.
Abstract
We have therefore systematically developed a method to rapidly determine the major Cu-, Fe-, and Zn-containing metalloproteins in rabbit plasma (0.5 mL) based on size-exclusion chromatography (SEC; stationary phase Superdex 200, mobile phase phosphate-buffered saline pH 7.4) and the simultaneous onl...
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PMID: 18781345
PDF is available here.
PDF is available here.
Abstract
Currently, no pharmaceuticals for the etiological treatment of neurodegenerative protein-misfolding diseases (e.g., ALS, Alzheimer's or prion diseases) are available. In this brief communication the development of chaperone-based medications from medicinal plants (e.g., Ginkgo biloba) are reviewed a...
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PMID: 19200033
PDF is available here.
PDF is available here.
Abstract
We show that the application of extracellular matrix component-laminin promotes oligogliogenesis from neural stem-like cells of human cord blood cells (HUCB-NSC). Although oligodendrocytes constitute a minor subpopulation of spontaneously differentiated HUCB-NSC, the manipulation of active compounds...
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PMID: 19325639
PDF is available here.
PDF is available here.
Abstract
We have dissected the structural and mechanistic features acquired by an optimized metallo-beta-lactamase (MbetaL) obtained by directed evolution. We show that antibiotic resistance mediated by this enzyme is driven by 2 mutations with sign epistasis. One mutation stabilizes a catalytically relevant...
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PMID: 19098096
PDF is available here.
PDF is available here.
EMBO Journal (27)24 2008
Abstract
We identified an ATPase (tRNA-two-thiouridine C, TtuC) required for the 2-thiolation of s(2)T in Thermus thermophilus and examined in vitro s(2)T formation by TtuC and previously identified s(2)T-biosynthetic proteins (TtuA, TtuB, and cysteine desulphurases). The C-terminal glycine of TtuB is first...
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PMID: 19037260
PDF is available here.
PDF is available here.
Biochemical Society transactions (36)Pt 6 2008
Abstract
The simultaneous excitation of paramagnetic molecules with optical (laser) and microwave radiation in the presence of a magnetic field can cause an amplitude, or phase, modulation of the transmitted light at the microwave frequency. The detection of this modulation indicates the presence of coupled...
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PMID: 19021521
PDF is available here.
PDF is available here.