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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Molecular Chaperones (9):
Recent article
Molecular Chaperones
Abstract
We discuss the spatial and temporal organization of cellular quality control strategies and their implications for human diseases linked to protein misfolding and aggregation....
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PMID: 21746797
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We will address how protein homeostasis (proteostasis) is achieved at the level of the cell and organism, and how the threshold of the stress response is set to detect and combat protein misfolding. For metazoans, the requirement for coordinated function and growth imposes additional constraints on...
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PMID: 21536706
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed proteome dynamics during plasma cell differentiation with combined 2-DE/MS. Thirty-two identified protein spots changed in relative abundance when lipopolysaccharide (LPS)-stimulated primary B cells differentiated into antibody-secreting plasma cells. A correlative analysis of protein an...
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PMID: 21319304
PDF is available here.
PDF is available here.
Ageing Research Reviews (10)2 2011
Abstract
All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable and functional proteome. A progressive deterioration in the ability of cells to preserve the stability of their proteome occurs with age and contributes to the functional loss characteristic...
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PMID: 20152936
PDF is available here.
PDF is available here.
Journal of Proteomics (74)2 2011
Abstract
We used a mouse hippocampal cell line (HT22) that expresses B-Raf at high levels, to identify B-Raf associated proteins under endogenous expression conditions, avoiding artificial interactions from overexpression studies. We used stringent procedures to co-immunoprecipitate proteins that specificall...
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PMID: 21055488
PDF is available here.
PDF is available here.
Abstract
We investigated whether the collagen chaperone HSP47 could be functionally correlated with APP. We found that HSP47 accumulates in amyloid deposits of two different mouse models and of some AD patients, is capable to physically interact with APP and can be relocalized by APP overexpression. Notably,...
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PMID: 21829458
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We have isolated ANKRD13C, a protein of unknown function, as an interacting partner for the DP receptor for prostaglandin D(2). In the present study we report the characterization of this novel protein as a regulator of DP biogenesis and trafficking in the biosynthetic pathway. Co-localization by co...
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PMID: 20959461
PDF is available here.
PDF is available here.
Abstract
Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms...
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PMID: 20446769
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)48 2010
Abstract
These results indicate that the cysteine-containing sensor II plays a critical role in redox sensing and the nucleotide and partner binding functions of torsinA and suggest that loss of this function of torsinA contributes to the development of DYT1 dystonia....
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PMID: 20861018
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)11 2010
Abstract
We have investigated bacterial adenosylcobalamin-dependent enzymes and elucidated their structure-based fine mechanisms. They tend to undergo mechanism-based inactivation during catalysis, because they use highly reactive radicals for catalyzing chemically difficult reactions. We have discovered mol...
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PMID: 21048403
PDF is available here.
PDF is available here.
Circulation (122)17 2010
Abstract
Biochemical Journal (432)1 2010
Abstract
We have investigated the possible effects on hA misfolding of the chaperones HSP (heat-shock protein) 70, GRP78/BiP (glucose-regulated protein of 78 kDa/immunoglobulin heavy-chain-binding protein) and HSP40/DnaJ. We demonstrate that hA underwent spontaneous time-dependent β-sheet formation and aggr...
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PMID: 20735358
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellu...
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PMID: 20962430
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We examined the interaction of kAE1 with the quality control system responsible for the folding of membrane glycoproteins and the retention and degradation of misfolded mutants. Using small molecule inhibitors to disrupt chaperone interactions, two functional, dominant kAE1 mutants (R589H and R901st...
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PMID: 20628050
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We identified novel targets of HSF1 in mammalian cells, which suppress the aggregation of polyglutamine (polyQ) protein. Among them, we show that one of the nuclear factor of activated T cells (NFAT) proteins, NFATc2, significantly inhibits polyQ aggregation in cells and is required for HSF1-mediate...
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PMID: 20834230
PDF is available here.
PDF is available here.
Abstract
Three housekeeping genes (dnaK, groEL and rpoB) of strains belonging to the genus Gluconacetobacter (37 strains) or related taxa (38 strains) were sequenced. Reference strains of the 15 species of the genus Gluconacetobacter were included. Phylogenetic trees generated using these gene sequences conf...
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PMID: 19915110
PDF is available here.
PDF is available here.
Biochemical Journal (430)3 2010
Abstract
We show that human ERAL1 is a mitochondrial protein important for the formation of the 28S small mitoribosomal subunit. We also show that ERAL1 binds in vivo to the rRNA component of the small subunit [12S mt (mitochondrial)-rRNA]. Bacterial Era associates with a 3' unstructured nonanucleotide immed...
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PMID: 20604745
PDF is available here.
PDF is available here.
Molecular Cell (39)4 2010
Abstract
We have identified two regulatory proteins, GFAP and EF1alpha, that mediate a previously unknown inhibitory effect of GTP on CMA. GFAP stabilizes the multimeric translocation complex against chaperone-mediated disassembly, whereas GTP-mediated release of EF1alpha from the lysosomal membrane promotes...
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PMID: 20797626
PDF is available here.
PDF is available here.
Human Molecular Genetics (19)16 2010
Abstract
We confirm here using different morphological and biochemical procedures that ubiquilin is present in autophagosomes in HeLa cells and in brain and liver tissue of mouse. Coimmunoprecipitation studies indicated that ubiquilin binds the autophagosome marker LC3 in a complex and that reduction of ubiq...
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PMID: 20529957
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We identified putative sites of post-translational modification in the NRL protein by in silico analysis. Here, we demonstrate the sumoylation of NRL in vivo and in vitro, with two small ubiquitin-like modifier (SUMO) molecules attached to the Lys-20 residue. NRL-K20R and NRL-K20R/K24R sumoylation m...
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PMID: 20551322
PDF is available here.
PDF is available here.
Abstract
Tubulin-folding cofactor A (TFC A) is a molecular post-chaperonin that is involved in the beta-tubulin-folding pathway. It has been identified in many organisms including yeasts, humans and plants. In this work, Arabidopsis thaliana TFC A was expressed in Escherichia coli and purified to homogeneity...
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PMID: 20693679
PDF is available here.
PDF is available here.
Abstract
We report the identification and characterization of scox, the single Drosophila melanogaster SCO-encoding gene. Null mutations of the scox gene are associated with larval lethality, while mutations in its 5'UTR are associated with motor dysfunction and female sterile phenotypes. All mutant phenotyp...
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PMID: 20388558
PDF is available here.
PDF is available here.
Abstract
We generated PAC1 conditional knockout mice. PAC1-null mice exhibited early embryonic lethality, demonstrating that PAC1 is essential for mammalian development, especially for explosive cell proliferation. In quiescent adult hepatocytes, PAC1 is responsible for producing the majority of the 20S prot...
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PMID: 20498273
PDF is available here.
PDF is available here.
Abstract
We expressed Abeta peptide as a new causing agent to endoplasmic reticulum (ER) stress to study ER stress occurred in plant. When the dimer of Abeta(1-42) peptide was expressed in maturing seed under the control of the 2.3-kb glutelin GluB-1 promoter containing its signal peptide, a maximum of about...
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PMID: 20331531
PDF is available here.
PDF is available here.
International Immunology (22)8 2010
Abstract
We recently demonstrated a novel post-endoplasmic reticulum (ER) chaperoning role of the CLIP peptides for the murine class II allele I-E(d). In the current study, we tested the generality of this CLIP chaperone function using a series of invariant chain (Ii) mutants designed to have varying CLIP af...
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PMID: 20547545
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (285)30 2010
Abstract
We report the crystal structure of a complex between the Pseudomonas translocator chaperone PcrH and a short region from the minor translocator PopD. PcrH displays a 7-helical tetratricopeptide repeat fold that harbors the PopD peptide within its concave region, originally believed to be involved in...
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PMID: 20385547
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We introduced mutations into the ER-lumenal Hsp70, BiP/Kar2p, and found that an R217A substitution in the J domain-interacting surface of BiP compromised the physical and functional interaction with Sec63p, an Hsp40 required for ER translocation. In contrast, interaction with Jem1p, an Hsp40 require...
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PMID: 20430885
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)28 2010
Abstract
We describe that cpSRP43 alone prevents aggregation of LHCP by formation of a complex with nanomolar affinity, whereas cpSRP54 is not required for this chaperone activity. Other stromal chaperones like trigger factor cannot replace cpSRP43, which implies that LHCPs require a specific chaperone. Alth...
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PMID: 20498370
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
We investigated the functional correlation between ERp44 and adiponectin in a pig model. The transcription of porcine ERp44 was regulated by PPARgamma, which was consistent with the finding of putative peroxisome proliferator response element sites within ERp44 promoter. Using chromatin immunoprecip...
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PMID: 20484463
PDF is available here.
PDF is available here.
Abstract
We report the successful purification and characterization of recombinant human mortalin in Escherichia coli. The recombinant protein was expressed in the form of inclusion bodies and purified by Ni-NTA affinity chromatography. The subsequently refolded protein was confirmed to be active by its ATPa...
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PMID: 20152901
PDF is available here.
PDF is available here.
Abstract
Intracellular quality control systems monitor protein conformational states. Irreversibly misfolded proteins are cleared through specialized degradation pathways. Their importance is underscored by numerous pathologies caused by aberrant proteins. In the cytosol, where most proteins...
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PMID: 20462951
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
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PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
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PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
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PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
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PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
The function of the lysosomal degradative pathway of autophagy in cellular injury is unclear, because findings in nonhepatic cells have implicated autophagy as both a mediator of cell death and as a survival response. Autophagic function is impaired in steatotic and aged hepatocytes,...
|
PMID: 20578144
PDF is available here.
PDF is available here.