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GAP-43 Protein (0):
Recent article
GAP-43 Protein
Toxicology (289)1 2011
Abstract
We hypothesized that the effects of these compounds could be reflected by changes in biochemical substrates and cholinergic receptors and have examined the levels of four proteins involved in maturation of the brain, neuronal growth and synaptogenesis and the densities of both muscarinic and nicotin...
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PMID: 21820030
PDF is available here.
PDF is available here.
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Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (24)10 2010
Abstract
To investigate the effect of chondroitinase ABC (ChABC) on the expression of growth associated protein 43 (GAP-43) and glial fibrillary acidic protein (GFAP) after spinal cord injury (SCI) in rats.
A total of 150 adult female SD rats, weighing 250-300 g, were randomly divided into ChABC treatment gr...
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PMID: 21046809
PDF is available here.
PDF is available here.
Abstract
We generated an ischemic infarction of the intrascleral portion of the optic nerve (ON) comparable to that which occurs in humans to investigate optic nerve axon degenerative events following optic nerve infarct and the potential for axon re-growth. Animals were euthanized at different times post in...
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PMID: 20621651
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)12 2010
Abstract
We investigated the effect of a high-fat diet (HFD) on (1) PUFA status in the plasma and brain, and (2) the expression of RA and fatty acid NR (RARbeta, RXRbetagamma and PPARdelta), and synaptic plasticity genes (GAP-43 and RC3), in young male Wistar rats. In the striatum of rats given a HFD for 8 w...
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PMID: 20102671
PDF is available here.
PDF is available here.
Abstract
We reported that transplanted bone marrow-derived cells were engrafted into the olfactory epithelium and then had characteristics of olfactory neuron cells. However, the engraftment rate was far from a practical level. Granulocyte colony-stimulating factor (G-CSF) is known to mobilize stem cells fro...
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PMID: 20502766
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)19 2010
Abstract
Epilepsy day 1: GAP-43 mRNA and protein expression at hippocampus dentate gyrus granular cell layer, hilus and CA3 pyramidal layer in the kindled group were higher than the sham group (P < 0.05). The expressions declined at Day 3 (P > 0.05). Expressions became elevated again at Day 7 and they were s...
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PMID: 20646586
PDF is available here.
PDF is available here.
Abstract
Chronic rhinosinusitis (CRS) is among the most common causes of olfactory loss. The loss of the sense of smell is thought to result from structural and functional changes occurring in the olfactory epithelium caused by inflammation. However, the cellular mechanisms underlying CRS-associated olfactor...
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PMID: 20537285
PDF is available here.
PDF is available here.
Brain research (1328) 2010
Abstract
Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of d...
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PMID: 20206610
PDF is available here.
PDF is available here.
Abstract
We previously found that a broad-spectrum MMP inhibitor (MMPi), GM6001 (or ilomastat), enhanced division of cultured primary SCs. Here, we tested the hypothesis that the ability of MMPi to stimulate SC mitosis may advance nerve regeneration in vivo. GM6001 administration immediately after rat sciati...
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PMID: 20448483
PDF is available here.
PDF is available here.
Neuroreport (21)5 2010
Abstract
We discovered that the matrix metalloprotease-2 (MMP-2), a major actor in extracellular matrix recomposition, is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. There was a remarkable coincidence of MMP-2 accumulation and GAP-43 exp...
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PMID: 20173666
PDF is available here.
PDF is available here.
Abstract
There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and derm...
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PMID: 20109036
PDF is available here.
PDF is available here.
Abstract
Our study demonstrates that minimal volumes of unstimulated diagnostic marrow tap forms a minimally invasive and reliable source for isolation of BMMNCs to establish cultures of mesenchymal stem cells and expand them. The plasticity observed in these cells towards mesenchymal (adipogenic, osteogenic...
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PMID: 19947916
PDF is available here.
PDF is available here.
Neurosurgery (66)3 2010
Abstract
Compound muscle action potential responses were not different 8 weeks after end-to-side as compared with end-to-end coaptation. Double fluorescence of spinal motoneurons (L4-L6) and dorsal root ganglion neurons (L4-L6) elucidated events of collateral sprouting of sensory and motor donor axons. Morph...
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PMID: 20173551
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
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PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
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PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
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PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
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PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Abstract
These results show that aged regenerating nerve is sensitive to IGF-1 treatment....
|
PMID: 19802878
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)3 2010
Abstract
We therefore studied possible cellular mechanisms accompanying the recovery process in a non-human primate model system, in which the lateral frontal motor cortex areas controlling the preferred upper limb were unilaterally lesioned, and the animals eventually regained fine hand motor function. Immu...
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PMID: 20030560
PDF is available here.
PDF is available here.
Abstract
We transplanted enhanced green fluorescent protein (EGFP)-expressing adult canine SC (cSC) into a 5mm epineural pouch in the sciatic nerve of adult rats (n=9). The epineurial pouch technique serves as proof of principle to follow the fate of the transplanted cSC for up to 14 days after surgery. Fluo...
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PMID: 19962404
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of nerve growth factor (NGF) and its association with cardiac sympathovagal balance in a rodent model of self-limited peritonitis. Male Wistar rats were randomized into the following groups: normal control, sham, gastric perforation (GP), and GP treated with methylpred...
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PMID: 19487977
PDF is available here.
PDF is available here.
Abstract
We investigate the extracellular environment of sprouting neurons after controlled cortical impact injury in adult rats to determine the spatial and temporal arrangement of inhibitory and growth-promoting molecules in relation to growth-associated protein 43-positive (GAP43+) neurons. Spontaneous co...
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PMID: 20084019
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
We demonstrated that REST, HuR, and PTB proteins are expressed predominantly in epithelial cells in mouse and rat lenses, and showed these factors are also replaced by the predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate le...
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PMID: 21139978
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)10 2009
Abstract
We report that treadmill training (TMT) facilitates axonal regeneration via the upregulation of phospho-ERK1/2 protein levels in Schwann cells in the injured sciatic nerve. Low-intensity, but not high-intensity, TMT increased neurite outgrowth of dorsal root ganglion (DRG) sensory neurons and potent...
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PMID: 19257802
PDF is available here.
PDF is available here.
Abstract
I immunostaining, and the majority of synapses that do form remain functionally immature. These findings highlight the importance of sGC in the regulation of neurite outgrowth and synapse formation, and in the functional maturation of cerebellar granule cells in vitro....
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PMID: 19461654
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To observe degenerative intervertebral disc and to examine innervation of degenerative discs in the rabbit anular-injury model. METHODS: Two different magnitudes of anular injury at 5 mm depth were performed by 11 blade or 16 gauge needle at the L3-L4 or L5-L6 discs in New Zealand white r...
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PMID: 19830861
PDF is available here.
PDF is available here.
Brain Research (1283) 2009
Abstract
We studied if progesterone also prevented axonal damage, a main cause of neurological disability. To this end, some axonal parameters were compared in EAE mice pretreated with progesterone a week before immunization with MOG(40-54) and in a group of steroid-free EAE mice. On day 16th after EAE induc...
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PMID: 19497309
PDF is available here.
PDF is available here.
Biochemical Journal (421)3 2009
Abstract
We have examined membrane association, subcellular distribution and intracellular trafficking of GAP-43 in CHO (Chinese hamster ovary)-K1 cells. Using biochemical assays and confocal and video microscopy in living cells we demonstrated that GAP-43, at steady state, localizes at the recycling endosom...
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PMID: 19442238
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)28 2009
Abstract
We performed an in silico promoter analysis and found a putative NFAT site within the GAP-43 promoter. Using in vitro and in vivo experiments, we demonstrated that NFAT-3 regulates GAP-43, but unexpectedly, does not promote but represses the expression of GAP-43 in neurons and in the developing brai...
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PMID: 19443652
PDF is available here.
PDF is available here.
Abstract
We investigated the role of the inflammatory tumor necrosis factor/nuclear factor-kappaB (NF-kappaB) axis on events subsequent to sciatic nerve crush injury in adult rats. Electrophoretic mobility shift assays revealed that within 6 hours after crush, NF-kappaB DNA-binding activity increased signifi...
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PMID: 19458540
PDF is available here.
PDF is available here.
Neuroreport (20)8 2009
Abstract
These results suggest that topical application of bFGF promotes proliferation of globose basal cells and supporting cells....
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PMID: 19369908
PDF is available here.
PDF is available here.
Abstract
Posttranscriptional events such as RNA stabilization are important for cell differentiation, but little is known about the impact of AU-rich binding proteins (AUBPs) on the fate of neural cells. Expression of destabilizing AUBPs such as AUF1 and neuronal-specific stabilizing proteins such as HuB, Hu...
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PMID: 19115409
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)5 2009
Abstract
We found an early microglial response, with the highest increase of isolectin B4 (IB4) and Iba1 expression at 3 days, and a slower and progressive response of astrocytes, shown by increasing expression of glial fibrillary acidic protein (GFAP) during the 28 days studied. Accumulation of phosphorylat...
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PMID: 19331524
PDF is available here.
PDF is available here.
Abstract
We report that the tumor suppressor p53 and its acetyltransferases CBP/p300 form a transcriptional complex that regulates the axonal growth-associated protein 43, a well-characterized pro-axon outgrowth and regeneration protein. Acetylated p53 at K372-3-82 drives axon outgrowth, GAP-43 expression, a...
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PMID: 19057620
PDF is available here.
PDF is available here.
Abstract
We show that (1) GAP-43 is upregulated in response to S18986 and BDNF in control cultures; (2) this upregulation of GAP-43 is essential for mediating the neuroprotective effects of S18986 and BDNF; (3) administration of S18986 and BDNF leads to an increase in the expression of the glutamate transpor...
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PMID: 19136940
PDF is available here.
PDF is available here.
Archives of Toxicology (83)4 2009
Abstract
The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impair...
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PMID: 18633600
PDF is available here.
PDF is available here.
Abstract
We investigated whether EGFR is required for cutaneous innervation using Egfr null and skin-targeted Egfr mutant mice. Neuronal markers; including PGP9.5, GAP-43, acetylated tubulin, and neurofilaments; revealed that Egfr null dorsal skin was hyperinnervated with a disorganized pattern of innervatio...
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PMID: 18830272
PDF is available here.
PDF is available here.
Abstract
Positive immunostaining of NCSC (GAP43, c-kit, NF68, vimentin and Phox2b) and undifferentiated cell (ABCG2) markers was observed in all NB subtypes. N- and I-type cells displayed cytoplasmic membrane GD2 staining, while nuclear calcyclin was restricted to S-type. N- and I-type cells showed similar p...
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PMID: 19216736
PDF is available here.
PDF is available here.
Abstract
The biochemical and morphological changes suggest that apoptosis as well as axonal regrowth take place following retinal detachment. Collectively, these findings may explain the limited success following repair surgery in terms of visual acuity and physiological function of the retina. Our study may...
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PMID: 18815803
PDF is available here.
PDF is available here.
Abstract
FK506 might have neuroprotective effects against HIBD in neonatal rats....
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PMID: 19149927
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)2 2009
Abstract
We have investigated two clonal mouse olfactory placode (OP) cell lines as a model system for studying endogenous odorant receptor (OR) regulation. Both lines can be differentiated into bipolar neurons with transcriptional profiles consistent with mature sensory neurons. We show that single cells ex...
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PMID: 19012738
PDF is available here.
PDF is available here.
Abstract
These results may provide a basis for a future method of treating ASCI....
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PMID: 19761692
PDF is available here.
PDF is available here.
Abstract
Our data suggest that BMSCs promote axonal regeneration by reducing neurocan expression in peri-infarct astrocytes.
Copyright 2008 Wiley-Liss, Inc....
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PMID: 18618668
PDF is available here.
PDF is available here.
European Journal of Pharmacology (596)1-3 2008
Abstract
These results suggest that in order for cells to combat the deleterious effects of glucocorticoids, a hyperactivation of pCREB may be necessary to restore differentiation and plasticity....
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PMID: 18762182
PDF is available here.
PDF is available here.
Abstract
Our study demonstrated an abnormal development of the CST in the hyt/hyt mouse, manifested by reduced axon quantity and retarded growth pattern at the lumbar spinal cord.
(c) 2008 Wiley-Liss, Inc....
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PMID: 18543337
PDF is available here.
PDF is available here.
Neuroscience Letters (443)3 2008
Abstract
Our results suggest that voluntary exercise could reinforce the beneficial effects of SC transplantation and FGF-2 gene therapy in peripheral nerve reconstruction approaches....
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PMID: 18692548
PDF is available here.
PDF is available here.
Abstract
We employed an olfactory sensory neuron-specific gene manipulation system in combination with in vivo imaging of transparent zebrafish embryos to examine the functional role of Il1rapl1b in synaptic vesicle accumulation and subsequent morphological remodeling of axon terminals, the characteristic fe...
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PMID: 18657618
PDF is available here.
PDF is available here.