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Glucose Transporter Type 3 (0):
Recent article
Glucose Transporter Type 3
Abstract
We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value.
Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A....
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PMID: 20428049
PDF is available here.
PDF is available here.
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Abstract
Thus far, some potentially interesting predictive gene profiles (consisting of 4-825 genes) have been described. The studies have focused on predicting survival, the development of lymph node metastases and the occurrence of distant metastases. The overlap of genes between studies was limited, proba...
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PMID: 20084003
PDF is available here.
PDF is available here.
Abstract
We have assayed not only the expression of GLUT-1, GLUT-3 and TGF-beta1 proteins, but also the uptake of 2-fluoro-[18F]-2-deoxy-D-glucose (18FDG), a tracer for cancer diagnosis. Western blot analysis and whole body autoradiography were used to measure the 18FDG uptake of tumor cells. Elevated 18FDG...
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PMID: 20054803
PDF is available here.
PDF is available here.
Neuroendocrinology (91)1 2010
Abstract
These results show that the adrenals regulate basal GLUT3 gene profiles in the DVC alone; during hypoglycemia, these glands suppress (DVC) or increase GLUT3 (LHA and VMH) mRNA, and selectively elevate GLUT4 transcripts in the LHA. The data demonstrate divergent adrenal control of DVC neuronal monoca...
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PMID: 19996571
PDF is available here.
PDF is available here.
Abstract
To examine the distribution of glucose transport 3 (GLUT 3) in different brain regions of aged rats and to investigate its role in ageing process of the nervous system.
The GLUT 3 expression in different brain regions was examined with immunohistochemical method in rats aged 3, 18 and 30 months, res...
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PMID: 20175235
PDF is available here.
PDF is available here.
Endokrynologia Polska (61)2 2010
Abstract
Peripheral blood lymphocytes may become an interesting model system to study the effects of insulin on cellular glucose transport. Flow cytometry is suitable for this investigation and may be used as a method to estimate the influence of insulin on GLUTprotein translocation and the dynamics of gluco...
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PMID: 20464705
PDF is available here.
PDF is available here.
Abstract
Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organ...
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PMID: 20119820
PDF is available here.
PDF is available here.
Abstract
In all 31 cases, tumors were visible on FDG PET and positive for Glut1 and Glut3. The correlation between the percentage of Glut1+ cells and SUVmax was statistically significant across all 31 cases (r = 0.73, P<0.0001, 95% confidence interval: 0.50-0.86) and across the 25 cases of nonHodgkin lymphom...
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PMID: 19536037
PDF is available here.
PDF is available here.
Oncology Research (17)7 2009
Abstract
We investigated the relationship of FDG uptake and the expressions of glucose transporter type 1 (Glut-1), glucose transporter type 3 (Glut-3), and hexokinase II (HK-II) in R-S cells of HL. There were 25 tissue-proven HL patients from January 2003 to July 2007 in our hospital. Of the 25 HL patients,...
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PMID: 19408578
PDF is available here.
PDF is available here.
BMC Cancer (9)1 2009
Abstract
Hierarchical clustering analyses failed to show significant segregation of patients. In patients (n=20) with available tumor and matched normal mucosa, 77 genes were found to be differentially expressed (P< 0.05) in the tongue tumor samples compared to their matched normal controls. Among the 45 ove...
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PMID: 19138406
PDF is available here.
PDF is available here.
Biochemistry (New York) (74)1 2009
Abstract
In this study, three subfamily members of the human 12-transmembrane-domain cell-surface receptors GLUT1, GLUT2, and GLUT3 were heterologously expressed in the fission yeast Schizosaccharomyces pombe utilizing GST-GLUT fusion proteins. These fusion proteins were driven by the full-length nmt1 promot...
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PMID: 19232052
PDF is available here.
PDF is available here.
Abstract
Vitamin C is a wide spectrum antioxidant essential for humans, which are unable to synthesize the vitamin and must obtain it from dietary sources. There are two biologically important forms of vitamin C, the reduced form, ascorbic acid, and the oxidized form, dehydroascorbic acid. Vitamin C exerts m...
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PMID: 19391462
PDF is available here.
PDF is available here.
Abstract
(18)F-FDG SPECT-CT can be as a prospective tool that can judge the malignancy or benignity of head and neck tumor, stage and classify the tumor, distinguish recurrence or necrosis or fibrosis of the tumor after treatment by surgery or radiotherapy, and detect unknown primary tumor. Glut-1 may largel...
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PMID: 19317609
PDF is available here.
PDF is available here.
Abstract
We present a novel function for ascorbic acid. Ascorbic acid is an important water-soluble antioxidant and cofactor in various enzyme systems. We have previously demonstrated that an increase in neuronal intracellular ascorbic acid is able to inhibit glucose transport in cortical and hippocampal neu...
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PMID: 18506475
PDF is available here.
PDF is available here.
Abstract
We describe the characterization of heterozygous mice with regard to neuronal function, glucose homeostasis, and, since GLUT3 might be a component of the neuronal glucose-sensing mechanism, food intake and energy balance. Levels of GLUT3 mRNA and protein in brain were reduced by 50% in Slc2a3+/- mic...
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PMID: 18780771
PDF is available here.
PDF is available here.
Journal of Physiology (586)Pt 18 2008
Abstract
Experimental reduction in placental growth often leads to increased placental efficiency measured as grams of fetus produced per gram of placenta, although little is known about the mechanisms involved. This study tested the hypothesis that the smallest placenta within a litter is the most efficient...
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PMID: 18653658
PDF is available here.
PDF is available here.
Neuropsychopharmacology (33)10 2008
Abstract
We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) beta(2)- and beta(3)-ARs consolidate memory by different mechanisms; beta(3)-ARs stimulate central gluco...
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PMID: 18046311
PDF is available here.
PDF is available here.
Oncology Reports (20)3 2008
Abstract
I (Hex I) and II in high-grade glioma. The retrospective study involved 27 patients with WHO classification grade III and IV glioma, with either newly diagnosed or recurrent tumours. Patients underwent dynamic and static [18F]FDG-PET to glucose metabolic rate (MRGlu) and standardised uptake value (S...
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PMID: 18695903
PDF is available here.
PDF is available here.
Abstract
We propose that the modulation of glucose uptake by angiotensin IV and LVV-hemorphin 7 is region-specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity-dependent glucose uptake in hippocampal n...
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PMID: 18702730
PDF is available here.
PDF is available here.
Abstract
Glucose metabolism is vital to most mammalian cells, and the passage of glucose across cell membranes is facilitated by a family of integral membrane transporter proteins, the GLUTs. There are currently 14 members of the SLC2 family of GLUTs, several of which have been the focus of this series of re...
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PMID: 18577699
PDF is available here.
PDF is available here.
Abstract
Endocrine-Related Cancer (15)2 2008
Abstract
We analyzed the mRNA expression of thyroid differentiation genes, glucose transporter (GLUT)-1 and GLUT-3, in 78 PTCs according to the presence of BRAFV600E or RET/PTC rearrangements. We found BRAFV600E and RET/PTC rearrangements in 35.8 and 19.4% of PTCs respectively. The mRNA expression of NIS and...
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PMID: 18509003
PDF is available here.
PDF is available here.
Abstract
We examined male and female glucose transporter isoform-3 (GLUT3; placenta)-null heterozygous(+/-) mutation-carrying mice and compared them with age- and sex-matched wild-type(+/+) littermates. No difference in postnatal (1-2 days, 6-7 days, 12-13 days, 20-21 days), postsuckling (1-2 mo), and adult...
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PMID: 18445753
PDF is available here.
PDF is available here.
Nature Cell Biology (10)5 2008
Abstract
We have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and IKKbeta and subsequent NF-kappaB activity were enhanced. Activation of NF-kappaB, by loss of p53, caused an increase i...
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PMID: 18391940
PDF is available here.
PDF is available here.
Abstract
The glucose transporters GLUT-1 and GLUT-3 are targets of the hypoxia-inducible transcription factor HIF-1alpha and it has been shown that nucleus pulposus (NP) cells in rat intervertebral discs (IVD) express both HIF-1alpha and GLUT-1. However, there is limited data on the expression of HIF-1alpha...
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PMID: 18172662
PDF is available here.
PDF is available here.
Abstract
In hyperthyroidism: 1) basal abundance of GLUT3 and GLUT4 on the plasma membrane is increased and 2) the sensitivity of the recruitment of GLUT3 and GLUT4 transporters on the plasma membrane in response to IGF-I is increased. These findings may contribute to the understanding of the mechanism by whi...
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PMID: 18299470
PDF is available here.
PDF is available here.
Joint Bone Spine (75)2 2008
Abstract
Here we demonstrated that hypoxia induced an elevated expression level of GLUT-1 and -3 in chondrocytes. Also elevated was hypoxia inducible factor-1alpha (HIF-1alpha) protein level. On the contrary, deletion of HIF-1alpha led to complete loss of the hypoxia-induced gene expression of GLUT-1 and 3....
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PMID: 17983831
PDF is available here.
PDF is available here.
Abstract
I and II group. Moreover, there was a significant correlation between the expression of Glut1 and HIF-1 alpha (r=0.854, P<0.01). CONCLUSION: Glut1 and HIF-1 alpha are highly expressed in NSCLC, and their expressions are associated with tumor differentiation and clinical stage....
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PMID: 18422279
PDF is available here.
PDF is available here.
Abstract
We investigated the hypothesis that estradiol exerts site-specific regulatory effects on basal and insulin-induced hypoglycemia (IIH)-associated MCT2 and neuronal glucose transporter mRNA profiles, and expression of genes that encode the substrate sensor, glucokinase (GCK), and the sulfonylurea rece...
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PMID: 18084728
PDF is available here.
PDF is available here.
Endocrinology (149)1 2008
Abstract
Aging is associated with a reduction in metabolic function, insulin resistance, increased incidence of neurodegenerative diseases, and memory or cognitive dysfunction. In aging females, loss of gonadal function determines the beginning of the period of reduced metabolic function. Estrogens have neur...
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PMID: 17901235
PDF is available here.
PDF is available here.
Abstract
GLUT-1 gene expression level and protein expression were correlated with lymph node metastasis, poor survival and clinical stage of HNCs. The GLUT-3 gene expression level was high in HNCs, and its expression was associated with an increased incidence of lymph node metastasis of HNCs.
2008 S. Karger...
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PMID: 18401196
PDF is available here.
PDF is available here.
Abstract
We determined in the well-characterized breast cancer cell line ZR-75, if the cAMP analogue 8-br-cAMP was capable of regulating GLUT1 and GLUT3 expression and thus glucose uptake. We demonstrated that 8-br-cAMP transiently up-regulates GLUT3 mRNA levels. The use of actinomycin-D and the cloning of 1...
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PMID: 17559076
PDF is available here.
PDF is available here.
Endocrinology (148)12 2007
Abstract
We investigated possible modes of a TCDD-mediated toxicity, particularly in glucose metabolism, in pluripotent P19 mouse embryonic carcinoma cells. Undifferentiated P19 cells were exposed to 1-100 nM TCDD and characterized for AhR signaling. For studying cell differentiation, P19 cells were exposed...
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PMID: 17872374
PDF is available here.
PDF is available here.
Brain Research (1176) 2007
Abstract
We investigated the hypothesis that during glucoprivation, lactate regulates neuronal monocarboxylate and glucose transporter gene transcription in the DVC, and adjustments in these gene profiles are correlated with altered GK and SUR1 mRNA expression. We also examined whether caudal hindbrain lacta...
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PMID: 17889836
PDF is available here.
PDF is available here.
Chinese Medical Journal (120)19 2007
Abstract
Chronic hyperglycemia downregulates GLUT(1) and GLUT(3) expression at both mRNA and protein levels in the rat brain, which is not due to the decrease of the density of microvessels. The downregulation of GLUT(1) and GLUT(3) expression might be the adaptive reaction of the body to prevent excessive g...
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PMID: 17935675
PDF is available here.
PDF is available here.
Journal of Neurochemistry (102)3 2007
Abstract
We observed that cultured neurons express the sodium-vitamin C cotransporter 2 and the facilitative glucose transporters (GLUT) 1 and 3, however, in hippocampal brain slices GLUT3 was the main transporter detected. Functional activity of GLUTs was confirmed by means of kinetic analysis using 2-deoxy...
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PMID: 17630983
PDF is available here.
PDF is available here.
Oncology Reports (18)2 2007
Abstract
We immunohistochemically examined the expression of the glucose transporters (GLUT)1, GLUT3 and GLUT4, in 154 tumor samples of epithelial ovarian carcinoma. In addition, we investigated the correlations between the expression of GLUTs and the vascular endothelial growth factor (VEGF), and microvesse...
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PMID: 17611657
PDF is available here.
PDF is available here.
Abstract
We found that HIF-1alpha protein levels and mRNA stability were similar at 20 and 2% O(2); there was a small, but significant increase in HIF-1alpha transactivation domain activity in hypoxia. With respect to HIF-1alpha target genes GAPDH, GLUT-1, and GLUT-3, mRNA and protein levels were independent...
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PMID: 17442734
PDF is available here.
PDF is available here.
Human Reproduction (22)8 2007
Abstract
Our results indicate that the alterations in female reproduction in diabetes were partially reversed after tungstate treatment by a mechanism(s) involving the normalization of serum FSH and LH levels, and ovarian and uterine expression of FSH receptors and GLUT3....
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PMID: 17588954
PDF is available here.
PDF is available here.
Reproduction (134)1 2007
Abstract
These results indicate that cryopreservation affects the status of sperm cells of Iberian boars by altering the distribution of some membrane receptors and decreasing the percentage values of parameters linked to sperm quality....
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PMID: 17641093
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of hypoxia on the regulation of trophoblast glucose transporter (GLUT) expression and activity in BeWo choriocarcinoma cells, a trophoblast cell model, and human placental villous tissue explants. GLUT1 expression in BeWo cells was upregulated by the hypoxia-inducing chem...
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PMID: 17442736
PDF is available here.
PDF is available here.
Journal of Physiology (581)Pt 3 2007
Abstract
We hypothesized that transient hyperglycaemia in early pregnancy results in (1) increased placental growth and (2) an up-regulation of placental nutrient transport capacity, which leads to fetal overgrowth at term. In order to test this hypothesis, pregnant rats were given intraperitoneal injections...
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PMID: 17430988
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to investigate the relation between the standardised uptake value (SUV) on (18)F-fluoro-2-deoxy-glucose-positron emission tomography scan and hypoxia related markers (HIF-1alpha and CAIX), a proliferation-related marker (Ki-67) and glucose transporters (GLUT-1 and GLUT-...
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PMID: 17512190
PDF is available here.
PDF is available here.
Neuropsychopharmacology (32)6 2007
Abstract
Repeated stress causes an energy-compromised status in the brain, with a decrease in glucose utilization by the brain cells, which might account for excitotoxicity processes seen in this condition. In fact, brain glucose metabolism mechanisms are impaired in some neurodegenerative disorders, includin...
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PMID: 17119541
PDF is available here.
PDF is available here.
Abstract
We created a novel GLUT3-null mouse and observed arrested early embryonic development and loss at neurulation stage when both alleles were mutated. This loss occurred despite the presence of other related isoforms, particularly GLUT1. In contrast, when a single allele was mutated, despite increased...
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PMID: 17213475
PDF is available here.
PDF is available here.
Abstract
Immunostaining showed that GLUT1 was significantly increased in hypoxic regions of the human colon and breast tumors. The expression profiles of all glucose transporters in NCI 60 cancer cells exhibited distinct expression patterns. Phloretin exhibited more than 60% glucose uptake inhibition. Hypoxi...
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PMID: 16906425
PDF is available here.
PDF is available here.
Biology of Reproduction (76)3 2007
Abstract
We assume that reduction of offspring birth weight in presence of maternal hypercholesterolemia may be related to the offspring's hypoglycemia and the reduction of the cell surface expression of placental SLC2A1....
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PMID: 17135483
PDF is available here.
PDF is available here.
Abstract
The results suggest that inhibition of glucose uptake is not the mechanism for the cerebral effects of antenatal glucocorticoids....
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PMID: 17359461
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (87)2 2007
Abstract
The sensitivity, specificity, and accuracy of (18)F-FDG coincidence imaging and registration with integrated CT (SPECT/CT) in diagnosis of the head and neck tumors was 100.0%, 87.5%, and 96.0% respectively, all significantly higher than those of the anatomical imaging (64.7%, 50.0%, and 60.0% respec...
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PMID: 17418018
PDF is available here.
PDF is available here.
Chemotherapy (53)4 2007
Abstract
We revisit Warburg's original hypothesis and review the recent clinical and basic research on the expression of GLUT family members in human cancers and in cell lines derived from human tumors. We also explore the links between hypoxia-induced genes, glucose transporters and angiogenic factors. Hypo...
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PMID: 17595539
PDF is available here.
PDF is available here.
Abstract
Glucose is one of the major fetal nutrients. Maternofetal transfer requires transport across the several placental membranes. This transfer is mediated by one or more of the fourteen known isoforms of glucose transporter. So far only Glucose Transporters 1 and 3 (GT1, GT3) have been shown to be loca...
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PMID: 17027079
PDF is available here.
PDF is available here.
Renal Failure (29)3 2007
Abstract
Western blotting analysis revealed that GLUT-1 levels were increased by 53% in HGEC cultured under experimental diabetes compared to cells grown in 5mM glucose. GLUT-3 levels were also increased by 15% under diabetic conditions. GLUT-4 levels were decreased by 20% in diabetes. Fluorescence Activated...
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PMID: 17497451
PDF is available here.
PDF is available here.
Abstract
We investigated whether habituated neuronal reactivity in CNS sensing sites to hypoglycemia is correlated with modified monocarboxylate and/or glucose uptake by using quantitative real-time RT-PCR to analyze neuronal monocarboxylate transporter (MCT2) and glucose transporter variant (GLUT and GLUT4)...
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PMID: 17416968
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1769)11-12 2007
Abstract
We have previously shown that GLUT3 is expressed in human skeletal muscle cells. The structure of the human GLUT3 gene has not been previously reported nor has there been any evaluation of the 5'-untranslated region (UTR). To this end, we have cloned and sequenced the human GLUT3 gene. Insulin-like...
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PMID: 17920708
PDF is available here.
PDF is available here.
Abstract
I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers....
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PMID: 16803853
PDF is available here.
PDF is available here.
Abstract
GLUT3 mRNA expression and the synthesis of GLUT3 can be down-regulated by hypoglycemia pre-HI, coupled with aggravation of cerebral pathology, but up-regulated by higher hyperglycemia pre-HI, coupled with improvement of cerebral pathology. This suggested that adequate glucose supplement before HI ca...
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PMID: 17052401
PDF is available here.
PDF is available here.
Behavioural Brain Research (172)2 2006
Abstract
These results suggest a compensatory higher GLUT4 inclusion at the cellular neuronal membrane in the cerebral cortex, hippocampus and cerebellum of the Kir6.2(-/-) K-ATP knockout mice. However, there was no change in GLUT4 gene expression assessed by TaqMan PCR except for a decrease in the cerebellu...
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PMID: 16797737
PDF is available here.
PDF is available here.
Abstract
We conclude that glycolysis is regulated by both the specific availability of a concrete sugar and the internal equilibrium between ATP and ADP levels. Furthermore, localization of proteins involved in the control of monosaccharide uptake and phosphorylation suggests that glycolysis starts at concre...
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PMID: 16804879
PDF is available here.
PDF is available here.
Abstract
We developed a unique model of adult-onset GH/IGF-I deficiency by using dwarf rats specifically deficient in GH and IGF-I. The deficiency in plasma IGF-I is similar to that observed with age (e.g., 50% decrease), and replacement of GH restores levels of IGF-I to that found in young animals with norm...
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PMID: 16912061
PDF is available here.
PDF is available here.
FEBS Letters (580)18 2006
Abstract
In the brain, glucose is transported by GLUT1 across the blood-brain barrier and into astrocytes, and by GLUT3 into neurons. In the present study, the expression of GLUT1 and GLUT3 mRNA and protein was determined in adult neural stem cells cultured from the subventricular zone of rats. Both mRNAs an...
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PMID: 16854415
PDF is available here.
PDF is available here.