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Neuronal Apoptosis-Inhibitory Protein (0):
Recent article
Neuronal Apoptosis-Inhibitory Protein
Abstract
The inhibitor of apoptosis (IAP) family of proteins contains key modulators of apoptosis and inflammation that interact with caspases through baculovirus IAP-repeat (BIR) domains. Overexpression of IAP proteins frequently occurs in cancer cells, thus counteracting the activated apoptotic program. Th...
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PMID: 19923725
PDF is available here.
PDF is available here.
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Abstract
Pediatrics International (51)2 2009
Abstract
Deletion of the SMN1 gene is a major cause of SMA in Iran, and NAIP gene deletions were common in the present patients with type I SMA. Also, the incidence of NAIP deletion is higher in more severe SMA....
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PMID: 19405914
PDF is available here.
PDF is available here.
Acta Biochimica Polonica (56)1 2009
Abstract
We analyzed possible phenotype modifiers of the disease - the size of the deletion in the SMA region, the number of SMN2 gene copies, as well as the effect of gender. Among the factors analyzed, two seem to influence the SMA phenotype: the number of SMN2 gene copies and a deletion in the NAIP gene....
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PMID: 19287802
PDF is available here.
PDF is available here.
Infection and Immunity (77)1 2009
Abstract
We found that MOLF/Ei-derived macrophages also restrict L. pneumophila growth, yet the Naip5 protein is identical to the A/J Naip5 at the six-amino-acid signature. The MOLF/Ei restrictive trait, unlike that of B6-derived macrophages, was not dominant over the A/J trait. In spite of this phenotypic d...
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PMID: 18981241
PDF is available here.
PDF is available here.
Clinical Immunology (130)1 2009
Abstract
The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected w...
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PMID: 18819842
PDF is available here.
PDF is available here.
Abstract
We demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. To further elucidate the host flagellin-sensing pathway, we generated mice deficient in the intracellular sensor Naip5. These mice...
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PMID: 18724372
PDF is available here.
PDF is available here.
Archives de Pédiatrie (15)7 2008
Abstract
We report on the cases of three siblings with SMA. The weakness muscular observes at three siblings but more earlier and severe to the index case with a fast evolution towards respiratory distress syndrome resulting in its death at 5 years. The homozygous deletions of exons 7 and 8 of the telomeric...
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PMID: 18538551
PDF is available here.
PDF is available here.
Abstract
We report here that expression of the IAP family of genes in peripheral blood samples and brain tissues from MS cases support a role for differential regulation of these potent anti-apoptotic proteins in the pathology of MS. XIAP mRNA and protein levels were elevated in peripheral blood mononuclear...
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PMID: 18566024
PDF is available here.
PDF is available here.
Pediatrics International (50)3 2008
Abstract
The SMN2 copy number was related to the clinical severity of SMA among Vietnamese patients. The presence of one NAIP copy, that is, heterozygous NAIP deletion, was common in Vietnamese SMA, regardless of clinical phenotype....
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PMID: 18533950
PDF is available here.
PDF is available here.
Journal of Immunology (180)10 2008
Abstract
We demonstrate that flagellin-deficient L. pneumophila replicate more efficiently in human THP-1 macrophages, primary monocyte-derived macrophages, and alveolar macrophages, and in A549 lung epithelial cells compared with wild-type bacteria. Additionally, we note expression of the mNAIP5 ortholog hN...
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PMID: 18453601
PDF is available here.
PDF is available here.
Abstract
Twenty-one genes were determined to be differentially expressed in PBMCs of ERT-naïve children with Fabry disease compared with healthy controls; neuronal apoptosis inhibitory protein ranked as the most significantly differentially expressed gene. Comparison of gene expression in children with Fa...
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PMID: 18339188
PDF is available here.
PDF is available here.
Abstract
We demonstrate here that Pseudomonas aeruginosa activates caspase 1 and induces IL-1beta secretion in infected macrophages. While live, virulent P. aeruginosa activate IL-1beta secretion through caspase 1 and Ipaf, strains that have mutations in the T3SS or in flagellin did not. Ipaf-dependent caspa...
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PMID: 18256184
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)1 2008
Abstract
We demonstrate genetically that estrogen can tip this balance toward cell survival in uterine epithelial cells by inducing the expression of baculoviral inhibitors of apoptosis repeat-containing 1 (Birc1), a family of antiapoptotic proteins. In neonatal mice, both 17beta-estradiol and the potent syn...
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PMID: 17901126
PDF is available here.
PDF is available here.
Neurology India (56)3 2008
Abstract
Among the SMA Type I patients, 43% showed deletions of SMN1 and NAIP. In patients Type II SMA, 57% showed deletions of the SMN1 exons. CONCLUSION: Thus, deletions were found to occur in 47.8% of the Type I and II patients. Lower sensitivity of gene deletion study in clinically suspected SMA needs fu...
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PMID: 18974562
PDF is available here.
PDF is available here.
Abstract
Inflammatory breast cancer (IBC) patients show poor survival and a significant incidence of epidermal growth factor receptor-2 (ErbB2) overexpression. A distinct mechanism involving increased expression of X-linked inhibitor of apoptosis protein (XIAP) and survivin, key members of th...
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PMID: 18202008
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)47 2007
Abstract
We demonstrate for the first time the translocation of bacterial flagellin into the cytosol of host macrophages by the vacuolar pathogen, Salmonella enterica serotype Typhimurium. Translocation of flagellin into the host cell cytosol was directly demonstrated using beta-lactamase reporter constructs...
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PMID: 17911114
PDF is available here.
PDF is available here.
Journal of Immunology (179)10 2007
Abstract
We examined the role of TLR5 during the murine response to aerosolized Lp infection. At 4 h after infection, Tlr5(-/-) mice had lower numbers of polymorphonuclear neutrophils (PMNs) in their broncho-alveolar lavage fluid in comparison to wild-type (WT) mice. At 24 and 72 h, the PMN recruitment was s...
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PMID: 17982089
PDF is available here.
PDF is available here.
Cellular Microbiology (9)10 2007
Abstract
We hypothesized that Naip5 and Ipaf may act in partnership with other antimicrobial signalling pathways in macrophages. Indeed, we found that macrophages lacking either tumour necrosis factor (TNF)-alpha or type I interferon (IFN) signalling are permissive for growth of L. pneumophila, even in the p...
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PMID: 17506816
PDF is available here.
PDF is available here.
Abstract
We found 80% neuronal apoptosis inhibitory protein gene deletion in 5q-spinal muscular atrophy patients (91% spinal muscular atrophy-I, 50% spinal muscular atrophy-II and -III), and in 5% (two of forty) of spinal muscular atrophy parents. All the neuronal apoptosis inhibitory protein-deleted samples...
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PMID: 17903057
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)36 2007
Abstract
We further investigated the function of XAF1 by examining its relationship with other IAPs. Immunoprecipitation studies indicate that XAF1 binds to XIAP, cIAP1, cIAP2, Livin, TsIAP, and NAIP but not Survivin, an IAP that prevents mitotic catastrophe and in which antiapoptotic activity is exerted thr...
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PMID: 17613533
PDF is available here.
PDF is available here.
Abstract
We report here the production of a specific anti-NAIP antibody and the profile of NAIP expression in human adult tissues by Western blot and immunohistochemical detection methods. NAIP was detected in a number of tissues by Western blot analysis, but immunohistochemistry revealed that NAIP's presenc...
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PMID: 17510375
PDF is available here.
PDF is available here.
Journal of Korean Medical Science (22 Suppl) 2007
Abstract
Neuronal apoptosis inhibitory protein (NAIP) is a recently identified inhibitor of apoptosis protein. However, the clinical relevance of NAIP expression is not completely understood. In an attempt to determine the clinical relevance of NAIP expression in breast cancer, the levels of NAIP and survivi...
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PMID: 17923748
PDF is available here.
PDF is available here.
Journal of Immunology (178)12 2007
Abstract
We show that cytosolic delivery of recombinant flagellin activated caspase-1 in A/J macrophages carrying a mutant Naip5 allele, and in C57BL/6 (B6) macrophages congenic for the mutant Naip5 allele (B6-Naip5(A/J)), but not in Ipaf(-/-) cells. In line with these results, A/J and B6-Naip5(A/J) macropha...
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PMID: 17548639
PDF is available here.
PDF is available here.
Infection and Immunity (75)4 2007
Abstract
We show that genetic susceptibility of mice to infection by L. longbeachae is independent of allelic polymorphism of naip5. L. longbeachae replicates within bone marrow-derived macrophages and in the lungs of A/J, C57BL/6, and BALB/c mice, while L. pneumophila replicates in macrophages in vitro and...
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PMID: 17261610
PDF is available here.
PDF is available here.
Abstract
We examined the biogenesis of Legionella-containing vacuoles (LCVs) formed in permissive A/J macrophages and in their Birc1e/Naip5 transgenic non-permissive counterpart. Birc1e/Naip5 effects on acquisition of lysosomal and ER markers were evident within 1-2 h following infection. A significantly hig...
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PMID: 17087731
PDF is available here.
PDF is available here.
Neurobiology of Disease (26)1 2007
Abstract
We examined three members of the IAP family that are implicated in the regulation of neuronal death. We assessed NAIP, XIAP, and cIAP-2 protein levels in the entorhinal cortex of non-demented, cognitively impaired and Alzheimer's disease cases. Levels of paired helical filament-1 (PHF-1), a marker o...
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PMID: 17292615
PDF is available here.
PDF is available here.
Journal of Biochemistry (141)3 2007
Abstract
These results indicate that Trp323 of BIR3 plays a pivotal role both in maintaining necessary conformation for caspase-9 interaction and to a lesser extent, recognition of Smac-type peptide. Moreover, decreased stability of the mutant compared with the wild type indicates that W323 is essential for...
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PMID: 17179183
PDF is available here.
PDF is available here.
Neurobiology of Disease (25)3 2007
Abstract
We investigated whether anti-apoptosis contributes to survival, compromises apoptosis effector functions and/or delays death in CA1 neurons 1-7 days after TFI. As surrogate markers for bioenergetic failure, the IHC of respiratory chain complex (RCC) subunits was investigated. Dentate granule cell (D...
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PMID: 17207631
PDF is available here.
PDF is available here.
Abstract
Flagellin is bacterial protein that serves as a danger signal across a wide variety of eukaryotes and is a potent inducer of inflammatory effector responses in the mammalian gut. Recent findings utilizing purified flagellin and flagellate/aflagellate bacteria in in vitro and in vivo systems have rev...
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PMID: 17082224
PDF is available here.
PDF is available here.
Pediatrics International (49)1 2007
Abstract
Deletion of the SMN1 exon 7 is a major cause of SMA in Malaysia, and NAIP gene deletions are not rare in type I SMA in Malaysia. The lower percentage of the SMN1 gene deletion may be due to the possibility that the present study included some patients without SMN1 gene abnormality and/or some patien...
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PMID: 17250498
PDF is available here.
PDF is available here.
Abstract
We show here that NAIP has multiple promoters sharing no similarity between human and rodents. Moreover, we demonstrate that multiple, domesticated long terminal repeats (LTRs) of endogenous retroviral elements provide NAIP promoter function in human, mouse, and rat. In human, an LTR serves as a tis...
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PMID: 17222062
PDF is available here.
PDF is available here.
Biochemistry (76) 2007
Abstract
I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-kappaB or inflammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-kappaB. Potentially harm...
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PMID: 17328678
PDF is available here.
PDF is available here.
Bratislavske lekarske listy (108)3 2007
Abstract
Homozygous absence of SMN1 exons 7 and 8, or exon 7 only, was found in 80% of patients. Of those patients, 45% were also deleted for NAIP exon 5. Conclusion: The molecular basis of SMA in Egyptian patients has a similar pattern to that reported in most populations, but a larger study is recommended...
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PMID: 17682539
PDF is available here.
PDF is available here.
Abstract
We studied the relationship between NAIP-deletion and clinical phenotype in Malaysian patients. A total of 39 patients lacking SMN1 (12 type I, 19 type II, and 8 type III patients) were enrolled into this study. Seven out of 12 patients with type I SMA (approximately 60%) showed NAIP deletion. On th...
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PMID: 17932457
PDF is available here.
PDF is available here.
Abstract
We evaluated the intracellular growth of the flaA mutant bacteria as well as another aflagellated fliA mutant, within bone marrow-derived macrophages from mice with an intact (C57BL/6, BALB/c) or mutated (A/J) Birc1e/Naip5 gene. The flaA mutant L. pneumophila multiplied within C57BL/6 and BALB/c mac...
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PMID: 17380047
PDF is available here.
PDF is available here.
Annals of Medicine (39)8 2007
Abstract
We will present the current knowledge on the role of these proteins in immunity and inflammatory diseases....
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PMID: 18038361
PDF is available here.
PDF is available here.
Immunogenetics (58)10 2006
Abstract
Phylogenetic analyses of conserved [neuronal apoptosis inhibitory protein (NAIP), MHC class II transcription activator (CIITA), incompatibility locus protein from Podospora anserina (HET-E), and telomerase-associated protein (TP1)] (NACHT) domains were used to reconstruct the evolutionary history of...
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PMID: 17006665
PDF is available here.
PDF is available here.
Abstract
We previously showed that the transcription factor, Pax2, suppresses apoptosis in UB cells during kidney development and optimizes branching morphogenesis. Here, we report that PAX2 directly binds to a specific recognition motif in the human neuronal apoptosis inhibitory protein (NAIP) gene promoter...
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PMID: 16735463
PDF is available here.
PDF is available here.
Neurology India (54)3 2006
Abstract
Neurology India (54)3 2006
Abstract
Exons 7 and 8 of SMN and NAIP (exon 5) were homozygously deleted in 73% of SMA I and 27% of SMA II patients. SMN exon 7 and 8 deletions without NAIP deletions were seen in 27% of type I SMA and 46% of SMA type II patients. Two patients of type III SMA showed single deletion of SMN exon 7 along with...
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PMID: 16936383
PDF is available here.
PDF is available here.
La Tunisie medicale (84)8 2006
Abstract
We examined the deletion of SMN and NAIP genes in 60 Tunisian families. There were 35 patients with type I SMA. 18 with type II SMA. 6 with type III SMA and I with type IV SMA. The age of onset was before 6 months for type I, between 6 months and 2 years for type II, between 2 years and 17 years for...
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PMID: 17175684
PDF is available here.
PDF is available here.
EMBO Journal (25)14 2006
Abstract
We report that the decreased expression of the neuronal glutamate transporter excitatory amino-acid carrier 1 (EAAC1) following nerve injury is associated with motor neuron death in the mouse. Glutamate transporters play a crucial role in prevention of neuronal death by suppressing glutamate toxicit...
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PMID: 16858406
PDF is available here.
PDF is available here.
Abstract
We used cDNA microarrays to compare gene expression profiles of colorectal biopsies from 25 CRC patients and 13 normal mucosa from adjacent non-cancerous tissues. Findings were validated by real-time PCR; in addition, western blotting and immunochemistry analysis were carried out as further confirma...
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PMID: 16773188
PDF is available here.
PDF is available here.
Abstract
We report that mouse macrophages restricted L. pneumophila replication and initiated a proinflammatory program of cell death when flagellin contaminated their cytosol. Nuclear condensation, membrane permeability, and interleukin-1beta secretion were triggered by type IV secretion-competent bacteria...
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PMID: 16606669
PDF is available here.
PDF is available here.
Abstract
We tested the novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in the hepatic cancer (HCC) HepG2, HA22T/VGH and HuH-6 cells. The sensitivity to the cell growth inhibitory and apoptotic effects of the agent increased along with the levels of constitutively activated NF-kappaB, which w...
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PMID: 16525642
PDF is available here.
PDF is available here.
Abstract
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases....
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PMID: 16498449
PDF is available here.
PDF is available here.
Nature Immunology (7)3 2006
Abstract
We describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages. Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication. Caspase-1 was require...
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PMID: 16444259
PDF is available here.
PDF is available here.
Oncology Reports (14)4 2005
Abstract
We established cisplatin-resistant LNCaP sublines. We examined the effects of cisplatin on cell growth and apoptosis in LNCaP cells and LNCaP sublines by 2-(4-lodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt (WST-1) assay and Hoechst 33258 staining, and analyzed cr...
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PMID: 16142363
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)26 2005
Abstract
We evaluate the ability of neurotrophin-3 (NT-3) to protect neurons against the toxicity induced by aggregated Abeta. We showed that in primary cultures of cortical neurons, NT-3 reduces Abeta-induced apoptosis by limiting caspase-8, caspase-9, and caspase-3 cleavage. This neuroprotective effect of...
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PMID: 15797869
PDF is available here.
PDF is available here.
Abstract
Neuronal apoptosis inhibitory protein (NAIP/BIRC1), the inhibitor of apoptosis protein (IAP) family member, suppresses neuronal cell death induced by a variety of insults, including cell death from ischemia and stroke. The goal of the present study was to develop an efficient method for identificati...
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PMID: 15729293
PDF is available here.
PDF is available here.
Trends in Microbiology (13)7 2005
Abstract
Genetic analysis in mice is a powerful approach for the identification of genes and proteins that have a key role at the interface of the host-pathogen interaction. The Lgn1 locus has been found to control the intracellular replication of Legionella pneumophila in murine macrophages. Using functiona...
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PMID: 15935674
PDF is available here.
PDF is available here.
Abstract
I patients showed only one allele from both markers whereas in Type II and III patients, 2-3 alleles were observed. The SMN2 copy number in our type III patients showed that patients carry 3-5 copies of SMN2 gene. Our results suggest that extent of deletions encompassing H4F5, SMN1, NAIP and copy nu...
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PMID: 16000867
PDF is available here.
PDF is available here.
Journal of Neurology (252)6 2005
Abstract
In view of the paucity of deletion studies of survival of motor neuron (SMN) and neuronal apoptosis inhibitor protein (NAIP) genes in Indian SMA patients, this study has been undertaken to determine the status of SMN1, SMN2 and NAIP gene deletions in Indian SMA patients. Clinically and neurophysiolo...
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PMID: 15772743
PDF is available here.
PDF is available here.
Abstract
We show here that hippocampal neurons from hippocalcin-deficient mice are more vulnerable to degeneration, particularly using thapsigargin, elevating intracellular calcium. Caspase-12 was activated in neurons lacking hippocalcin, while calpain was unchanged. Neuronal viability was accompanied by end...
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PMID: 15607944
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (105)1 2005
Abstract
Abstract
We propose here a testable model in which the NOD-LRR protein Naip5 dictates whether murine macrophages elevate autophagy or pyroptosis as a barrier to infection....
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PMID: 16874072
PDF is available here.
PDF is available here.
Journal of Immunology (173)10 2004
Abstract
We demonstrate in this study that CLAN modulates endogenous caspase-1 activation and subsequent IL-1beta secretion from human macrophages after exposure to LPS, peptidoglycan, and pathogenic bacteria. CLAN was also found to mediate a direct antibacterial effect within macrophages after Salmonella in...
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PMID: 15528373
PDF is available here.
PDF is available here.
Infection and Immunity (72)11 2004
Abstract
We have investigated the resistance of C57BL/6J macrophages to L. pneumophila infection by examining the fate of both the bacterium and the infected cells compared to that in macrophages from the permissive A/J strain. Our results indicate that although the trafficking of the L. pneumophila-containi...
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PMID: 15501747
PDF is available here.
PDF is available here.
Abstract
We searched for homozygous deletion of Survival Motor Neuron (SMN1) and Neuronal Apoptosis Inhibitory Protein (NAIP) genes in Malay patients with SMA and found homozygous deletion of SMN1 exon 7 and 8 in all the patients while homozygous deletion of NAIP exon 5 was detected in only our type 1 patien...
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PMID: 15779584
PDF is available here.
PDF is available here.