Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neuronal Calcium-Sensor Proteins (5):
Recent article
Neuronal Calcium-Sensor Proteins
Abstract
We used two mouse lines overexpressing human A53T-SNCA and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms. To characterize the progression, we employed young adult as well as old mice. Analysis of striatal neurotransmitter content demonstrated...
|
PMID: 20628651
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We report complete NMR chemical shift assignments of the NCS homolog from fission yeast (Schizosaccharomyces pombe), referred to in this study as Ncs1p. (BMRB no. 16446)....
|
PMID: 19851889
PDF is available here.
PDF is available here.
Biochemical Society transactions (37)Pt 6 2009
Abstract
Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of synaptic plasticity induced, e.g. LTP (long-term potentiation) or LTD (long-term d...
|
PMID: 19909276
PDF is available here.
PDF is available here.
Biology of the Cell (101)2 2009
Abstract
These results suggest that calaxin is a potential Ca(2+)-dependent modulator of outer arm dynein in metazoan cilia and flagella....
|
PMID: 18620543
PDF is available here.
PDF is available here.
Cell and Tissue Research (335)2 2009
Abstract
The visinin-like protein (VSNL) subfamily, including VILIP-1 (the founder protein), VILIP-2, VILIP-3, hippocalcin, and neurocalcin delta, constitute a highly homologous subfamily of neuronal calcium sensor (NCS) proteins. Comparative studies have shown that VSNLs are expressed predominantly in the b...
|
PMID: 18989702
PDF is available here.
PDF is available here.
Abstract
We have directly compared the Ca2+ signaling mechanisms involved in NMDAR-LTD and mGluR-LTD. While both forms of LTD involve Ca2+ release from intracellular stores, the Ca2+ sensors involved are different; NMDAR-LTD involves calmodulin, while mGluR-LTD involves the neuronal Ca2+ sensor (NCS) protein...
|
PMID: 19109914
PDF is available here.
PDF is available here.
Abstract
We have developed a protocol to produce large quantities of high purity myristoylated and non-myristoylated neuronal calcium sensor 1 (NCS-1) protein. NCS-1 is a member of the neuronal calcium sensor (NCS) family and plays an important role in modulating G-protein signaling and exocytosis pathways i...
|
PMID: 18634883
PDF is available here.
PDF is available here.
Abstract
We explored the thermosensation model to investigate the possible effects of vitamin E administration on memory behaviors in Caenorhabditis elegans. Administration of 100 and 200microg/mL of vitamin E had no significant effects on the memory for different time intervals, whereas relatively high conc...
|
PMID: 18191592
PDF is available here.
PDF is available here.
Neurochemistry International (53)1-2 2008
Abstract
We investigated if methylphenidate could alter neuronal calcium sensor 1 expression in five brain regions (striatum, hippocampus, prefrontal cortex, cortex and cerebellum) in young and adult rats. These regions were chosen because some are located in brain circuits related with attention deficit hyp...
|
PMID: 18514368
PDF is available here.
PDF is available here.
Neurochemical Research (33)3 2008
Abstract
We did not find any changes in DARPP-32 and NCS-1 protein expression in any brain region investigated....
|
PMID: 17763944
PDF is available here.
PDF is available here.
Journal of Molecular Biology (376)4 2008
Abstract
We determined the specificity of Ca(2+) binding using NMR and EF-hand mutants. Ca(2+) titration, as monitored by [(15)N,(1)H] heteronuclear single quantum coherence, suggests that Ca(2+) binds to the EF2 and EF3 almost simultaneously, followed by EF4. Our NMR data suggest that Mg(2+) binds to EF2 an...
|
PMID: 18199453
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1780)2 2008
Abstract
We have assessed the ability of NCS proteins to interact directly with calcineurin in vitro and report a specific if weak association between various NCS proteins and the phosphatase. In an extension to these analyses we have also examined the effects of over-expression of NCS-1 or NCS-1 mutants on...
|
PMID: 18005668
PDF is available here.
PDF is available here.
Abstract
We compared the biophysical properties of somata and growth cone whole-cell calcium channel currents using Ba2+ and Ca2+ as current carriers. We found that somata and growth cone currents exhibit similar high-voltage activation properties. However, Ba2+ and Ca2+ currents in growth cones and somata a...
|
PMID: 18279316
PDF is available here.
PDF is available here.
Development (134)24 2007
Abstract
We show that neuronal calcium sensor-1 (NCS-1) regulates neurite extension and branching, and activity-dependent Ca2+ signals in growth cones. An NCS-1 C-terminal peptide enhances only neurite branching and moderately reduces the Ca2+ signal in growth cones compared with dsRNA knockdown. Our finding...
|
PMID: 18039973
PDF is available here.
PDF is available here.
Abstract
We have examined the localization of all human ARF isoforms and their interactions with two ARF1 binding proteins, neuronal calcium sensor-1 (NCS-1) and phosphatidylinositol-4 kinase-IIIbeta (PI4Kbeta). Use of a fluorescent protein fragment complementation method showed direct interactions between A...
|
PMID: 17555535
PDF is available here.
PDF is available here.
Abstract
We found that prolonged exposure of a neuroblastoma cell line and primary rat dorsal root ganglia with therapeutic concentrations of Taxol leads to a reduction in inositol trisphosphate (InsP(3))-mediated Ca(2+) signaling. We also observed a Taxol-specific reduction in neuronal calcium sensor 1 (NCS...
|
PMID: 17581879
PDF is available here.
PDF is available here.
Immunological Reviews (217) 2007
Abstract
We have investigated whether Ca(2+)-binding proteins, which have been implicated in the control of neurons and neuroendocrine secretion, play a role in controlling mast cell function. These studies have identified synaptotagmins (Syts) II, III, and IX as well as neuronal Ca(2+) sensor 1 (NCS-1) as i...
|
PMID: 17498067
PDF is available here.
PDF is available here.
Abstract
We demonstrate that stable expression of IL1RAPL1 in PC12 cells induces a specific silencing of N-type voltage-gated calcium channels (N-VGCC) activity that explains a secretion deficit observed in these IL1RAPL1 cells. Importantly, this modulation of VGCC activity is mediated by NCS-1. Indeed, a sp...
|
PMID: 17502602
PDF is available here.
PDF is available here.
Abstract
In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of t...
|
PMID: 17311005
PDF is available here.
PDF is available here.
Journal of Neurochemistry (100)3 2007
Abstract
We investigated whether molecules known to modulate neurosecretion, such as the heterotrimeric G proteins and neuronal calcium sensor-1 (NCS-1), are also localized in these microdomains. After immuno-isolation, flotation gradients from Triton X-100-treated synaptosomal membranes revealed the presenc...
|
PMID: 17144906
PDF is available here.
PDF is available here.
Neurochemical Research (32)1 2007
Abstract
Our results indicated that chronic ECS increased the expression of NCS-1 only in cerebellum. Such results on the expression of proteins involved in signaling pathways that are relevant for neuropsychiatric disorders and treatment, in particular ECT, can contribute to shed light on the mechanisms rel...
|
PMID: 17160505
PDF is available here.
PDF is available here.
Abstract
We identified a taxol binding protein, neuronal Ca(2+) sensor 1 (NCS-1), a Ca(2+) binding protein that interacts with the inositol 1,4,5-trisphosphate receptor from a human brain cDNA phage display library. Taxol increased binding of NCS-1 to the inositol 1,4,5-trisphosphate receptor. Short hairpin...
|
PMID: 17114292
PDF is available here.
PDF is available here.
Abstract
In both nonexcitable and excitable cells, the inositol 1,4,5-trisphosphate receptor (IP(3)R) is the primary cytosolic target responsible for the initiation of intracellular calcium (Ca(2+)) signaling. To fulfill this function, the IP(3)R depends on interaction with accessory subunits and regulatory...
|
PMID: 17132820
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (291)1-2 2006
Abstract
Frequenin is a member of the neuronal Ca(2+) sensor protein family, implicated in being the modulator of the neurotransmitter release, potassium channels, phosphatidylinositol signaling pathway and the Ca(2+)-dependent exocytosis of dense-core granules in the PC12 cells. Frequenin exhibits these bio...
|
PMID: 16733800
PDF is available here.
PDF is available here.
Abstract
We demonstrate that recycling through the endocytic recycling compartment (ERC) is an essential step in Fc epsilonRI-induced activation of extracellular signal-regulated kinase (ERK)1/2. We show that ERK1/2 acquires perinuclear localization and colocalizes with Rab 11 and internalized transferrin in...
|
PMID: 16837555
PDF is available here.
PDF is available here.
Abstract
We have identified the transcriptional co-repressor C-terminal binding protein (CtBP)2 as an interactor for calsenilin and have shown that the two proteins can interact in vivo. In co-immunoprecipitation studies, calsenilin also interacted with CtBP1, a CtBP2 homolog. Our data also showed a calsenil...
|
PMID: 16787403
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)26 2006
Abstract
We observed a stimulation-induced recruitment of NCS-1 and PI4K-beta from the intracellular compartment toward the plasma membrane. This recruitment was highly correlated to the intracellular Ca(2+) rise induced by secretagogues. Using fluorescence resonance energy transfer between PI4K-beta-ECFP an...
|
PMID: 16638749
PDF is available here.
PDF is available here.
Abstract
We tested the effect of lithium, a salt widely used for treatment of bipolar disorders. Lithium inhibited the enhancing effect of NCS-1 on InsP3R1 function, suggesting that InsP3R1/NCS-1 interaction is an essential component of the pathomechanism of bipolar disorder....
|
PMID: 16691292
PDF is available here.
PDF is available here.
Journal of Physiology (572)Pt 1 2006
Abstract
We propose a mechanism involving the neuronal calcium sensor-1 (NCS-1) protein. Inhibitory mutants of TRPC5 and NCS-1 enhance neurite outgrowth similarly. Mutant NCS-1 does not inhibit surface-expression of TRPC5 but generally suppresses channel activity, irrespective of whether it is evoked by carb...
|
PMID: 16469785
PDF is available here.
PDF is available here.
Journal of Cell Biology (172)7 2006
Abstract
We demonstrate that an EF-hand Ca2+-binding protein neuronal Ca2+ sensor-1 (NCS-1), one of the key proteins for various neuronal functions, also acts as an important survival factor. Overexpression of NCS-1 rendered cultured neurons more tolerant to cell death caused by several kinds of stressors, w...
|
PMID: 16549499
PDF is available here.
PDF is available here.
Neuroreport (17)3 2006
Abstract
We examined the effects of chronic haloperidol and clozapine on cortical D2 dopamine receptors and six different dopamine receptor interacting proteins. Using comparative immunoblot analysis, we found that treatment with either haloperidol or clozapine increased D2 dopamine receptors, calcium activa...
|
PMID: 16462601
PDF is available here.
PDF is available here.
Journal of Cell Biology (17)3 2006
Abstract
We examined the effects of chronic haloperidol and clozapine on cortical D2 dopamine receptors and six different dopamine receptor interacting proteins. Using comparative immunoblot analysis, we found that treatment with either haloperidol or clozapine increased D2 dopamine receptors, calcium activa...
|
PMID: 16462601
PDF is available here.
PDF is available here.
Abstract
We review some of the current evidence and new ideas that are being proposed as a result, as well as future perspectives that are now being recognized....
|
PMID: 16640119
PDF is available here.
PDF is available here.
Journal of Biomolecular NMR (36 Suppl 1)S1 2006
Abstract
Journal of Neuroscience (25)47 2005
Abstract
We examined the effects of the life-extending (Age) mutations, such as the age-1 (phosphatidylinositol 3-OH kinase) and daf-2 (insulin/IGF-1 receptor) mutations, on associative learning behavior called isothermal tracking. This thermotaxis learning behavior associates paired stimuli, temperature, an...
|
PMID: 16306402
PDF is available here.
PDF is available here.
Biochemical Journal (391)Pt 2 2005
Abstract
We have shown that an N-terminal myristoylated hippocalcin peptide is able to specifically reproduce the membrane targeting of hippocalcin/NCS-1 when introduced into permeabilized cells. The peptide binds to liposomes containing phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] with high affinit...
|
PMID: 16053445
PDF is available here.
PDF is available here.
Abstract
Our confocal immunofluorescence results on the whole-mount muscle and on semithin cross-sections are indicative of the localization of NCS-1 to motor axon terminals. There is no evidence of immunoreactivity in the postsynaptic side of the neuromuscular junctions or teloglial Schwann cells. These res...
|
PMID: 16088942
PDF is available here.
PDF is available here.
Journal of Neurobiology (64)3 2005
Abstract
We have analyzed the functional role of neuronal calcium sensor-1 (Ncs-1) in zebrafish development. We identified two orthologs of the mammalian NCS-1 gene. Full-length cDNAs encoding zebrafish Ncs-1a and Ncs-1b polypeptides were cloned and characterized. Whole-mount in situ hybridization revealed t...
|
PMID: 15898063
PDF is available here.
PDF is available here.
Abstract
We investigated in the primate prefrontal cortex the ultrastructural localization of D2 and we compared it with that of the neuronal calcium sensor-1 (NCS-1), a neuron-specific calcium-binding and D2-interacting protein. D2 immunoreactivity, revealed with preembedding immunoperoxidase in single labe...
|
PMID: 15973684
PDF is available here.
PDF is available here.
Abstract
We define the role of the Ca2+-binding protein neuronal Ca2+ sensor-1 (NCS-1) in insulin secretion. In pancreatic beta cells, NCS-1 increases exocytosis by promoting the priming of secretory granules for release and increasing the number of granules residing in the readily releasable pool. The effec...
|
PMID: 16014415
PDF is available here.
PDF is available here.
Abstract
I will provide an overview of the current, and rapidly expanding, knowledge of how this important family of proteins might be involved in various major CNS diseases, the proposed role of NCS proteins in pathophysiological signaling and the development of pharmacological tools and novel research stra...
|
PMID: 15982480
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)16 2005
Abstract
We have investigated the equilibrium unfolding and refolding of myristoylated and non-myristoylated NCS-1. The unfolding of these two forms of NCS-1 in the presence of calcium is best characterized by a five-state equilibrium model, and multiple intermediates accumulate during unfolding. Calcium exe...
|
PMID: 15699030
PDF is available here.
PDF is available here.
Journal of Neuroscience (25)13 2005
Abstract
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and membrane-to-cytosol translocation of the fluor...
|
PMID: 15800195
PDF is available here.
PDF is available here.
Abstract
We have identified a novel Ca(2+)-dependent interaction between neuronal calcium sensor-1 (NCS-1) and the GTPase ARF1. Both of these proteins are localized to the Golgi complex, and both regulate phosphatidylinositol 4-kinase IIIbeta (PI(4)Kbeta). Spatial and temporal control of phosphatidylinositol...
|
PMID: 15576365
PDF is available here.
PDF is available here.
Abstract
We examined the expression of NCS-1 in the developing and mature olfactory system to determine whether this molecule may be playing a role in establishing and/or maintaining olfactory circuitry. During development, expression of NCS-1 in the olfactory epithelium was localized in the dendritic knobs...
|
PMID: 15611992
PDF is available here.
PDF is available here.
Abstract
We used nerve-ending preparations where membrane channels are bypassed through membrane permeabilization made by mechanical disruption or streptolysin-O. Nerve ending NCS-1 and phosphatidylinositol 4-kinase (PI4K) are largely or entirely particulate, so their concentrations in nerve endings remain c...
|
PMID: 15659215
PDF is available here.
PDF is available here.
Abstract
We searched databases for sequences encoding potential members of the neuronal calcium sensor (NCS) family of Ca2+-binding proteins. As a result, genes for five new putative Ca2+-binding proteins were identified. Based on amino acid sequence alignments and phylogenetic analyses, one of these genes (...
|
PMID: 15606490
PDF is available here.
PDF is available here.
Abstract
We investigated mGluR- and time-dependent changes in the expression of two different NCS proteins. Following DHPG application in vivo NCS-1 and VILIP-1 expression increased, with significant levels reached after 8 and 24h. The effect was attenuated by treatment with the group I mGluR specific antago...
|
PMID: 15336574
PDF is available here.
PDF is available here.
Biological Psychiatry (56)6 2004
Abstract
Up-regulation of calcyon and NCS-1 in the second schizophrenia cohort strengthens the proposition that abnormalities of the dopamine system in this disease may lie in altered levels of dopamine receptor-interacting proteins. Also, up-regulation of both calcyon and NCS-1 in the cortex of schizophreni...
|
PMID: 15364041
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)26 2004
Abstract
We present the role of myristoylation of NSC-1 in governing Ca(2+) binding and Ca(2+)-induced conformational changes in NCS-1 as compared with the role in the nonmyristoylated protein. The (45)Ca binding and isothermal titration calorimetric data show that myristoylation increases the degree of coop...
|
PMID: 15102861
PDF is available here.
PDF is available here.
Abstract
We have synthesised peptides corresponding to all the four EF-hands and studied their conformation and calcium-binding. Our data confirm that the first putative site, a non-canonical one (EF1), does not bind calcium. We have investigated if this lack of binding is due to the presence of non-favoured...
|
PMID: 15203236
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)14 2004
Abstract
We have used sequence comparison combined with information from structural analyses to attempt to identify candidate residues within the NCS proteins that determine whether or not the Ca(2+)/myristoyl switch operates in cells and have tested their functional significance by mutagenesis. The results...
|
PMID: 14726528
PDF is available here.
PDF is available here.
Cerebellum (3)2 2004
Abstract
We first summarize distribution of NCS-1 in the cerebellum. NCS-1 is mainly detected in postsynaptic sites, such as somata and dendrites of Purkinje cells, stellate/basket cells and granule cells. In addition, GABAergic inhibitory stellate/basket cell axon terminals also contain NCS-1. Secondly, we...
|
PMID: 15233574
PDF is available here.
PDF is available here.
Neuroscience (123)2 2004
Abstract
We have examined the expression of NCS-1 in adult rat dorsal root ganglion (DRG) neurons. NCS-1 immunoreactivity was present in most DRG neurons, including many calcitonin gene-related peptide (CGRP) expressing ones. NCS-1 showed some colocalization with the synaptic vesicle protein synaptophysin an...
|
PMID: 14698749
PDF is available here.
PDF is available here.
Abstract
We have analyzed the biochemistry of the long form splice variant of CaBP1 (L-CaBP1) and show that, in vitro, a recombinant form of the protein is able to bind Ca2+ with high affinity and undergo a conformational change. We also describe the localization of endogenous and overexpressed L-CaBP1 in th...
|
PMID: 14570872
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)49 2003
Abstract
We demonstrate using both genetic and biochemical approaches that the observed structural conservation between Saccharomyces cerevisiae frequenin (Frq1) and human NCS-1 is also reflected at the functional level. In yeast, the sole essential target of Frq1 is the phosphatidylinositol 4-kinase isoform...
|
PMID: 14512421
PDF is available here.
PDF is available here.
Inflammation (27)6 2003
Abstract
We show that human neutrophils and promyelocitic cells express neuronal calcium sensor-1 (NCS-1), a calcium binding protein involved in exocytosis in various cell types. Both mRNA and protein were found in mature cells and precursors. NCS-1 is shown to be mainly associated with azurophilic granules...
|
PMID: 14760944
PDF is available here.
PDF is available here.
Journal of Cell Science (116)Pt 23 2003
Abstract
We have explored factors affecting the localisation of Kv4.2 and the targeting of KChIP1 and other NCS proteins by using GFP-variant fusion proteins expressed in HeLa cells. ECFP-Kv4.2 expressed alone was not retained in the ER but reached the Golgi complex. In cells co-expressing ECFP-Kv4.2 and KCh...
|
PMID: 14600268
PDF is available here.
PDF is available here.
Journal of Immunology (171)10 2003
Abstract
We examined the possible occurrence and function of neuronal Ca(2+) sensor 1 (NCS-1/frequenin) in the mast cell line rat basophilic leukemia, RBL-2H3. This protein has been implicated in the control of neurosecretion from dense core granules in neuronal cells as well as in the control of constitutiv...
|
PMID: 14607934
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)44 2003
Abstract
We examine the specificity and sites of these proteins for interaction with Kv channel proteins. Immunoprecipitation and green fluorescent protein imaging show that KChIPs (but not NCS-1) effectively bind to Kv4.3 protein and localize at the plasma membrane when channel proteins are coexpressed. Ana...
|
PMID: 12928444
PDF is available here.
PDF is available here.