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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neuropeptides (29):
- Delta Sleep-Inducing Peptide
- Opioid Peptides
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Peptide PHI
- Hypothalamic Hormones
- Galanin
- Cholecystokinin
- Neurophysins
- Gastrin-Releasing Peptide
- Gastric Inhibitory Polypeptide
- Vasopressins
- Tachykinins
- Secretin
- Pancreatic Polypeptide
- Calcitonin
- Urocortins
- Neuropeptide Y
- Motilin
- FMRFamide
- Vasoactive Intestinal Peptide
- Neurotensin
- Galanin-Like Peptide
- Calcitonin Gene-Related Peptide
- Bombesin
- Melanocyte-Stimulating Hormones
- Carnosine
- Angiotensins
- Gastrins
- Bradykinin
Recent article
Neuropeptides
Journal of Infectious Diseases (204)10 2011
Abstract
We have previously developed a rat model of K. pneumoniae meningoencephalitis. Cortistatin (CST) is a recently discovered neuropeptide with endocrine activities in humans. In this study, we found that brain infection by K. pneumoniae increased endogenous prepro-CST messenger RNA expression, which oc...
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PMID: 21940421
PDF is available here.
PDF is available here.
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Abstract
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (27)8 2011
Abstract
To investigate the effects of adipose-derived stem cell (ADSC) transplanting on the outgrowth of neuronal axons and the expressions of GFAP, Neuritin, NF-200 in the brain post focal cerebral ischemia in rats.
54 male adult Sprague-Dawley rats were randomly divided int...
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PMID: 21806883
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
We will review the data about the connections of POP with conventional neurotransmitter systems and provide an overview of the role of POP in neurotransmission....
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PMID: 21222629
PDF is available here.
PDF is available here.
Abstract
The neuropeptides hypocretin-1 and -2 (orexin A and B) are critical in the regulation of arousal and maintenance of wakefulness. Understanding the role of the hypocretin system in sleep/wake regulation has come from narcolepsy-cataplexy research. Deficiency of hypocretin results in l...
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PMID: 21170610
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We demonstrate that differentiation into the T(H)1 and T(H)17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate T(H)1 and T(H)17 responses in vitro and in vivo and did n...
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PMID: 21358638
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)4 2011
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.
Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
PDF is available here.
Abstract
Hypothalamic neuropeptides play essential roles in regulating energy and body weight balance. Energy imbalance and obesity have been linked to hypothalamic signaling defects in regulating neuropeptide genes; however, it is unknown whether dysregulation of neuropeptide exocytosis coul...
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PMID: 21315262
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
Studies of pituitary-related disorders would be facilitated by enhanced knowledge of the pituitary proteome. To construct a data set of human pituitary proteins, separate protein extracts were prepared from 15 post-mortem pituitaries and analyzed by data independent label-free nanofl...
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PMID: 21268279
PDF is available here.
PDF is available here.
Abstract
This paper is devoted to the mechanisms of development of chronic atrophic pharyngitis. A method is proposed for studying microcirculation in the mucous membrane at the posterior pharyngeal wall of the patients with this condition using laser Doppler flowmetry. The role of chronic somatic pathology i...
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PMID: 21720287
PDF is available here.
PDF is available here.
Abstract
We performed chromatin immunoprecipitation (ChIP) analysis, double-immunostaining, a luciferase reporter assay, and an in utero electroporation study. ChIP analysis showed that endogenous NR6A1 binds to a putative NR6A1-binding site. Double-immunostaining indicated almost all hypocretin neurons were...
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PMID: 21056546
PDF is available here.
PDF is available here.
Abstract
We report that orexin-A induces invivo neovascularization in a mouse Matrigel plug and ex vivo sprouting of endothelial cells in rat aortic rings. We also show that orexin-A increases migration and tube formation in human umbilical vein endothelial cells (HUVECs), and this effect is mediated by orex...
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PMID: 21040705
PDF is available here.
PDF is available here.
Abstract
The crystal structure of the neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) is reported revealing the solid-state conformation of its molecules and their association in the crystal.
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PMID: 20838690
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We used pharmacological tools to identify peptidylglycine α-amidating monooxygenase (PAM), a type I secretory granule membrane protein, as a γ-secretase substrate. PAM, an essential enzyme, catalyzes the final step in the synthesis of the majority of neuropeptides that control metabolic homeostasi...
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PMID: 20817724
PDF is available here.
PDF is available here.
Abstract
We show that keratinocytes express sortilin mRNA, and the presence of sortilin protein is shown in cultured keratinocytes and in normal human skin. We have also shown that the cutaneous neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and galanin are abl...
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PMID: 20613775
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We found that the endocytic adaptor epsin binds and regulates the biological properties of the signaling molecule RalBP1 (Ral-binding protein 1). Epsin interacted with the N terminus of RalBP1 via its characteristic epsin N-terminal homology (ENTH) domain. A combination of siRNA-mediated knock-down...
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PMID: 20709745
PDF is available here.
PDF is available here.
Abstract
We present the most recent advances in the understanding of the roles played by nerve endings and neuropeptides in local inflammatory processes of the ocular surface, in order to better clarify their function in physiologic and pathologic conditions and to open new research, diagnostic, and therapeu...
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PMID: 20706114
PDF is available here.
PDF is available here.
Nature Chemistry (2)10 2010
Abstract
We describe a comprehensive route for the synthesis of cortistatins from a common precursor, which in turn is assembled from two fragments of similar structural complexity. Cortistatins A and J, and for the first time K and L, have been synthesized in parallel processes from like intermediates prepa...
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PMID: 20861906
PDF is available here.
PDF is available here.
Abstract
We screened the recently sequenced genome of the parasitic wasp, Nasonia vitripennis, for the presence of these signaling molecules and annotated 30 precursor genes encoding 51 different mature neuropeptides or protein hormones. Twenty-four of the predicted mature Nasonia neuropeptides could be expe...
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PMID: 20695486
PDF is available here.
PDF is available here.
Neuroscience Letters (482)3 2010
Abstract
We have determined whether general anesthesia would affect plasma orexin A (OXA) and norepinephrine concentrations. Twelve patients scheduled for elective ophthalmic surgery under general anesthesia with sevoflurane, fentanyl and vecuronium were studied. Arterial blood was collected before and 1 and...
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PMID: 20655366
PDF is available here.
PDF is available here.
Neuroscience (170)1 2010
Abstract
We examined QA toxicity on orexin neurons and melanin-concentrating hormone (MCH) neurons in vivo. Contrary to the expectation, injection of QA (60 and 120 nmol) into the lateral hypothalamus of male C57BL/6 mice caused selective loss of MCH neurons rather than orexin neurons, and this toxicity of Q...
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PMID: 20620197
PDF is available here.
PDF is available here.
Neuroscience Letters (481)2 2010
Abstract
We previously reported that peripherally injected lipopolysaccharide (LPS) induces apoptosis in the OB in young adult mice. Therefore, this study was undertaken to examine whether peripherally injected LPS induces apoptotic cell death also in the SVZ. Two mouse strains were used: C3H/HeN and Toll-li...
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PMID: 20600591
PDF is available here.
PDF is available here.
Abstract
We generated mice with a conditionally deleted allele of Ptpn12. By removing PTP-PEST in T cells, we determined that PTP-PEST was not necessary for T cell development or primary responses. However, PTP-PEST was required for secondary T cell responses, anergy prevention, and autoimmunity induction. P...
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PMID: 20727793
PDF is available here.
PDF is available here.
Hormones and Behavior (58)4 2010
Abstract
Animals living in temperate climates with predictable seasonal changes in food availability may use seasonal information to engage different metabolic strategies. Siberian hamsters decrease costs of thermoregulation during winter by reducing food intake and body mass in response to decreasing or sho...
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PMID: 20600050
PDF is available here.
PDF is available here.
Abstract
We performed a large-scale gene profiling experiment which plotted global expression changes in the rat dorsal root ganglion in three peripheral neuropathic pain models. This resulted in the discovery that the potassium channel alpha subunit KCNS1, involved in neuronal excitability, is constitutivel...
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PMID: 20724292
PDF is available here.
PDF is available here.
Abstract
Levels of juvenile hormone III (JH), FGLamide allatostatin peptides (ASTs), ASTs precursor (preproAST) mRNA and methyl farnesoate epoxidase (CYP15A1) mRNA were measured in embryos of the cockroach Blattella germanica. JH starts to rise just after dorsal closure, reaches maximal levels between 60% an...
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PMID: 20542115
PDF is available here.
PDF is available here.
Neuroscience (169)3 2010
Abstract
We investigated the role of mTOR in Sprague-Dawley rats using the carrageenan model of inflammatory pain. mRNA of Ras homolog enriched in brain (Rheb), a GTPase that positively regulates mTOR activation, was significantly increased 2 h following carrageenan injection. Four hours after induction of i...
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PMID: 20538043
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
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Diabetologia (53)8 2010
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The series of Camerino Symposia present the most recent knowledge and discoveries in the growing field of drug-receptor interactions and the design and mechanisms of drug action. Lead discovery, G protein-coupled receptors (GPCRs) and polypharmacology were the general subjects covere...
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PMID: 21426016
PDF is available here.
PDF is available here.
Chemmedchem (5)8 2010
Abstract
Behavioral Neuroscience (124)4 2010
Abstract
We sought to determine whether different CFC methods vary in their sensitivity to the arrest of adult neurogenesis. Adult neurogenesis was arrested in mice using low-dose, targeted x-irradiation, and the effects of irradiation were assayed in conditioning procedures that varied in the use of a discr...
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PMID: 20695644
PDF is available here.
PDF is available here.
Abstract
We outline the recent knowledge about the mechanism of development of drug addiction....
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PMID: 20715474
PDF is available here.
PDF is available here.
Neuroreport (21)11 2010
Abstract
We examined hypocretin levels in dementia with Lewy bodies and Alzheimer's disease cases and correlated these with sleep habits and clinical characteristics. Although limited hypocretin alterations were observed in Alzheimer's disease, we show reduced neocortical hypocretin immunoreactivity in demen...
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PMID: 20531237
PDF is available here.
PDF is available here.
Abstract
Advances in understanding host innate/adaptive immunity and abrogation of immune privilege in ocular viral and bacterial infections have been accomplished using animal models. In Pseudomonas aeruginosa keratitis, mouse models have shown that IL-12-driven IFN-gamma production in Th1 responder strains...
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PMID: 20662654
PDF is available here.
PDF is available here.
Abstract
We report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational ch...
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PMID: 20670830
PDF is available here.
PDF is available here.
Abstract
We found apoE isoform-dependent effects of (137)Cs irradiation on cognitive function of female mice 3 months following irradiation. Alterations in the number of immature neurons and in the levels of the dendritic marker microtubule-associated protein 2 (MAP-2) might contribute to the cognitive chang...
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PMID: 20458592
PDF is available here.
PDF is available here.
Abstract
We examined the effect of orexin on cytosolic Ca(2+) concentrations ([Ca(2+)](i)) in the granule cell domain (GCD) cells of the cochlear nucleus that carry non-auditory information to the dorsal cochlear nucleus. Application of orexin concentration-dependently increased [Ca(2+)](i), and in two third...
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PMID: 20457199
PDF is available here.
PDF is available here.