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Olfactory Marker Protein (0):
Recent article
Olfactory Marker Protein
Abstract
We reported that transplanted bone marrow-derived cells were engrafted into the olfactory epithelium and then had characteristics of olfactory neuron cells. However, the engraftment rate was far from a practical level. Granulocyte colony-stimulating factor (G-CSF) is known to mobilize stem cells fro...
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PMID: 20502766
PDF is available here.
PDF is available here.
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Abstract
Chronic rhinosinusitis (CRS) is among the most common causes of olfactory loss. The loss of the sense of smell is thought to result from structural and functional changes occurring in the olfactory epithelium caused by inflammation. However, the cellular mechanisms underlying CRS-associated olfactor...
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PMID: 20537285
PDF is available here.
PDF is available here.
Neuroreport (20)8 2009
Abstract
These results suggest that topical application of bFGF promotes proliferation of globose basal cells and supporting cells....
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PMID: 19369908
PDF is available here.
PDF is available here.
Cell and Tissue Research (335)3 2009
Abstract
Age-related changes were examined in the distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa. The olfactory mucosa of female ICR mice at postnatal ages from 10 days to 16 months were investigated histologically by hematoxylin and eosi...
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PMID: 19142664
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)2 2009
Abstract
We have investigated two clonal mouse olfactory placode (OP) cell lines as a model system for studying endogenous odorant receptor (OR) regulation. Both lines can be differentiated into bipolar neurons with transcriptional profiles consistent with mature sensory neurons. We show that single cells ex...
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PMID: 19012738
PDF is available here.
PDF is available here.
Neuroreport (19)11 2008
Abstract
We developed a procedure to purify olfactory cilia membranes by differential centrifugation of rat olfactory epithelium extracts. We tested whether known scaffolding proteins that might participate in the assembly of the complex chemotransduction apparatus are present in the purified membrane fracti...
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PMID: 18596612
PDF is available here.
PDF is available here.
Brain Research (1203) 2008
Abstract
We have now investigated their role during regeneration. We have recently generated a line of transgenic mice, BGAT-Tg, that mis-express the blood group A (BGA) carbohydrate on all primary olfactory axons rather than just on accessory olfactory axons as in wild-type mice. Following unilateral bulbec...
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PMID: 18316067
PDF is available here.
PDF is available here.
Abstract
Neurospheres are potentially good tools to study olfactory neurogenesis. For this purpose, it is necessary to characterize neurospheres derived from the olfactory system. This study is aimed at identifying the regional difference of cellular composition within neurospheres derived from the adult mou...
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PMID: 17938947
PDF is available here.
PDF is available here.
Abstract
We report that BIG-2/contactin-4, an axonal glycoprotein belonging to the immunoglobulin superfamily, is expressed in a subpopulation of mouse olfactory sensory neurons. A mosaic pattern of glomerular arrangement is observed with strongly BIG-2-positive, weakly positive, and negative axon terminals...
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PMID: 18367085
PDF is available here.
PDF is available here.
Abstract
Sensitized mice challenged with allergen demonstrated elevated eosinophil infiltration of the respiratory and olfactory mucosae, with olfactory sensory neuron apoptosis. Remarkably, massive neuronal apoptosis without eosinophil infiltration occurred in nonsensitized mice after a single dose of extra...
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PMID: 18312881
PDF is available here.
PDF is available here.
Abstract
Distribution of olfactory marker protein (OMP) on a tissue section of vomeronasal organ (VNO) was successfully measured by atomic force microscopy (AFM). Anti-OMP antibodies were covalently crosslinked with the tip of the AFM and were used as a probe to observe the distribution of OMP on a tissue se...
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PMID: 17923395
PDF is available here.
PDF is available here.
Neuroscience (151)3 2008
Abstract
We set out to establish Ca(2+)-dependent signaling networks in ORN cilia by proteomic analysis. We subjected a ciliary membrane preparation to Ca(2+)/calmodulin-affinity chromatography using mild detergent conditions in order to maintain functional protein complexes involved in olfactory Ca(2+) sign...
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PMID: 18155848
PDF is available here.
PDF is available here.
Abstract
Finding the dynamics of an entire macromolecule is a complex problem as the model-free parameter values are intricately linked to the Brownian rotational diffusion of the molecule, mathematically through the autocorrelation function of the motion and statistically through model selection. The soluti...
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PMID: 18085411
PDF is available here.
PDF is available here.
Abstract
We bred OR-tagged transgenic mice to homozygosity with mice that had a gene-targeted deletion of the Shaker potassium ion channel (Kv1.3) to elucidate how activity modulates synaptic connections that formulate the sensory map. Here we report that the Kv1.3 ion channel, which is predominantly express...
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PMID: 18022950
PDF is available here.
PDF is available here.
Abstract
Induction of anosmia was confirmed by behavioral tests. The thickness and cell number of olfactory neuroepithelium were decreased more significantly in the dexamethasone treatment group than in the combination treatment group. The expression of olfactory marker protein (OMP) in olfactory epithelium...
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PMID: 18588762
PDF is available here.
PDF is available here.
Journal of Physiology (585)Pt 3 2007
Abstract
We used suction-pipette recordings from isolated ORNs of OMP(-/-) mice to investigate its role in olfactory transduction. Vertebrate olfactory transduction is initiated when odourants bind to receptor proteins to activate an adenylyl cyclase via a G protein-coupled signalling pathway. This leads to...
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PMID: 17932148
PDF is available here.
PDF is available here.
Abstract
We review several lines of evidence that support the existence of a heterogeneous population of neural and glial progenitors in the olfactory mucosa, and highlight the differences in the identity and activity of progenitors found in the embryonic and adult OE. In particular, we show how recent advan...
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PMID: 17851769
PDF is available here.
PDF is available here.
Abstract
We reported that one goat V1rs (gV1ra1) is expressed by ORNs and VRNs. To investigate the characteristics of vomeronasal-receptor-expressing ORNs in mammals we performed double-label in situ hybridization for gV1ra1, G alpha i2, G alpha olf, olfactory marker protein (OMP), and growth association pro...
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PMID: 17492642
PDF is available here.
PDF is available here.
Chemical Senses (32)6 2007
Abstract
We report that GG neurons express trace amine-associated receptors (TAARs) that have most recently been described as a novel class of olfactory receptors. It was observed that several TAAR subtypes are expressed by defined subpopulations of GG neurons distinct from the V2r83-positive cells. Analyzin...
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PMID: 17556730
PDF is available here.
PDF is available here.
Nature Neuroscience (10)6 2007
Abstract
We show that mouse horizontal basal cells (HBCs) function as adult olfactory neuroepithelium neural stem cells and examine their distinct dynamics in olfactory neuroepithelium maintenance and regeneration. Fate-mapping analysis after olfactory neuroepithelium lesioning shows that HBCs are competent...
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PMID: 17468753
PDF is available here.
PDF is available here.
Neuroreport (18)7 2007
Abstract
We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growt...
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PMID: 17426590
PDF is available here.
PDF is available here.
Abstract
We apply for the first time the use of liposome-encapsulated clodronate to selectively deplete macrophages during the OSN degeneration/regeneration cycle in order to elucidate the role(s) of macrophages in regulating cellular mechanisms that lead to apoptosis and neurogenesis. Mice were injected int...
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PMID: 17226772
PDF is available here.
PDF is available here.
Abstract
We investigated the spatial distribution of the three VGLUTs in the rat olfactory bulb, a brain region containing a variety of glutamate synapses, both axodendritic and dendrodendritic. Using multilabelling confocal microscopy and electron microscopic immunocytochemistry, we showed that each VGLUT i...
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PMID: 17425564
PDF is available here.
PDF is available here.
Abstract
We extended this genetic evidence by establishing the transcriptional profile of differentiating olfactory sensory neurons (OSNs) in Klf7(-/-) mice, and by identifying relevant genes that are directly regulated by KLF7. Functional clustering of DNA microarray data revealed that loss of KLF7 affects...
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PMID: 17123745
PDF is available here.
PDF is available here.
Neuroscience Letters (413)2 2007
Abstract
Olfactory marker protein (OMP) is a protein expressed in the mature olfactory and vomeronasal neurons of many vertebrates, such as mammals, amphibians and bony fishes. Aim of this work was to investigate the OMP expression in the olfactory epithelium of the shark Scyliorhinus canicula (Linnaeus, 175...
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PMID: 17174032
PDF is available here.
PDF is available here.
Neuroreport (17)17 2006
Abstract
We examined the role of matrix metalloproteinase-9 in a model of olfactory nerve injury in mice. We measured changes in matrix metalloproteinase-9 protein levels for up to 60 days following olfactory nerve transection. Matrix metalloproteinase-9 levels increased within hours after injury, peaked at...
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PMID: 17164665
PDF is available here.
PDF is available here.
Abstract
The Grueneberg ganglion (GG) is a cluster of neurones present in the vestibule of the anterior nasal cavity. Although its function is still elusive, recent studies have shown that cells of the GG transcribe the gene encoding the olfactory marker protein (OMP) and project their axons to glomeruli of...
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PMID: 16805845
PDF is available here.
PDF is available here.
Abstract
We here report that a cluster of neurons, distinct from these two systems, located at the very tip of the mouse nose and called the Grüneberg ganglion expresses the mature olfactory-sensory neuron-specific marker olfactory marker protein (OMP), but is unlikely to express known odorant or pheromone...
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PMID: 16819977
PDF is available here.
PDF is available here.
Brain Research (1091)1 2006
Abstract
We propose that normal generation of otoconia requires a complex temporal and spatial control of developmental and biochemical events. In this review, we suggest a new hypothetical model for normal otoconial and otolith formation based on matrix vesicle mineralization in bone which we believe to be...
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PMID: 16529728
PDF is available here.
PDF is available here.
Abstract
We have recently shown that unilateral naris occlusion (UNO) causes an increase in olfactory marker protein (OMP) immunoreactivity (IR) in mouse olfactory sensory neurons (OSN) from the occluded side of the nasal cavity and a decrease in OMP-IR on the non-occluded side, relative to controls. Given O...
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PMID: 16493579
PDF is available here.
PDF is available here.
Experimental Neurology (198)2 2006
Abstract
We repeated a study reporting that delayed transplantation of olfactory lamina propria (OLP) into the site of a complete spinal cord transection led to significant improvement in hindlimb motor function and induced axon regeneration. Adult female rats received complete spinal cord transections at T1...
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PMID: 16494866
PDF is available here.
PDF is available here.
Abstract
We report the identification of a novel population of OMP-expressing neurons located bilaterally in the anterior/dorsal region of each nasal cavity at the septum. These cells are clearly separated from the regio olfactoria, harboring the olfactory sensory neurons. During mouse development, the arran...
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PMID: 16273384
PDF is available here.
PDF is available here.
Abstract
We have now identified a novel third population of olfactory marker protein-expressing sensory neurons that is located in a discrete pocket of the rostral nasal septum, which we refer to as the septal organ of Grüneberg (SOG). Neurons in this region of the septum are located in the submucosa, in sm...
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PMID: 16374816
PDF is available here.
PDF is available here.
Abstract
We determined that Nogo-A was preferentially expressed by immature olfactory receptor neurons extending axonal processes toward the olfactory bulb. At all developmental stages, Nogo-A protein was preferentially targeted in olfactory axons emerging from the olfactory epithelium. Using an in vitro mod...
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PMID: 16262653
PDF is available here.
PDF is available here.
Abstract
We report that neurons of the mouse GG express olfactory marker protein, which is normally expressed in mature olfactory or vomeronasal sensory neurons. The approx. 500 cells in each GG are arranged in several densely packed cell clusters. Individual cells give rise to single axons, which fasciculat...
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PMID: 16307607
PDF is available here.
PDF is available here.
Abstract
We have reported that alpha6beta1 integrin regulates the directed migration of neuroblasts from the adult rodent subventricular zone (SVZ) through the rostral migratory stream (RMS). ADAM (a disintegrin and metalloprotease) proteins bind integrins. Here, we show that ADAM21, but not ADAM2, -3, -9, -...
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PMID: 16052496
PDF is available here.
PDF is available here.
Journal of Neurocytology (34)3-5 2005
Abstract
All three olfactory epithelia, the olfactory epithelium proper (OE), the septal organ of Masera (SO), and the vomeronasal organ of Jacobson (VNO) originate from the olfactory placode. Here, their diverse neurochemical phenotypes were analyzed using the immunohistochemical expression pattern of diffe...
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PMID: 16841165
PDF is available here.
PDF is available here.
Abstract
Brain Research (1052)1 2005
Abstract
These results demonstrate that bone marrow cells can be engrafted in the olfactory epithelium and then differentiate into olfactory neuron cells....
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PMID: 15996641
PDF is available here.
PDF is available here.
Biochemistry (Washington) (44)28 2005
Abstract
Nuclear magnetic resonance (NMR) (15)N relaxation measurements of the olfactory marker protein (OMP) including longitudinal relaxation (T(1)), transverse relaxation (T(2)), and (15)N-{(1)H} NOE data were collected at low protein concentrations (
PDF is available here.
PDF is available here.
Abstract
We have examined the projections of primary olfactory axons in OMP-tau:LacZ mice and OMP-GFP mice, two independent lines in which the OMP coding region has been replaced by reporter molecules. We found that axons overshoot their target layer and grow into the external plexiform layer in these OMP nu...
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PMID: 15912500
PDF is available here.
PDF is available here.
Abstract
We report the distribution of Bex1 and Bex2 mRNAs in several brain regions and the development and characterization of an antibody to mouse Bex1 protein that cross-reacts with Bex2 (but not Bex3), and its use to determine the cellular distribution of Bex proteins in the murine brain. The specificity...
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PMID: 15861462
PDF is available here.
PDF is available here.
Mechanisms of Development (122)6 2005
Abstract
We identified two major otolith matrix proteins, OMP-1 (otolith matrix protein-1) and Otolin-1, from salmonid species. To assess the function of these proteins in otolith formation, we performed antisense morpholino oligonucleotide (MO)-mediated knockdown of omp-1 and otolin-1 in zebrafish embryos....
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PMID: 15905077
PDF is available here.
PDF is available here.
Brain Research (1044)1 2005
Abstract
We show, using Western blot analysis and immunocytochemistry, that unilateral naris occlusion (UNO) on postnatal day 1 alters OMP immunoreactivity (IR) differentially on the occluded and non-occluded sides of the nasal cavity in 18, 24 and 70-day-old mice. Compared to untreated animals, UNO-treated...
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PMID: 15862783
PDF is available here.
PDF is available here.
Journal of Neuroscience (25)20 2005
Abstract
We found that these OSNs express different sets of signal transduction machineries: the ciliated OSNs express OR-type odorant receptors, cyclic nucleotide-gated channel A2 subunit, and olfactory marker protein (OMP), whereas the microvillous OSNs express V2R-type receptors and transient receptor pot...
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PMID: 15901770
PDF is available here.
PDF is available here.
Brain Research (1041)1 2005
Abstract
We previously reported increased apoE levels in the olfactory bulb (OB) following olfactory epithelium (OE) lesion in mice, and hypothesized that apoE may play a vital role in olfactory nerve (ON) regeneration. To directly test this hypothesis, we examined the rate of ON regeneration following OE le...
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PMID: 15804503
PDF is available here.
PDF is available here.
Abstract
We identified 54 differentially expressed transcripts. One-third of the transcripts encode proteins with no known function, but the others have functions that correlate with challenges faced by OSNs. The OSNs expressed a diversity of signaling protein genes, including stomatin (Epb7.2), S100A5, Ddit...
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PMID: 15682396
PDF is available here.
PDF is available here.
Abstract
The birth and differentiation of neurons have been extensively studied in the olfactory epithelium (OE) of rodents but not in humans. The goal of this study was to characterize cellular composition and molecular expression of human OE in vivo and in vitro. In rodent OE, there are horizontal basal ce...
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PMID: 15678478
PDF is available here.
PDF is available here.
Journal of Neurocytology (34)1-2 2005
Abstract
We observed increased numbers of newly generated growth associated protein 43 (GAP43)-positive immature olfactory sensory neurons. OMP-positive neurons were continuously produced from the newly generated GAP43-positive cells. The expression of the signal transduction components adenylyl cyclase type...
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PMID: 16374708
PDF is available here.
PDF is available here.
Journal of Neurocytology (34)1-2 2005
Abstract
The present study examined interspecies, intersexual, and age-related changes in size of the vomeronasal neuroepithelium (VNNE) of two species of greater bushbabies (genus Otolemur, Infraorder Lorisiformes, Suborder Strepsirrhini). Tissue blocks containing the vomeronasal organs of nine O. crassicau...
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PMID: 16374715
PDF is available here.
PDF is available here.
Abstract
We demonstrate that olfactory sensory neurons are found in both the caudal nasal and the frontal sinus epithelia. Olfactory ensheathing glia were found in the mucosa at both these sites implying that surgical access for harvesting cells for transplantation would be straightforward....
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PMID: 15500833
PDF is available here.
PDF is available here.
Chemical Senses (30)2 2005
Abstract
We previously developed a new culture system for vomeronasal receptor neurons (VRNs), referred to as the vomeronasal pocket (VN pocket). However, very few VRNs were found to express the olfactory marker protein (OMP) and to have protruding microvilli in VN pockets, indicating that these VRNs are imm...
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PMID: 15703330
PDF is available here.
PDF is available here.
Neuroscience (131)3 2005
Abstract
We previously found that an ATRA supplement enhanced olfactory recovery rate in adult mice after olfactory bulb deafferentation. In this study, we examined the cellular localization of RARalpha, RARbeta, and RARgamma and the effects of surgery and ATRA treatment using immunocytochemistry. Mice recei...
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PMID: 15730877
PDF is available here.
PDF is available here.
Molecular Brain Research (132)2 2004
Abstract
We generated a line of mice expressing Bcl-2, a protein with anti-apoptotic properties, in mature olfactory receptor neurons using the Olfactory Marker Protein (OMP) promoter. OMP-bcl-2 transgenic mice showed selective expression of Bcl-2 in mature sensory neurons of the olfactory neuroepithelium (O...
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PMID: 15582160
PDF is available here.
PDF is available here.
Abstract
These results indicate a critical cell biological function for Mecp2 in mediating the final stages of neuronal development.
Copyright 2004 Elsevier Inc....
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PMID: 15345242
PDF is available here.
PDF is available here.
Abstract
We have now further characterized the interaction of OMP and Bex1/2 by in vitro binding assays and by immuno-coprecipitation experiments. OMP is a 19 kDa protein but these immunoprecipitation studies have revealed the unexpected presence of a 38 kDa band in addition to the expected 19 kDa band. Furt...
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PMID: 15198671
PDF is available here.
PDF is available here.
Behavioral Neuroscience (118)3 2004
Abstract
Mice from which the olfactory marker protein (OMP) gene has been deleted demonstrate a number of neurophysiologic and behavioral defects that suggest OMP is an important component in olfactory signal transduction and is critically involved in odor processing. Recently, the potential pleiotropic effe...
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PMID: 15174942
PDF is available here.
PDF is available here.
Abstract
We have targeted expression of synapto-pHluorin, a pH-sensitive protein that reports synaptic vesicle fusion, to olfactory sensory neurons in mouse. Synapto-pHluorin selectively labeled presynaptic terminals of sensory neurons in glomeruli of the olfactory bulb. Odorant stimulation evoked large-ampl...
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PMID: 15066261
PDF is available here.
PDF is available here.
Neuroscience (123)4 2004
Abstract
Axon guidance molecules and related proteins such as semaphorin 3A, neuropilin-1, plexin-1, netrin-1, growth-associated protein, olfactory marker protein, cypin and collapsin response mediator proteins guide the development of neural circuits in the olfactory bulb. In this study, transcriptions of t...
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PMID: 14751288
PDF is available here.
PDF is available here.
Laryngoscope (113)12 2003
Abstract
These findings suggest that the regenerative activity of the neuroepithelium might be well demonstrated by PCNA immunoreactivity and that regeneration of the neuroepithelium can be activated several days after SO2 injury. The two NOS isoforms, iNOS and nNOS, might contribute to neuroprotection in th...
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PMID: 14660920
PDF is available here.
PDF is available here.