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Synapsins (0):
Recent article
Synapsins
Abstract
We show an innovative procedure of perfusion and fixation of brain tissue, that allows, by applying Golgi-Cox impregnation and immunofluorescence in the same histological section, to obtain high-quality histological material, with a very simple and inexpensive method. This procedure is based on thre...
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PMID: 21461741
PDF is available here.
PDF is available here.
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Abstract
We discuss the role of synapsin in synaptogenesis and synaptic function, especially on short term plasticity.
Copyright © 2011 Elsevier Ltd. All rights reserved....
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PMID: 21843652
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
I phosphorylation via activation of PKA and CaMK II, which are mediated by cyclic AMP levels and Ca(2+) influx.
Copyright (c) 2010 Elsevier B.V. All rights reserved....
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PMID: 20080157
PDF is available here.
PDF is available here.
Abstract
We derived a double knockout (DKO) mouse lacking both synapsin II and Rab3a. We found that Rab3a deletion rescued epileptic-like seizures typical for synapsin II gene deleted animals (Syn II(-)). Furthermore, action potential evoked release was drastically reduced in DKO synapses, although spontaneo...
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PMID: 20338242
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
Synapsin 2 proteins are key elements of the synaptic machinery and still hold the centre stage in neuroscience research. Although fully sequenced at the nucleic acid level in mouse and rat, structural information on amino acid sequences and post-translational modifications (PTMs) is limited. Knowled...
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PMID: 19609639
PDF is available here.
PDF is available here.
Biochemical Journal (426)1 2010
Abstract
We used a synthetic 25-mer peptide encompassing the most conserved region of domain E (Pep-E) to analyse the role of domain E in regulating the interactions between synapsin I and liposomes mimicking the phospholipid composition of SVs (SV-liposomes) and other pre-synaptic protein partners. In affin...
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PMID: 19922412
PDF is available here.
PDF is available here.
Abstract
We examined the possibility that vitamin E supplemented in the diet may help counteract the effects of TBI on the molecular substrates underlying synaptic plasticity and cognitive function in the hippocampus.
Rats were fed a regular diet with or without 500 IU/kg of vitamin E for 4 w...
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PMID: 19841436
PDF is available here.
PDF is available here.
BMC Neuroscience (11) 2010
Abstract
We used a co-culture technique in combination with morphometrics on immunostained neurons to investigate the role of astrocytes in the development delays associated with hippocampal neuron development.
We found that hippocampal neurons grown on Fragile X astrocytes exhibited a significant difference...
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PMID: 20955577
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)12 2009
Abstract
We sought to better understand the roles rostral or caudal sprouting may play in ChABC-mediated functional improvement. To achieve this, ChABC or vehicle was injected rostral or caudal to a unilateral C5 injury. When injected rostral to a hemisection, ChABC promoted significant sprouting of 5HT+ fib...
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PMID: 19659409
PDF is available here.
PDF is available here.
Abstract
I immunostaining, and the majority of synapses that do form remain functionally immature. These findings highlight the importance of sGC in the regulation of neurite outgrowth and synapse formation, and in the functional maturation of cerebellar granule cells in vitro....
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PMID: 19461654
PDF is available here.
PDF is available here.
Abstract
The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied. Samples of P14 and P21 rat cerebellar cortex were exposed to a specific...
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PMID: 19886034
PDF is available here.
PDF is available here.
Journal of Neurophysiology (102)1 2009
Abstract
GABA release by dopaminergic amacrine (DA) cells of the mouse retina was detected by measuring Cl- currents generated by isolated perikarya in response to their own neurotransmitter. The possibility that the Cl- currents were caused by GABA release from synaptic endings that had survived the dissoci...
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PMID: 19403749
PDF is available here.
PDF is available here.
Neuroscience (161)2 2009
Abstract
We have characterized the transduction of mouse somatosensory cortical neuron types by recombinant AAV pseudotyped with serotype 1 capsid (rAAV2/1) and by recombinant lentivirus pseudotyped with the vesicular stomatitis virus (VSV) glycoprotein. Both vectors used human synapsin (hSyn) promoter drivi...
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PMID: 19318117
PDF is available here.
PDF is available here.
Cerebral Cortex (19)6 2009
Abstract
We used microelectrode array and patch-clamp recordings to study network activity in primary cortical neurons from wild-type (WT) or SynI knockout (KO) mice. SYN1 deletion was associated with increased spontaneous and evoked activities, with more frequent and sustained bursts of action potentials an...
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PMID: 19020204
PDF is available here.
PDF is available here.
Abstract
We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) begin...
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PMID: 18831070
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)4 2009
Abstract
We explore the contribution of the glutamatergic release in cerebral cortex synaptosomes isolated from rats with experimental autoimmune encephalomyelitis, an animal model reproducing many features of MS. We found that the Ca(2+)-dependent but not the Ca(2+)-independent glutamate release induced by...
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PMID: 19209405
PDF is available here.
PDF is available here.
Brain Research (1248) 2009
Perinatal development of the mammillothalamic tract and innervation of the anterior thalamic nuclei.
Abstract
Axonal projections originating from the mammillary bodies represent important pathways that are essential for spatial information processing. Mammillothalamic tract is one of the main efferent projection systems of the mammillary body belonging to the limbic "Papez circuit". This study was aimed to...
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PMID: 19026995
PDF is available here.
PDF is available here.
BMC Neuroscience (10)1 2009
Abstract
In the present study we used Vesicular Stomatitis Virus G glycoprotein-pseudotyped lentivirual vectors to express EGFP from three different promoters in the mouse hippocampus. In contrast to lentiviral transduction of pyramidal cells in CA1, we identified sub-region specific differences in transgene...
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PMID: 19144149
PDF is available here.
PDF is available here.
Abstract
I in the brain of young mice. The results showed that 20% FR did not retard the body weight gain of mice, while the 60% and 80% FR reduced the mice's body weight. The memory after 24 hr of learning was not changed by FR, whereas long-term memory was improved significantly in 20% FR mice. In addition...
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PMID: 19125380
PDF is available here.
PDF is available here.
Abstract
Autoimmunity (42)8 2009
Abstract
We have previously described that antibodies and T cells against myelin basic protein (MBP) rose under conditions to induce acute experimental autoimmune encephalomyelitis (EAE) bind other proteins present in the synaptosomal fraction, some of them identified as synapsin I. The aim of this study was...
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PMID: 19886738
PDF is available here.
PDF is available here.
Behavioural Brain Research (196)1 2009
Abstract
We studied the relation between sex, kindled fear behavior, and synapsin I immunoreactivity in various brain regions. Male and female adult Long-Evans rats received either 99 left amygdala kindling stimulations or sham stimulations. One day after the final stimulation, fear behavior was assessed in...
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PMID: 18703092
PDF is available here.
PDF is available here.
Abstract
We were interested in how bath application of the peptide hormone might influence synaptic plasticity following high frequency stimulation (HFS). We found that CNP application decreased the population spike (PS) amplitude after HFS, thereby affecting long-term potentiation (LTP) in acute hippocampal...
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PMID: 18952057
PDF is available here.
PDF is available here.
Abstract
We specifically deleted the hrs gene, ESCRT-0, in the neurons of mice by crossing loxP-flanked hrs mice with transgenic mice expressing the synapsin-I Cre protein (SynI-cre). Histological analyses revealed that both apoptosis and a loss of hippocampal CA3 pyramidal neurons occurred in the hrs(flox/f...
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PMID: 19008375
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)46 2008
Abstract
We show that the expression of several isoforms of synapsins, a group of phosphoproteins thought to regulate the dynamics of synaptic vesicle storage and release, is induced by auditory stimulation with birdsong in the caudomedial nidopallium (NCM) of the zebra finch (Taeniopygia guttata) brain. Thi...
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PMID: 19005052
PDF is available here.
PDF is available here.
Abstract
Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse fo...
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PMID: 18543340
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)43 2008
Abstract
We examined the synaptic effects of introducing each isoform into glutamatergic cultured hippocampal neurons from synapsin triple knock-out mice. Remarkably, we found that synapsin IIa was the only isoform that could rescue the synaptic depression phenotype of the triple knock-out mice; other isofor...
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PMID: 18945891
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)41 2008
Abstract
We investigated the role of the ubiquitin-proteasome system and the regulation of one of its components, ubiquitin C-terminal hydrolase (ap-uch), in LTD. LTD was sensitive to presynaptic inhibition of the proteasome and was associated with upregulation of ap-uch mRNA and protein. This upregulation a...
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PMID: 18842884
PDF is available here.
PDF is available here.
Neuroscience Letters (443)3 2008
Abstract
Our results suggest that voluntary exercise could reinforce the beneficial effects of SC transplantation and FGF-2 gene therapy in peripheral nerve reconstruction approaches....
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PMID: 18692548
PDF is available here.
PDF is available here.
Molecular Neurobiology (38)2 2008
Abstract
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles whereas the BK channel colocalizes with voltage-sensitive Ca(2+) channels in the plasma membrane. Mounting evidence suggests that t...
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PMID: 18759010
PDF is available here.
PDF is available here.
Journal of Physiology (586)Pt 19 2008
Abstract
We document that reducing Ca(2+) concentration [Ca(2+)](o) in the extracellular medium from 2 to 0.5 mm led to an approximately 40% decrease in both docked and undocked synaptic vesicles in wild-type nerve terminals of the mouse diaphragm. The same treatment reduced the number of undocked vesicles i...
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PMID: 18669537
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)39 2008
Abstract
We have shown previously that Schwann cell-conditioned medium (SC-CM) promotes synaptogenesis in Xenopus nerve-muscle cocultures. The present study aimed to identify the synaptogenic molecules in SC-CM. Combining biochemical approaches and in vitro bioassays, we found that SC-CM contains transformin...
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PMID: 18815246
PDF is available here.
PDF is available here.
Neuroscience (155)4 2008
Abstract
We performed a lateral cervical ( approximately C4) hemisection in adult rats. Seven days after hemisection, the BDNF inhibitor trkB IgG was injected into the cervical spinal cord below the lesion ( approximately C5-C6). Half of the rats were exposed to voluntary running wheels for 14 days. Locomoto...
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PMID: 18672032
PDF is available here.
PDF is available here.
Psychopharmacology (200)1 2008
Abstract
Daily cyclosporine administration potentiated the locomotor response to repeated cocaine 5 min after cocaine injection and attenuated the sustained locomotor response 15 to 40 min after cocaine. Furthermore, cyclosporine pretreatment for 17 days augmented the acute locomotor response to acute cocain...
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PMID: 18587562
PDF is available here.
PDF is available here.
Abstract
We have examined the effect of single and repeated electroconvulsive seizures (ECS), an animal model of ECT, on the expression of 14 SVPs in the rat frontal cortex and the hippocampus using quantitative real-time polymerase chain reaction (real-time qPCR). Only in the frontal cortex, the mRNA level...
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PMID: 18563845
PDF is available here.
PDF is available here.
Brain Research (1224) 2008
IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons.
Abstract
We investigated temporal and spatial changes of Kilon expression and its modulatory functions for synapse number using hippocampal cultured neurons. Kilon was observed to localize chiefly at axons and presynaptic terminals at early culture stage, however, it was seen mainly at dendritic postsynaptic...
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PMID: 18602091
PDF is available here.
PDF is available here.
Abstract
We demonstrate in vitro that RGMa, an RGM homolog, inhibits neurite growth and cortical neuron branching on mouse embryonic day 16. Further, exposure of cultured neurons to RGMa significantly reduced the number of colocalized immunoreactive clusters of synapsin 1 and PSD-95 in the spines. This RGMa-...
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PMID: 18519029
PDF is available here.
PDF is available here.
Abstract
I present a new methodology that overcomes these three problems by using zinc-formaldehyde (ZnFA) for fixation. The success of this technique is demonstrated in the brain of the desert locust and evaluated by comparison with fixation in formaldehyde and immunostaining against synapsin to reveal the...
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PMID: 18585788
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)2 2008
Abstract
We have begun to examine endocannabinoid-dependent short-term depression (STD) of inhibitory synaptic transmission under well-controlled physiological and pharmacological conditions in an environment free of other cells. Application of the CB1 synthetic agonist WIN55212-2 and endogenous cannabinoids...
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PMID: 18497350
PDF is available here.
PDF is available here.
Toxicology (249)2-3 2008
Abstract
I had no effect on this measure. The ontogenetic expression of neurotypic proteins was reduced after treatment with both inhibitors. In particular, Synapsin 1 and GAP-43 expression were both significantly reduced by chemical treatment. These data demonstrate that neurotypic proteins can be used as b...
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PMID: 18584932
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of four pre-synaptic proteins (growth-associated protein-43, synapsin-I, synaptophysin, and synaptotagmin) and two post-synaptic proteins (post-synaptic density protein-95 and Ca(2+)/calmodulin-dependent protein kinase II) in the hippocampus and cerebral cortex, respec...
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PMID: 18316211
PDF is available here.
PDF is available here.
Abstract
I was also reduced in whole retina and isolated synaptosomes from 1-month diabetic rats, as compared to controls. These data suggest that diabetes has a profound impact on presynaptic protein expression in the retina, and may provide a mechanism for the well-established defects in vision and the ele...
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PMID: 18662330
PDF is available here.
PDF is available here.
Abstract
We previously developed a rodent model in which exposure to an ethanol (EtOH) diet, followed by carbachol (Cch) stimulation, redirects exocytosis from the apical to the basolateral plasma membrane of acinar cells, resulting in ectopic zymogen enzyme activation and pancreatitis. This redirection of e...
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PMID: 18535671
PDF is available here.
PDF is available here.
Neuroscience (154)2 2008
Abstract
We also determined if these treatments reduced injury-induced oxidative stress. Following a CCI or sham injury, rats received AMPH (1 mg/kg/day) or saline treatment via an ALZET pump and were housed with or without access to a running wheel for 7 days. CCI rats ran significantly less than sham contr...
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PMID: 18479829
PDF is available here.
PDF is available here.
Neuroscience (153)4 2008
Abstract
We investigate the effects of progressive depletion of Stoned B protein (STNB) on the release properties of neuromuscular synapses using a novel set of synthetic stnB hypomorphic alleles. Decreasing neuronal STNB expression to < or =35% of wild-type level causes a strong reduction in excitatory junc...
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PMID: 18436388
PDF is available here.
PDF is available here.
Journal of Cell Biology (181)5 2008
Abstract
We use interference RNAs to eliminate Piccolo expression from cultured hippocampal neurons to assess its involvement in synapse formation and function. Our data show that Piccolo is not required for glutamatergic synapse formation but does influence presynaptic function by negatively regulating SV e...
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PMID: 18519737
PDF is available here.
PDF is available here.
Abstract
We present a genome-wide linkage analysis by means of a 500 K SNP platform. The analysis was done on a large pedigree affected with Parkinsonian-pyramidal syndrome (PPS), and the results showed linkage to chromosome 22. Sequencing of candidate genes revealed a disease-associated homozygous variation...
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PMID: 18513678
PDF is available here.
PDF is available here.
Abstract
We constructed vectors for the expression of LTB and LTBSC proteins. LTBSC is a fusion protein that comprises the amino acid sequence from the C-domain of rat synapsin fused to the C-terminal end of LTB. Both constructions have a coding sequence for a 6His-tag fused in-frame. LTBSC was expressed in...
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PMID: 18400513
PDF is available here.
PDF is available here.
Abstract
We examined the effects of developmental exposure of rats to PCP on various aspects of brain development, male reproductive function, and adrenal function, all of which are under thyroid hormones regulation. PCP was administered to dams and their offspring via drinking water (6.6 mg l(-1)) during ge...
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PMID: 19082768
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)20 2008
Abstract
We test this model by disrupting the cytoskeleton in a live-cell model system wherein we directly visualize transport of SCb cargoes. We focused on three SCb proteins that we previously showed were cotransported in our system: alpha-synuclein, synapsin-I, and glyceraldehyde-3-phosphate dehydrogenase...
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PMID: 18480281
PDF is available here.
PDF is available here.
Abstract
We learn from this study, although increasing complexity of protein knowledge, that the estrous cycle and not only the sex per se has to be taken into account for design of future studies and interpretation of previous work at the protein level....
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PMID: 18036704
PDF is available here.
PDF is available here.
Abstract
These results suggest, therefore, that Ca2+ entrance mediated by P2X7 receptor induces glutamate release and in parallel synapsin-I phosphorylation....
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PMID: 18242779
PDF is available here.
PDF is available here.
Journal of Neurotrauma (25)5 2008
Abstract
These results indicate that depletion of antioxidant systems following trauma could adversely affect synaptic function and plasticity. Because of the observed differences in the time-course of various markers, it may be necessary to stagger selective types of anti-oxidant therapy to target specific...
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PMID: 18533843
PDF is available here.
PDF is available here.
Abstract
We describe the form, distribution, and cytology of Kenyon cell groups in the process of generation and growth in comparison to developed parts of the mushroom bodies in adult crickets of the species Gryllus bimaculatus. A subset of growing Kenyon cells with sprouting processes has been distinguishe...
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PMID: 18306378
PDF is available here.
PDF is available here.
Abstract
We identified a novel long isoform of Drosophila ankyrin2 (ank2-L). We demonstrate that loss of presynaptic Ank2-L not only causes synapse disassembly and retraction but also disrupts neuronal excitability and NMJ morphology. We provide genetic evidence that ank2-L is necessary to generate the membr...
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PMID: 18439405
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that synapsin III plays a role in adult neurogenesis with synapsin III knockout and wild-type mice. Immunocytochemistry of the adult hippocampal dentate gyrus revealed that synapsin III colocalizes with markers of neural progenitor cell development (nestin, PSA-NCAM, NeuN, a...
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PMID: 18271024
PDF is available here.
PDF is available here.
Neuroscience (152)3 2008
Abstract
We first examined the balance between cell birth-death in the hippocampus and subventricular zone (SVZ) of pre-pubertal and adult rats subjected to chronic-mild-stress (CMS). CMS led to increased corticosterone secretion and induced depressive-like symptoms (assessed in the forced-swimming test); th...
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PMID: 18291594
PDF is available here.
PDF is available here.
Abstract
Abstract
We report that the synaptic expression of mGluRs can be regulated by NMDA receptor-dependent synaptic plasticity, but that this is dependent on the subtype of mGluR. Silent synapses, but not active synapses, were found to lack Group I mGluRs showing that mGluRs must be inserted into synapses after t...
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PMID: 18191411
PDF is available here.
PDF is available here.
Biological Chemistry (389)3 2008
Abstract
We show that two non-coding microRNAs, miR124a and miR96, modulate the expression of proteins involved in insulin exocytosis and affect secretion of the beta-cell line MIN6B1. miR124a increases the levels of SNAP25, Rab3A and synapsin-1A and decreases those of Rab27A and Noc2. Inhibition of Rab27A e...
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PMID: 18177263
PDF is available here.
PDF is available here.