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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Synaptophysin (0):
Recent article
Synaptophysin
Toxicology (289)1 2011
Abstract
We hypothesized that the effects of these compounds could be reflected by changes in biochemical substrates and cholinergic receptors and have examined the levels of four proteins involved in maturation of the brain, neuronal growth and synaptogenesis and the densities of both muscarinic and nicotin...
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PMID: 21820030
PDF is available here.
PDF is available here.
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Brain research (1360) 2010
Abstract
We examined the pathophysiology of neuronal and glial cells of the nigrostriatal pathway following unilateral infusion of varying doses of rotenone into the substantia nigra or medial forebrain bundle of adult male Sprague-Dawley rats, sacrificed 14 and 60 days after infusion. Immunofluorescence tec...
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PMID: 20807515
PDF is available here.
PDF is available here.
Neuroscience (169)3 2010
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease. There are a limited number of therapeutic options available for the treatment of AD. Curcuminoids (a mixture of bisdemethoxycurcumin, demethoxycurcumin and curcumin) is the main chemical constituent found in turmeric, a well known curry spice,...
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PMID: 20538041
PDF is available here.
PDF is available here.
Abstract
In adult albino mice the effects of increased intraocular pressure on the outer retina and its circuitry was investigated at intervals ranging 3-14 weeks. Ocular hypertension (OHT) was induced by cauterizing the vessels draining the anterior part of the mice eye, as recently reported (Salinas-Navarr...
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PMID: 20650699
PDF is available here.
PDF is available here.
Abstract
Abstract
We propose the use of immunohistochemistry (IHC) as a potential diagnostic tool. We examined 116 BMB and 115 bone marrow clot (BMC) specimens from 60 newly diagnosed neuroblastoma patients for tumor cells. Neuroendocrine IHC markers, such as CD56, chromogranin A, and synaptophysin were applied to di...
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PMID: 20216406
PDF is available here.
PDF is available here.
Abstract
Abstract
Taken together, these results indicate that treatment with melatonin in goat kids in situations of stress due to premature weaning could play an important role in the improvement of histo-physiological function of the pineal gland....
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PMID: 20514091
PDF is available here.
PDF is available here.
Abstract
We investigated the subcellular localization of HER2 protein in 1053 primary breast cancer tissues. HER2 protein was stained by various immunohistochemical methods and studied by immunoelectron microscopy to confirm the intracellular localization. Thirty-four of 1053 specimens showed cytoplasmic sta...
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PMID: 21073134
PDF is available here.
PDF is available here.
Abstract
This study was conducted to determine the clinical significance of neuroendocrine differentiation in cases of T3-T4 node-negative colorectal cancer. Eighty-nine patients diagnosed with T3-T4 node-negative colorectal cancer who underwent curative resection were enrolled. Tumors expressing neuroendocr...
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PMID: 19372085
PDF is available here.
PDF is available here.
Abstract
Zinc with or without glutamine improved weight gain as compared to untreated, undernourished controls. In addition, zinc supplementation improved cliff avoidance and head position during swim behaviors especially on days 9 and 10. Using design-based stereological methods, we found a significant incr...
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PMID: 20371167
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)19 2010
Abstract
Epilepsy day 1: GAP-43 mRNA and protein expression at hippocampus dentate gyrus granular cell layer, hilus and CA3 pyramidal layer in the kindled group were higher than the sham group (P < 0.05). The expressions declined at Day 3 (P > 0.05). Expressions became elevated again at Day 7 and they were s...
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PMID: 20646586
PDF is available here.
PDF is available here.
Brain research (1328) 2010
Abstract
Repeated seizures induce permanent alterations of the brain in experimental models and patients with intractable temporal lobe epilepsy (TLE), which is a common form of epilepsy in humans. Together with cell loss and gliosis in many brain regions, synaptic reorganization is observed principally in t...
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PMID: 20144592
PDF is available here.
PDF is available here.
Schizophrenia Research (118)1-3 2010
Abstract
Although the etiology of schizophrenia remains unknown, diverse neuropathological evidence suggests a disorder of synaptic connectivity. Apoptosis is a form of cell death that helps determine synaptic circuitry during neurodevelopment and altered regulation of apoptosis has been implicated in schizo...
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PMID: 20067857
PDF is available here.
PDF is available here.
Abstract
Abstract
We evaluated the effects of long-term treatment with CHF5074, a new gamma-secretase modulator, on hippocampal neurogenesis, cortical synaptophysin levels, and contextual memory in transgenic mice carrying the double Swedish mutation of AbetaPP (Tg2576). Six-month old Tg2576 mice were treated with CH...
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PMID: 20164581
PDF is available here.
PDF is available here.
Abstract
A 58-year-old woman presented with a lump on the left side of the neck. Investigations by ultrasound-guided fine needle aspiration, magnetic resonance imaging, and positron emission tomography were all indicative of a diagnosis of a solitary malignant mass with no primary lesion identified. The pati...
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PMID: 20303047
PDF is available here.
PDF is available here.
Abstract
We encountered an extremely rare case of combined neuroendocrine carcinoma with squamous cell carcinoma, occurring at the buccal gingiva in a 62-year-old woman. Left partial maxillectomy was performed. Histological examinations revealed solid nests with extensive necrosis and nuclear palisading at t...
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PMID: 20303044
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)4 2010
Abstract
World Journal of Biological Psychiatry (11)2 Pt 2 2010
Abstract
In light of the differential interactions seen between benzodiazepine, GABA transporter (GAT) inhibition and drug tolerance, the locomotor effects of a GAT1-specific inhibitor (SKF89976A) following diazepam tolerance were analysed and compared with the concomitant expression of synap...
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PMID: 19452356
PDF is available here.
PDF is available here.
Abstract
We conclude that synaptophysin is a reliable marker in human fetal brain and that sIR provides the means for objective assessment of cerebral maturation in normal brains and to enable interpretation of abnormal synaptic patterns in pathological conditions....
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PMID: 20142767
PDF is available here.
PDF is available here.
Abstract
We evaluated changes in the expression of neuronal nuclear and other proteins in the mouse hippocampus after 17-Gy whole-brain irradiation. Expression of neuronal nuclei (NeuN), neuron-specific enolas, prospero-related homeobox 1 (Prox1), calbindin D28k, and synaptophysin 1 in the CA1, CA3, and dent...
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PMID: 20142763
PDF is available here.
PDF is available here.
Abstract
We reported a case of ACC which was manifested by subcutaneous nodule as initial clinical symptom. To our knowledge, this is the first reported case of ACC presenting as subcutaneous fat necrosis in Korea....
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PMID: 20168061
PDF is available here.
PDF is available here.
Abstract
Journal of Neuroscience (30)3 2010
Abstract
We report that AP-3 and BLOC-1 differentially regulate the composition of presynaptic terminals in the striatum and dentate gyrus of the hippocampus. Quantitative immunoelectron microscopy demonstrated that the majority of AP-3 immunoreactivity in both wild-type striatum and hippocampus localizes to...
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PMID: 20089890
PDF is available here.
PDF is available here.
Neuroendocrinology (91)2 2010
Abstract
ZM447439 dose-dependently inhibited proliferation of all three cell lines with IC(50) values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation and caspase 3 and 7 activation. Furthermore, we...
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PMID: 19923785
PDF is available here.
PDF is available here.
Abstract
We present a new genetic synaptic labeling method that relies on expression of a presynaptic marker, synaptophysin-GFP (Syp-GFP) in individual neurons in vivo. We assess the reliability of this method and use it to analyze the spatial patterning of synapses in developing and mature cerebellar granul...
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PMID: 20634890
PDF is available here.
PDF is available here.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (51)1 2010
Abstract
We compared quantitatively the regional distribution of GABAA-receptor alpha1-subunit (GABAAR-alpha1) expression in three brain areas: neocortex, hippocampus and cerebellum by RT-qPCR. TaqMan probe was used in order to avoid detection of non-specific amplification products and synaptophysin as inter...
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PMID: 20191118
PDF is available here.
PDF is available here.
Abstract
We induced cerebrovascular hypoperfusion by bilateral carotid occlusion surgery in adult rats and investigated its impacts on spatial memory, synapses, and accumulation of oligomeric amyloid-β. We found progressive spatial memory deficits, as tested by Morris water maze, starting 30 days after occl...
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PMID: 20634588
PDF is available here.
PDF is available here.
Abstract
We detected reduced expression of synaptophysin in both the pathologically susceptible inferior temporal cortex and hippocampus, consistent with previous reports. PSD-95 and SAP-102 mRNA was reduced, albeit not significantly. Proteins were precisely quantified against recombinant truncated protein s...
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PMID: 20634587
PDF is available here.
PDF is available here.
Abstract
We report that pre-mixing Aβ(1-40) with Aβ(1-42) significantly reduced the effects of Aβ(1-42) on synapses; it increased both synaptic vesicle recycling and synaptophysin content. These results are consistent with reports that Aβ(1-40) forms oligomers with Aβ(1-42) and that these are less toxic...
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PMID: 20634578
PDF is available here.
PDF is available here.
Abstract
Immunohistochemical investigation of the regional distribution of neuronal and glial elements in the barrels of somatic cortex was carried out in rats (n=10). High level of synaptophysin protein expression was detected in the in barrel walls together with the accumulation of astroglial cells in their...
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PMID: 20593579
PDF is available here.
PDF is available here.
Abstract
Ketamine combined with penehyclidine hydrochloride may inhibit more significantly learning and memory abilities and the synaptophysin expression in the hippocampus CA3 region than ketamine alone in neonatal rats. Penehyclidine hydrochloride alone has no effect on learning and memory abilities and th...
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PMID: 20113636
PDF is available here.
PDF is available here.
Abstract
We report a case of an endometrial tumor that was a combination of an SCC and endometrioid adenocarcinoma with squamous components and that penetrated half of the thickness of the uterine wall. CASE: A 59-year-old, postmenopausal woman suffering from postmenopausal bleeding presented for care. The p...
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PMID: 20337215
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)2 2010
Abstract
These results have important therapeutic implications, as estrone, a main component of a widely used hormone replacement therapy, was shown to have either a negative effect or no effect on learning and memory. It may be possible to use 17alpha-estradiol and lower doses of estrogens as potential alte...
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PMID: 19847162
PDF is available here.
PDF is available here.
Srpski arhiv za celokupno lekarstvo (138)1-2 2010
Abstract
NSE, ChrA and SYN expression were noted in 56 (23.7%), 33 (13.9%) and 39 (16.5%) patients, respectively. Better therapeutic response was significantly higher in patients with expression of NSE, ChrA and SYN (p < 0.05). There was significant correlation between therapy response and the percentage of...
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PMID: 20422910
PDF is available here.
PDF is available here.
Bratislavske lekarske listy (111)1 2010
Abstract
In the rare case of Synaptophysin-negative central neurocytoma, its neuronal differentiation should be substantiated by electron-microscopic examination. Unfortunately in the routine work, biopsy samples are usually fixed in formalin fixative which does not preserve ultrastructure well. In such situ...
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PMID: 20429311
PDF is available here.
PDF is available here.
Neurobiology of Aging (30)11 2009
Abstract
We now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve terminals). Compared to synaptosomal membranes from 2-month-old rats, the density of presynaptic proteins (synaptophysin or SNAP-...
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PMID: 18304697
PDF is available here.
PDF is available here.
Cell and Tissue Research (338)2 2009
Abstract
We asked whether it also affected dental or periodontal cells or dental innervation by altering voltage-gated sodium channel Na(v)1.6 immunoreactivity (IR) or neural synaptophysin. Daily dexamethasone (0.2 mg/kg) given for 1 week to rats caused 12-fold increased intensity of Na(v)1.6-IR in dendritic...
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PMID: 19763626
PDF is available here.
PDF is available here.
Oncology Reports (22)4 2009
Abstract
Tubulin is a major component of microtubules. Class III beta-tubulin (beta III) is a neuron-associated beta-tubulin isotype and expressed in the normal central and peripheral nervous systems. According to a previous study, beta III is not expressed in normal skin and squamous cell carcinoma. However...
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PMID: 19724850
PDF is available here.
PDF is available here.
Brain Research (1284) 2009
Abstract
We explored whether transplantation of neural stem cells (NSCs) modified by GDNF gene provides a better therapeutic effect than native NSCs after stroke. Primary rat NSCs were transfected with GDNF plasmid (GDNF/NSCs, labeled by green fluorescent protein from AdEasy-1, GFP). Adult rats were subjecte...
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PMID: 19520066
PDF is available here.
PDF is available here.
FASEB Journal (23)8 2009
Abstract
We previously reported that in Tg19959 transgenic AD mice, partial deficiency of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) exacerbated amyloid pathology. We therefore asked whether MnSOD overexpression would prove beneficial against AD pathogenesis, by studying the...
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PMID: 19346295
PDF is available here.
PDF is available here.
Abstract
We have studied (P)RR expression in mouse brain, as well as the effect of transfection of Delta4-(P)RR on neuronal differentiation of rat neuroendocrine PC-12 cells induced by nerve growth factor (NGF). In situ hybridization showed a wide distribution of (P)RR, including in key regions involved in t...
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PMID: 19474391
PDF is available here.
PDF is available here.
Abstract
We examined voluntary wheel-running, memory, and hippocampal plasticity in APOE epsilon3 and APOE epsilon4 transgenic mice at 10-12 months of age.
Sedentary epsilon4 mice exhibited deficits in cognition on the radial-arm water maze (RAWM), a task dependent on the hippocampus. Six wee...
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PMID: 19560099
PDF is available here.
PDF is available here.
Turkish Neurosurgery (19)3 2009
Abstract
Glioblastoma multiforme (GB) is the most aggressive, and the most frequent primary tumor of the brain in adults. Presence of less-differentiated areas which exhibit a small cell morphology and neural immunophenotype is quite uncommon in GBs. Tumor tissue which had been determined in the frontotempor...
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PMID: 19621291
PDF is available here.
PDF is available here.
European Spine Journal (18 Suppl 2)s2 2009
Abstract
A case of ganglioneurocytoma of the spinal cord in a 51-year-old man is reported. Patient presented with a progressively worsening back pain and hyposthenia of lower limbs. Magnetic resonance imaging of the spinal cord revealed an intradural lesion in the T10-11 spinal segments, hyperintense on T1-w...
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PMID: 18813960
PDF is available here.
PDF is available here.
Abstract
Our study suggested that PESCC was a rare and aggressive tumor with high malignancy. Superficial PESCC had rapid progression and poor prognosis compared with superficial squamous cell carcinoma of the esophagus at the same stage. The systemic therapy based on combination of postoperative chemotherap...
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PMID: 19515193
PDF is available here.
PDF is available here.
Abstract
We report three instructive cases of extra-adrenal paraganglioma which were found in unusual sites such as urinary bladder, thyroid gland and on the wall of the inferior vena cava....
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PMID: 19694315
PDF is available here.
PDF is available here.
Child's Nervous System (25)6 2009
Abstract
BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive infantile neoplasm of uncertain origin. This study was performed to assess the clinicopathologic and immunohistochemical features of four AT/RT cases. CASE REPORTS: Two cases were male and two were female, and their ages range...
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PMID: 19212771
PDF is available here.
PDF is available here.
Neurotoxicity Research (15)4 2009
Abstract
We recently demonstrated that Delta(9)-tetrahydrocannabinol (THC) chronic administration in female adolescent rats induces alterations in the emotional circuit ending in depressive-like behavior in adulthood. Since cognitive dysfunction is a major component of depression, we assessed in these animal...
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PMID: 19384563
PDF is available here.
PDF is available here.
Abstract
The SERPINB8 is expressed in normal neuroendocrine cells of several organs as well as in neuroendocrine tumors of the pancreas, where it can be used as an additional diagnostic immunohistochemical marker....
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PMID: 19188865
PDF is available here.
PDF is available here.
Abstract
(1) Visceral hypersensitivity was noted in the chronic infection group, although the inflammation was nearly eliminated (P<0.05). Severe inflammation and downregulation of visceral sensitivity were observed in the acute infection group (P<0.05). (2) There were many more synaptic vesicles and longer...
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PMID: 19058006
PDF is available here.
PDF is available here.
Abstract
SSTR2A was expressed in one small cell carcinoma and two neuroendocrine large cell carcinomas. The cell membrane of cells in these carcinomas showed strong immunohistochemical reactivity for SSTR2A. SSTR2A-positive cases are also frequently positive for the expression of chromogranin A. Treatment wi...
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PMID: 18726606
PDF is available here.
PDF is available here.
Abstract
We performed a "proof-of-principle" study using tail tip fibroblasts from a mouse model of Parkinson's disease (Aphakia) as the donor cell nuclei for nuclear transfer and derived "customized" ESCs for in vitro analysis. Aphakia mice contain deletions in the pitx3 gene and show selective loss of dopa...
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PMID: 19196042
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)5 2009
Abstract
We previously found that GDNF facilitates dopamine release in a manner dependent on adenosine A2A receptor activation. As motor dysfunction also involves modifications of striatal glutamatergic innervation, we now tested if GDNF and its receptor system, Ret (rearranged during transfection) and GDNF...
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PMID: 19141075
PDF is available here.
PDF is available here.
Muscle & Nerve (39)3 2009
Abstract
We show here that alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) receptor subunits, together with glutamate, are present at the mammalian NMJ. Both AMPA and NMDA (N-methyl-D-aspartate) glutamate receptor subunits display overlapping postsynaptic localization patterns with Dlg at all NM...
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PMID: 19208409
PDF is available here.
PDF is available here.
Abstract
We cultured rat hippocampal neurons over a three-week period to correlate synapse density with the increase in spontaneous spiking activity. We followed the network development as synapse formation and spike rate in two serum-free media optimized for either (a) neuron survival (Neurobasal/B27) or (b...
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PMID: 19104141
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)4 2009
Abstract
We analyzed the distribution of five septins, Sept6, Sept7, Sept8, Sept9 and Sept11, in various rat tissues by western blot analyses and found all septins to be expressed in brain. We also examined the developmental changes of expression of these septins in the rat brain and found that the level of...
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PMID: 19196426
PDF is available here.
PDF is available here.
Abstract
We have determined practical requirements for antigen colocalization on subcellular structures. The calibration standards used were 175-nm fluorescent microspheres and microtubules (approximately 255 nm) in cultured astrocytes. The colocalization problem became apparent with detection of anti-alpha-...
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PMID: 19220688
PDF is available here.
PDF is available here.
Abstract
We investigated whether GA has a positive influence on the loss of inputs to the motoneurons during the course of EAE in rats. Lewis rats were subjected to EAE associated with GA or placebo treatment. The animals were sacrificed after 15 days of treatment and the spinal cords processed for immunohis...
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PMID: 19274346
PDF is available here.
PDF is available here.