Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Synucleins (3):
Recent article
Synucleins
Abstract
Synuclein is a soluble, natively unfolded protein that is highly enriched in the presynaptic terminals of neurons in the central nervous system. Interest in -synuclein has increased markedly following the discovery of a relationship between its dysfunction and several neurodegenerative diseases, inc...
|
PMID: 20522010
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The purposes of this research were to study the restoration on the cognitive ability of rat models with vascular dementia (VaD) by repetitive transcranial magnetic stimulation (rTMS) treatment and its impacts on synaptic plasticity in hippocampal CA1 area and to further explore the molecular mechani...
|
PMID: 19953343
PDF is available here.
PDF is available here.
Physical Biology (6)3 2009
Abstract
We develop a simple dynamical model for the on-going conflict between alphaSN aggregation and the maintenance of a functional proteasome in the healthy cell, based on the premise that proteasomal activity can be titrated out by mature alphaSN fibrils and their protofilament precursors. In the presen...
|
PMID: 19411740
PDF is available here.
PDF is available here.
Abstract
Gangliosides are abundantly expressed in the nervous system, and deregulated expression or activity of gangliosides is associated with the progression of various disorders, including lysosomal storage diseases, Guillain-Barre syndrome and Alzheimer disease. By contrast, previous stud...
|
PMID: 19458475
PDF is available here.
PDF is available here.
Developmental Dynamics (237)9 2008
Abstract
We report the cloning and characterization of three synucleins from zebrafish, sncga, sncgb, and sncb. The sequences of these zebrafish synucleins are very similar to those of the human proteins. We used whole-mount in situ hybridization to analyze their spatial and temporal expression patterns duri...
|
PMID: 18521955
PDF is available here.
PDF is available here.
Neuroreport (19)13 2008
Abstract
We report a reduction in monomeric and oligomeric alpha-synuclein and a reduction in phosphorylated alpha-synuclein (S129) upon rifampicin treatment. This reduction in alpha-synuclein aggregation was accompanied by reduced neurodegeneration. On the basis of its anti-aggregenic properties, we conclud...
|
PMID: 18695506
PDF is available here.
PDF is available here.
Abstract
Since the earliest descriptions of Alzheimer's disease (AD), the presence of senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the typical pathological hallmarks of the disease. Studies over the last twenty years, however, have reported a considerable degree of heterogeneit...
|
PMID: 20021381
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)26 2008
Abstract
We show that the antimalaria drug chloroquine inhibits proteasome function in eukaryotic cell extracts and in preparations of purified 20S archaeal proteasome from Thermoplasma acidophilium. Methyl-TROSY-based NMR spectroscopy experiments conducted with the 670 kDa 20S proteasome localize chloroquin...
|
PMID: 18540636
PDF is available here.
PDF is available here.
Trends in Neurosciences (31)6 2008
Abstract
Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the detri...
|
PMID: 18471904
PDF is available here.
PDF is available here.
Acta Neuropathologica (115)5 2008
Abstract
We immunohistochemically examined the involvement of tauopathy/synucleinopathy, cell death and oxidative damage in the brains of three cases each of MPS IIIB and MPS II and age-matched controls. In cases of MPS IIIB, the density of GABAergic interneurons in the cerebral cortex immunoreactive for cal...
|
PMID: 18060551
PDF is available here.
PDF is available here.
Abstract
Alzheimer and a number of other neurodegenerative diseases are characterized by the presence of reactive microglia and reactive astrocytes in association with the lesions. The classic view that microglia exist primarily in either a resting or activated state needs to be broadened in view of recent r...
|
PMID: 18487845
PDF is available here.
PDF is available here.
Proteomics (8)6 2008
Abstract
We present evidence to show that S6b coexists with a reporter for proteasomal dysfunction (ubiquitin(+1)), and we conclude that S6b transcript up-regulation and the dysfunction in tauopathies may be functionally related....
|
PMID: 18283660
PDF is available here.
PDF is available here.
Abstract
We systematically approach each dementia and review cognitive, psychiatry and neurological features of each. We also compare and contrast each dementia and the synucleinopathies and taupoathies alike. Our goal is to provide the clinician with sufficient knowledge to competently and confidently diagn...
|
PMID: 18288932
PDF is available here.
PDF is available here.
Abstract
We report the results from systematic screening of nearly 900 candidate genetic targets, prioritized by bioinformatic associations to existing PD genes and pathways, via RNAi knockdown. Depletion of 20 gene products reproducibly enhanced misfolding of alpha-syn over the course of aging in the nemato...
|
PMID: 18182484
PDF is available here.
PDF is available here.
Abstract
Abstract
We have shown that autophagy, a cytosolic, non-specific bulk degradation system, is an important clearance route for many cytosolic toxic, aggregate-prone proteins, like mutant huntingtin and mutant alpha-synucleins. Induction of autophagy enhances the clearance of both soluble and aggregated forms...
|
PMID: 18425452
PDF is available here.
PDF is available here.
Abstract
We present a comprehensive analysis of protein elements in Lewy bodies by comparative mass spectrometry. Cortical LB inclusions were enriched by sucrose gradient centrifugation from postmortem brains, and a negative control sample was prepared from specimen without LB pathology. Whereas approximatel...
|
PMID: 18508479
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (88)1 2008
Abstract
To investigate changes of synapse related protein, such as synaptophysin (SYP) and postsynaptic dense material 95 (PSD-95), in brains of 10 months old transgenic mice, and the effects of Epimedium flavonoids (EF) on expression of SYP and PSD-95 in brain of 10 months old of APP transgenic mice.
|
PMID: 18346377
PDF is available here.
PDF is available here.
Acta Neuropathologica (114)5 2007
Abstract
We have previously reported neuronal accumulation of both alpha- and beta-synucleins in brain tissue of a GM2 gangliosidosis mouse model. Although alpha-synuclein has been implicated in several neurodegenerative disorders including Parkinson's disease, dementia with Lewy bodies and multiple system a...
|
PMID: 17653558
PDF is available here.
PDF is available here.
Journal of Molecular Biology (372)3 2007
Abstract
We compared the structural properties of the highly helical states adopted by all three synucleins in association with detergent micelles in an attempt to delineate the basis for functional differences between the three proteins. Here, we report a comparison of the structural and dynamic properties...
|
PMID: 17681534
PDF is available here.
PDF is available here.
Brain Research (1170) 2007
Abstract
We investigated the capture of alpha-, beta-, and gamma-syn proteins as lipid-associated proteins from normal and DLB brain lysates, and from normal human cerebrospinal fluid (CSF). These were eluted from Lipidex-1000 and analyzed by SDS-NuPAGE followed by Western blotting. Using this methodology, w...
|
PMID: 17692832
PDF is available here.
PDF is available here.
Abstract
We reported that microglial activation enhances wild type (WT) alpha-synuclein-elicited dopaminergic neurodegeneration. In the present study, using a primary mesencephalic culture system, we tested whether mutated alpha-synuclein could activate microglia more powerfully than WT alpha-synuclein, ther...
|
PMID: 17600340
PDF is available here.
PDF is available here.
Neurotoxicology (28)4 2007
Abstract
Several epidemiological studies have suggested a role for environmental pesticide exposures in idiopathic Parkinson's disease. The purpose of this study was to test the hypothesis that exposure to pesticides such as endosulfan and/or zineb during critical periods of postnatal development could resul...
|
PMID: 17512982
PDF is available here.
PDF is available here.
Movement Disorders (22)5 2007
Abstract
Seminars in Neurology (26)5 2006
Abstract
Parkinson's disease (PD) is a significant neurodegenerative disease of the elderly, affecting 1 to 2% of those over 60 years of age. The disorder is characterized by resting tremor, bradykinesia, rigidity, postural instability, and pathologically by alpha-synuclein-positive Lewy bodies. For most, th...
|
PMID: 17048150
PDF is available here.
PDF is available here.
Abstract
To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects.
|
PMID: 17068986
PDF is available here.
PDF is available here.
Neuropathology (26)5 2006
Abstract
Previous studies have shown that beta-synuclein (beta-syn), the homologue of alpha-syn, inhibited alpha-syn aggregation and stabilized Akt cell survival signaling molecule, suggesting that beta-syn was protective against alpha-syn-related neurodegenerative disorders, such as Parkinson's disease and...
|
PMID: 17080714
PDF is available here.
PDF is available here.
Abstract
We report a new model of PD in mice, based on chronic inoculation with neurotoxins in the nasal cavity, which is a natural route of contact with the environment. C57BL/6 mice, submitted to daily intranasal inoculation with MPTP for 30 days, developed motor deficits that correlated with a progressive...
|
PMID: 17067291
PDF is available here.
PDF is available here.
Abstract
The synucleinopathies are neurodegenerative disorders defined by inclusions composed of aberrantly fibrillized alpha-synuclein, but factors contributing to this process remain largely unknown. The authors examined the glucocerebrosidase gene in 75 autopsy specimens with different synucleinopathies a...
|
PMID: 16790605
PDF is available here.
PDF is available here.
Abstract
We determined the frequency of LBs in a large series of autopsy-confirmed cases of PSP and studied the density and distribution of LBs, including Parkinson disease stage, in cases with LBs (PSP/LBD). PSP/LBD was compared with pure LB disease (LBD), including assessment of neuronal loss in key brains...
|
PMID: 16691119
PDF is available here.
PDF is available here.
Journal of Neurochemistry (97 Suppl 1) 2006
Abstract
I summarize the main findings obtained from the characterization of DAT-interacting proteins and discuss the functional implications of these novel interactions. Based on these new data, I propose to use the term DAT proteome to explain how interacting proteins regulate DAT function. These novel int...
|
PMID: 16635244
PDF is available here.
PDF is available here.
Annals of Neurology (59)3 2006
Abstract
Neurodegenerative diseases are often classified based on the abnormal accumulation of synuclein or tau. Traditionally, these disorders have been viewed as distinct clinical and pathological entities. However, advances in molecular genetics and protein biochemistry have shown intriguing overlaps. The...
|
PMID: 16489609
PDF is available here.
PDF is available here.
Archives of Neurology (63)3 2006
Abstract
We are faced with many novel challenges. These include the definition of the phenotypic and genotypic spectrum of the monogenic forms, a revised terminology and classification of parkinsonian syndromes, identification of genetic susceptibility factors, and development of guidelines for genetic testi...
|
PMID: 16533959
PDF is available here.
PDF is available here.
Abstract
We have identified and characterized the synuclein gene family from the pufferfish Fugu rubripes. It consists of four genes, which encode alpha-, beta-, gamma1-, and gamma2-synucleins. They range from 113 to 127 amino acids in length and share many of the characteristics of human synucleins, includi...
|
PMID: 16489753
PDF is available here.
PDF is available here.
Glycobiology (15)12 2005
Abstract
We have extended the analysis of agrin's function in neurodegenerative diseases to investigate its role in Parkinson's disease (PD). Alpha-synuclein is a critical molecular determinant in familial and sporadic PD, with the formation of alpha-synuclein fibrils being enhanced by sulfated macromolecule...
|
PMID: 16037493
PDF is available here.
PDF is available here.
Journal of Molecular Biology (353)2 2005
Abstract
The aggregation of alpha-synuclein is believed to be a critical step in the etiology of Parkinson's disease. A variety of biophysical techniques were used to investigate the aggregation and fibrillation of alpha-synuclein in which one of the four intrinsic Tyr residues was replaced by Trp, and two o...
|
PMID: 16171820
PDF is available here.
PDF is available here.
Abstract
We then employed a proteomic approach, two-dimensional gel electrophoresis (2-DE) in conjunction with mass spectrometry analysis, to identify the protein candidates associated with the MA-induced neurotoxicity. In striatal samples, 2-DE analysis revealed that the intensities of nine protein spots we...
|
PMID: 16181420
PDF is available here.
PDF is available here.
Abstract
We investigated the association between inflammation and plaque pathology in PS-1 AD. Classic cored, cotton wool and diffuse Abeta plaques were observed in all cases. PS-1 cases also exhibited a novel plaque pathology with a significantly greater inflammatory response in the form of reactive microgl...
|
PMID: 16150121
PDF is available here.
PDF is available here.
Abstract
Alpha-synuclein is a major component of several pathological lesions diagnostic of specific neurodegenerative disease such as Parkinson's disease. This study focuses on the non-amyloid beta component of Alzheimer's disease amyloid, a key region for the aggregation and fibril formation of alpha-synuc...
|
PMID: 16081040
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)36 2005
Abstract
We recently found that an interaction with lipid rafts is crucial for the normal, pre-synaptic localization of alpha-synuclein. To understand how alpha-synuclein interacts with lipid rafts, we have now developed an in vitro binding assay to rafts purified from native membranes. Recapitulating the sp...
|
PMID: 16020543
PDF is available here.
PDF is available here.
Journal of Molecular Biology (351)5 2005
Abstract
We show that human wild-type alpha synuclein (WT alpha-syn), and the inherited mutants A53T or A30P, when expressed in the yeast Saccharomyces cerevisiae triggers events that are diagnostic of apoptosis: loss of membrane asymmetry due to the externalization of phosphatidylserine, accumulation of rea...
|
PMID: 16051265
PDF is available here.
PDF is available here.
Neuroreport (16)13 2005
Abstract
We report here that chronic cocaine abuse results in an increase in alpha-synuclein expression in the human striatum. Immunoblot analysis in the ventral putamen showed that alpha-synuclein protein was increased in striatal synaptosomes from cocaine users compared with age-matched drug-free controls....
|
PMID: 16110277
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)35 2005
Abstract
A30P and A53T mutations of the presynaptic protein alpha-synuclein are associated with familial forms of Parkinson disease. NMR spectroscopy demonstrates that Parkinsonism-linked mutations greatly perturb specific tertiary interactions essential for the native state of alpha-synuclein. However, alph...
|
PMID: 16020550
PDF is available here.
PDF is available here.
Experimental Neurology (195)1 2005
Abstract
Electrophoresis (26)17 2005
Abstract
The aggregation of alpha-synuclein in the dopaminergic neurons of the substantia nigra is a critical step in the Parkinson's disease (PD). The etiology of the disease is unknown but recent epidemiological and experimental studies have renewed interest in the hypothesis that environmental factors, es...
|
PMID: 16143978
PDF is available here.
PDF is available here.
Abstract
Oxidative stress has been well documented in the substantia nigra in Parkinson disease (PD), but little is known about oxidative damage, particularly lipoxidation, advanced glycation (AGE), and AGE receptors (RAGE) in other structures, including the cerebral cortex, in early stages of diseases with...
|
PMID: 16141792
PDF is available here.
PDF is available here.
Neuropathology (25)3 2005
Abstract
We examined the regional pattern of Lewy pathology in brains of dementia with Lewy bodies (DLB) to clarify whether Lewy pathology uniformly progresses or not. Thirty-five autopsied DLB cases were examined using alpha-synuclein-immunohistochemistry, and the regional degree of Lewy pathology in the br...
|
PMID: 16193834
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)34 2005
Abstract
We examined the effect of wild type and mutant alpha-synuclein (A30P) on multiple aspects of proteasome homeostasis, protein synthesis, as well as the ability of cells to survive stationary phase aging. These data demonstrate that alpha-synuclein alters proteasome composition, impairs proteasome-med...
|
PMID: 15941712
PDF is available here.
PDF is available here.
Abstract
The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result fro...
|
PMID: 16102530
PDF is available here.
PDF is available here.
Abstract
We present a general method to quantify and characterize protein aggregates by dual-colour scanning for intensely fluorescent targets (SIFT). In addition to high sensitivity, this approach offers a unique opportunity to study co-aggregation processes. As the ratio of two fluorescently labelled compo...
|
PMID: 15978545
PDF is available here.
PDF is available here.
Lancet Neurology (4)8 2005
Abstract
Abstract
Trends in Neurosciences (28)8 2005
Abstract
The past decade has been a fruitful one for geneticists involved in Parkinson's disease (PD) research. The initial hurdle of identifying the first gene underlying parkinsonism was cleared with apparent ease in 1997 and four additional genes have since been found to contain mutations causing this dis...
|
PMID: 15955578
PDF is available here.
PDF is available here.
Fatty acid incorporation is decreased in astrocytes cultured from alpha-synuclein gene-ablated mice.
Abstract
We measured fatty acid incorporation into astrocytes isolated from wild-type and alpha-synuclein gene-ablated mice. alpha-Synuclein deficiency decreased palmitic acid (16:0) incorporation 31% and arachidonic acid [20:4 (n-6)] incorporation 39%, whereas 22:6 (n-3) incorporation was unaffected. In neu...
|
PMID: 16033426
PDF is available here.
PDF is available here.
Abstract
Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biolog...
|
PMID: 16024878
PDF is available here.
PDF is available here.
Movement Disorders (20)8 2005
Abstract
We present an autopsy-confirmed case of "minimal-change" multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa-induced dyskinesia.
Copyright 2005 Movement Disorder Society...
|
PMID: 15852363
PDF is available here.
PDF is available here.
Movement Disorders (20)8 2005
Abstract
We describe a case of progressive camptocormia as part of the initial presentation of a patient with multiple system atrophy.
Copyright 2005 Movement Disorder Society...
|
PMID: 15986475
PDF is available here.
PDF is available here.
Abstract
Abstract
We demonstrate that the phosphorylation state of a 14-residue peptide fragment of alpha-synuclein, a protein implicated in Parkinson's Disease, dramatically affects the metal ion affinity of the peptide. Whereas the unphosphorylated peptide and its phosphoserine analogue show weak Tb3+ binding, its...
|
PMID: 15998051
PDF is available here.
PDF is available here.
Journal of Molecular Biology (350)2 2005
Abstract
We define intrinsic propensities for the aggregation of individual amino acids and develop a method for identifying the regions of the sequence of an unfolded peptide or protein that are most important for promoting amyloid formation. This method is applied to the study of three polypeptides associa...
|
PMID: 15925383
PDF is available here.
PDF is available here.