Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Tubulin (0):
Recent article
Tubulin
Abstract
We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
Fifty-six patients with thymic epithelial tumors were included in this...
|
PMID: 21289518
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Biochemical Journal (432)3 2010
Abstract
We have investigated how the model nematode Caenorhabditis elegans responds to and metabolizes albendazole, one of the most important anthelmintic drugs for human and animal use. Using a mutant strain lacking the β-tubulin drug target to minimize generalized stress responses, we show that the trans...
|
PMID: 20929438
PDF is available here.
PDF is available here.
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Abstract
The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds...
|
PMID: 21080725
PDF is available here.
PDF is available here.
Abstract
We measured the effect of temperature on the flexural rigidity of a single taxol-stabilized microtubule and found that the flexural rigidity is 2.5×10(-24)Nm(2), independent of temperature in the 20-35°C range. Employing the same technique here, we have measured the flexural rigidity of microtubul...
|
PMID: 20920471
PDF is available here.
PDF is available here.
Abstract
We present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules, sufficient for precise docking of crystal structures of the component proteins. We find that the Ndc80 complex binds the microtubule with a tubulin monomer repeat, recognizi...
|
PMID: 20944740
PDF is available here.
PDF is available here.
Parasitology Research (107)5 2010
Abstract
Albendazole is a benzimidazole drug which can be used to treat liver fluke (Fasciola hepatica) infections. Its mode of action is believed to be the inhibition of microtubule formation through binding to β-tubulin. However, F. hepatica expresses at least six different isotypes of β-tubulin, and thi...
|
PMID: 20676683
PDF is available here.
PDF is available here.
Neuroscience Letters (482)3 2010
Abstract
We report a novel interaction between tubulin and the photoreceptor cGMP phosphodiesterase (PDE6) gamma subunit (PDE gamma). The specificity and molecular details of the PDE gamma:tubulin interaction were analyzed through the experiments of pull down, microtubule co-sedimentation, and NMR spectrosco...
|
PMID: 20655363
PDF is available here.
PDF is available here.
Abstract
Our data highlight a potential role of α-synuclein in regulating the microtubule dynamics in neurons. The association of α-synuclein with tubulin may further provide insight into the biological and pathophysiological function of synuclein....
|
PMID: 19826908
PDF is available here.
PDF is available here.
Abstract
A bicistronic expression vector can be used to generate stable cell lines expressing green fluorescent protein (GFP)-tubulin and photoactivatable (PA)-GFP-tubulin. This vector, pIRES (originally available from BD Biosciences/Clontech), expresses the gene of interest (GFP-tubulin) and a selection mar...
|
PMID: 20810628
PDF is available here.
PDF is available here.
Abstract
Important advances in our understanding of the organization and dynamics of the cytoskeleton have been made by direct observations of fluorescently tagged cytoskeletal proteins in living cells. In early experiments, the cytoskeletal protein of interest was purified, covalently modified with a fluore...
|
PMID: 20810643
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)9 2010
Abstract
Neural stem cells (NSCs) are capable of self-renewal and differentiation into three principle central nervous system cell types under specific local microenvironments. Chitosan films (Chi-F), chitosan porous scaffolds (Chi-PS) and chitosan multimicrotubule conduits (Chi-MC) were used...
|
PMID: 20371303
PDF is available here.
PDF is available here.
Veterinary Parasitology (172)1-2 2010
Abstract
The study was designed to compare the in vitro egg hatch test (EHT) and molecular allele-specific polymerase chain reaction PCR (AS-PCR) methods as tools for detection of benzimidazole resistance in Haemonchus contortus, a nematode parasite of small ruminants. Comparisons were made during the course...
|
PMID: 20684865
PDF is available here.
PDF is available here.
Abstract
A series of 5-(3',4',5'-trimethoxyphenyl)pyrrolo[3,4-a]carbazole-1,3(2H,10H)-diones was designed as cis-restricted analogues of 3-aroylindoles, arylthioindoles and 3-benzylidoneindolin-2-ones derived from combretastatin A4 (CA-4). Starting from various indoles, compounds were synthesized by means of...
|
PMID: 20538383
PDF is available here.
PDF is available here.
A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps.
Abstract
We show here that PRC1 autonomously bundles antiparallel microtubules and recruits Xklp1, a kinesin-4, selectively to overlapping antiparallel microtubules. The processive motor Xklp1 controls overlap size by overlap length-dependent microtubule growth inhibition. Our results mechanistically explain...
|
PMID: 20691901
PDF is available here.
PDF is available here.
Biochemical Journal (430)1 2010
Abstract
We have explored the relationship between polyamine levels and MT assembly in HeLa and epithelial NRK (normal rat kidney) cells using DFMO (alpha-difluoromethylornithine), an irreversible inhibitor of ornithine decarboxylase, and APCHA [N-(3-aminopropyl)-N-cyclohexylamine], a spermine synthase inhib...
|
PMID: 20524932
PDF is available here.
PDF is available here.
Journal of Cell Biology (190)1 2010
Abstract
We provide evidence in support of an inherent role for Arpc1b, a component of the Arp2/3 complex, in regulation of mitosis and demonstrate that its depletion inhibits Aurora A activation at the centrosome and impairs the ability of mammalian cells to enter mitosis. We discovered that Arpc1b colocali...
|
PMID: 20603326
PDF is available here.
PDF is available here.
Abstract
Lung cancer is the leading cause of cancer-related mortality in the United States. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Most patients with NSCLC present with locoregionally advanced or metastatic disease, for which response rates and...
|
PMID: 20679541
PDF is available here.
PDF is available here.
Cytoskeleton (67)7 2010
Abstract
We have used differentiating neuroblastoma cells as a model system. These cells express the betaI, betaII, and betaIII isotypes. Although there is no difference prior to differentiation, a striking difference is seen after differentiation. Both betaI and betaIII occur in cell bodies and neurites, wh...
|
PMID: 20506160
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Cellular Microbiology (12)7 2010
Abstract
We have discovered four sirtuin genes in Entamoeba histolytica, two of which are similar to eukaryotic sirtuins and two to bacterial and archaeal sirtuins. The eukaryotic sirtuin homologue, EhSir2a, showed NAD(+)-dependent deacetylase activity and was sensitive to class III HDAC inhibitors. Localiza...
|
PMID: 20148900
PDF is available here.
PDF is available here.
Abstract
We characterized the zebrafish ortholog nphp3 by morpholino oligo (MO)-mediated knockdown. When nphp3 function was suppressed by either of the two MOs blocking the translation of the protein or the splicing of mRNA, zebrafish embryos displayed hydrocephalus and pronephric cysts. Knockdown of nphp3 a...
|
PMID: 20462968
PDF is available here.
PDF is available here.
Abstract
We showed the effects of Inganen on MT organization using ultraviolet spectrophotometer and fluorometry. The fluorescent spectroscopy showed a significant tubulin conformational change at the presence of Inganen which decrease polymerization of tubulin as well as the ultraviolet spectroscopy results...
|
PMID: 20566439
PDF is available here.
PDF is available here.
Abstract
Largazole 4a and analogues with modifications at the C7 position, as well as 2,4'-bithiazole 5a, have been synthesized using an acyclic cross-metathesis of the corresponding depsipeptide structures assembled by N-C6(O) or C15(O)-N lactam formation. Similar to the parent system 4a, the series of larg...
|
PMID: 20491440
PDF is available here.
PDF is available here.
Journal of Proteomics (73)8 2010
Abstract
Sample pre-treatment is a critical step for an efficient and reliable analysis and it is highly dependent on the complexity of the matrix. This work shows an example of application of an immunoprecipitation approach using a new magnetic beads-based format, which allows a selective/sp...
|
PMID: 20206311
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
Our findings indicate that betaIII-tubulin mediates not only drug sensitivity but also the incidence and progression of lung cancer. betaIII-Tubulin is a cellular survival factor that, when suppressed, sensitizes cells to chemotherapy via enhanced apoptosis induction and decreased tumorigenesis. Fin...
|
PMID: 20501838
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We report that FoxM1 overexpression confers resistance to the human epidermal growth factor receptor 2 monoclonal antibody Herceptin and microtubule-stabilizing drug paclitaxel, both as single agents and in combination. FoxM1 altered microtubule dynamics to protect tumor cells from paclitaxel-induce...
|
PMID: 20530690
PDF is available here.
PDF is available here.
Journal of Cell Biology (189)6 2010
Abstract
We demonstrate that glutamylation, and in particular the generation of long glutamate side chains, promotes the severing of microtubules. In human cells, the generation of long side chains induces spastin-dependent microtubule disassembly and, consistently, only microtubules modified by long glutama...
|
PMID: 20530212
PDF is available here.
PDF is available here.
Abstract
We report here that the beating asymmetry is crucial for ciliary function and requires tubulin glutamylation, a unique posttranslational modification that is highly abundant in cilia. WT murine tracheal cilia have an axoneme-intrinsic structural curvature that points in the direction of effective st...
|
PMID: 20498047
PDF is available here.
PDF is available here.
Abstract
We show that this dual sensory-motile role of eukaryotic cilia is preserved in the most sensitive of all invertebrate hearing organs, the Johnston's organ of the mosquito. The Johnston's organ displays spontaneous oscillations, which have been identified as being a characteristic of amplification in...
|
PMID: 20129974
PDF is available here.
PDF is available here.
Abstract
These results reveal an important mechanism that involves EGF-induced HDAC6 activation and alpha-tubulin deacetylation, subsequently affecting corneal epithelial migration in the wound-healing process....
|
PMID: 20089874
PDF is available here.
PDF is available here.
Abstract
Thus, p-ANCAs in autoimmune liver diseases are directed against human TBB-5 cross-reacting with the bacterial protein FtsZ, probably reflecting an abnormal immune response to intestinal microorganisms in susceptible, possibly genetically predisposed individuals....
|
PMID: 19951907
PDF is available here.
PDF is available here.
Experimental Neurology (223)2 2010
Abstract
The purpose of this study was to determine the fate and the effects of undifferentiated embryonic stem cells (ESCs) in mice after contusive lesion of the spinal cord (SCI). Reproducible traumatic lesion to the cord was performed at T8 level by means of the Infinite Horizon Device, and was followed b...
|
PMID: 20100476
PDF is available here.
PDF is available here.
Neurobiology of Aging (31)6 2010
Abstract
We showed that macrophage activation in the eye by intravitreal application of zymosan increased retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve injury. It is known that the intrinsic ability of CNS neurons to survive and to regrow axons after optic nerve injury differ...
|
PMID: 18755527
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)20 2010
Abstract
We use in utero electroporation and genetic fate mapping to show that SNPs and RGCs cohabit the VZ but display different cell cycle kinetics and generate phenotypically different progeny. In addition, we find that RGC progeny undergo additional rounds of cell division as intermediate progenitor cell...
|
PMID: 20484645
PDF is available here.
PDF is available here.
Abstract
We suggest a new class of peroxisomes involved in microtubule (MT) formation. Eukaryotic cells assemble MTs from distinct points in the cell. In the fungus Aspergillus nidulans, septum-associated microtubule-organizing centers (sMTOCs) are very active in addition to the spindle pole bodies (SPBs). P...
|
PMID: 20348383
PDF is available here.
PDF is available here.
Abstract
We use the three bead dumbbell assay to show for the first time, that cytoplasmic dynein is a non-processive motor at low ATP concentrations. Processivity can be restored even in the absence of dynactin by increasing the ATP concentration to 100muM. We propose that an altered occupancy of the differ...
|
PMID: 19961937
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
|
PMID: 20142434
PDF is available here.
PDF is available here.