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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Nerve Tissue Proteins (24):
- Synapsins
- Olfactory Marker Protein
- Neurofilament Proteins
- Microtubule-Associated Proteins
- Synaptophysin
- Glucose Transporter Type 3
- S100 Proteins
- Nerve Growth Factors
- Natriuretic Peptide, Brain
- Fragile X Mental Retardation Protein
- Neuronal Calcium-Sensor Proteins
- Neuronal Apoptosis-Inhibitory Protein
- Chromogranins
- Chimerin Proteins
- Neuropeptides
- Hu Paraneoplastic Encephalomyelitis Antigens
- Neurogranin
- Neuroendocrine Secretory Protein 7B2
- GAP-43 Protein
- Dopamine and cAMP-Regulated Phosphoprotein 32
- Tubulin
- Synucleins
- Myelin Proteins
- Agrin
Recent article
Nerve Tissue Proteins
Journal of Neurochemistry (119)5 2011
Abstract
We have used neuroblastoma cells expressing NDM29 at its basal level (Mock cells) or at 5.4-fold higher levels (S1 cells) to investigate whether a functional differentiation correlates with morphological and biochemical development induced by NDM29 expression. First, analyzing the expression of spec...
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PMID: 21933186
PDF is available here.
PDF is available here.
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Human Molecular Genetics (20)21 2011
Abstract
We previously found that loss-of-function mutations in the transcription factor GLIS2, a putative vertebrate ortholog of Drosophila Ci, cause nephronophthisis type 7 in humans and mice. Kidney tubular cells in Glis2-knockout mice acquire mesenchymal phenotype, but the cellular mechanisms of this tra...
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PMID: 21816948
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We show that Fgf8 and Sema3f, produced by early dental epithelium, respectively, attract and repulse mesenchymal cells, which cause them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pa...
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PMID: 21924961
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
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PMID: 22014525
PDF is available here.
PDF is available here.
Abstract
Our simple culture system might offer the potential of a source of mature β cells....
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PMID: 21926540
PDF is available here.
PDF is available here.
Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Abstract
We conclude that HPs and SSA/Ps in Korean patients share some, but not all, clinical and molecular characteristics to those that occur in Americans. The data support the theory that the right and left colon are biologically different with regard to susceptibility to serrated cancer, and that anatomi...
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PMID: 21836485
PDF is available here.
PDF is available here.
Abstract
We describe the 2.5 Å crystal structure of Gemin2 bound to SmD1/D2/F/E/G pentamer and SMN's Gemin2-binding domain, a key assembly intermediate. Remarkably, through its extended conformation, Gemin2 wraps around the crescent-shaped pentamer, interacting with all five Sm proteins, and gripping its b...
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PMID: 21816274
PDF is available here.
PDF is available here.
Abstract
Journal of Neuroscience (31)31 2011
Abstract
We generated mice (termed "Nes-Met") in which met is inactivated from midembryonic stages onward in the CNS only. Adult animals showed motor behavioral defects suggestive of impaired innervation of pectoral muscles. Correspondingly, in neonatal spinal cords of Nes-Met mutants, we observed death of a...
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PMID: 21813676
PDF is available here.
PDF is available here.
Abstract
We show that the endocytic adaptor protein Numb, previously characterized for its role in cell proliferation, subsequently plays an important role in cell migration. In neural precursors stimulated with the chemotactic factor BDNF, Numb binds to activated TrkB, the BDNF receptor, and functions both...
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PMID: 21571219
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Immunoprecipitation (IP) uses the specificity of antibodies to isolate target proteins (antigens) out of complex sample mixtures. Three different approaches for performing IP will be discussed; traditional (classical) method, oriented affinity method and direct affinity method. The traditional metho...
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PMID: 18369874
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Preparative electrophoresis is a protein fractionation approach useful for the enrichment of low-abundance gene products. Preparative electrophoresis is usually performed in the PrepCell apparatus. Proteins are separated according to their size in a cylindrical gel in the presence of an ionic deterg...
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PMID: 18369871
PDF is available here.
PDF is available here.
Abstract
In the normal brain, cellular types that compose the neurovascular unit, including neurons, astrocytes and endothelial cells express pannexins and connexins, which are protein subunits of two families that form plasma membrane channels. Most available evidence in mammals indicated th...
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PMID: 21288190
PDF is available here.
PDF is available here.
Abstract
We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippo...
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PMID: 21521612
PDF is available here.
PDF is available here.
Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
PDF is available here.
Human Molecular Genetics (20)8 2011
Abstract
We generated transgenic mice expressing cDNA that encodes htt N118-82Q with the mouse prion promoter vector. In mice generated in this manner, we demonstrate robust inclusion pathology accompanied by early death and failure to gain weight. These phenotypes are the most robust abnormalities identifie...
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PMID: 21307087
PDF is available here.
PDF is available here.
Abstract
Autism is a developmental disorder of the central nervous system characterized by impairments in social interaction, communication and restricted repetitive and stereotyped behavior. It is generally assumed that in most cases autism has a polygenic cause, but the pathogenesis is stil...
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PMID: 21375492
PDF is available here.
PDF is available here.
Current Eye Research (36)4 2011
Abstract
We examined mouse and rat lenses to determine if alternative splicing of neuronal nPTB and Fox-1/Fox-2 isoforms also occurs in lenses.
Immunoblot, immunofluorescence, and RT-PCR were used to examine expression and alternative splicing of transcripts in lens and brain....
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PMID: 21714144
PDF is available here.
PDF is available here.
Current Biology (21)5 2011
Abstract
We carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulation of a target that is not subject to Ago2-mediated catalytic cleavage. By quantitating the number of molecules of the miRNA and its target in steady state and in the course of its decay,...
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PMID: 21353554
PDF is available here.
PDF is available here.
Abstract
We report two rare genetic aberrations in a schizophrenia patient that may act together to confer disease susceptibility. A previously unreported balanced t(9;17)(q33.2;q25.3) translocation was observed in two schizophrenia-affected members of a small family with diverse psychiatric disorders. The p...
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PMID: 21302349
PDF is available here.
PDF is available here.
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.
Abstract
We have established a homogenous, expandable, and self-renewable population of multipotent NPs from hiPSCs, using an adherent system and defined medium supplemented with a combination of factors. The established hiPSC-NPs highly expressed Nestin and Sox1. These NPs were continuously propagated for ~...
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PMID: 20632795
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)7 2011
Abstract
We now tested the mice with regard to neuromotor parameters, behavior, learning and memory, and synaptic plasticity and correlated this with histological and biochemical parameters in different stages of switching Tau(RD) on or off. The mice are normal in neuromotor tests. However, pro-aggregant Tau...
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PMID: 21325519
PDF is available here.
PDF is available here.
Abstract
We show that Dab1, an essential component of the reelin pathway, is required in radially migrating neurons for glia-independent somal translocation, but not for glia-guided locomotion. During migration, Dab1 acts in translocating neurons to stabilize their leading processes in a Rap1-dependent manne...
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PMID: 21315259
PDF is available here.
PDF is available here.
Abstract
We identify five distinct classes of fru neuron that trigger or compose the song. Our data suggest that P1 and pIP10 neurons in the brain mediate the decision to sing, and to act upon this decision, while the thoracic neurons dPR1, vPR6, and vMS11 are components of a central pattern generator that t...
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PMID: 21315261
PDF is available here.
PDF is available here.
Abstract
We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone...
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PMID: 21315260
PDF is available here.
PDF is available here.
Abstract
We show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mu...
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PMID: 21315255
PDF is available here.
PDF is available here.
Biomedical Materials (6)1 2011
Abstract
Two-dimensional (2D) culture systems provide useful information about many biological processes. However, some applications including tissue engineering, drug transport studies, and analysis of cell growth and dynamics are better studied using three-dimensional (3D) culture systems....
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PMID: 21205998
PDF is available here.
PDF is available here.
Developmental Cell (20)1 2011
Abstract
We performed a protein-protein interaction screen with the Robo4 extracellular domain. We find that Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors. We show that Robo4 maintains vessel integrity by activating...
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PMID: 21238923
PDF is available here.
PDF is available here.
Abstract
We expressed its actin-binding domain (ABD) in CA1 pyramidal neurons in hippocampal slice cultures. The ABD of βI-spectrin bundled actin in principal dendrites and was concentrated in dendritic spines, where it significantly increased the size of the spine head. These effects were not observed afte...
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PMID: 21297961
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We show that vesicle trafficking is coordinated through at least two mechanisms. First, a significant proportion of STVs and PTVs are transported together before forming a stable terminal. Second, individual PTVs and STVs share pause sites within the axon. Importantly, for both STVs and PTVs, encoun...
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PMID: 21569270
PDF is available here.
PDF is available here.
Abstract
Our results showed that T. stromaticum spores prevented the expression and production of inflammatory mediators in macrophages stimulated with interferon (IFN)-γ plus lipopolysaccharide (LPS) and neutrophils stimulated with phorbol myristate 13-acetate (PMA). Quantitative polymerase chain reaction...
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PMID: 21623538
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
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PMID: 21466690
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
These results raise the possibility that certain forms of synaptic plasticity may occur within the cortex while synaptic potentiation takes place within synapses in the hippocampus and amygdala. This hypothesis is supported by electrophysiological evidence obtained from freely moving animals that ne...
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PMID: 21912749
PDF is available here.
PDF is available here.
Abstract
We investigated the possible mechanisms underlying AGE-related suppression of insulin synthesis. In the rat pancreatic β-cell line INS-1, we found that AGEs induced dephosphorylation of Foxo1 and increased its accumulation in the nucleus. The translocation of Foxo1 subsequently inhibited pancreatic...
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PMID: 21533167
PDF is available here.
PDF is available here.
Abstract
We have sought to more fully characterize the inputs these cells receive in vivo over the course of their developmental dispersal. These studies have recently revealed that hemocyte migration is intimately associated with the development of the ventral nerve cord (VNC), a structure used by hemocytes...
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PMID: 21150318
PDF is available here.
PDF is available here.
Abstract
The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parki...
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PMID: 21482412
PDF is available here.
PDF is available here.
Abstract
Affinity chromatography permits the isolation of a target analyte from a complex mixture and can be utilised to purify proteins, carbohydrates, drugs, haptens, or any analyte of interest once an affinity pair is available. It involves the exploitation of specific interactions between a binding affin...
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PMID: 20978976
PDF is available here.
PDF is available here.
Abstract
We demonstrate in zebrafish that Wnt16 controls a novel genetic regulatory network required for HSC specification. Non-canonical signalling by Wnt16 is required for somitic expression of the Notch ligands deltaC (dlc) and deltaD (dld), and these ligands are, in turn, required for the establishment o...
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PMID: 21654806
PDF is available here.
PDF is available here.
Development (138)3 2011
Abstract
We have discovered that the Wnt receptor Ryk promotes GABAergic neuron production while repressing oligodendrocyte formation in the ventral telencephalon. We demonstrate that Ryk controls the cell-fate switch by negatively regulating expression of the intrinsic oligodendrogenic factor Olig2 while in...
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PMID: 21205786
PDF is available here.
PDF is available here.
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
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PMID: 21197711
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)6 2010
Abstract
We generated Riplet-deficient mice. Fibroblasts, macrophages, and conventional dendritic cells from Riplet-deficient animals were defective for the production of IFN and other cytokines in response to infection with several RNA viruses. However, Riplet was dispensable for the production of IFN in re...
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PMID: 21147464
PDF is available here.
PDF is available here.
Abstract
Glucocorticoid-induced muscle atrophy results from muscle protein catabolism and reduced protein synthesis, associated with increased expression of two muscle-specific ubiquitin ligases (MAFbx and MuRF1), and of two inhibitors of protein synthesis, REDD1 and 4EBP1. MAFbx, MuRF1, REDD1 and 4EBP1 are...
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PMID: 21094144
PDF is available here.
PDF is available here.
Abstract
We have now examined the expression of Sema3A and its receptor components Npn1 and PlxA during development of the mouse cornea. Sema3A and Npn1 showed similar patterns of expression by immunohistofluorescence analysis, with such expression being prominent in the corneal epithelium during both embryo...
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PMID: 21075075
PDF is available here.
PDF is available here.
Abstract
We identify a neural circuit responsive to cVA, a pheromone that elicits sexually dimorphic behaviours. We have combined neural tracing using an improved photoactivatable green fluorescent protein (PA-GFP) with electrophysiology, optical imaging and laser-mediated microlesioning to map this circuit...
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PMID: 21124455
PDF is available here.
PDF is available here.
Brain research (1360) 2010
Abstract
We examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol (PTZ) model.
Mice (2-3months old) with Cx36 wildtype (WT) or Cx36KO genotype were treated with vehicle or 10-40mg/kg of the convulsant PTZ by intraperitoneal injection. Seizure and seizure-like behaviors...
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PMID: 20833151
PDF is available here.
PDF is available here.
Abstract
We provide further evidence of this by showing that PlexinA1 is expressed in Xenopus neural crest cells and is required for their migration. PlexinA1 expression is detected in migrating cranial neural crest cells and knockdown of PlexinA1 expression using Morpholino oligonucleotides inhibits neural...
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PMID: 20946874
PDF is available here.
PDF is available here.
Abstract
We report the identification of novel interconnections in the interaction network of this endocytic adaptor. We show that the membrane-deforming protein SGIP1 (Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1) and the signaling adaptor Reps1 (RalBP associa...
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PMID: 20946875
PDF is available here.
PDF is available here.
Abstract
We identified the cytoskeleton-associated α-N/E-catenins as novel nesprin-2-binding partners. The association involves the C termini of nesprin-2 giant and α-N/E-catenins. α-E/T/N-catenins are known primarily for their roles in cadherin-mediated cell-cell adhesion. Here, we show that, in addition...
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PMID: 20801886
PDF is available here.
PDF is available here.
Developmental Biology (347)1 2010
Abstract
We genetically created such neuroblasts, and found that in embryos, they were initially mitotic and then gradually differentiated into neurons, frequently forming a clone of cells homogeneous in temporal identity. By contrast, larval neuroblasts with the same genotype continued to proliferate withou...
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PMID: 20599889
PDF is available here.
PDF is available here.
Abstract
to report on symptoms and therapies used in childhood narcolepsy-cataplexy.
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PMID: 21102987
PDF is available here.
PDF is available here.
Abstract
Osteoclasts are multinucleated cells that have a unique role in bone degradation. Modulation of osteoclast formation and/or its activity is an important approach for the treatment of bone-destructive diseases such as osteoporosis and rheumatoid arthritis. In this study, Gymnasterkore...
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PMID: 20831919
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)1 2010
Abstract
Treatment with a tolerogenic peptide, hCDR1, designed for the specific treatment of systemic lupus erythematosus (SLE) ameliorated the serological and kidney-related clinical manifestations in murine models of induced and spontaneous lupus. Furthermore, hCDR1 reduced brain pathology...
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PMID: 20659591
PDF is available here.
PDF is available here.
Abstract
We present crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto). These structures, together with biop...
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PMID: 20877282
PDF is available here.
PDF is available here.
Abstract
We report the crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states. Before binding, the Sema6A ectodomain was in the expecte...
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PMID: 20881961
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
We identified the novel retinal extracellular matrix protein pikachurin, and observed that it is localized in the synaptic cleft of the photoreceptor ribbon synapse. In order to investigate the biological functions of pikachurin, we generated a pikachurin knock-out mouse. These mice showed improper...
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PMID: 21141075
PDF is available here.
PDF is available here.
Abstract
We studied the clinical and neuropathologic effects of intravenously administered human MSCs (hMSCs) in C57BL/6 mice with EAE. Human MSCs significantly reduced the clinical disease severity, particularly in later disease. Large numbers of hMSCs migrated into gray and white matter at all levels of th...
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PMID: 20940628
PDF is available here.
PDF is available here.
Abstract
We performed a proteomic study of the human brain after ischemic stroke using a 2-dimensional differential gel electrophoresis-based proteomic approach. In brain samples from 6 deceased stroke patients and 3 control subjects, there was an average of 1,442 ± 231 protein spots in the gels. Changes of...
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PMID: 20940630
PDF is available here.
PDF is available here.