Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Nuclear Proteins (30):
- Tumor Suppressor Protein p53
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Retinoblastoma Protein
- Proto-Oncogene Proteins c-fos
- Protamines
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Fanconi Anemia Complementation Group E Protein
- NF-kappa B
- Hepatocyte Nuclear Factors
- Proliferating Cell Nuclear Antigen
- Antigens, Nuclear
- Proto-Oncogene Proteins c-rel
- Retinoblastoma-Like Protein p130
- Proto-Oncogene Proteins c-mdm2
- BRCA2 Protein
- Retinoblastoma-Like Protein p107
- Proto-Oncogene Proteins c-myc
- Oncogene Protein p55(v-myc)
- ran GTP-Binding Protein
- Karyopherins
- Fanconi Anemia Complementation Group F Protein
- Nuclear Matrix-Associated Proteins
- Histones
- Fanconi Anemia Complementation Group D2 Protein
- Antennapedia Homeodomain Protein
- CCAAT-Enhancer-Binding Proteins
- Proto-Oncogene Proteins c-jun
- Fanconi Anemia Complementation Group A Protein
- Chromosomal Proteins, Non-Histone
- BRCA1 Protein
Recent article
Nuclear Proteins
Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
|
PMID: 22014525
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Abstract
We conclude that HPs and SSA/Ps in Korean patients share some, but not all, clinical and molecular characteristics to those that occur in Americans. The data support the theory that the right and left colon are biologically different with regard to susceptibility to serrated cancer, and that anatomi...
|
PMID: 21836485
PDF is available here.
PDF is available here.
Molecular Immunology (48)15-16 2011
Abstract
We investigated gene regulation at the IL-3/GM-CSF gene cluster. We found BRG1, a SWI/SNF remodeling ATPase, bound a distal element, CNSa. BRG1 binding was strongest in differentiated, stimulated T helper cells, paralleling IL-3 and GM-CSF expression. Depletion of BRG1 reduced IL-3 and GM-CSF transc...
|
PMID: 21831442
PDF is available here.
PDF is available here.
Abstract
We show that the edges of the rDNA array are exceptionally susceptible to meiotic DSBs, revealing an inherent heterogeneity in the rDNA array. We find that this localized DSB susceptibility necessitates a border-specific protection system consisting of the meiotic ATPase Pch2 and the origin recognit...
|
PMID: 21822291
PDF is available here.
PDF is available here.
Abstract
We show that two PARP1 inhibitors, PJ-34 and 3-AB, attenuate AKT phosphorylation at serine 473 (S473) independent of DNA repair impairment. These inhibitors decrease the AKT-associated phosphorylation of FOXO3A, enhance the nuclear retention of FOXO3A, and activate its transcriptional activity. We f...
|
PMID: 21821012
PDF is available here.
PDF is available here.
Abstract
We deleted the cohesin locus Rad21 in mouse thymocytes at a time in development when these cells stop cycling and rearrange their T-cell receptor (TCR) α locus (Tcra). Rad21-deficient thymocytes had a normal lifespan and retained the ability to differentiate, albeit with reduced efficiency. Loss of...
|
PMID: 21832993
PDF is available here.
PDF is available here.
Molecular Cell (43)3 2011
Abstract
We performed a time-resolved analysis of the in vivo interactors of cyclins E1, A2, and B1 by quantitative mass spectrometry. This global analysis of context-dependent protein interactions reveals the temporal dynamics of cyclin function in which networks of cyclin-cdk interactions vary according to...
|
PMID: 21816347
PDF is available here.
PDF is available here.
Nature Cell Biology (13)8 2011
Abstract
How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Sta...
|
PMID: 21808242
PDF is available here.
PDF is available here.
Genes & Development (25)15 2011
Abstract
We discuss our current understanding of the molecular mechanism of substrate recognition by CRL4(Cdt2) and how this E3 ligase helps to maintain genome integrity....
|
PMID: 21828267
PDF is available here.
PDF is available here.
Genes & Development (25)15 2011
Abstract
The U5 snRNP (small ribonucleoprotein) contains several functionally crucial splicing factors that form an extensive interaction network both in the snRNP and within the spliceosome. In this issue of Genes & Development, Weber and colleagues (pp. 1601-1612) shed light on the dynamic...
|
PMID: 21828266
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)7 2011
Abstract
Developmental Cell (20)6 2011
Abstract
We report here a role for Cohibin at telomeres and show that functions of the complex at chromosome ends and rDNA maintain replicative life span. Cohibin binds LEM/SUN domain-containing nuclear envelope proteins and telomere-associated factors. Disruption of Cohibin or the envelope proteins abrogate...
|
PMID: 21664583
PDF is available here.
PDF is available here.
Abstract
Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome.
To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes...
|
PMID: 21642682
PDF is available here.
PDF is available here.
Abstract
We report here the regulation of members of the NR4A family of nuclear receptors by the BRAF-MEK-ERK cascade in melanoma cells. Expression profiling of melanoma cells in which both the NR4A1 and NR4A2 family members have been down-regulated by siRNA revealed alterations in genes associated with prol...
|
PMID: 21362156
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We recently identified miR-146a as a negative regulator of the interferon pathway and linked the abnormal activation of this pathway to the underexpression of miR-146a in SLE patients. To explore why the expression of miR-146a is reduced in SLE patients, we conducted short parallel sequencing of pot...
|
PMID: 21738483
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We investigate how chromatin structure is modified following UV irradiation to facilitate DNA repair in yeast. Using a combination of chromatin immunoprecipitation to measure histone acetylation levels, histone acetylase occupancy in chromatin, MNase digestion, or restriction enzyme endonuclease acc...
|
PMID: 21698136
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We find that AR transcriptional output is decreased in human and murine tumors with PTEN deletion and that PI3K pathway inhibition activates AR signaling by relieving feedback inhibition of HER kinases. Similarly, AR inhibition activates AKT signaling by reducing levels of the AKT phosphatase PHLPP....
|
PMID: 21575859
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We show that mice lacking the ATM cofactor ATMIN in B cells (ATMIN(ΔB/ΔB)) have impaired ATM signaling and develop B cell lymphomas. Notably, ATMIN(ΔB/ΔB) cells exhibited defective peripheral V(D)J rearrangement and CSR, resulting in translocations involving the Igh and Igl loci, indicating that...
|
PMID: 21575860
PDF is available here.
PDF is available here.
Abstract
We think about iGluR function. Recently, a number of novel transmembrane proteins have been uncovered that may also serve as iGluR auxiliary proteins. Here we review pivotal developments in our understanding of the role of TARPs in AMPA receptor trafficking and gating, and provide an overview of how...
|
PMID: 21521608
PDF is available here.
PDF is available here.
Abstract
We were referred a difficult diagnostic case of acute promyelocytic leukemia with no pathogenic X-RARA fusion identified by routine metaphase cytogenetics or interphase fluorescence in situ hybridization (FISH). The case patient was enrolled in an institutional review board-approved protocol, with c...
|
PMID: 21505136
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We report that BMI1 contains a functional recognition motif for the F box protein βTrCP, which regulates ubiquitination and proteasome-mediated degradation of various proteins. We show that overexpression of wild-type βTrCP but not the ΔF mutant of it promotes BMI1 ubiquitination and degradation,...
|
PMID: 21430439
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
|
PMID: 21415597
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We demonstrate that the absence of E2F1 leads to spontaneous DNA breaks and impaired recovery following exposure to ionizing radiation. E2F1 deficiency results in defective NBS1 phosphorylation and foci formation in response to DSBs but does not affect NBS1 expression levels. Moreover, an increased...
|
PMID: 21512314
PDF is available here.
PDF is available here.
Human Molecular Genetics (20)8 2011
Abstract
We generated transgenic mice expressing cDNA that encodes htt N118-82Q with the mouse prion promoter vector. In mice generated in this manner, we demonstrate robust inclusion pathology accompanied by early death and failure to gain weight. These phenotypes are the most robust abnormalities identifie...
|
PMID: 21307087
PDF is available here.
PDF is available here.
Abstract
We show here that Mpk1 additionally serves a function in transcription elongation that is also independent of its catalytic activity. This function is mediated by an interaction between Mpk1 and the Paf1 subunit of the Paf1C elongation complex. A mutation in Paf1 that blocks this interaction causes...
|
PMID: 21376235
PDF is available here.
PDF is available here.
Abstract
Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Recent reports have...
|
PMID: 21350580
PDF is available here.
PDF is available here.
Abstract
We show that mammalian Dpy-30, a core subunit of the SET1/MLL histone methyltransferase complexes, modulates H3K4 methylation in vitro, and directly regulates chromosomal H3K4 trimethylation (H3K4me3) throughout the mammalian genome. Depletion of Dpy-30 does not affect ESC self-renewal, but signific...
|
PMID: 21335234
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
We perform an extensive analysis of the developing central nervous system in global p63-/- mice and their wildtype littermates. Brain and spinal cord of embryos and newborn mice were assessed in vivo for neuroanatomy, histology, apoptosis, proliferation, stemness and differentiation, and in vitro fo...
|
PMID: 21293190
PDF is available here.
PDF is available here.
Abstract
We focus on developing mouse skin, where progenitor cells execute a switch from symmetric to predominantly asymmetric divisions concomitant with stratification. Using in vivo skin-specific lentiviral RNA interference, we investigate spindle orientation regulation and provide direct evidence that LGN...
|
PMID: 21331036
PDF is available here.
PDF is available here.
Abstract
We reported that a human microRNA, hsa-miR-138, could inhibit the adipogenic differentiation of hAD-MSCs. Our results showed that miR-138 was significantly down-regulated during adipogenic differentiation. Overexpression of miR-138 in hAD-MSCs could effectively reduce lipid droplets accumulation, in...
|
PMID: 20486779
PDF is available here.
PDF is available here.
Abstract
We have established a tethering system, in which the Gal4 DNA binding domain (DBD) of the Flag:Gal4 DBD:Ote▵LEM fusion protein physically interacts with the Gal4 binding sites upstream of bamP-gfp to artificially recruit the reporter gene gfp to the nuclear membrane. Our data demonstrated that the...
|
PMID: 21356524
PDF is available here.
PDF is available here.
Molecular Cell (41)2 2011
Abstract
We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Using a nonbiased genome-wide approach, we have identified hundreds of reproducible, AID-dependent DSBs in mouse splenic B cells shortly after induction of CSR in culture. Most interestingly, AID induce...
|
PMID: 21255732
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Glial cells missing 2 (Gcm2) is a master regulatory gene of parathyroid gland development, and it is exclusively expressed in the parathyroid gland. Diagnostic application of anti-Gcm2 antibody has not been reported yet. In this study, a total of 58 cases of parathyroid lesions including 40 adenomas...
|
PMID: 21164298
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
|
PMID: 20947453
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
|
PMID: 20947453
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
|
PMID: 20947453
PDF is available here.
PDF is available here.
Science Signaling (4)177 2011
Abstract
The ability to coordinate membrane trafficking events in space and time is of fundamental importance in biology. Polarized trafficking is essential for processes as diverse as cytokinesis, regulated endocytosis, cell motility, and morphogenesis, yet the interface between cellular sig...
|
PMID: 21673314
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
|
PMID: 21466690
PDF is available here.
PDF is available here.
Abstract
Our recent study shows that p53, a downstream effector of the telomere damage signaling, also functions upstream of the telomere‐capping protein complex by inhibiting one of its components, TRF2 (telomeric repeat binding factor 2). Since TRF2 inhibition leads to ATM activation, a novel positive fe...
|
PMID: 21266744
PDF is available here.
PDF is available here.
Abstract
The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parki...
|
PMID: 21482412
PDF is available here.
PDF is available here.
Abstract
We report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute...
|
PMID: 21239865
PDF is available here.
PDF is available here.
Abstract
We show that Rtt107 is recruited to DSBs induced by the HO endonuclease. Rtt107 phosphorylation by Mec1 and its interaction with the Smc5-Smc6 complex are both required for Rtt107 loading to breaks, while Rtt107 regulators Slx4 and Rtt101 are not. We demonstrate that Rtt107 has an effect on the effi...
|
PMID: 21647453
PDF is available here.
PDF is available here.
Abstract
We have analyzed the protein-protein interactions between the seven assembly factors bound to late cytoplasmic pre-40S ribosomes using recombinant proteins in binding assays. Our data show that these factors form two modules: one comprising Enp1 and the export adaptor Ltv1 near the beak structure, a...
|
PMID: 21283762
PDF is available here.
PDF is available here.
Abstract
I (RNA pol I) or Spliced Leader (SL) transcription, demonstrating participation particularly in nuclear mRNA metabolism in T. cruzi. The double knockout of the TcSub2 gene is lethal in T. cruzi, suggesting it has an essential function. Alternatively, RNA interference assays were performed in Trypano...
|
PMID: 21687672
PDF is available here.
PDF is available here.
Abstract
We report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as WWTR1) as nuclear relays of mechanical signals exerted by ECM rigidity and cell shape. This regulation requires Rho GTPase activity and tensio...
|
PMID: 21654799
PDF is available here.
PDF is available here.
Abstract
We here investigated the contribution of ZFPM1 to human Th1/Th2 differentiation.
The cDNA of ZFPM1 was cloned and introduced into human cord blood CD4+ T cells by a lentiviral transduction system. Then, the expression of IL-4 and IFN-γ mRNA was determined by quantitative real-time R...
|
PMID: 21646796
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We examined Prr15 expression by in situ hybridization (ISH) on mouse intestinal tumors caused by different gene mutations, and on human colorectal cancer (CRC) samples. Prr15/PRR15 expression was consistently observed in mouse gastrointestinal (GI) tumors caused by mutations in the Apc gene, as well...
|
PMID: 21061267
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We have determined the human male specific lethal 3 (hMSL3) chromo-barrel domain structure by x-ray crystallography to a resolution of 2.5 Å (r = 0.226, R(free) = 0.270). hMSL3 contains a canonical methyllysine binding pocket made up of residues Tyr-31, Phe-56, Trp-59, and Trp-63. A six-residue in...
|
PMID: 20943666
PDF is available here.
PDF is available here.
Abstract
We found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and p73 were induced to stabilize in association with a significant reduction of MDM2 and Itch, suggesting that, in addition to Itch, MDM2 cou...
|
PMID: 21093410
PDF is available here.
PDF is available here.
Abstract
We established a series of stable transfectants expressing wild-type and three mutant LANA; amino terminus, carboxyl terminus and amino terminus plus DNA binding domain, as a new strategy to assess systematically the interactions and binding domains with cellular proteins. Using the system, we repor...
|
PMID: 21056547
PDF is available here.
PDF is available here.
Abstract
We report that mice lacking the POZ (Poxvirus and zinc finger) domain of the transcription factor Miz-1 (Zbtb17(ΔPOZ/ΔPOZ)) almost entirely lacked follicular B cells, as shown by the fact that their progenitors failed to activate the Jak-Stat5 pathway and to upregulate the antiapoptotic gene Bcl2...
|
PMID: 21167753
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We analysed the function of DCAFs and Cul4-linked proteins, and identified specific subsets required for progression through G1 and S phase. We discovered C6orf167/Mms22-like protein (Mms22L) as a putative human orthologue of budding yeast Mms22, which, together with cullin Rtt101, regulates genome...
|
PMID: 21113133
PDF is available here.
PDF is available here.
Abstract
We show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proli...
|
PMID: 20977890
PDF is available here.
PDF is available here.
Abstract
We have recently encountered in our consultation practice 4 cases of invasive breast carcinoma (confirmed by clinical findings and other immunophenotypic features) that showed unequivocal tumor cell expression of TTF-1. However, the frequency with which TTF-1 expression is observed in breast carcino...
|
PMID: 21107096
PDF is available here.
PDF is available here.
Discovery medicine (10)55 2010
Abstract
Double bromodomain proteins bind to acetylated lysines in histones, bringing associated histone modification and nucleosome remodeling activity to chromatin. The ability of bromodomain regulators to alter chromatin status and control gene expression has long been appreciated to be im...
|
PMID: 21189220
PDF is available here.
PDF is available here.
Abstract
We have investigated the effect of insertion of sites of differing affinities, either upstream or within the transcribed gene, on complex binding and transcription upregulation. Insertion of four copies of the 18D11 fragment upstream or at the 3' end of a reporter gene led to strong MSL complex bind...
|
PMID: 20977887
PDF is available here.
PDF is available here.
Abstract
We show here that ChREBP inactivation in clonal pancreatic MIN6 β-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. Conversely, adenovirus-mediated over-expression of ChREBP...
|
PMID: 20934404
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
The mammalian mitochondrial inner membrane protein Oxa1L is involved in the insertion of a number of mitochondrial translation products into the inner membrane. During this process, the C-terminal tail of Oxa1L (Oxa1L-CTT) binds mitochondrial ribosomes and is believed to coordinate the synthesis and...
|
PMID: 20739282
PDF is available here.
PDF is available here.