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Oxidative Phosphorylation Coupling Factors (0):
Recent article
Oxidative Phosphorylation Coupling Factors
Journal of Hypertension (28)11 2010
Abstract
We recently showed that coupling factor 6, a component of adenosine trisphosphate (ATP) synthase, induces hypertension by intracellular acidosis, which is related to reactive oxygen species generation. We investigated the effect of high-salt diet on the cardiac performance and reactive oxygen specie...
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PMID: 20811295
PDF is available here.
PDF is available here.
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Journal of Hypertension (27)9 2009
Abstract
We cultured resistance arteriole VSMCs from the mesenteric artery network of spontaneously hypertensive rats (SHRs, n = 8) and Wistar-Kyoto rats (WKY, n = 8) by enzymatic method. The gene expression of CF6 was higher by 76 +/- 24% in SHR-derived VSMCs compared with WKY rat-derived VSMCs (P < 0.05) c...
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PMID: 19474762
PDF is available here.
PDF is available here.
Hypertension Research (32)3 2009
Abstract
We recently showed that endogenous prostacyclin inhibitor coupling factor 6 (CF6) forces the clockwise rotation of F(1) motor of plasma membrane adenosine triphosphate synthase and induces intracellular acidosis and c-Src activation. We investigated the role of CF6 in regulation of sFlt-1, and its m...
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PMID: 19262480
PDF is available here.
PDF is available here.
Abstract
We found that, compared with the control group, 12 spots in standard in vitro fertilization group and 18 spots in intracytoplasmic sperm injection group were identified as significantly differentially expressed proteins. Among them, six spots were differentially expressed in both standard IVF and IC...
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PMID: 18792929
PDF is available here.
PDF is available here.
Abstract
We report the crystal structure of the bovine mitochondrial FB mutant with Gly-3-Glu substitution determined at a resolution of 0.96 A and that of the WT polypeptide at a resolution of 2.9 A. The structure reveals an oblong, oval-shaped molecule with a unique globular N-terminal domain that is propo...
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PMID: 18768789
PDF is available here.
PDF is available here.
Atherosclerosis (200)1 2008
Abstract
We examined the effects of CF6 on PECAM-1 expression and shear-mediated NO release, comparatively with those of angiotensin II (AngII). Treatment of human umbilical vein endothelial cells (HUVEC) and aortic endothelial cells (HAEC) with CF6 at 10(-7)M or AngII at 10(-7)M for 24h suppressed PECAM-1 g...
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PMID: 18243211
PDF is available here.
PDF is available here.
Abstract
Pretreatment of HUVECs with rosiglitazone inhibited TNF-alpha-induced expression of CF6 in a dose-dependent manner. The activation of CF6 stimulated by TNF-alpha was suppressed by ROS in a dose-dependent manner. CONCLUSION: TNF-alpha-induced enhancement of the gene expression and release of CF6 is m...
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PMID: 18819888
PDF is available here.
PDF is available here.
Neuroscience Letters (438)2 2008
Abstract
Prolonged, H(2)S-induced hypothermia is a simple and efficacious method to limit the damage inflicted by stroke in aged rats....
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PMID: 18456407
PDF is available here.
PDF is available here.
Abstract
These results suggest that the N-terminal domain and, in particular, the proximal N-terminal amino acids are important for the coupling activity and protein-protein interactions of bovine factor B....
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PMID: 18319055
PDF is available here.
PDF is available here.
Circulation Journal (71)5 2007
Abstract
The results suggest that an increased CF6 level may be responsible in part for the decreased prostacyclin level observed in patients with coronary heart disease, in particular after PTCA and stent therapy. As a potential risk factor for coronary heart disease, CF6 might have important clinical signi...
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PMID: 17456993
PDF is available here.
PDF is available here.
Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus.
Abstract
These results suggest that CF6 might be an obvious marker of impaired endothelium and might contribute to vascular damage in diabetes....
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PMID: 16899312
PDF is available here.
PDF is available here.
Abstract
We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucose level enhanced CF6 expression and peptide secretion in HUVECs in a time- and concentration-dependent manner, which was independent of increas...
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PMID: 17174010
PDF is available here.
PDF is available here.
Journal of Hypertension (24)3 2006
Abstract
CF6 changes the gene expression profile to be proatherogenic and functions as a novel stimulator for ADMA release by enhancing its synthesis and suppressing its degradation....
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PMID: 16467652
PDF is available here.
PDF is available here.
Abstract
We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease. Because HN was recently found to block proapoptotic Bax function and exert its v...
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PMID: 16639504
PDF is available here.
PDF is available here.
Journal of Physiology (569)Pt 2 2005
Abstract
We use optical and magnetic resonance spectroscopy to independently quantify mitochondrial ATP synthesis and O2 uptake to determine in vivo P/O. Resting ATP demand (equal to ATP synthesis) was lower in the skeletal muscle of 30-month-old C57Bl/6 mice compared to 7-month-old controls (21.9 +/- 1.5 ve...
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PMID: 16254011
PDF is available here.
PDF is available here.
Abstract
We showed a high plasma level of CF6 in human hypertension. The present study focused on the identification and characterization of a receptor for CF6 and its post-receptor signaling pathway. Incubation of human umbilical vein endothelial cells (HUVECs) with an excess of free CF6 reduced by 50% the...
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PMID: 16230521
PDF is available here.
PDF is available here.
Abstract
Abstract
PTH and phosphate concentrations were significantly higher in dogs with HAC compared with control dogs. PTH concentrations reduced significantly with treatment, such that there was no longer a difference between the HAC and control groups. Phosphate concentrations also reduced significantly with tre...
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PMID: 16300115
PDF is available here.
PDF is available here.
Cardiovascular Research (67)1 2005
Abstract
The shear-induced gene expression and release of CF6 in HUVEC are mediated by the ROS-related activation of NF-kappaB signaling pathway. Troglitazone and 15d-PGJ2 inhibit them at the IkappaB protein level....
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PMID: 15949477
PDF is available here.
PDF is available here.
Hypertension Research (27)10 2004
Abstract
We measured the plasma CF6 level of patients with acute myocardial infarction (AMI) to observe dynamic changes of CF6. All patients showed elevated plasma CF6 levels upon admission for treatment of AMI. Their CF6 levels peaked approximately 72 h after the onset of AMI and remained high for 7 days. A...
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PMID: 15785006
PDF is available here.
PDF is available here.
Human Molecular Genetics (13)12 2004
Abstract
We investigated an established amyloid precursor protein (APP) transgenic mouse model (the Tg2576 mouse model) for gene expression profiles at three stages of disease progression: long before (2 months of age), immediately before (5 months) and after (18 months) the appearance of Abeta plaques. Usin...
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PMID: 15115763
PDF is available here.
PDF is available here.
Cardiovascular Research (62)3 2004
Abstract
TNF-alpha stimulates the gene expression of CF6 via activation of NF-kappa B signaling pathway, and promotes the release of CF6 from ECV-304 and HUVEC....
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PMID: 15158150
PDF is available here.
PDF is available here.
Abstract
Clinical and biochemical changes suggestive of hypoadrenocorticism were observed in a 10-year-old male neutered Staffordshire bull terrier shortly after beginning therapy with trilostane for the treatment of hyperadrenocorticism. The dog's condition was stabilised with intravenous fluids, fludrocort...
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PMID: 15206477
PDF is available here.
PDF is available here.
Journal of Hypertension (21)12 2003
Abstract
The patients with essential hypertension (EH) (n = 30) received a series of normal salt diet (12 g salt/day) for 3 days, low salt diet (2 g salt/day) for 7 days, and high salt diet (20-23 g salt/day) for 7 days. Normotensive control subjects (n = 27) received normal and low salt diets. The plasma le...
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PMID: 14654753
PDF is available here.
PDF is available here.
Kidney International (64)6 2003
Abstract
Plasma levels of CF6 and ADMA were threefold higher in hemodialysis patients than in control individuals, and there was a positive correlation between these two compounds (r=0.25, P < 0.05). Plasma CF6 level was positively correlated with serum creatinine level (r=0.36, P < 0.01) and was reduced aft...
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PMID: 14633154
PDF is available here.
PDF is available here.
Regulatory Peptides (113)1-3 2003
Abstract
We describe the chemical synthesis of human CF-6, (33-108)-NH(2), its C-terminal fragment (55-108)-NH(2), which is termed pCF-6; the rat CF-6, (33-108)-NH(2), its C-terminal fragment pCF-6, (55-108)-NH(2); and two N-terminal fragments of the rat pro-coupling factor-6, (24-52)-NH(2) and (33-52)-NH(2)...
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PMID: 12686462
PDF is available here.
PDF is available here.
Abstract
We found that two short, complementary sequences in voltage-gated K+ channels are essential for coupling the voltage sensors to the intracellular activation gate. One sequence is the so called S4-S5 linker distal to the voltage-sensing S4, while the other is around the COOH-terminal end of S6, a reg...
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PMID: 12407078
PDF is available here.
PDF is available here.
Circulation (104)25 2001
Abstract
Vascular endothelial cells are a source of CF6, and shear stress regulates the release of the surface-associated CF6....
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PMID: 11748113
PDF is available here.
PDF is available here.
Abstract
We demonstrated recently that coupling factor 6, an essential component of the energy-transducing stalk of mitochondrial ATP synthase, suppresses the synthesis of prostacyclin in vascular endothelial cells. Here, we tested the hypothesis that coupling factor 6 is present on the cell surface and is i...
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PMID: 11581303
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (276)11 2001
Abstract
We demonstrate that expression of bovine F(6) complements a null mutant in ATP14 gene in yeast Saccharomyces cerevisiae. Subunit h of the yeast ATP synthase is encoded by ATP14 and is just 14.5% identical to bovine F(6). Expression of bovine F(6) in an atp14 null mutant strain recovers oxidative pho...
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PMID: 11083870
PDF is available here.
PDF is available here.
Abstract
These studies allow dissociation of the contribution and consequences of uncoupling of mitochondrial oxidative phosphorylation and cyclooxygenase inhibition in the pathophysiology of NSAID enteropathy. While uncoupling of enterocyte mitochondrial oxidative phosphorylation leads to increased intestin...
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PMID: 10792129
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (274)14 1999
Abstract
We created selective culture conditions using galactose and oligomycin that elicited a pathological phenotype in T8993G cells and that allowed for the rapid selection of wild-type over T8993G mutant cells. We then generated cytoplasmic hybrid clones containing heteroplasmic levels of the T8993G muta...
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PMID: 10092618
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (273)48 1998
Abstract
We purified the inhibitory substance from the heart of spontaneously hypertensive rats by collecting active fractions after gel-filtration column chromatography and two steps of reverse-phase high performance liquid chromatography. The amino acid composition and automated gas-phase sequencing of the...
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PMID: 9822642
PDF is available here.
PDF is available here.
Abstract
Our understanding of the significance of reperfusion injury is however restricted by the profuse literature in animal models and limited literature in the clinical situation. This article reviews the pathophysiology, clinical manifestations of reperfusion injury to the heart and discusses the possib...
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PMID: 9049675
PDF is available here.
PDF is available here.
Abstract
Abstract
The mitochondrial NADH/NAD+ ratio for free nucleotides in rat pancreatic islets was judged from the cell content in L-glutamate and L-alanine, 2-ketoglutarate and pyruvate, and NH4+. At a physiological concentration of D-glucose, such a ratio averaged 9.6 +/- 1.1%. A rise in hexose concentrations, a...
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PMID: 7753041
PDF is available here.
PDF is available here.
Abstract
We investigate which type of editing is ancestral and which is derived, by analysing RNA editing in the different lineages, using a kinetoplastid phylogeny reconstructed from nuclear small subunit ribosomal RNA sequences. We conclude that the ancestral cryptogenes were pan-edited, and we hypothesize...
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PMID: 8127370
PDF is available here.
PDF is available here.
Abstract
A cDNA clone encoding the precursor to the rat mitochondrial protein coupling factor 6 (F6) has been isolated and sequenced. The deduced amino acid sequence of the rat precursor protein shows 78% and 74% identity with the human and bovine F6 pre-proteins, respectively.
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PMID: 1386054
PDF is available here.
PDF is available here.
Abstract
The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic...
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PMID: 1495890
PDF is available here.
PDF is available here.
Abstract
Escherichia coli strain KF148(SD-) defective in translation of the uncC gene for the epsilon subunit of H(+)-ATPase could not support growth by oxidative phosphorylation due to lack of F1 binding to Fo (M. Kuki, T. Noumi, M. Maeda, A. Amemura, and M. Futai, 1988, J. Biol. Chem. 263, 17, 437-17, 442)...
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PMID: 1530778
PDF is available here.
PDF is available here.
Abstract
We have determined the complete nucleotide sequence of ATPase 6 mRNA from Leishmania tarentolae. RNA editing occurs only in the 5' one-third of the mRNA and is the most extensive observed to date in this species. We have identified a potential gRNA sequence, encoded in a minicircle, for a portion of...
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PMID: 1837067
PDF is available here.
PDF is available here.
Abstract
Protons are the most common coupling ions in bacterial energy conversions. However, while many organisms, such as the alkaliphilic Bacilli, employ H(+)-bioenergetics for electron transport phosphorylation, they use Na+ as the coupling ion for transport and flagellar movement. The Na+ gradient requir...
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PMID: 1665692
PDF is available here.
PDF is available here.
Abstract
The nucleotide sequence of the import precursor of coupling factor 6 (factor 6) of human H(+)-ATP synthase has been determined from a recombinant cDNA clone isolated by screening a human kidney cDNA library with a cDNA for rat factor 6 as a probe. The sequence was composed of 466 nucleotides includi...
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PMID: 1830479
PDF is available here.
PDF is available here.
Abstract
Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments. A human fetal muscle cDNA clone encoding this protein was isolated by screening a lambda gt10 library with oligodeoxyribonucleotide probes. T...
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PMID: 1825642
PDF is available here.
PDF is available here.
Rivista di neurologia (61)4 1991
Abstract
We have analyzed by Southern blotting and Polymerase Chain Reaction (PCR) the mtDNA in primary muscle cultures (myoblast-myotube stages and at clonal densities) and in fibrogenic subclones obtained from 9 patients with partial COx deficiency who had in their muscle biopsy a subpopulation of mtDNA sh...
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PMID: 1667713
PDF is available here.
PDF is available here.
FEBS Letters (277)1-2 1990
Abstract
Bovine heart mitochondrial coupling factor B was isolated and purified to homogeneity in its active form. The amino-terminal amino acid sequence of the alkylated protein was determined. Two chains with exactly the same sequence except for the presence of an additional Phe at the amino-terminus on on...
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PMID: 2148527
PDF is available here.
PDF is available here.
Abstract
The nucleotide sequence of the import precursor of coupling factor 6 (factor 6) of rat liver H(+)-ATP synthase has been determined from a recombinant cDNA clone isolated by screening a rat liver cDNA library with a probe DNA. The sequence was composed of 458 nucleotides including a coding region for...
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PMID: 2145831
PDF is available here.
PDF is available here.
Abstract
We find that MURF4 transcripts of T. brucei are extensively edited throughout by the addition and deletion of numerous uridines, creating potential initiation and termination codons and a continuous open reading frame. A potential guide RNA sequence occurs in a minicircle between inverted repeats. T...
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PMID: 2140530
PDF is available here.
PDF is available here.
Presse Medicale (19)14 1990
Abstract
Abstract
Our observations with trilostane may reflect tissue differences in the enzyme and/or differences in endogenous vs exogenous steroids (i.e. in the conversion of 3 beta-OHDg to 3-ketodesogestrel there is no requirement for isomerization). Kinetic parameters of 3 alpha-HSDH were also determined....
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PMID: 2137889
PDF is available here.
PDF is available here.
Abstract
Heart mitochondria isolated from 14- to 21-day-old chicks are highly coupled and often have respiratory control ratio (RCR) values exceeding 100. This paper presents data from a study of some of the properties of these mitochondria. The studies show that: (a) The ADP:O ratios and the state 4 rates o...
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PMID: 2153362
PDF is available here.
PDF is available here.
Abstract
Rotenone-sensitive NADH dehydrogenase activity and Lubrol stimulation of cytochrome oxidase activity were measured to assess the opposite membrane polarity of beef heart mitoplast and inside-out particle preparations. The ATP-Pi exchange activity of mitoplasts was not affected by their incubation at...
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PMID: 2561442
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (264)19 1989
Abstract
The atpA and atpB genes coding for the alpha and beta subunits, respectively, of membrane ATPase were cloned from a methanogen Methanosarcina barkeri, and the amino acid sequences of the two subunits were deduced from the nucleotide sequences. The methanogenic alpha (578 amino acid residues) and bet...
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PMID: 2544575
PDF is available here.
PDF is available here.
Abstract
Rabbit peritoneal neutrophils, permeabilized with Triton X-100, contain inositol phosphate 5-phosphomonoesterase activity capable of converting [3H]inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) to [3H]inositol 1,4-bisphosphate. This activity is found predominantly associated with the soluble component...
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PMID: 2843177
PDF is available here.
PDF is available here.
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences / Chung-kuo k'o hsueh yuan, chu pan (31)3 1988
Abstract
By incubating soluble F1 of the beef heart mitochondria with radio active 7-chloro-4-nitro-2,1,3-benzoxadiazole (14C)-NBD-C1 in the dark, a labeled F1 with NBD/F1 molar ratio of 1:1 (0.995:1) was obtained, but 98% of the ATPase activity was inhibited. The inactivated ATPase activity of the NBD-label...
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PMID: 2901143
PDF is available here.
PDF is available here.
Abstract
Two uncouplers of oxidative phosphorylation, 2,4-dinitrophenol (DNP) and carbonyl cyanide m-chlorophenylhydrazone (CCCP), were tested for their ability to modify the survival of cultured Chinese hamster ovary (CHO) and Chinese hamster V79 cells treated with hyperthermia. The uncouplers were used und...
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PMID: 3385224
PDF is available here.
PDF is available here.
FEBS Letters (226)1 1987
Abstract
A polypeptide purified from an extract of thermostable, porcine intestinal peptides was found to correspond to coupling factor 6, previously known as a component of the mitochondrial oxidative phosphorylation system. The intestinal presence of this peptide offers a new source for preparation of the...
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PMID: 2961617
PDF is available here.
PDF is available here.
Abstract
Site-directed mutagenesis was used to generate three mutations in the uncB gene encoding the a-subunit of the F0 portion of the F0F1-ATPase of Escherichia coli. These mutations directed the substitution of Arg-210 by Gln, or of His-245 by Leu, or of both Lys-167 and Lys-169 by Gln. The mutations wer...
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PMID: 2891376
PDF is available here.
PDF is available here.
Abstract
Neurological dysfunction resulting from an ischemic insult in the central nervous system (CNS) is believed to be an indirect outcome of impaired energy production. Recent studies suggest that prostaglandin Bx (PGBx), an oligomer of PGB1 and 15-keto-PGB1, may be beneficial in protecting mitochondrial...
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PMID: 3509135
PDF is available here.
PDF is available here.
Abstract
Repeated extraction of bovine heart submitochondrial particles with ammonia and EDTA (AE) yields a preparation that is highly deficient in coupling factor B (FB). The activity of the thrice extracted particle (AE-P3) in ATP-driven NAD+ reduction by succinate and the 32Pi-ATP exchange activity were s...
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PMID: 2434494
PDF is available here.
PDF is available here.