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Phosphoproteins (26):
- Smad Proteins, Receptor-Regulated
- Interferon Regulatory Factor-7
- Interferon Regulatory Factor-3
- Caveolin 2
- Caveolin 1
- Tumor Suppressor Protein p53
- Synapsins
- Retinoblastoma-Like Protein p130
- Fanconi Anemia Complementation Group A Protein
- Cortactin
- Retinoblastoma-Like Protein p107
- Focal Adhesion Kinase 1
- Dopamine and cAMP-Regulated Phosphoprotein 32
- CDC2 Protein Kinase
- Caseins
- bcl-Associated Death Protein
- Plectin
- Crk-Associated Substrate Protein
- Paxillin
- Fanconi Anemia Complementation Group D2 Protein
- Fanconi Anemia Complementation Group G Protein
- Vitellogenins
- Stathmin
- BRCA1 Protein
- Retinoblastoma Protein
- Phosvitin
Recent article
Phosphoproteins
Proteomics (11)18 2011
Abstract
This review covers progress in proteome research on Mycoplasma pneumoniae made over the last 5 years. This bacterium is one of the smallest known self-replicating bacteria. With fewer than 700 proposed proteins, it is well suited to a comprehensive proteome analysis. While all of the...
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PMID: 21751371
PDF is available here.
PDF is available here.
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Abstract
We deleted the cohesin locus Rad21 in mouse thymocytes at a time in development when these cells stop cycling and rearrange their T-cell receptor (TCR) α locus (Tcra). Rad21-deficient thymocytes had a normal lifespan and retained the ability to differentiate, albeit with reduced efficiency. Loss of...
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PMID: 21832993
PDF is available here.
PDF is available here.
Abstract
We used large-scale quantitative phosphoproteomics experiments to define the signaling networks downstream of mTORC1 and mTORC2. Characterization of one mTORC1 substrate, the growth factor receptor-bound protein 10 (Grb10), showed that mTORC1-mediated phosphorylation stabilized Grb10, leading to fee...
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PMID: 21659605
PDF is available here.
PDF is available here.
Abstract
We found that the degradation of aqueous based silk is much faster than HFIP based silk scaffolds. Also, HFIP based silk scaffolds supported the soft dental pulp formation better than the aqueous based silk scaffolds. No distinct hard tissue regeneration was found in any of the implants, with or wit...
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PMID: 21484985
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Tyrosine phosphorylation plays a major role in intracellular signal transduction pathways. Phosphorylated tyrosine residues initiate signaling pathways by recruiting proteins containing Src homology-2 (SH2) domains. Herein is described a high-throughput assay to detect interactions between phosphory...
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PMID: 18370317
PDF is available here.
PDF is available here.
Cell Host & Microbe (9)4 2011
Abstract
We show that the Leishmania protease GP63 cleaves the mammalian/mechanistic target of rapamycin (mTOR), a serine/threonine kinase that regulates the translational repressor 4E-BP1. mTOR cleavage results in the inhibition of mTOR complex 1 (mTORC1) and concomitant activation of 4E-BP1 to promote Leis...
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PMID: 21501832
PDF is available here.
PDF is available here.
Abstract
We performed a large scale analysis of the phosphoproteome in mouse embryonic stem (mES) cells. Using multiplex strategies, we detected 4581 proteins and 3970 high confidence distinct phosphosites in 1642 phosphoproteins. Notably, 22 prominent phosphorylated stem cell marker proteins with 39 novel p...
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PMID: 21149613
PDF is available here.
PDF is available here.
Journal of Proteomics (74)4 2011
Abstract
We used 2D-DIGE analysis of phospho-enriched fractions to identify phosphoproteins involved in regulating response to dasatinib in an isogenic pair of melanoma cell lines, one sensitive to dasatinib (WM-115) and the other resistant (WM-266-4). In WM-115 cells treated with dasatinib, 18 unique protei...
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PMID: 21237296
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We report an unbiased analysis of the cytotoxic T lymphocyte (CTL) serine-threonine phosphoproteome by high-resolution mass spectrometry. We identified approximately 2,000 phosphorylations in CTLs, of which approximately 450 were controlled by T cell antigen receptor (TCR) signaling. A significantly...
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PMID: 21399638
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Developmental Cell (20)3 2011
Abstract
The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (...
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PMID: 21397842
PDF is available here.
PDF is available here.
Abstract
We investigate the function of Yap1, the transcriptional effector of the Hippo signaling pathway, in skin biology. Using gain- and loss-of-function studies, we show that Yap1 is a critical modulator of epidermal stem cell proliferation and tissue expansion. Yap1 mediates this effect through interact...
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PMID: 21376238
PDF is available here.
PDF is available here.
Reproductive Sciences (18)3 2011
Abstract
We conclude that enhanced cortisol production in LTH adrenals is the result of enhanced protein expression of StAR and potential downstream signaling pathways....
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PMID: 21079237
PDF is available here.
PDF is available here.
Abstract
We show that TAp63α is kept in an inactive dimeric state. We reveal that relief of inhibition leads to tetramer formation with ∼20-fold higher DNA affinity. In vivo, phosphorylation-triggered tetramerization of TAp63α is not reversible by dephosphorylation. Furthermore, we show that a helix in t...
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PMID: 21335238
PDF is available here.
PDF is available here.
Abstract
We identified two heterozygous frameshift mutations in the perilipin gene (PLIN1) in three families with partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes. Subcutaneous fat from the patients was characterized by smaller-than-normal adipocytes, macrophage infiltration, and fi...
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PMID: 21345103
PDF is available here.
PDF is available here.
Abstract
We report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as WWTR1) as nuclear relays of mechanical signals exerted by ECM rigidity and cell shape. This regulation requires Rho GTPase activity and tensio...
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PMID: 21654799
PDF is available here.
PDF is available here.
Abstract
Redox-dependent thylakoid protein phosphorylation regulates both the short- and long-term acclimation of the photosynthetic apparatus to changes in environmental conditions. The major thylakoid phosphoproteins belong to photosystem II (D1, D2, CP43, PsbH) and its light-harvesting antenna (Lhcb1, Lhc...
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PMID: 20960130
PDF is available here.
PDF is available here.
Abstract
We investigated the role of Spry1 in the development of the endothelial and hematopoietic lineages during development.
Quantitative RT-PCR analysis demonstrates that Spry1, Spry2, and Spry4 are expressed in Flk1(+) hemangioblasts in vivo, and decline significantly in c-Kit(+) and CD4...
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PMID: 21483770
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
I collagen mineralization model. In the presence of a polyacrylic acid-containing mineralization medium optimal intrafibrillar mineralization of the EDC-cross-linked collagen was achieved using 500 and 1000 μg ml⁻¹ PVPA. The mineralized fibrils exhibited a hierarchical order of intrafibrillar mi...
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PMID: 20688200
PDF is available here.
PDF is available here.
Abstract
We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We evaluated the human plasma proteome in healthy neonates, children and adults using the 2D-DIGE approach. We demonstrate significan...
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PMID: 21365000
PDF is available here.
PDF is available here.
Abstract
Phosphorylation dysregulation has been implicated in various diseases including cancer. The phosphorylation change of proteins in secretome may be a novel source for the discovery of biomarkers and drug targets. In this study, the phosphoproteins in cancer secretome (phosphosecretome...
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PMID: 20726782
PDF is available here.
PDF is available here.
Science Signaling (4)163 2011
Abstract
We found that Vav1 selectively entered SLP-76 microclusters, rather than TCR microclusters, influencing their stability and function. The carboxyl terminus of Vav1, which consists of Src homology domains, was both necessary and sufficient for the entry of Vav1 into SLP-76 microclusters; however, thi...
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PMID: 21386095
PDF is available here.
PDF is available here.
Abstract
We found that for responses measured above 0.2%, inter-laboratory %CVs were, on average, 35%. No differences in inter-laboratory variation were observed if a 4-color antibody cocktail or a 7-color combination was used. Moreover, the data allowed identification of important sources of variability for...
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PMID: 20727897
PDF is available here.
PDF is available here.
Molecular Biology Reports (36 Suppl 1) 2010
Abstract
Biochemical Journal (432)3 2010
Abstract
We reported previously that this motif was necessary for YAP2 localization in the nucleus and for promoting cell detachment and apoptosis. In the present study, we show that the tight junction protein ZO (zonula occludens)-2 uses its first PDZ domain to form a complex with YAP2. The endogenous ZO-2...
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PMID: 20868367
PDF is available here.
PDF is available here.
Abstract
We explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N→S acyl transfer....
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PMID: 20835458
PDF is available here.
PDF is available here.
Abstract
We exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments...
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PMID: 20888800
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We hypothesized that this can be improved by electro-spun, supramolecular polymer membranes which show clear benefits in ease of processability. We found that after 7 d, in comparison to conventional microporous membranes, renal tubular cells cultured on top of our fibrous supramolecular membranes...
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PMID: 20715132
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We identified a receptor adaptor interacting specifically with one receptor complex but not others. NHERF1, an adaptor known for its role in desensitization, internalization, and regulation of the ERK signaling cascade for several GPCRs, interacts via its PDZ2 domain with the CCR5 homodimer but not...
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PMID: 20801883
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We investigate the role of USP8 in countering ligand-induced ubiquitination and down-regulation of EGFR and characterize a subset of protein-protein interaction determinants critical for this function. USP8 depletion accelerates receptor turnover, whereas loss of hepatocyte growth factor-regulated s...
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PMID: 20736164
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
These results demonstrate a new hierarchical phosphorylation for 4E-BP1 regulation in which Thr(69) is phosphorylated first followed by Thr(36)/Thr(45) phosphorylation, and Ser(64) is phosphorylated last. Thr(69) phosphorylation alone allows binding to eIF4E, and subsequent Thr(36)/Thr(45) phosphory...
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PMID: 20736160
PDF is available here.
PDF is available here.
Cancer Research (70)21 2010
Abstract
We have examined how HSP90 inhibitors affect LATS1 and the related protein LATS2, two kinases that relay antiproliferative signals in the Hippo tumor suppressor pathway. Both LATS1 and LATS2 were depleted from cells treated with the HSP90 inhibitors 17-allylamino-17-demethoxygeldanamycin (17-AAG), r...
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PMID: 20841485
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)9 2010
Abstract
We have investigated the in vitro and in vivo effects of watercress, which is a rich source of PEITC. We first demonstrated that, similar to PEITC, crude watercress extracts inhibited cancer cell growth and HIF activity in vitro. To examine the effects of dietary intake of watercress, we obtained pl...
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PMID: 20546646
PDF is available here.
PDF is available here.
Abstract
We report the screening for the mRNA expression of the ACTH-R, steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase, 21-hydroxylase (all in 38 cortisol-secreting ATs), 17α-hydroxylase, and 11β-hydroxylase (both in 28 cortisol-secre...
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PMID: 20920783
PDF is available here.
PDF is available here.
Abstract
We demonstrated that the insulin (INS) and amino acid (AA)-induced activation of mTORC1 is developmentally regulated in skeletal muscle (Suryawan A et al. Am J Physiol Endocrinol Metab 293: E1597-E1605, 2007). The present study aimed to characterize in more detail the effects of the postprandial ris...
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PMID: 20724570
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We have identified and characterized MPP8 as a methyl-H3K9-binding protein. MPP8 displays an elevated expression pattern in various human carcinoma cells, whereas knocking-down MPP8 results in the loss of cellular mesenchymal marker as well as the reduction of tumour cell migration and invasiveness,...
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PMID: 20871592
PDF is available here.
PDF is available here.
Abstract
We describe fluorescence-based 2-D gel electrophoresis methods for visualization of low abundant, cancer relevant tyrosine phosphorylated (pTyr) proteins. The methods investigated were fluorescent Western blotting and two-dimensional difference gel electrophoresis (2-D DIGE) for detection of non-enr...
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PMID: 20888324
PDF is available here.
PDF is available here.
Abstract
We show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis. Metastatic mouse and human tumours deficient in TAp63 express Dicer at very low levels, and we found that modulation of expression of Dicer and miR-...
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PMID: 20962848
PDF is available here.
PDF is available here.
Abstract
We find that Toll is recruited from the plasma membrane to Rab5(+) early endosomes. The distribution of a constitutively active form of Toll, Toll(10b), is shifted from the plasma membrane to early endosomes. Inhibition of endocytosis on the ventral side of the embryo attenuates Toll signaling ventr...
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PMID: 20921412
PDF is available here.
PDF is available here.
Experimental Cell Research (316)17 2010
Abstract
We found that the migration ability of human lung adenocarcinoma cells was significantly impaired following the increased protein level of HLJ1 under acidic culture conditions. However, HLJ1 transcriptional activity was no different in the normal and acidic culture medium. Incubation of the cells in...
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PMID: 20615403
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
These results suggested that Dvl2 is involved in mitotic progression by regulating the dynamics of MT plus-ends and the SAC in Plk1-dependent and -independent manners....
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PMID: 20823832
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We report that our budding yeast two-hybrid assay identified hsSsu72 phosphatase as a Rad21-binding protein. Additional experiments revealed that Ssu72 directly interacts with Rad21 and SA2 in vitro and in vivo, and associates with sister chromatids in human cells. Interestingly, depletion or mutati...
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PMID: 20818333
PDF is available here.
PDF is available here.
Abstract
CPI-17 is a unique phosphoprotein that specifically inhibits myosin light chain phosphatase in smooth muscle and plays an essential role in agonist-induced contraction. To elucidate the in situ mechanism for G protein-mediated Ca²+-sensitization of CPI-17 phosphorylation, α-toxin-permeabilized art...
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PMID: 20833141
PDF is available here.
PDF is available here.
Abstract
We demonstrated that rosiglitazone suppressed IL-6-stimulated lipolysis in differentiated porcine adipocytes by inactivation of extracellular signal-related kinase (ERK). Meanwhile, rosiglitazone enhanced the lipolysis response of adipocytes to isoprenaline. In addition, rosiglitazone significantly...
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PMID: 20921996
PDF is available here.
PDF is available here.
Abstract
We have not only validated the role of PP2A in regulation of eIF4E phosphorylation but also demonstrated the mechanism underlying this process. Inhibition of PP2A using either okadaic acid or PP2A small interfering RNA (siRNA) increased eIF4E phosphorylation, which could be abolished by the presence...
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PMID: 20927323
PDF is available here.
PDF is available here.
Cell Research (20)10 2010
Abstract
We reported that Dvl also functions in the nucleus by stabilizing the β-catenin/TCFs transcriptional complex. Here we describe that Dvl may function as a repressor of NF-κB. Our data show that Dvl directly binds to p65 and their interaction occurs in the nucleus. Dvl expression inhibits p65-mediat...
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PMID: 20628365
PDF is available here.
PDF is available here.
Abstract
We first tried to replicate the association between the SNP and memory performance in a Japanese subjects.
We examined the association between the SNP and memory performance measured by the Wechsler Memory Scale-Revised (WMS-R) in 187 healthy Japanese people.
The T al...
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PMID: 20509760
PDF is available here.
PDF is available here.
Abstract
We report regeneration of dental-pulp-like tissue by cell homing and without cell transplantation. Upon in vivo implantation of endodontically treated real-size, native human teeth in mouse dorsum for the tested 3 weeks, delivery of basic fibroblast growth factor and/or vascular endothelial growth f...
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PMID: 20486799
PDF is available here.
PDF is available here.
Proteomics (10)19 2010
Abstract
Larval attachment and metamorphosis, commonly referred to as larval settlement, of marine sessile invertebrates can be triggered or blocked by chemical cues and affected by changes in overall protein expression pattern and phosphorylation dynamics. This study focuses on the effects o...
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PMID: 20827734
PDF is available here.
PDF is available here.
PLoS Genetics (6)10 2010
Abstract
We investigate the consequences of desmosome loss for carcinogenesis by analyzing conditional knockout mice lacking Perp, a p53/p63 regulated gene that encodes an important component of desmosomes. Analysis of Perp-deficient mice in a UVB-induced squamous cell skin carcinoma model reveals that Perp...
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PMID: 20975948
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
We found that IP3R1 binds an endosomal isoform of the IP3R-associated cGMP-dependent kinase substrate (IRAG). IRAG is a substrate of cGMP-dependent kinase-1 (PKG1) and binds the PKG1 isoform PKG1β, which was the predominant form of PKG1 in human osteoclasts. Western blots of IRAG were consistent wi...
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PMID: 20567233
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)10 2010
Abstract
We hypothesized that cerebellar injury would locally upregulate steroidogenic factors upstream of aromatase, providing the requisite substrate for neuroestrogen synthesis. We tested this hypothesis by lesioning the cerebellum of adult songbirds using both males and females that peripherally synthesi...
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PMID: 20925573
PDF is available here.
PDF is available here.
Neuroscience Letters (482)3 2010
Abstract
Our results indicate that the integrity of the BBB could be impaired in the inflammatory pathophysiology of RA.
(c) 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20654699
PDF is available here.
PDF is available here.
Abstract
We recently reported that PED is overexpressed in human cancers and mediates resistance to induced apoptosis. To better understand its role in cancer, we investigated on PED interactome in non-small cell lung cancer (NSCLC). By the Tandem Affinity Purification (TAP), we identified and characterized...
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PMID: 20648624
PDF is available here.
PDF is available here.
Journal of Proteomics (73)10 2010
Abstract
In the field of proteomics there is an apparent lack of reliable methodology for quantification of posttranslational modifications. Present study offers a novel post-digest ICPL quantification strategy directed towards characterization of phosphorylated and glycosylated proteins. The...
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PMID: 20601274
PDF is available here.
PDF is available here.
Journal of Proteomics (73)10 2010
Abstract
We stress the advantages of using sub-cellular fractionation, protein separation, quantitation and affinity purification techniques to identify hitherto unidentified signalling and regulatory proteins. For example, proteomic analysis of B-cell plasma membranes isolated from patients with mantle cell...
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PMID: 20346427
PDF is available here.
PDF is available here.
Journal of Proteomics (73)10 2010
Abstract
We stress the advantages of using sub-cellular fractionation, protein separation, quantitation and affinity purification techniques to identify hitherto unidentified signalling and regulatory proteins. For example, proteomic analysis of B-cell plasma membranes isolated from patients with mantle cell...
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PMID: 20346427
PDF is available here.
PDF is available here.
EMBO Journal (29)18 2010
Abstract
We describe studies of dynamin PH domain mutations found in centronuclear myopathy (CNM) that increase dynamin's GTPase activity without altering phosphoinositide binding. CNM mutations in the PH domain C-terminal α-helix appear to cause conformational changes in dynamin that alter control of the G...
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PMID: 20700106
PDF is available here.
PDF is available here.
Abstract
We hypothesize that rapid larval settlement of H. elegans could be mediated through changes in phosphorylation status of proteins rather than extensive de novo synthesis of proteins. To test this hypothesis, 2D gel-based multiplexed proteomics technology was used to monitor the changes in protein ex...
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PMID: 20666481
PDF is available here.
PDF is available here.