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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Protein Precursors (10):
Recent article
Protein Precursors
Abstract
We show that recombinant hepsin cleaves pro-MSP at the consensus site Arg(483)-Val(484) with superior efficiency compared with the known activators MT-SP1 and hepatocyte growth factor activator (HGFA). At least 50% of pro-MSP was processed within 1 hour at a hepsin concentration of 2.4 nmol/L and at...
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PMID: 21875933
PDF is available here.
PDF is available here.
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Abstract
The aim of this study is to assess the role of novel biomarkers for the diagnostic evaluation of acute coronary syndrome (ACS).
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PMID: 21835288
PDF is available here.
PDF is available here.
Abstract
Macrophage migration inhibitory factor (MIF) was originally described as a cytokine that inhibits migration of macrophages at the site of inflammation. Subsequently it was also identified as a stress-induced hormone released from the anterior pituitary lobe in response to some pro-in...
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PMID: 21091281
PDF is available here.
PDF is available here.
Development (138)8 2011
Abstract
We generated three mouse lines, each of which lacks one out of three prominent PCDH15 isoforms (CD1, CD2 and CD3). Surprisingly, mice lacking PCDH15-CD1 and PCDH15-CD3 form normal hair bundles and tip links and maintain hearing function. Tip links are also present in mice lacking PCDH15-CD2. However...
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PMID: 21427143
PDF is available here.
PDF is available here.
Abstract
Anemia is an important complication of inflammatory bowel disease (IBD). Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, proh...
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PMID: 21285884
PDF is available here.
PDF is available here.
Abstract
We show that the CatD ortholog of the budding yeast Saccharomyces cerevisiae (Pep4p) harbors a dual cytoprotective function, composed of an anti-apoptotic part, conferred by its proteolytic capacity, and an anti-necrotic part, which resides in the protein's proteolytically inactive propeptide. Thus,...
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PMID: 21593793
PDF is available here.
PDF is available here.
Abstract
We examined whether STA-21, a small Stat3 inhibitor, could be useful in ameliorating the skin lesions not only in the model mouse but also in human psoriasis. Treatment with STA-21 markedly inhibited the cytokine-dependent nuclear translocation of Stat3 in normal human keratinocytes in vitro. Kerati...
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PMID: 20811392
PDF is available here.
PDF is available here.
Abstract
We report the crystal structures of the precursor p62-E1 heterodimer and of the mature E3-E2-E1 glycoprotein complexes. The resulting atomic models allow the synthesis of a wealth of genetic, biochemical, immunological and electron microscopy data accumulated over the years on alphaviruses in genera...
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PMID: 21124458
PDF is available here.
PDF is available here.
Clinical Science (119)12 2010
Abstract
Sepsis and the severe systemic response syndrome are very common illnesses that are responsible for a great amount of morbidity and death. These closely related conditions are characterized by a remarkable increase in the prohormone ProCT (procalcitonin). ProCT is both a marker of sepsis and a harmf...
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PMID: 20649514
PDF is available here.
PDF is available here.
The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals.
Abstract
A series of substrate-based α-keto-β-aldehyde (glyoxal) sequences have been synthesised and evaluated as inhibitors of the caspase family of cysteine proteases. A number of potent inhibitor sequences have been identified. For example, a palmitic acid containing sequence pal-Tyr-Val-Ala-Asp-glyoxal...
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PMID: 20955686
PDF is available here.
PDF is available here.
Abstract
To investigate the correlation of hypoproteinemia with inflammation parameters C-reactive protein (CRP), procalcitonin (PCT) and WBC in children with sepsis.
Seventy-three children with sepsis (including 22 severe sepsis) and 40 non-sepsis children (control group) were enrolled. Serum albumin levels...
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PMID: 21083981
PDF is available here.
PDF is available here.
Abstract
We attempted to determine the underlying mechanism that induces inflammation in the intestines of neonate mice after oral Shigella infection. Wild-type BALB/c mice of different ages (7, 14, and 35 days old) were orally administered GFP-expressing Shigella flexneri 5a M90T strain (5 x 10⁹ CFU) and...
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PMID: 20888321
PDF is available here.
PDF is available here.
Abstract
We show that keratinocytes express sortilin mRNA, and the presence of sortilin protein is shown in cultured keratinocytes and in normal human skin. We have also shown that the cutaneous neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and galanin are abl...
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PMID: 20613775
PDF is available here.
PDF is available here.
Abstract
We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocy...
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PMID: 20947764
PDF is available here.
PDF is available here.
Abstract
In children with HF, NT-proBNP is associated with cardiac symptoms and indices of LV systolic dysfunction and remodeling. NT-proBNP >1000 pg/mL identifies highly symptomatic children. Within subject serial measurements of NT-proBNP are needed for a reliable and accurate determination of disease stat...
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PMID: 20934575
PDF is available here.
PDF is available here.
Biofouling (26)7 2010
Abstract
These results indicate a high level of control over the distribution of proteins, presumably with different functions, in the byssus of this freshwater species....
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PMID: 20924840
PDF is available here.
PDF is available here.
Abstract
The objective of this paper was to evaluate the sequence of feline prepro-adrenomedullin (AM) and its tissue distribution and to investigate whether expression of feline AM mRNA increases in association with spontaneous cardiomyopathy. The feline prepro-AM cDNA sequence and deduced amino acids were...
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PMID: 20460835
PDF is available here.
PDF is available here.
La Revue du praticien (60)7 2010
Abstract
Abstract
Patients with various chronic liver diseases frequently have increased body iron stores. Prohepcidin is an easily measurable precursor of hepcidin, which is a key regulator of iron homeostasis. This study investigated the serum prohepcidin levels in patients with various chronic live...
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PMID: 20924211
PDF is available here.
PDF is available here.
FEBS Journal (277)18 2010
Abstract
We found that hypoxia/SD induced nuclear factor kappa Bp65-dependent IL-1β and TNF-α transcription. Furthermore, hypoxia/SD stimulated the translation of pro-IL-1β and its processing to mature IL-1β, although the translation of TNF-α was unchanged. Unexpectedly, the release of IL-1β and TNF-α...
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PMID: 20681988
PDF is available here.
PDF is available here.
Acta Diabetologica (47)3 2010
Abstract
We investigate whether serum levels of proamylin or amylin or the proamylin/amylin ratios are different among normal subjects and patients with impaired glucose regulation (IGR) and T2DM. Totally 79 subjects were divided into three groups according to the results of oral glucose tolerance test (OGTT...
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PMID: 20509034
PDF is available here.
PDF is available here.
Abstract
Although many antimicrobial components (i.e. antimicrobial peptides) have been found in many social Hymenoptera venoms, no antimicrobial compound is purified and characterized from parasitic Hymenoptera. From the venoms of the ectoparasitic wasp, Nasonia vitripennis, a defensin-like antimicrobial pe...
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PMID: 20362606
PDF is available here.
PDF is available here.
Abstract
A 74-year-old man was diagnosed with nephrotic syndrome due to focal segmental glomerulosclerosis, and steroid therapy was initiated. Subsequently, he was affected by deep mycosis, and hence, voriconazole (VRCZ) was administered. On the 16th day, he was transferred to our hospital because of somnole...
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PMID: 20567873
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We evaluated the clinical value of perioperative alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) levels in predicting recurrence of hepatocellular carcinoma (HCC) after curative resection, with a focus on the time course as surveillance tools. A total of 165 consecutive HCC patients...
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PMID: 20596642
PDF is available here.
PDF is available here.
Abstract
We use small interfering RNA knockdown to study the role of individual PKC isoforms as regulators of keratinocyte differentiation induced by the potent differentiating stimulus, 12-O-tetradecanoylphorbol-13-acetate (TPA). PKC-delta knockdown reduces TPA-activated involucrin promoter activity, nuclea...
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PMID: 20445555
PDF is available here.
PDF is available here.
Abstract
We transduced human keratinocytes (KCs) with lentiviral constructs expressing tetracycline (TET)-inducible small hairpin RNA (shRNA). TET-induced expression of AREG shRNA markedly reduced autocrine extracellular signal-regulated kinase phosphorylation, strongly inhibited autocrine KC growth with an...
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PMID: 20428186
PDF is available here.
PDF is available here.
Journal of Hypertension (28)8 2010
Abstract
Anthropometric, cardiovascular and renal factors exerted a different impact on NT-proANP levels at different ages in our study population. Higher NT-proANP levels were associated with increased cardiovascular risk....
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PMID: 20453667
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)28 2010
Abstract
We also examined the sensitivity, specificity and accuracy of combination detection.
The expressions of BJ-TSA-9, CK19 and Pre-proGRP mRNA in non-small cell lung cancer patients were 56.7%, 57.5%, 35.0%, higher than that of benign pulmonary disease (0.9%, 6.6%, 5.7%) and healthy groups (0, 3.8%, 0,...
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PMID: 20979858
PDF is available here.
PDF is available here.
American Heart Journal (160)1 2010
Abstract
After a median follow-up of 5.8 years, 92 patients (20.7%) had died. The GRACE risk score was significantly higher in patients who died (median 146 vs 93, P < .001) and provided a c-statistic regarding mortality of 0.78. A significant increase of the c-statistic was achieved only after addition of G...
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PMID: 20598977
PDF is available here.
PDF is available here.
Abstract
Abstract
I minute Apgar scores, our results do not support utilization of these cord blood levels as the sole tool to predict neonatal outcome....
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PMID: 20862823
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We investigated the therapeutic efficacy of a peptide in the leader sequence of preproinsulin, which was selected because of its binding affinity to the MHC I-A(g7) molecule. Preproinsulin-1 L7-24 peptide (L7-24) emulsified in Freund's incomplete adjuvant was administered subcutaneously to NOD mice....
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PMID: 20359955
PDF is available here.
PDF is available here.
Clinical Chemistry (56)7 2010
Abstract
Clinical Chemistry (56)7 2010
Abstract
Both furin and corin are involved in the proBNP processing pathway, giving rise to distinct BNP forms. The significance of the presence of unprocessed proBNP in circulation that could be cleaved by the endogenous convertases should be further investigated for better understanding BNP physiology....
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PMID: 20489134
PDF is available here.
PDF is available here.
Abstract
Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid, specific, and of sufficient sensitivity to detect increases in PCT serum levels within 4 to 6 h of initi...
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PMID: 20421436
PDF is available here.
PDF is available here.
Abstract
We evaluated PCT's clinical efficacy in assessing bacterial infection severity, measuring PCT and systemic inflammatory response syndrome (SIRS) markers in 180 subjects with suspected infection. PCT titer was higher with increasing infection severity. PCT was thus useful in identifying those in crit...
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PMID: 20715553
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective, observational study in a level III multidisciplinary neonatal intensive care unit. We enrolled twenty-five (n=25) neonates undergoing major surgery (for gastroschisis, atresia of the small intestine, congenital diaphragmatic hernia, esophageal atresia, coarctation of the...
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PMID: 20440673
PDF is available here.
PDF is available here.
Abstract
Gonadotrophin-releasing hormone-1 (GnRH-1) is essential for mammalian reproduction, controlling release of gonadotrophins from the anterior pituitary. GnRH-1 neurones migrate from the nasal placode into the forebrain during development. Although first located within the nasal placode, the embryonic...
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PMID: 20646175
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
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PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
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PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
A chimeric mammalian globular cytochrome b(5) fused to Escherichia coli alkaline phosphatase signal sequence (SS) was used as a model probe to investigate the influence of substituting each one of the standard 20 amino acids at its N-terminus on the Sec-dependent export of the precur...
|
PMID: 20506367
PDF is available here.
PDF is available here.