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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Proteome (0):
Recent article
Proteome
Abstract
We present the results of studies confirming the importance of DCI to HCV pathogenesis. Computational models incorporating proteomic data from HCV patient liver biopsy specimens recapitulated our original predictions regarding DCI and link HCV-associated alterations in cellular metabolism and liver...
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PMID: 21917952
PDF is available here.
PDF is available here.
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Abstract
These results indicate that F. alocis has virulence properties that may enhance its ability to survive and persist in the periodontal pocket and may play an important role in infection-induced periodontal disease....
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PMID: 21825062
PDF is available here.
PDF is available here.
Abstract
We review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness....
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PMID: 20673161
PDF is available here.
PDF is available here.
Molecular BioSystems (7)10 2011
Abstract
We applied a stochastic calculus of domain binding provided by a rule-based modelling approach to formalise the highly combinatorial signalling pathway in the PSD and perform the numerical analysis of the relative distribution of protein complexes and their sizes. We specified the combinatorics of p...
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PMID: 21874189
PDF is available here.
PDF is available here.
Proteomics (11)17 2011
Abstract
We hereby provide a two-year update on the HUPO Human Plasma Proteome Project (HPPP) informed by advances presented at the HPPP sessions at the HUPO World Congresses in Toronto in September 2009 and in Sydney in September 2010.
Copyright © 2011 WILEY-VCH Verlag GmbH...
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PMID: 21850651
PDF is available here.
PDF is available here.
Abstract
To study and establish a proteome reference map and regulation network of neonatal rat cardiomyocyte.
Cultured cardiomyocytes of neonatal rats were used. All proteins expressed in the cardiomyocytes were separated and identified by two-dimensional polyacrylamide gel e...
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PMID: 21841810
PDF is available here.
PDF is available here.
Eukaryotic Cell (10)9 2011
Abstract
We analyzed the structure of the macronuclear TtVPS13A gene, which was found to be composed of 17 exons spanning 12.5 kb and was predicted to encode a protein of 3,475 amino acids (aa). A strain expressing a TtVPS13A-green fluorescent protein (GFP) fusion protein was constructed, and the protein was...
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PMID: 21764909
PDF is available here.
PDF is available here.
Proteomics (11)18 2011
Abstract
This review covers progress in proteome research on Mycoplasma pneumoniae made over the last 5 years. This bacterium is one of the smallest known self-replicating bacteria. With fewer than 700 proposed proteins, it is well suited to a comprehensive proteome analysis. While all of the...
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PMID: 21751371
PDF is available here.
PDF is available here.
Proteomics (11)18 2011
Abstract
We present a simple, time- and cost-efficient approach to tackle the proteome of prokaryotic organisms. To obtain large data sets of complex biological experiments high-throughput and time- and cost-efficient methods still have to be developed and refined. In this study, we combined well-approved te...
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PMID: 21751368
PDF is available here.
PDF is available here.
Proteomics (11)17 2011
Proteome characterization of sea star coelomocytes--the innate immune effector cells of echinoderms.
Abstract
Sea star coelomic fluid is in contact with all internal organs, carrying signaling molecules and a large population of circulating cells, the coelomocytes. These cells, also known as echinoderm blood cells, are responsible for the innate immune responses and are also known to have an...
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PMID: 21751360
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
Salinity in agricultural land is a major problem worldwide, placing a severe constraint on crop growth and productivity in many regions, and increased salinization of arable land is expected to have devastating global effects. Though plants vary in their sensitivity to salt stress, h...
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PMID: 21440686
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
One of the most prominent hallmarks of the expected climate change in Europe is the higher prevalence of longer and more intense periods of summer drought. To preserve European oak forests, of considerable importance for European economical and ecological development, under these con...
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PMID: 21439417
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
We have analyzed the adaptive responses of Lupinus albus roots to long-term B deficiency. Large morphological differences were observed between plants grown with or without B, and 265 polypeptides were found to be responsive to B deficiency out of a total of 406 polypeptides detected by two-dimensio...
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PMID: 21406259
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
In common with other aerobic organisms, plants are exposed to reactive oxygen species resulting in formation of post-translational modifications related to protein oxidoreduction (redox PTMs) that may inflict oxidative protein damage. Accumulating evidence also underscores the import...
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PMID: 21406256
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
Membrane proteins are an interesting class of proteins because of their functional importance. Unfortunately their analysis is hampered by low abundance and poor solubility in aqueous media. Since shotgun methods are high-throughput and partly overcome these problems, they are prefer...
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PMID: 21334471
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
Plant acclimation to stress is associated with profound changes in proteome composition. Since proteins are directly involved in plant stress response, proteomics studies can significantly contribute to unravel the possible relationships between protein abundance and plant stress acc...
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PMID: 21329772
PDF is available here.
PDF is available here.
Abstract
We report an isotope labeling shotgun proteome analysis strategy to validate the spectrum-to-sequence assignments generated by using sequence-database searching for the construction of a more reliable MS/MS spectral library. This strategy is demonstrated in the analysis of the E. coli K12 proteome....
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PMID: 21726074
PDF is available here.
PDF is available here.
Abstract
We present a Java library to parse the msf files that constitute the output of Proteome Discoverer. The parser is also implemented as a graphical user interface allowing convenient access to the information found in the msf files, and in Rover, a program to analyze and validate quantitative proteomi...
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PMID: 21714566
PDF is available here.
PDF is available here.
Abstract
We previously described a highly sensitive multidimensional chromatographic strategy based on a combination of hydrophilic interaction liquid chromatography and reversed phase chromatography, which allows proteomic analysis with minimal sample losses. Here we apply this strategy to the analysis of a...
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PMID: 21696214
PDF is available here.
PDF is available here.
Abstract
Chondrocytes are widely used as an in vitro model of cartilage diseases such as osteoarthritis (OA). As the unique residents of mature cartilage, they are responsible of the synthesis and release of proteins essential for a proper tissue turnover. In this work, the stable isotope lab...
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PMID: 21692455
PDF is available here.
PDF is available here.
Abstract
We here isolated N-terminal peptides of a Saccharomyces cerevisiae proteome and analyzed both annotated and alternative TIS. We analyzed this N-terminome of S. cerevisiae which resulted in the identification of 650 unique N-terminal peptides corresponding to database annotated TIS. Furthermore, 56 u...
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PMID: 21619078
PDF is available here.
PDF is available here.
Abstract
We used GeLC-MS/MS, in which proteins are separated using 1-DE and identified using nanoLC-MS/MS, to generate high-quality protein catalogs. To maximize the number of identifications, all data sets were searched against the target databases using two search engines, Mascot and Paragon. As a result,...
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PMID: 21615180
PDF is available here.
PDF is available here.
Abstract
We performed comparative proteomic analyses (2D-DIGE and MALDI-TOF/TOF and iTRAQ/SCX-LC-MS/MS) of cells at three different conditions: exponential, late stationary phase, and biofilms. These results were compared with alterations in the proteome resulting from exposure to a biofilm inhibitory compou...
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PMID: 21612302
PDF is available here.
PDF is available here.
Abstract
The Golgi is an ancient and fundamental eukaryotic organelle. Evolutionary cell biological studies have begun establishing the repertoire, processes, and level of complexity of membrane-trafficking machinery present in early eukaryotic cells. This article serves as a review of the li...
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PMID: 21646379
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
The HUPO Brain Proteome Project (HUPO BPP) held its 14th workshop during the HUPO 9th Annual World Congress in Sydney, Australia. The principal aim of this project is to discover prognostic and diagnostic biomarkers associated with neurodegenerative diseases and brain aging, with the...
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PMID: 21796782
PDF is available here.
PDF is available here.
Abstract
We obtained and analysed samples of blood serum from 23 patients with MF, and 29 psoriasis patients and 22 healthy donors as controls. Protein profiling was carried out using SELDI TOF MS SELDI-TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented....
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PMID: 21751413
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We investigated the ability of this platform to discriminate between the "sputome" of patients with asthma and chronic obstructive pulmonary disease, and between these groups and those of healthy control subjects. Six m/z peaks emerged as potential diagnostic peptidic patterns able to differentiate...
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PMID: 21751363
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We analysed hearts of HCRs and LCRs from generation 22 of selection using DIGE and identified proteins from MS database searches. The running capacity of HCRs was six-fold greater than LCRs. DIGE resolved 957 spots and proteins were unambiguously identified in 369 spots. Protein expression profiling...
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PMID: 21751351
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We have used 2-DE coupled with MS to identify proteins differentially expressed in the livers of juvenile gilthead sea bream (Sparus aurata) grown under fish-farm conditions and fed with a 100 mg/kg MA-enriched diet (MA(100)). After the comparison of the protein profiles from MA(100) fed fish and...
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PMID: 21751345
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. aeruginosa, their proteins have not been compr...
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PMID: 21751344
PDF is available here.
PDF is available here.
Abstract
We discuss the spatial and temporal organization of cellular quality control strategies and their implications for human diseases linked to protein misfolding and aggregation....
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PMID: 21746797
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that a high-fat diet (HFD) modifies the liver mitochondrial proteome and alters proteins involved in NO metabolism, namely arginase 1 and endothelial NO synthase. Male C57BL/6 mice were fed a control or HFD and liver mitochondria were isolated for proteomics and reactive oxy...
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PMID: 20919931
PDF is available here.
PDF is available here.
Systems Biology, IET (5)4 2011
Abstract
The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. K...
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PMID: 21823758
PDF is available here.
PDF is available here.
Abstract
After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the es...
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PMID: 21742803
PDF is available here.
PDF is available here.
Abstract
We have produced human CFTR in the prokaryotic expression host Lactococcus lactis. The full-length protein was detected in the membrane of the bacterium, but the yields were too low (< 0.1% of membrane proteins) for in vitro functional and structural characterization, and induction of the expression...
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PMID: 21742800
PDF is available here.
PDF is available here.
ISME Journal (5)7 2011
Abstract
Our results confirm the importance of pH and related geochemical factors in fine-tuning acidophilic microbial community structure and function at the species and strain level, and demonstrate the broad utility of proteomics in laboratory community studies....
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PMID: 21228889
PDF is available here.
PDF is available here.
Abstract
We used large-scale quantitative phosphoproteomics experiments to define the signaling networks downstream of mTORC1 and mTORC2. Characterization of one mTORC1 substrate, the growth factor receptor-bound protein 10 (Grb10), showed that mTORC1-mediated phosphorylation stabilized Grb10, leading to fee...
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PMID: 21659605
PDF is available here.
PDF is available here.
Journal of Proteomics (74)7 2011
Abstract
Matrix vesicles (MVs), released by budding from apical microvilli of osteoblasts during bone formation and development, are involved in the initiation of mineralization by promoting the formation of hydroxyapatite in their lumen. To gain additional insights into MV biogenesis and fun...
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PMID: 21515422
PDF is available here.
PDF is available here.
Abstract
Abstract
We utilized a proteomics strategy to characterize proteome-wide alterations between MP-treated MKN28 lines and their untreated counterparts. A total of 97 spots were positively identified as differentially expressed, and of these 62 proteins were up-regulated, whereas 35 proteins were down-regulated...
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PMID: 21574062
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Proteomics (11)12 2011
Abstract
We concurrently profiled the proteome of dorsal-lateral (DLP) and ventral (VP) prostate lobes of both TRAMP and littermate WT C57BL/6 mice of 18 wk by 2-D LC-MALDI-TOF/TOF with iTRAQ labeling. A total of 483 and 748 proteins were identified at critical false discovery rates of 1 and 5%. In WT mice...
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PMID: 21598396
PDF is available here.
PDF is available here.
Proteomics (11)12 2011
Abstract
We describe the benefits of heat treatment of neutrophils in reducing protein degradation for subsequent proteome analysis. Neutrophils isolated from four healthy volunteers were each divided into three aliquots and subjected to different preparation methods for 2-DE: (i) Heat treatment, (ii) resusp...
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PMID: 21598391
PDF is available here.
PDF is available here.
Proteomics (11)11 2011
Abstract
We utilize multidimensional protein identification technology to characterize the murine left ventricle (LV), right ventricle (RV), and atria (A) proteomes, identifying thousands of distinct proteins. Moreover, using multidimensional algorithm protein map tool, relative abundances of proteins among...
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PMID: 21598388
PDF is available here.
PDF is available here.
Proteomics (11)12 2011
Abstract
We identified 46 proteins that were altered at protein expression levels. The protein changes detected by 2-DE/MS were verified by functional protein assays. These identified proteins include some key proteins involved in cellular stress response, metabolism, adhesion, cytoskeletal dynamics, cell gr...
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PMID: 21595037
PDF is available here.
PDF is available here.
Proteomics (11)12 2011
Abstract
We also found differences at post-translational level. The results indicated that late embryogenesis abundant Rab21 was more strongly phosphorylated in the embryos of the sensitive varieties than in the embryos of the tolerant ones. We propose that the differences found in the phosphorylation status...
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PMID: 21595035
PDF is available here.
PDF is available here.
Proteomics (11)12 2011
Abstract
Designing an experiment for quantitative proteomic analysis is not a trivial task. One of the key factors influencing the success of such studies is the number of biological replicates included in the analysis. This, along with the measured variation will determine the statistical po...
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PMID: 21591257
PDF is available here.
PDF is available here.
Abstract
In the cell, protein folding into stable globular conformations is in competition with aggregation into non-functional and usually toxic structures, since the biophysical properties that promote folding also tend to favor intermolecular contacts, leading to the formation of β-sheet-...
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PMID: 21538897
PDF is available here.
PDF is available here.
Abstract
We will address how protein homeostasis (proteostasis) is achieved at the level of the cell and organism, and how the threshold of the stress response is set to detect and combat protein misfolding. For metazoans, the requirement for coordinated function and growth imposes additional constraints on...
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PMID: 21536706
PDF is available here.
PDF is available here.
Abstract
We developed a simple, safe, and rapid method to prepare highly purified outer membrane (OM) fragments from these pathogens. Shotgun proteomic analyses of OMs by trypsin shaving and mass spectrometry identified >155 proteins, the majority of which are clearly outer membrane proteins (OMPs). These in...
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PMID: 21391724
PDF is available here.
PDF is available here.
Abstract
Childhood pilocytic astrocytoma is the most frequent brain tumor affecting children. Proteomics analysis is currently considered a powerful tool for global evaluation of protein expression and has been widely applied in the field of cancer research. In the present study, a series of...
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PMID: 21466243
PDF is available here.
PDF is available here.
Abstract
The "invisible" proteome of a Cola drink, stated to be produced with a kola nut extract, has been investigated via capture with combinatorial peptide ligand libraries (CPLL). Indeed, a few proteins in the M(r) 15-20 kDa range could be identified by treating large beverage volumes (1...
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PMID: 21452894
PDF is available here.
PDF is available here.
Abstract
We validate the high degree of sample purity and evaluate several possible sources of bias in the proteomic data. We compare the classes of proteins identified in the current oocyte proteome with protein classes identified in our previously determined oocyte transcriptome. The oocyte proteome appear...
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PMID: 21452892
PDF is available here.
PDF is available here.
Abstract
We used a comparative approach aiming to identify candidate proteins potentially implicated in these pathways. We examined changes occurring, in the proteome of a Helicoverpa armigera-derived cell line, upon induction by actinomycin D. We identified 13 proteins for which the relative abundance was s...
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PMID: 21452889
PDF is available here.
PDF is available here.
Abstract
Root hairs are unicellular extensions of specialized epidermis cells. Under limiting conditions, they significantly increase the water and nutrient uptake capacity of plants by enlarging their root surface. Thus far, little is known about the initiation and growth of root hairs in th...
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PMID: 21417484
PDF is available here.
PDF is available here.
Abstract
We were able to showed that PGC1-α expression is dramatically reduced in GRMD compared to healthy muscle. Collectively, these results provide novel insights into the molecular pathology of the clinically relevant animal model of DMD, and indicate that defective energy metabolism is a central hallma...
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PMID: 21410286
PDF is available here.
PDF is available here.
Abstract
We analyzed how Hb exposure could modulate the macrophage phenotype on a proteome level. We identified and relatively quantified 3691 macrophage proteins, representing the largest human macrophage proteome published to date. The Hb polarized macrophage phenotype was characterized by an induced Hb:Hp...
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PMID: 21405025
PDF is available here.
PDF is available here.