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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, Drug (3):
Recent article
Receptors, Drug
Abstract
We show here that this isoform is an important regulator of sodium transport. KS-WNK1(-/-) mice display an increased activity of the Na-Cl cotransporter NCC, expressed specifically in the distal convoluted tubule, where it participates in the fine tuning of sodium reabsorption. Moreover, the express...
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PMID: 20921400
PDF is available here.
PDF is available here.
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Abstract
We investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the response to excess Aldo. A 14-day Aldo infusion at 0.35 mg x kg(-1) x day(-1) via an osmotic minipump in conjunction with normal salt intake did not produce obvious disturbances in fluid metabolism in WT mice as sugge...
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PMID: 20335314
PDF is available here.
PDF is available here.
Abstract
ATP-sensitive K(+) (K(ATP)) channel subunits were investigated in rat submandibular gland (SMG). RT-PCR detected the presence of mRNA transcripts of the Kir6.1, Kir6.2, SUR2A, and SUR2B in the SMG, whereas SUR1 mRNA was barely detected. Western blot analysis provided the evidence that these four K(A...
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PMID: 19934381
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)5 2010
Abstract
The greatest contributing factor to bias and variability in parameter estimation was RE of the measured concentrations of ligand bound; however, SNLR provided more accurate and less bias estimates. Subtraction of B(NS) from total ligand binding data provided poor estimation of specific ligand bindin...
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PMID: 20221897
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Abstract
We demonstrate the effects of short-term vasopressin administration (30 min) on NCC activation in Brattleboro rats with central diabetes insipidus (DI) using the V2 receptor agonist desmopressin (dDAVP). The fraction of NCC abundance in the luminal plasma membrane was significantly increased upon dD...
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PMID: 20007345
PDF is available here.
PDF is available here.
Anesthesiology (112)3 2010
Abstract
Xenon represents a novel KATP channel opener that increases KATP currents independently of the sulfonylurea receptor-1 subunit by reducing ATP inhibition of the channel. Through this action and by its ability to readily partition across the blood-brain barrier, xenon has considerable potential in cl...
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PMID: 20179498
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
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PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
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PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Clinical Endocrinology (72)2 2010
Abstract
We investigated the clinical, biochemical, and genetic characteristics of five, chronic, nonhypertensive and hypokalaemic Japanese patients.
Serum and urinary electrolytes, plasma renin activity and plasma aldosterone concentration were measured in five patients (four males and one f...
|
PMID: 19508680
PDF is available here.
PDF is available here.
Abstract
We developed a method of genetic diagnosis for Gitelman's syndrome using DNA sequencing. A patient was found to be a compound heterozygote with a single base substitution at nucleotide 2552 (CTC-to-CAC, L849H) and a substitution at nucleotide 2561 (CGC-to-CAC, R852H) in exon 22. Familial linkage ana...
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PMID: 20229814
PDF is available here.
PDF is available here.
Abstract
This is the first report of a patient with clinically severe autosomal-recessive diffuse CHI due to a compound heterozygous ABCC8 mutation that has resulted in spontaneous resolution at such an early age. Compound heterozygote ABCC8 mutations result in complex interactions, and it is possible that t...
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PMID: 20215776
PDF is available here.
PDF is available here.
Abstract
We demonstrated that caveolin-3 co-immunopreciptiated Kir6.2 in COS-7 cells transfected with Kir6.2/SUR2A/caveolin-3, whereas Kir6.2 was not detected in the caveolin-3 immunoprecipitates in cells transfected with either caveolin-3 or Kir6.2/SUR2A alone. In cells transfected with Kir6.2C4A/caveolin-3...
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PMID: 20332621
PDF is available here.
PDF is available here.
Neuroendocrinology (91)1 2010
Abstract
These results show that the adrenals regulate basal GLUT3 gene profiles in the DVC alone; during hypoglycemia, these glands suppress (DVC) or increase GLUT3 (LHA and VMH) mRNA, and selectively elevate GLUT4 transcripts in the LHA. The data demonstrate divergent adrenal control of DVC neuronal monoca...
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PMID: 19996571
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)12 2009
Abstract
We term progressive secondary hemorrhage (PSH). Molecular mechanisms of PSH are unknown and efforts to reduce it by promoting coagulation have met with equivocal results. We hypothesized that PSH might be due to upregulation and activation of sulfonylurea receptor 1 (SUR1)-regulated NC(Ca-ATP) chann...
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PMID: 19604096
PDF is available here.
PDF is available here.
Abstract
A one month old baby was admitted for diabetic keto-acidosis. There was no neurological or dysmorphic features. On genetic analysis a heterozygous missense mutation of ABCC8 gene which codes for SUR1 was detected. His insulin requirement progressively came down and by 6 months insulin was stopped an...
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PMID: 20469787
PDF is available here.
PDF is available here.
Indian Journal of Pediatrics (76)11 2009
Abstract
We report a 2 month male child presenting with diabetic ketoacidosis (DKA) and seizures treated with intravenous fluids and intravenous insulin infusion till the ketoacidosis was reversed, thereafter responding well to sulphonylureas and at age of 13 months going into complete remission. At age of 1...
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PMID: 20092027
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)20 2009
Abstract
Our study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing. And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion....
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PMID: 20079163
PDF is available here.
PDF is available here.
Abstract
Our findings indicate that the common K23/A1369 variant K(ATP) channel displays decreased ATP inhibition that may contribute to the observed increased risk for type 2 diabetes. Moreover, the increased sensitivity of the K23/A1369 variant to the A-site sulfonylurea drug gliclazide may provide a pharm...
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PMID: 19587354
PDF is available here.
PDF is available here.
Abstract
We reference k4 as the rate of offset of unlabeled ligand in convention with Motulsky and Mahan (1)]. We derived a kinetic rate equation based on the dissociation rate constant for an unlabeled compound competing for the same site as a labeled compound and describe a model to simul...
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PMID: 19308787
PDF is available here.
PDF is available here.
Abstract
We created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) levels in IPCs as well as decreased PI3K activity and increased FoxO nuclear localization in periphery. This reduced systemic...
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PMID: 20195385
PDF is available here.
PDF is available here.
Abstract
The E23K variant leads to overactivity of the K(ATP) channel, resulting in reduced insulin secretion. Initially, insulin sensitivity is enhanced, thereby maintaining normal glucose tolerance. Presumably, over time, as insulin secretion falls further or insulin resistance develops, glucose levels ris...
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PMID: 19491206
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)27 2009
Abstract
We explore how WNK4 affects the trafficking of NCC through its interactions with intracellular sorting machinery. An analysis of NCC cell surface lifetime showed that WNK4 did not alter the net rate of cotransporter internalization. In contrast, direct measurements of forward trafficking revealed th...
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PMID: 19401467
PDF is available here.
PDF is available here.
Abstract
We found no evidence to support a requirement for bidirectional sequencing. Semiautomated analysis of good quality unidirectional sequence data has high sensitivity and is suitable for heterozygote mutation scanning in clinical diagnostic laboratories. Further work is required to determine minimum q...
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PMID: 19405871
PDF is available here.
PDF is available here.
Abstract
We report here the development of a microarray-based ligand binding assay that supports multiplexed analysis of G protein-coupled receptor systems in a 96-well microplate format that is compatible with the equipment and infrastructure typical of high-throughput screening laboratories. A prototype mi...
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PMID: 19604106
PDF is available here.
PDF is available here.
Abstract
Brain imaging tools such as positron emission tomography (PET) and functional magnetic resonance imaging have been successfully used to investigate in vivo human brain functions. In particular, PET has been widely used to visualize various molecules such as receptors, transporters, and amyloid prote...
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PMID: 19562942
PDF is available here.
PDF is available here.
Abstract
The utility and possibility of PET in the drug development of the neuropsychiatry field is discussed in this review. Positron emission tomography (PET) is a nuclear medicine imaging technique which visualizes and quantifies the distributions of various molecular targets in vivo. This technique has b...
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PMID: 19562943
PDF is available here.
PDF is available here.
Cell and Tissue Research (335)3 2009
Abstract
We have investigated the impact of Sur1 gene inactivation on mouse islet cell morphology, structure and basic physiology. Pancreata were collected from young, adult and old wild-type (WT) and Sur1 ( -/- ) mice. After immunostaining for hormone, the total endocrine tissue, cell proportion, cell size...
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PMID: 19142666
PDF is available here.
PDF is available here.
Human Mutation (30)2 2009
Abstract
The beta-cell ATP-sensitive potassium (K(ATP)) channel is a key component of stimulus-secretion coupling in the pancreatic beta-cell. The channel couples metabolism to membrane electrical events bringing about insulin secretion. Given the critical role of this channel in glucose homeostasis it is th...
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PMID: 18767144
PDF is available here.
PDF is available here.
Abstract
We studied a rat model of mild-to-moderate SAH intended to minimize ischemia/hypoxia to examine the role of sulfonylurea receptor 1 (SUR1) in the inflammatory response induced by SAH. mRNA for Abcc8, which encodes SUR1, and SUR1 protein were abundantly upregulated in cortex adjacent to SAH, where tu...
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PMID: 18854840
PDF is available here.
PDF is available here.
Abstract
SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive (KATP) channel is an octameric complex of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits, and it l...
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PMID: 18990670
PDF is available here.
PDF is available here.
Abstract
We analyse the dynamics of an inhibitor I which can either bind to a receptor R or to a plasma protein P. Assuming typical association and dissociation rates, we find that after an initial dose of inhibitor, there are three time scales: a short one, measured in fractions of seconds, in which the inh...
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PMID: 18938179
PDF is available here.
PDF is available here.
Abstract
Although stimulants as the treatment of choice are widely prescribed in ADHD, little is known about their long-term neurobiological effects. Hence, for the first time the present study examined the long-term effects of chronic methylphenidate (MPH) administration on striatal 5-hydroxytryptamine tran...
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PMID: 19172439
PDF is available here.
PDF is available here.
Abstract
The key to detecting and classifying drug effect at seven transmembrane (7TM) receptors is the pharmacological assay. Drug discovery had been rooted in testing of molecules on intact animal tissue until technology provided high-throughput binding assays for screening. While this allowed for the test...
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PMID: 19580378
PDF is available here.
PDF is available here.
Abstract
'All our knowledge has its origins in our perceptions.' Leonardo da Vinci Scientific progress is often enabled by the development of new tools and technologies that have given us new ways of perceiving the world. In the early days of our science, optical microscopy gave us the ability to observe cel...
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PMID: 19640219
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (54)3-4 2009
Abstract
Abstract
We determined the effects of age and sex on the blood pressure (BP) response to angiotensin II (Ang II) infusion and evaluated the potential mechanistic role of the thiazide-sensitive NaCl cotransporter (NCC) and the epithelial sodium channel (ENaC).
Male and female mice (approximately 3 or 21 month...
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PMID: 19844087
PDF is available here.
PDF is available here.
European Journal of Pharmacology (601)1-3 2008
Abstract
We studied the mRNA expression profile of K(ATP) channel subunits in the pig and human middle meningeal artery (MMA) and in the pig middle cerebral artery (MCA). We determined the order of potency of four K(ATP) channel openers when applied to isolated pig MMA and MCA, and we examined the potential...
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PMID: 18996111
PDF is available here.
PDF is available here.
Abstract
We sought to examine the therapeutic potential of the SUR-1-selective potassium channel opener (KCO), NN414, to amplify counterregulatory response to hypoglycemia. RESEARCH DESIGN AND METHODS-- In vivo dose-response studies with NN414 delivered intravenously to normal Sprague-Dawley rats before the...
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PMID: 18776135
PDF is available here.
PDF is available here.
Circulation Research (103)12 2008
Abstract
Circulation Research (103)12 2008
Abstract
We show that this K(ATP) subunit is also expressed in mouse myocardium and is the dominant SUR isoform in the atrium. This suggests differential sarcolemmal K(ATP) composition in atria and ventricles, and, to test this, K(ATP) currents were measured in isolated atrial and ventricular myocytes from w...
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PMID: 18974387
PDF is available here.
PDF is available here.