Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Selenium-Binding Proteins (0):
Recent article
Selenium-Binding Proteins
Clinical Cancer Research (16)7 2010
Abstract
We examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium....
|
PMID: 20332323
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We used cDNA microarrays to analyze gene expression differences between human colorectal tumors and paired adjacent normal mucosa. We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003). Importan...
|
PMID: 18435490
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)38 2008
Abstract
Selenium is an important nutrient. The lack of selenium will suppress expression of various enzymes that will lead to cell abnormality and diseases. However, high concentrations of free selenium are toxic to the cell because it adversely affects numerous cell metabolic pathways. In Methanococcus van...
|
PMID: 18650445
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (88)27 2008
Abstract
Well-resolved and reproducible 2-DE profile of rat I/R lung tissues and normal lung tissues were obtained. In the I/R lung tissue profile, the average spot number from 3 gels was 489 +/- 52 spots (P > 0.05) with an average matching rate of 89.28% (P > 0.05), and in the control group, the average spo...
|
PMID: 19040010
PDF is available here.
PDF is available here.
Plant Physiology (147)1 2008
Abstract
In Arabidopsis (Arabidopsis thaliana), the putative selenium-binding protein (SBP) gene family is composed of three members (SBP1-SBP3). Reverse transcription-polymerase chain reaction analyses showed that SBP1 expression was ubiquitous. SBP2 was expressed at a lower level in flowers and roots, wher...
|
PMID: 18354042
PDF is available here.
PDF is available here.
Gynecologic Oncology (109)1 2008
Abstract
We have shown for the first time that SELENBP1 is expressed in both normal ovaries and ovarian tumors in the hen and that SELENBP1 expression is altered in the vicinity of the tumor. Furthermore, SELENBP1 expression in normal ovarian surface epithelium and in ovarian tumors parallels that previously...
|
PMID: 18272210
PDF is available here.
PDF is available here.
Abstract
We comprehensively compared retinal autoantigens recognized by sera from BD patients with uveitis or healthy donors using proteomic technique, 2-dimensional electrophoresis (2DE) followed by Western blotting (WB). Six protein spots showing high reactivity with the serum from the BD patients were det...
|
PMID: 17343851
PDF is available here.
PDF is available here.
Abstract
An established model for mechanistic analysis of lung carcinogenesis involves administration of 3-methylcholanthrene to mice followed by several weekly injections of the tumor promoter 2,6-di-tert-butyl-4-methylphenol (BHT). BHT is metabolized to quinone methides (QMs) responsible for promoting tumo...
|
PMID: 17305404
PDF is available here.
PDF is available here.
Proteomics (6)24 2006
Abstract
We investigated the changes in the hepatic proteome in murine models for toxic-induced fibrogenesis and sclerosing cholangitis. A comprehensive comparison of protein changes observed is made and the mechanistical basis of the expression changes is discussed. Hepatic fibrosis was induced by repetitiv...
|
PMID: 17109383
PDF is available here.
PDF is available here.
International Journal of Cancer (118)10 2006
Abstract
We investigated the effects of selenium and androgen on normal human ovarian surface epithelial (HOSE) cells and cancer cells. Interestingly, SELENBP1 mRNA and protein levels were reduced by androgen and elevated by selenium treatment in the normal HOSE cells, whereas reversed responses were observe...
|
PMID: 16380993
PDF is available here.
PDF is available here.
Electrophoresis (27)8 2006
Abstract
Liver samples from female and male mice of two subspecies, Mus musculus musculus and Mus musculus domesticus, were investigated by a combination of 2-DE and MALDI-MS. The image analysis of the generated 2-DE patterns revealed several protein spots with significant differences in intensity/abundance...
|
PMID: 16532517
PDF is available here.
PDF is available here.
Abstract
Selenium binding proteins (SeBP) represent a family of proteins that are believed to be involved in controlling the oxidation/reduction in many physiological processes. The cDNA of Zhikong Scallop Chlamys farreri selenium binding protein (zSeBP) was cloned by expressed sequence tag (EST) and RACE te...
|
PMID: 15975653
PDF is available here.
PDF is available here.
Abstract
We established a protocol for conservative analysis and interpretation of gene expression data from the dorsolateral prefrontal cortex of SZ patients using statistical and bioinformatic methods that limit false positives. We also compared brain gene expression profiles with those from peripheral blo...
|
PMID: 16223876
PDF is available here.
PDF is available here.
Abstract
A selenium-binding protein (SeBP) from Methanococcus vannielii was recently identified, and its gene was isolated and overexpressed in Escherichia coli [Self, W. T., Pierce, R. & Stadtman, T. C. (2004) IUBMB Life 56, 501-507]. SeBP and recombinant SeBP (rSeBP) migrated as approximately 42-kDa specie...
|
PMID: 16103372
PDF is available here.
PDF is available here.
Abstract
We developed a method that involves inflation of the lungs via the trachea with medium containing (14)C-naphthalene followed by incubation in situ. The viability of this preparation is supported by maintenance of glutathione levels, rates of naphthalene metabolism, and exclusion of ethidium homodime...
|
PMID: 15892573
PDF is available here.
PDF is available here.
Abstract
These results indicate that 3-MST and GAPDH have more suitable potentials as a physiological selenium-delivery protein than rhodanese. In the presence of a selenium-binding protein, a low level of selenodiglutathione formed from SeO3(2-) and glutathione could effectively replace the high concentrati...
|
PMID: 15653770
PDF is available here.
PDF is available here.
Abstract
We compared proteomes of three different fibrosis models with the appropriate control (tissue inhibitor of metalloproteinases-1 (TIMP-1) overexpressing HepG2 cells in comparison to a HepG2 control, freshly isolated HSC in comparison to activated HSC and healthy mouse liver in comparison to fibrotic...
|
PMID: 15650968
PDF is available here.
PDF is available here.
Iubmb Life (56)8 2004
Abstract
The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A sel...
|
PMID: 15545230
PDF is available here.
PDF is available here.
Abstract
We examined the cytotoxic effect of AAP using COS cells stably expressing SeBP. Expression of SeBP enhanced the susceptibility of the cells to AAP-induced cytotoxicity. Several clones of SeBP-expressed COS cells were obtained, and they exhibited different degrees of susceptibility toward AAP. It was...
|
PMID: 15499197
PDF is available here.
PDF is available here.
Iubmb Life (56)7 2004
Abstract
Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocyste...
|
PMID: 15545220
PDF is available here.
PDF is available here.
Abstract
I showed that selenium-binding protein (SBP) was exclusively located at the leading edges of rapidly growing protrusions in newly plated T98G glioma cells, and at the growing tips of the neurites in SH-SY5Y neuroblastoma cells. Double staining by anti-SBP antibody and deoxyribonuclease (DNase I) tha...
|
PMID: 15108003
PDF is available here.
PDF is available here.
Abstract
These results suggest that the upregulation of OsSBP expression conferred enhanced tolerance to different pathogens, possibly by increasing plant sensitivity to endogenous defense responses. Additionally, the OsSBP protein might have a role in modulating the defense mechanism to biotic stress in ric...
|
PMID: 15118317
PDF is available here.
PDF is available here.
Journal of Pathology (202)3 2004
Abstract
The effects of selenium, an essential nutrient with anti-carcinogenic properties, are mediated by selenium-binding proteins. The protein expression status of human selenium-binding protein 1 (SBP1) in human tumours and the exact function of this protein are not known. In this study, quantitative two...
|
PMID: 14991897
PDF is available here.
PDF is available here.
Abstract
Selenium can be metabolized for protein synthesis by two major pathways in vivo. In a specific pathway it can be inserted into polypeptide chains as the amino acid selenocysteine, as directed by the UGA codon. Alternatively, selenium can be substituted for sulfur to generate the free amino acids sel...
|
PMID: 12084818
PDF is available here.
PDF is available here.
Abstract
We have isolated and characterized a Lotus japonicus gene (Ljsbp) encoding a putative polypeptide with striking homology to the mammalian 56-kDa selenium-binding protein (SBP). cDNA clones homologous to LjSBP were also isolated from soybean, Medicago sativa, and Arabidopsis thaliana. Comparative exp...
|
PMID: 12026169
PDF is available here.
PDF is available here.
Abstract
Mammalian selenium-containing proteins can be divided into three groups: proteins containing nonspecifically incorporated selenium, specific selenium-binding proteins, and specific selenocysteine-containing selenoproteins. Selenoproteins with known functions identified so far include five glutathion...
|
PMID: 11375445
PDF is available here.
PDF is available here.
Electrophoresis (21)11 2000
Abstract
Several studies with two-dimensional gel electrophoresis (2-DE) have shown that the abundance of numerous mouse liver proteins is altered in response to treatment with chemicals known to cause peroxisome proliferation. The peptide masses from tryptic digests of two liver proteins showing dramatic de...
|
PMID: 10892727
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (275)19 2000
Abstract
We purified from bovine brain cytosol a 56-kDa protein that shows a significant transport activity. Partial sequencing of four tryptic peptides obtained from the 56-kDa protein revealed its identity to a cytosolic protein previously characterized as a selenium-binding protein, SBP56. Recombinant SBP...
|
PMID: 10799528
PDF is available here.
PDF is available here.
BioFactors (9)1 1999
Abstract
We provide evidence that [75Se]selenocysteine is produced by bovine selenocysteine synthase from Ser-tRNASec and [75Se]Sep, synthesized from elemental 75Se and Tris(trimethylsilyl)phosphite. We also studied the stability of SeP by NMR measurement. SeP was stable during storage under nitrogen at -80...
|
PMID: 10221155
PDF is available here.
PDF is available here.
Electrophoresis (19)18 1998
Abstract
We present a detailed two-dimensional (2-D) protein map of rat bile duct epithelial cells (i.e., cholangiocytes) using a recently developed isolation procedure. In addition, we identify 27 major cholangiocyte proteins either by comparison to maps of known rat liver proteins (based on pI and Mr) or b...
|
PMID: 9932816
PDF is available here.
PDF is available here.
Cancer Research (58)14 1998
Abstract
We have found that the human selenium-binding protein gene hSP56 is differentially expressed by the relatively slow-growing, androgen-sensitive prostate cancer cell line LNCaP but not by the more rapidly growing androgen-insensitive lines PC-3 and DU145. We confirmed this differential expression by...
|
PMID: 9679983
PDF is available here.
PDF is available here.
FEBS Letters (430)3 1998
Abstract
I isozyme, as the major non-heme proteins in its red blood cells. It is possible that the absence of the high-activity CA II isozyme may be advantageous to the mole rat in adapting to the low O2 and high CO2 environment of its underground burrows. It is also likely that the 56 kDa SeBP may play an i...
|
PMID: 9688568
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (177)1-2 1997
Abstract
The mechanism of the antagonistic behaviour of selenium (Se) against cadmium (Cd) toxicity is investigated. This study reports the distribution of Cd at the organ and subcellular level after chronic treatments. The possible role of the selenium binding proteins (SBP) during Cd exposure are also eval...
|
PMID: 9450659
PDF is available here.
PDF is available here.
Abstract
We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein. The cDNA is 1,668 bp long and has an open reading frame encoding 472 amino acids. The calculated molecular weight is 52.25 kDa and the estim...
|
PMID: 9027582
PDF is available here.
PDF is available here.
Mammalian Genome (7)12 1996
Abstract
Toxicology Letters (87)1 1996
Abstract
A 54-kDa protein in rat liver cytosol was significantly induced by treatment with 3,4,5,3',4'-pentachlorobiphenyl (25 mg/kg, single i.p.) and 3-methylcholanthrene (20 mg/kg, once a day for 3 days, i.p.). The protein exhibited pI of 6.8 on two-dimensional gel electrophoresis. The amino acid sequences...
|
PMID: 8701438
PDF is available here.
PDF is available here.
Abstract
Acetaminophen is an analgesic and antipyretic which causes liver toxicity in humans and experimental animals with overdose. Acetaminophen (APAP) covalent binding to a cytosolic protein of approximately 58 kDa (58-ABP) has been associated with target organ toxicity. Since hepatic content of 58-ABP va...
|
PMID: 8812234
PDF is available here.
PDF is available here.
Abstract
Distribution study using 75Se shows that maximum accumulation was in liver tissues after 24h of 75Se administration. Induction of selenium binding protein (Se-P) in hepatic tissues of chick embryo was observed. Chick embryo hepatic Se-P was isolated after 24h of 75Se treatment using Sephadex G-75 co...
|
PMID: 8979505
PDF is available here.
PDF is available here.
Chemosphere (32)3 1996
Abstract
We obtained evidence that a toxic coplanar polychlorinated biphenyl (PCB) induces a counterpart of murine 56kDa selenium binding protein in rat liver cytosol. A 54kDa protein in the liver cytosol was significantly induced by 3,3',4,4',5-pentachlorobiphenyl and proved to be a major cytosolic protein...
|
PMID: 8907227
PDF is available here.
PDF is available here.
Abstract
These results suggest that the 58-ABP may be a common target for electrophiles in reactive intermediate toxicity....
|
PMID: 7473856
PDF is available here.
PDF is available here.
Medical Hypotheses (43)6 1994
Abstract
The model presented here suggests that a defect in a selenium transport protein may be a necessary but not sufficient precondition for a sub-type of schizophrenia--a type of schizophrenia that has been characterized by negative symptoms, brain damage, and a lack of primarily paranoid ideation. A def...
|
PMID: 7739414
PDF is available here.
PDF is available here.
Carcinogenesis (14)3 1993
Abstract
A full-length cDNA encoding a 56 kDa liver protein recently implicated in the detoxification of acetaminophen (AP56) has been cloned by virtue of its similarity to the 56 kDa selenium-binding protein (SP56): in fact, the deduced AP56 amino acid sequence differs at only 14 residues from SP56. Isolati...
|
PMID: 8453708
PDF is available here.
PDF is available here.
Abstract
Acetaminophen is metabolized by cytochrome P450 to a reactive metabolite that covalently binds to proteins and this binding correlates with the hepatotoxicity. The major protein adduct was previously reported to be a 55 kDa protein that was detected on Western blots using antisera specific for 3-(cy...
|
PMID: 1540179
PDF is available here.
PDF is available here.
Abstract
Aspergillus terreus was cultivated on Harrold's medium supplemented with 0.1% (w/v) cadmium chloride as well as on sulfur free medium amended with 0.1% (w/v) sodium selenite and potassium tellurite separately. The cell free extract of the fungus for each treatment was fractionated on a column packed...
|
PMID: 1713040
PDF is available here.
PDF is available here.
Carcinogenesis (11)11 1990
Abstract
Our working hypothesis is that selenium exerts its inhibitory effects on cell growth by modulating the properties of existing growth regulatory proteins. The two proteins that are readily labeled by selenium in many rodent tissues, SLP-56 and SLP-14, would fit into this category....
|
PMID: 2225343
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (264)23 1989
Abstract
We purified three selenium-binding proteins (molecular masses 56, 14, and 12 kDa) from mouse liver using column chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The aim of the present study was to determine the amino acid sequence of the 14-kDa protein thereby establishi...
|
PMID: 2760043
PDF is available here.
PDF is available here.
Carcinogenesis (9)2 1988
Abstract
The preventive and therapeutic potential of selenium (Se), a micronutrient, against cancer has been well documented in several test systems, but the mechanism of its action is not known. The possibility that Se might function in a manner similar to steroid hormones and retinoids through mediation of...
|
PMID: 3338111
PDF is available here.
PDF is available here.
Abstract