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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Serpins (10):
Recent article
Serpins
Abstract
We used immunohistochemistry (IHC) to detect the expression of Ets-1, angiopoietin-2 (Ang-2) and maspin in ovarian tumor and analyzed the relationship between the expression of these proteins and the clinical manifestation of ovarian cancer.
Ets-1 expression was much stronger in ovar...
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PMID: 21439064
PDF is available here.
PDF is available here.
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Obesity Facts (3)5 2010
Abstract
We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-...
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PMID: 20975299
PDF is available here.
PDF is available here.
Circulation (122)12 2010
Abstract
These results indicate that spontaneous activation of both Smad and non-Smad transforming growth factor-β signaling may contribute to profibrotic responses in aged PAI-1-deficient mice hearts and establish a possible link between endothelial-to-mesenchymal transition and cardiac fibrosis in PAI-1-d...
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PMID: 20823384
PDF is available here.
PDF is available here.
Abstract
PEDF downregulates VEGF expression and inhibits corneal NV induced by chemical cauterization. The results suggested that PEDF has therapeutic potential for corneal neovascular diseases....
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PMID: 20539216
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
We investigated the effect of PEDF gene loaded in PLGA nanoparticles (PEDF-PLGANPs) on the mouse colon carcinoma cells (CT26s) in vitro and in vivo. Blank PLGANPs (bPLGANPs) showed lower cytotoxicity than PEI to the CT26s. In vitro, PEDF-PLGANPs directly induced CT26 apoptosis and inhibit human umbi...
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PMID: 20664971
PDF is available here.
PDF is available here.
Abstract
Hyperglycemia was associated with reduced AAA diameter, increased plasma PAI-1 concentration and reduced plasmin generation. Aneurysmal aortic PAI-1 gene expression increased in parallel with plasma concentration, with peak expression occurring early after aneurysm initiation. CONCLUSION: Hyperglyce...
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PMID: 20561659
PDF is available here.
PDF is available here.
Abstract
We investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2...
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PMID: 20439934
PDF is available here.
PDF is available here.
Abstract
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (28)3 2010
Abstract
To express the genes of adenosine deaminase (ADA), C-lectin and serpin (serine protease inhibitor) in the salivary gland of Aedes albopictus.
Total RNA was extracted respectively from salivary glands of unfed (group SG) and engorged adult female Ae. albopictus mosquitoes (group BSG), female carcasse...
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PMID: 20806502
PDF is available here.
PDF is available here.
Journal of Proteomics (73)8 2010
Abstract
We identified more potential biomarkers in pleural effusion, which is closer to the affected organ, than in serum. Nevertheless, in both cases principal component analysis demonstrated that the pattern of significantly altered proteins discriminates between disease groups. The biomarker candidates c...
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PMID: 20230924
PDF is available here.
PDF is available here.
Abstract
The data suggest that p38 MAP kinase and ERK act upstream of GSK/beta-catenin in VEGF-induced activation of the uPA/uPAR system and that PEDF-mediated inhibition of the VEGF-induced increase in vascular permeability involves blockade of this pathway. These findings are important for developing preci...
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PMID: 20089873
PDF is available here.
PDF is available here.
Abstract
Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma. Recent reports have shown that SCCA can influence the invasion or metastasis of cancer cells. However, it remained unclear how SCCA acts to mediate these biological functions. To...
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PMID: 20428762
PDF is available here.
PDF is available here.
Veterinary Pathology (47)3 2010
Abstract
Several markers of malignancy have been proposed for canine mammary tumors on the mRNA and protein levels. However, their association with tumor malignancy applies only for mean values of large groups of tumors, but no single marker identified to date can be used to reliably predict malignancy for i...
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PMID: 20375427
PDF is available here.
PDF is available here.
Abstract
We perform a novel method in this study for the expression and purification of recombinant PEDF34 in E. coli, and make it convenient, soluble and high yield to obtain this small peptide of PEDF. Human PEDF34 gene was cloned into the fusion-protein expression vector pGEX-4T-1, and the recombinant pla...
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PMID: 20221677
PDF is available here.
PDF is available here.
Neurological Research (32)3 2010
Abstract
In relation to normal breast tissue, maspin mRNA expression was decreased in primary tumors and again decreased in brain metastases. Normalized C(T) values were 1 (normal tissue), 0.3 (primary tumors) and 0.13 (brain metastases). Immunohistochemistry revealed same tendencies. In comparison to poorly...
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PMID: 19909580
PDF is available here.
PDF is available here.
Journal of Neurosurgery (112)4 2010
Abstract
There is a likely genetic basis to sporadic IAs. However, the evidence base is small when compared against other complex disorders....
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PMID: 19780647
PDF is available here.
PDF is available here.
Abstract
We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increased tumor macrophage recruitment. The fraction of macrophages expressing inducible nitric oxide synthase, a marker of cytotoxic M1 macrophages, was increased, suggesting that PEDF could enhance antitumor immunity. In...
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PMID: 20360944
PDF is available here.
PDF is available here.
Biological Chemistry (391)4 2010
Abstract
We present a protein network that is built up on three-dimensional domain-domain interactions. The essential domains that link these systems are as follows: Cystatin, Peptidase_C1, Thyroglobulin_1, Insulin, CIMR (Cation-independent mannose-6-phosphate receptor repeat), fn2 (Fibronectin type II domai...
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PMID: 20180650
PDF is available here.
PDF is available here.
Abstract
We summarize structural features of PEDF that could affect various target organs such as blood vessels, tumors, and the central nervous system. In addition, since PEDF is recently identified as a regulator for glucose and lipid metabolism, we also discuss PEDF structures specially related to insulin...
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PMID: 20236052
PDF is available here.
PDF is available here.
Abstract
We also discuss here the pathophysiological role of PEDF in this devastating disorder....
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PMID: 20236051
PDF is available here.
PDF is available here.
Abstract
We have recently found that pigment epithelium derived factor (PEDF), a 50 kD glycoprotein, inhibits retinal, renal and brain hyperpermeability by counteracting the biological actions of VEGF. In this review, we discuss about the pathophysiological role of PEDF in vascular permeability, especially f...
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PMID: 20236056
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)7 2010
Abstract
The present data indicated that a long-term high-fat diet could induce obesity metabolic syndrome in SD rats and finally lead to lower vaspin of sera and periepididymal fat, while pioglitazone and chronic calorie-control ingestion could enhance the production of vaspin. It was undoubtedly demonstrat...
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PMID: 20497691
PDF is available here.
PDF is available here.
Biology of Reproduction (82)4 2010
Abstract
We compared the quantitative methylation changes of RASSF1 and SERPINB5 (also known as MASPIN) genes in placenta and plasma samples. We analyzed the methylation status of a total of 3569 CpG dinucleotides on these two genes in 83 different samples: 50 plasma samples (20 from pregnant women and 30 fr...
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PMID: 20075396
PDF is available here.
PDF is available here.
Journal of Proteomics (73)5 2010
Abstract
Combinatorial peptide ligand libraries have recently allowed considerable advances in the mapping of chicken egg yolk and white proteomics. Data from literature have been regrouped and elaborated for network and pathway analyses in order to convey a unified view of these proteomes. R...
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PMID: 20080220
PDF is available here.
PDF is available here.
Abstract
Statistically more infants who developed CLD had NE activity in at least one sample (10/20) compared with infants with resolved respiratory distress syndrome (RDS) (2/17). However, NE activity was present in a minority of samples, occurring as episodic peaks. Peak levels of MMP-9, MMP-9/TIMP-1 compl...
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PMID: 20335295
PDF is available here.
PDF is available here.
Abstract
We examined the effects of adenovirus-mediated gene transfer of PEDF on quinolinic acid (QA)-induced neurotoxicity in rats. Adenoviral vector containing the human PEDF gene (Ad.PEDF) or Escherichia coli beta-galactosidase gene (Ad.LacZ) was directly injected into the right striatum 7 days before the...
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PMID: 20142768
PDF is available here.
PDF is available here.
Acta Histochemica (112)2 2010
Abstract
We investigated the immunolocalization of maspin in LGMEC and GOC and evaluated its potential to distinguish between these two entities. Cases of LGMEC (n=6), GOC (n=8) and various odontogenic cysts with marked mucous metaplasia (OCMM, n=7), which served as controls, were immunohistochemically label...
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PMID: 19428058
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)3 2010
Abstract
We assess the effects of NSP treatment on plaque growth and T-helper (Th) lymphocyte activity in a mouse aortic allograft transplant model, with comparison to Serp-1. NSP and Serp-1 both significantly reduced plaque growth and T-cell invasion. T-bet (a Th1 differentiation marker) was significantly r...
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PMID: 20135065
PDF is available here.
PDF is available here.
Abstract
PEDF+DHA promotes the regeneration of corneal nerves. Neurotrophin-mediated NPD1 synthesis is suggested to precede nerve regeneration by demonstration of its accumulation upon addition of DHA and PEDF at earlier time points. Therefore, this signaling mechanism upregulates corneal nerve regeneration...
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PMID: 19797230
PDF is available here.
PDF is available here.
Abstract
The equivalence of both SCCA-IgM assays and the absence of reactivity not related to immune complexes support the analytical specificity of SCCA-IgM measurements. The results validate the assessment of SCCA-IgM for prognostic purposes in patients with cirrhosis....
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PMID: 20001440
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
Abstract
The incidence of major branch retinal vein occlusion was higher in the SRD group (38 of 46, 83%) than in the CME group (32 of 56, 66%, P = 0.01). The incidences of ischemic vein occlusion and macular ischemia was similar between the SRD group (18 of 46 and 20 of 46) and the CME group (20 of 56 and 2...
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PMID: 19881397
PDF is available here.
PDF is available here.
Abstract
We studied the effect of polarization of differentiated, human RPE monolayer cultures on expression and secretion of PEDF and VEGF. Polarized RPE demonstrated apical microvilli, expression of tight junction proteins, apical localization of Na/K- ATPase, and high transepithelial resistance (490 +/- 1...
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PMID: 20228934
PDF is available here.
PDF is available here.
Abstract
The aim of the study was to analyze the expression of Nm23-H1 and maspin proteins in a series of colorectal adenocarcinoma and to assess their applicability as prognostic factors in this type of cancer. 102 specimens of colorectal carcinoma were analyzed by immunohistochemistry with the use of anti-...
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PMID: 20099971
PDF is available here.
PDF is available here.
Abstract
We report a case of spuriously high level of SCCA in patient without carcinoma, renal failure, head-and-neck disease and lung disease. An early fifties female who had been undergone the diagnostic conization for high-grade cervical intraepithelial neoplasia ten years ago and observed without special...
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PMID: 20169941
PDF is available here.
PDF is available here.
Revista Medico-Chirurgicala (114)1 2010
Abstract
Alpha-Fetoprotein (AFP) is a serological marker currently available for the detection of hepatocellular carcinoma (CHC). Its poor sensitivity renders it unsatisfactory for this purpose and suggests the need for additional biomarkers. Squamous cell carcinoma associated antigen (SCCA) is physiological...
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PMID: 20509274
PDF is available here.
PDF is available here.
BMC Cell Biology (11)1 2010
Abstract
We propose that bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability....
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PMID: 20433722
PDF is available here.
PDF is available here.
BMC Neuroscience (11) 2010
Abstract
previously, we showed that Protease Nexin-1 (PN-1), a potent serine protease inhibitor, regulates the NMDAR availability and activity as well as SHH signaling. Compared with wild-type (WT), we detected a significant increase in BrdU-labeled cells in the dentate gyrus of mice lacking PN-1 (PN-1 -/-)...
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PMID: 20529321
PDF is available here.
PDF is available here.
Abstract
Abstract
These results suggest that the serum SCCA level may be a useful biomarker to evaluate the severity of allergic rhinitis caused by D farinae....
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PMID: 20128182
PDF is available here.
PDF is available here.
Abstract
Pigment epithelium-derived factor (PEDF), a glycoprotein with neuronal differentiating activity, possesses anti-inflammatory properties both in cell culture and animal models. However, the relationship between serum levels of PEDF and high-sensitivity C-reactive protein (hs-CRP), one of the represen...
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PMID: 20515558
PDF is available here.
PDF is available here.
Abstract
We report for the first time that NSCLC cells express both PI-9 mRNA and protein and that there is a subset of NSCLC cells with upregulated PI-9 mRNA and protein expression. Futhermore, our work revealed that the PI-9 protein expressed in NSCLC cells can inhibit the active GrB. Finally, analysis of...
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PMID: 19956856
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
Decreased expression of PEDF in primary human lens epithelial cells resulted in a decrease in the expression of vimentin and the increase of alphaB-crystallin expression, two proteins critical for maintaining lens clarity....
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PMID: 20104255
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
To evaluate the effect of the recombinant adeno-associated virus (rAAV) vector that expresses human pigment epithelium-derived factor (hPEDF) on reducing blood-retinal barrier (BRB) breakdown in the experimental diabetic rat model.
Diabetes was induced by an intraperitoneal (i.p.) injection of strep...
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PMID: 21139695
PDF is available here.
PDF is available here.
Cerebrovascular Diseases (29)1 2010
Abstract
The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity....
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PMID: 19907165
PDF is available here.
PDF is available here.
Medical Science Monitor (15)12 2009
Abstract
We propose 9 candidate genes: SERPINB1, FABP4, S100A8, HBEGF, IL7R, LRIG1, PTPN23, DPM2 and NUP214, as genes with high potential for association with sarcoidosis....
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PMID: 19946248
PDF is available here.
PDF is available here.
Abstract
The biological roles of PEDF are diverse and multidimensional. As an anti-cancer agent, PEDF has great potential as a focused anti-neoplastic therapy against a variety of tumor types....
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PMID: 19922300
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)6 2009
Abstract
We evaluated the anticoagulant effect of the algal sulfated galactan using serpin-free plasma. In contrast to heparin, the sulfated galactan is still able to prolong coagulation time and delay thrombin and FXa generation in serpin-free plasma. We further investigated this effect using purified blood...
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PMID: 19967150
PDF is available here.
PDF is available here.
Cell Research (19)12 2009
Abstract
Abstract
We discuss the role of pigment epithelium-derived factor (PEDF) as a possible new target molecule to therapeutically influence cardiovascular disease. PEDF is a multifunctional, pleiotropic protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic and...
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PMID: 19694500
PDF is available here.
PDF is available here.
Abstract
Our aim was to characterize the adipokine response and the extent of colitis in diet-induced obese (DIO) rats. DIO and control, diet-resistant (DR) animals were administered either saline or trinitrobenzene sulfonic acid (TNBS) to induce colitis. Macroscopic damage scores and myeloperoxidase (MPO) a...
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PMID: 20501435
PDF is available here.
PDF is available here.
Croatian Medical Journal (50)5 2009
Abstract
Higher immunostaining score was found in recurrent CSCC tissue sections than in non-recurrent CSCC sections. Serum HMGB1 levels in patients with recurrent CSCC were significantly higher than in patients with non-recurrent disease and healthy controls. The AUC of HMGB1, SCCA, CYFRA21-1, and CEA was 0...
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PMID: 19839069
PDF is available here.
PDF is available here.
Abstract
The results suggest the potential usefulness of MMP-9 in establishing the diagnosis of ESCC, especially when analyzed in combination with SCC-Ag....
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PMID: 19776700
PDF is available here.
PDF is available here.
Cancer Investigation (27)7 2009
Abstract
We performed a differential proteomic profiling study on the serum of HGPIN and prostate cancer patients. Eleven HGPIN patients were enrolled, their serum protein patterns (2D-electrophoresis and mass spectroscopy) were compared with fifteen prostate cancer patients, and the follow-up study was furt...
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PMID: 19637042
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that amylin and vaspin are localized in both human and rat placenta. In the rat term placenta vaspin was demonstrated in the trophoblast of the fetal villi, the labyrinth. Vaspin immunostaining in human placenta was localized in cytotrophoblast and syncytiotrophoblast in the...
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PMID: 19554505
PDF is available here.
PDF is available here.
Abstract
We characterized the serpin (SRPN) gene family in the mosquito Anopheles gambiae, the major malaria vector in Sub-Saharan Africa. We identified 18 A. gambiae SRPN genes, all on chromosomes 2 and 3, through searches of genomic DNA and EST databases. In addition to SRPN10, previously documented to exh...
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PMID: 19394412
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)31 2009
Abstract
Serpins form an enormous superfamily of 40-60-kDa proteins found in almost all types of organisms, including humans. Most are one-use suicide substrate serine and cysteine proteinase inhibitors that have evolved to finely regulate complex proteolytic pathways, such as blood coagulation, fibrinolysis...
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PMID: 19401470
PDF is available here.
PDF is available here.
Abstract
IL-1beta activation may play an important role in the pathogenesis of EBI after SAH. The neurovascular protection of Ac-YVAD-CMK may be provided by the inhibition of JNK-mediated MMP-9 induction and the consequent preservation of tight junction protein ZO-1....
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PMID: 19461019
PDF is available here.
PDF is available here.
Abstract
PEDF was localized mostly in the cytoplasm,while some in the nuclei. The distribution of PEDF in cytoplasm was in a granular pattern. 10% FBS increased the expression of PEDF both in keratinocytes and fibroblasts,but histamine and Phorbol 12-myristate 13-acetate (PMA) did not interfere the distribut...
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PMID: 19693969
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)27 2009
Abstract
We show here that intracellular neuroserpin polymers activate NF-kappaB by a pathway that is independent of the IRE1, ATF6, and PERK limbs of the canonical unfolded protein response but is dependent on intracellular calcium. This pathway provides a mechanism for cells to sense and react to the accum...
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PMID: 19423713
PDF is available here.
PDF is available here.