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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
BRCA1 Protein (0):
Recent article
BRCA1 Protein
Abstract
We would like to review recent patents and the relationship between triple negative and basal-like breast cancers, as well as BRCA1-linked breast carcinomas. Specifically, potential treatment modalities and current innovations that are designed for the predictive and prognostic values of triple nega...
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PMID: 21247402
PDF is available here.
PDF is available here.
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Cell Cycle (10)8 2011
Abstract
We show that RNF8 and RNF168 are recruited to DNA damage foci in late mitosis, presumably to prime sites for 53BP1 recruitment in early G1. Interestingly, we show that, although RNF8, RNF168 and 53BP1 are excluded from DSB sites during most of mitosis, they associate with mitotic structures such as...
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PMID: 21412056
PDF is available here.
PDF is available here.
Abstract
We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
Fifty-six patients with thymic epithelial tumors were included in this...
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PMID: 21289518
PDF is available here.
PDF is available here.
Abstract
We also compared the PGT → aromatase axis in preadipocytes versus adipocytes. Aromatase levels were markedly increased in preadipocytes versus adipocytes. This increase in aromatase was explained, at least in part, by reduced PGT levels leading to enhanced PGE(2) → cAMP → PKA signaling. In add...
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PMID: 21212407
PDF is available here.
PDF is available here.
Abstract
We show that BRCA1 expression is controlled by a dynamic equilibrium between transcriptional coactivators and co-repressors that govern histone acetylation and DNA accessibility at the BRCA1 promoter. Eviction of the transcriptional co-repressor and metabolic sensor, C terminal-binding protein (CtBP...
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PMID: 21102443
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
A simple approach based on electrochemical impedance spectroscopy of a DNA hybridization sensor for breast cancer is reported by immobilizing a BRCA1 related 19 mer oligonucleotides ssDNA sequence on a glassy carbon electrode modified with a poly 5-carboxyindole conducting polymer. Differential puls...
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PMID: 20859573
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
We investigated whether or not CHM-1 induced DNA damage and affected DNA repair gene expression in U-2 OS human osterogenic sarcoma cells. The comet assay showed that incubation of U-2 OS cells with 0, 0.75, 1.5, 3 and 6 μM of CHM-1 led to a longer DNA migration smear (comet tail). DNA gel electrop...
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PMID: 21036739
PDF is available here.
PDF is available here.
Abstract
Previous publications and utilisation of risk models for BRCA1 and BRCA2 mutation identification suggests that multiple primary disease in an individual is a strong predictor of a BRCA1/2 mutation and that this is more predictive than the same cancers occurring in close relatives.
This study assesse...
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PMID: 20472656
PDF is available here.
PDF is available here.
Hawaii medical journal (69)8 2010
Abstract
Cells ability to evade cell death and to proliferate post geno-/cell-toxic stresses, likely leads to formation of cancer. Activation of p38MAPK and p53 following these stresses help protect cells against cancer development by initiating apoptosis. The duration of p38MAPK and p53 activation is regula...
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PMID: 20845286
PDF is available here.
PDF is available here.
Abstract
We have characterized transcription at the progesterone receptor (PR) locus and identified noncoding transcripts that overlap the 3' end of the gene. Small RNAs complementary to sequences beyond the 3' terminus of PR mRNA modulated expression of PR, recruited argonaute 2 to a 3' noncoding transcript...
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PMID: 20581822
PDF is available here.
PDF is available here.
Life Sciences (87)3-4 2010
Abstract
The frequency of tumor hypermethylation was 27% in BRCA1, 32% in MGMT and 25% in GSTP1 and correlated with methylation of these genes in paired serum DNA. Immunohistochemical analysis showed no detectable expression of BRCA1 and MGMT in 51/89 (57%) and 35/89 (39%) tumors, respectively. MGMT promoter...
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PMID: 20470789
PDF is available here.
PDF is available here.
Abstract
Our clinic model has subsequently been adopted in other centres and this will greatly facilitate translational studies and provide a healthcare structure for management and follow-up of such people who are at a high cancer risk....
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PMID: 20472659
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Non-small-cell lung cancer (NSCLC) is a disseminated disease in 50% of cases, with a gloomy prognosis and median survivals of < 1 year. AREAS COVERED IN THIS REVIEW: Based on substantial advances, cancer biology insights and novel biotechnology tools, customized treatment pr...
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PMID: 20486827
PDF is available here.
PDF is available here.
Abstract
We address the role of FANCJ and MLH1 in DNA crosslink processing and how their functions could be linked in checkpoint and/or recombination pathways. We speculate that after DNA crosslink processing and repair, the FANCJ/MLH1 interaction is critical for recovery and restart of replication. These id...
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PMID: 20658644
PDF is available here.
PDF is available here.
Abstract
We have previously identified a K303R ERalpha mutation within the hinge region of ERalpha. This mutation results in an altered posttranslational regulation and increased in vitro growth in the presence of low estrogen concentrations. We sought to determine if cells expressing this mutant ERalpha wou...
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PMID: 19842032
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We use biochemical and cell-based transcriptional assays to assess the structural and functional defects associated with a large set of 117 distinct BRCA1 missense variants within the essential BRCT domain of the BRCA1 protein that have been documented in individuals with a family history of breast...
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PMID: 20516115
PDF is available here.
PDF is available here.
Abstract
We investigated how activation of this pathway by E2, the estrogenic environmental contaminants o,p'-DDT, beta-HCH and p,p'-DDE, and epidermal growth factor (EGF) influences the expression of ER target genes, such as TFF1, ER, PR, BRCA1 and CCND1, and the proliferation of breast cancer cells. Despit...
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PMID: 20206645
PDF is available here.
PDF is available here.
Abstract
We identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of 53BP1 abrogates the ATM-dependent checkpoint response and G2 cell-cycle arrest triggered by the accumulation of DNA breaks in Brca1-deleted cells. This effect of...
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PMID: 20453858
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)20 2010
Abstract
(1) In invasive sporadic ductal breast carcinoma, the positive rate of BRCA1 expression of 60.29% (41/68) was lower than the positive rate of BRCA1 expression at 85.30% (58/68) in adenosis of breast. And the difference of BRCA1 expression between two groups was statistically significant (P < 0.01);...
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PMID: 20646629
PDF is available here.
PDF is available here.
Veterinary Pathology (47)3 2010
Abstract
Several markers of malignancy have been proposed for canine mammary tumors on the mRNA and protein levels. However, their association with tumor malignancy applies only for mean values of large groups of tumors, but no single marker identified to date can be used to reliably predict malignancy for i...
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PMID: 20375427
PDF is available here.
PDF is available here.
Abstract
We have discovered that BRCA1 binding to FANCJ regulates DNA damage repair choice. Thus, when FANCJ binding to BRCA1 is ablated, the molecular mechanism chosen for the repair of damaged DNA is dramatically altered. Specifically, a FANCJ protein that cannot be phosphorylated at serine 990 or bind BRC...
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PMID: 20173781
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4. Loss of 53BP1 alleviates hypersensitivity of Brca1 mutant cells to PARP inhibition and restores...
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PMID: 20362325
PDF is available here.
PDF is available here.
Cancer Research (70)8 2010
Abstract
We hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate cancer progression through regulation of the cell cycle. We used immunohistochemistry to evaluate BRCA1 protein expression in archival tumor samples from 393 prostate cancer cases in the Physicians' Health...
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PMID: 20388772
PDF is available here.
PDF is available here.
Abstract
Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk....
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PMID: 20413709
PDF is available here.
PDF is available here.
Psychology & Health (25)4 2010
Abstract
This randomised controlled trial evaluated the impact of an enhanced counselling (EC) intervention on knowledge about the heritability of breast and ovarian cancer and distress, as a function of BRCA test result, among high-risk women. Before deciding about whether or not to undergo genetic testing,...
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PMID: 20204945
PDF is available here.
PDF is available here.
Genetics in Medicine (12)4 Suppl 2010
Abstract
Genetic testing for inherited susceptibility to breast and ovarian cancer can be compared with similar testing for colorectal cancer as a "natural experiment." Inherited susceptibility accounts for a similar fraction of both cancers and genetic testing results guide decisions about options for proph...
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PMID: 20393305
PDF is available here.
PDF is available here.
Future Oncology (6)4 2010
Abstract
Annals of Surgery (251)3 2010
Abstract
In one asymptomatic BRCA2 carrier (0.7%) an occult small invasive breast cancer was diagnosed, while in 6 asymptomatic carriers (4.0% BRCA1 and 4.3% BRCA2) and in 5 symptomatic carriers (2.5% BRCA1 and 10.7% BRCA2) DCIS was detected at prophylactic mastectomy. No breast cancer occurred in the asympt...
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PMID: 20134318
PDF is available here.
PDF is available here.
Abstract
Breast cancer remains a significant public health problem despite advances in the understanding of the molecular and cellular events that underlie the disease. Crucial pathways regulating the cell cycle, proliferation and survival of breast cancer cells have been investigated and aberrant components...
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PMID: 20187727
PDF is available here.
PDF is available here.
Anticancer Research (30)3 2010
Abstract
We have shown that emodin, aloe-emodin and rhein induced cytotoxic effects, including cell cycle arrest and apoptosis in SCC-4 human tongue cancer cells. However, details regarding their effects on DNA damage and repair gene expression in SCC-4 cells are not clear. We investigated whether or not emo...
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PMID: 20393018
PDF is available here.
PDF is available here.
Familial Cancer (9)1 2010
Abstract
We assessed recommendations for testing to a composite patient (a healthy 13-year-old female, mother is a BRCA mutation carrier) among 161 adolescent and family PCPs attending a national medical conference. Testing recommendations were measured with a multidimensional scale that assessed perspective...
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PMID: 19390990
PDF is available here.
PDF is available here.
Familial Cancer (9)1 2010
Abstract
We conclude with a summary of the role of social, behavioral, and decision science research to support the efforts of providers of familial cancer care regarding this important decision, and to improve the outcomes of cancer genetic testing for tested parents and their nontested children....
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PMID: 19609726
PDF is available here.
PDF is available here.
Familial Cancer (9)1 2010
Abstract
We assessed recommendations for testing to a composite patient (a healthy 13-year-old female, mother is a BRCA mutation carrier) among 161 adolescent and family PCPs attending a national medical conference. Testing recommendations were measured with a multidimensional scale that assessed perspective...
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PMID: 19390990
PDF is available here.
PDF is available here.
Familial Cancer (9)1 2010
Abstract
We conclude with a summary of the role of social, behavioral, and decision science research to support the efforts of providers of familial cancer care regarding this important decision, and to improve the outcomes of cancer genetic testing for tested parents and their nontested children....
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PMID: 19609726
PDF is available here.
PDF is available here.
Familial Cancer (9)1 2010
Abstract
We assessed recommendations for testing to a composite patient (a healthy 13-year-old female, mother is a BRCA mutation carrier) among 161 adolescent and family PCPs attending a national medical conference. Testing recommendations were measured with a multidimensional scale that assessed perspective...
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PMID: 19390990
PDF is available here.
PDF is available here.
Bulletin du cancer (97)3 2010
Abstract
Basal-like carcinomas represent 10 to 15% of invasive breast carcinomas and have been identified from gene expression studies. Morphologically, these tumors are undifferentiated histopronostic grade 3 carcinomas, identified in clinical practice according to their immunophenotype "triple zero" (estro...
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PMID: 20197250
PDF is available here.
PDF is available here.
Cell Cycle (9)4 2010
Abstract
We recently identified a novel gene, KLHDC8B, which appears responsible for some familial cases of cHL. KLHDC8B encodes a midbody kelch protein expressed during cytokinesis. Deficiency of KLHDC8B leads to binucleated cells, implicating its involvement in Reed-Sternberg cell formation. Interestingly,...
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PMID: 20107318
PDF is available here.
PDF is available here.
Cancer Investigation (28)2 2010
Abstract
We investigated the protein levels of RRM1 and two other DNA repair enzymes, ERCC1 and BRCA1, in 55 metastatic breast cancer (MBC) patients undergoing gemcitabine-based chemotherapy. With automated in situ protein quantification (AQUA v1.6), the average scores for RRM1, ERCC1, and BRCA1 ranged from...
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PMID: 19968494
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the BRCA1/BARD1 complex can ubiquitylate both free H2A and H2B histones and histones in the context of nucleosomal particles. These results raise the possibility that BRCA1/BARD1 can directly affect nucleosomal structure, dynamics, and function through its ability to modify nucle...
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PMID: 19916563
PDF is available here.
PDF is available here.
EMBO Journal (29)3 2010
Abstract
We investigate the functions of these mediator proteins in ATM activation and find that the presence of 53BP1 and BRCA1 can amplify the effects of MRN when interactions between MRN and ATM are compromised. This effect is dependent on a direct interaction between MRN and the tandem breast cancer carb...
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PMID: 20010693
PDF is available here.
PDF is available here.
Biochemical Society transactions (38)Pt 1 2010
Abstract
Modification by SUMOs (small ubiquitin-related modifiers) is largely transient and considered to alter protein function through altered protein-protein interactions. These modifications are significant regulators of the response to DNA damage in eukaryotic model organisms and SUMOylation affects a l...
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PMID: 20074042
PDF is available here.
PDF is available here.
Biochemical Society transactions (38)Pt 1 2010
Abstract
The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among th...
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PMID: 20074046
PDF is available here.
PDF is available here.
Abstract
We describe the discovery of a novel series of pyrrolo[1,2-a]pyrazin-1(2H)-one PARP inhibitors. Optimization led to compounds that display excellent PARP-1 enzyme potency and inhibit the proliferation of BRCA deficient cells in the low double-digit nanomolar range showing excellent selectivity over...
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PMID: 20031401
PDF is available here.
PDF is available here.
Cancer Research (70)3 2010
Abstract
We have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes regulated by BRCA1 on the level of transcription. Among the genes repressed by BRCA1, we have identified amphiregulin (AREG) and early growth response-1 (EGR1). Results indicate that BRCA1 regulates AREG...
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PMID: 20103632
PDF is available here.
PDF is available here.
Clinical Genetics (77)2 2010
Abstract
Clinical Genetics (77)2 2010
Abstract
Clinical Genetics (77)2 2010
Abstract
Clinical Genetics (77)2 2010
Abstract
Clinical Genetics (77)2 2010
Abstract
Abstract
Phase I clinical trial results confirm that PARP inhibitors have single agent activity in cancers with BRCA 1/2 mutations. Phase II data also suggest a benefit in combination with chemotherapy in triple-negative breast cancers without an increase in normal tissue toxicity. SUMMARY: There are current...
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PMID: 19934756
PDF is available here.
PDF is available here.
Abstract
We determined whether there was any difference in CCND1 (11q13) and ZNF217 (20q13) gene amplification with respect to BRCA status. Of 40 breast cancer samples examined, 15 and 9 were from BRCA1 and BRCA2 mutation carriers, respectively, and 16 from patients without mutation. Fluorescence in situ hyb...
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PMID: 20429623
PDF is available here.
PDF is available here.
Georgian medical news ()184-185 2010
Abstract
We set out to study the immunohistochemical expression of BRCA1 protein in breast cancer and assess associations with lymph node status, histologic grade and expression of other biomarkers. We examined 100 patients aged from 21 to 71 years diagnosed with invasive ductal carcinoma. Immunohistochemist...
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PMID: 20834076
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (128)1-3 2010
Abstract
We detected in these chromocenters the typical highly repeated DNA of this genus after in situ hybridization, the M31 chromodomain through immunofluorescence as well as dense Giemsa staining after C-banding. In species that present low amounts of heterochromatin, only 1 or 2 chromocenters were obser...
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PMID: 20389031
PDF is available here.
PDF is available here.
Abstract
We are developing assays to determine which mutations adversely affect the functions of the protein encoded by the BRCA1 gene. The functions of BRCA1 are mediated by numerous interactions that are required for cell-cycle and centrosome control, transcriptional regulation and the DNA damage response....
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PMID: 20721750
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time that BRCA1 is methylated both in breast cancer cell lines and breast cancer tumor samples at arginine and lysine residues through immunoprecipitation and western blot analysis. Arginine methylation by PRMT1 was observed in vitro and the region of BRCA1 504-802 shown...
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PMID: 20614009
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time that BRCA1 is methylated both in breast cancer cell lines and breast cancer tumor samples at arginine and lysine residues through immunoprecipitation and western blot analysis. Arginine methylation by PRMT1 was observed in vitro and the region of BRCA1 504-802 shown...
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PMID: 20614009
PDF is available here.
PDF is available here.
The Cancer Journal (16)1 2010
Abstract
We broaden the scope of this topic by addressing a "repair-defective" rather than "BRCA1-like" phenotype. We discuss structural and functional aspects of key repair proteins including BRCA1, BRCA2, BRCA1 interacting protein C-terminal helicase 1, and partner and localizer of BRCA2 and describe the p...
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PMID: 20164689
PDF is available here.
PDF is available here.
Abstract
We show that SUMO1, SUMO2 and SUMO3 accumulate at DSB sites in mammalian cells, with SUMO1 and SUMO2/3 accrual requiring the E3 ligase enzymes PIAS4 and PIAS1. We also establish that PIAS1 and PIAS4 are recruited to damage sites via mechanisms requiring their SAP domains, and are needed for the prod...
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PMID: 20016603
PDF is available here.
PDF is available here.
Abstract
We transformed immortalized human mammary epithelial cells, MCF10A, with or without BRCA1/p53 gene-specific knockdowns. Stable knockdown of BRCA1 alone in MCF10A cells led to centrosome amplification, impaired p53 protein stability, increased sensitivity towards DNA-damaging agents, defective chromo...
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PMID: 20038817
PDF is available here.
PDF is available here.