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Core Binding Factors (2):
Recent article
Core Binding Factors
Abstract
In three-dimensional versus two-dimensional cultures, osteogenesis increased significantly in human cells but decreased in murine cells; angiogenesis increased regardless of species. Since three-dimensional cultures represent in vivo conditions more closely, this species variation has important tran...
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PMID: 19952643
PDF is available here.
PDF is available here.
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Abstract
The biological and prognostic heterogeneity of both CBF-AML subtypes, including gene mutation and gene expression profiles as well as molecular response to therapy, has been recently described. SUMMARY: These new insights in the heterogeneity of CBF-AML suggest that a tailored approach might be pref...
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PMID: 19468270
PDF is available here.
PDF is available here.
Abstract
Thus, our data lends clinical credence to the observed modulation of ara-C by fludarabine and GCSF.
(c) 2008 American Cancer Society...
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PMID: 18932257
PDF is available here.
PDF is available here.
Abstract
We report a genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with common translocations, including t(8;21)/AML1(RUNX1)-ETO(RUNX1T1), inv(16)/CBFB-MYH11, t(15;17)/PML-RARA, and MLL rearrangements. Distinct miRNA expression patterns were observed for t(15;17), MLL rearr...
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PMID: 18832181
PDF is available here.
PDF is available here.
Abstract
We present a concise review on complementing mutations in CBF leukemias including pathophysiology, mouse models, and clinical implications....
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PMID: 18604246
PDF is available here.
PDF is available here.
Leukemia Research (32)9 2008
Abstract
We report on a 75-year-old female presenting with a Core-binding Factor (CBF) AML of M4eo subtype. The patient also had jaundice, highly elevated bilirubin, lipase, alkaline phosphatase (AP), CA 19-9, and a pancreatic mass highly suspicious of infiltrating pancreatic carcinoma. However, a biopsy dem...
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PMID: 18456326
PDF is available here.
PDF is available here.
Seminars in Oncology (35)4 2008
Abstract
Core binding factor (CBF) acute myeloid leukemia (AML) is cytogenetically defined by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22), which are found in approximately 15% of all adult de novo AML cases. At the molecular level, both cytogenetic abnormalities result in disruption...
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PMID: 18692691
PDF is available here.
PDF is available here.
JNCI Monographs (2008)39 2008
Abstract
Acquired genetic alterations such as balanced and unbalanced chromosome aberrations and submicroscopic gene mutations and changes in gene expression strongly affect pretreatment features and prognosis of adults with acute myeloid leukemia (AML). The most frequent chromosome/molecular rearrangements,...
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PMID: 18648004
PDF is available here.
PDF is available here.
FASEB Journal (22)7 2008
Abstract
We show that oocyte-specific deletion at the primary follicle stage of core 1 beta1,3-galactosyltransferase (T-synthase; generates core 1-derived O-glycans), leads to a sustained increase in fertility. T-syn mutant females ovulated 30-50% more eggs and had a sustained increase in litter size compare...
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PMID: 18276833
PDF is available here.
PDF is available here.
Plant Molecular Biology (67)3 2008
Abstract
A cluster of eleven CBF genes was recently mapped to the Frost resistance-2 (Fr-Am2) locus on chromosome 5 of diploid wheat (Triticum monococcum) using a cross between frost tolerant accession G3116 and frost sensitive DV92. The Fr-Am2 locus was mapped at the peak of two overlapping quantitative tra...
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PMID: 18317935
PDF is available here.
PDF is available here.
Abstract
IS induced aortic calcification with expression of osteoblast-specific proteins and aortic wall thickening. IS is not only a nephrotoxin but also a vascular toxin, and may contribute to the progression of aortic calcification in stage 5 CKD patients....
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PMID: 18334529
PDF is available here.
PDF is available here.
Nature Neuroscience (11)4 2008
Abstract
We found that, in rat hippocampus, the insertion of AMPA receptors (AMPARs) into spines during synaptic plasticity requires a specific motor protein, which we identified as myosin Va. We found that myosin Va associates with AMPARs through its cargo binding domain. This interaction was enhanced by ac...
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PMID: 18311135
PDF is available here.
PDF is available here.
Abstract
Enamel matrix derivative inhibited ALP activity from the early stage of culture (29-44% inhibition) on days 5 and 10 and decreased bone nodule formation by 37-67% on day 17. These effects of EMD were concentration dependent. Enamel matrix derivative inhibited mRNA expression of osteocalcin and core...
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PMID: 18302620
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)3 2008
Abstract
We examined the prognostic utility of serial bone marrow minimal residual disease (MRD) monitoring by RQ-PCR in a cohort of patients with CBF AML with long term clinical follow-up. Twenty-nine patients were evaluated with a median follow of 34 months. Twelve relapses occurred at a median of 11 month...
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PMID: 18297529
PDF is available here.
PDF is available here.
Abstract
We analyzed receptor tyrosine kinases (RTKs) and Ras mutations on 154 children with AML. Also, we examined the paired diagnosis and relapse samples in CBF-AML. CBF-AML accounted for 27% (41/154). c-KIT mutations were detected in 41.5% of CBF-AML at diagnosis (6 in exon 8, 10 in exon 17 and 1 in both...
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PMID: 17960171
PDF is available here.
PDF is available here.
Anticancer Research (28)5A 2008
Abstract
Three types of single-nucleotide polymorphism (SNP) were detected in the PDGFRA gene (exon 12, exon 13 and exon 18) while no mutation of PDGFRB was detected in the tested CBFLs. CONCLUSION: These data showed that no pathogenic mutations in PDGFRA and PDGFRB were detected in the context of CBFL witho...
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PMID: 19035305
PDF is available here.
PDF is available here.
Biochemistry (Washington) (46)49 2007
DNA recognition via mutual-induced fit by the core-binding domain of bacteriophage lambda integrase.
Abstract
Bacteriophage lambda integrase (lambda-Int), a phage-encoded DNA recombinase, cleaves its substrate DNA to facilitate the formation and later resolution of a Holliday junction intermediate during recombination. The core-binding and catalytic domains of lambda-Int constitute a bipartite enzyme that m...
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PMID: 18001133
PDF is available here.
PDF is available here.
Archives of Internal Medicine (167)21 2007
Abstract
Abstract
We investigated hypermethylation of the DKK1 promoter in patients with acute myeloid leukaemia (AML), especially core-binding factor (CBF) leukaemia. The methylation status of DKK1 was analysed using methylation-specific polymerase chain reaction in 47 patients with AML. DKK1 methylation was found i...
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PMID: 17686056
PDF is available here.
PDF is available here.
Abstract
We profiled gene expression in a large series (n = 93) of AML patients with CBF leukemia [(inv (16), n = 55; t(8;21), n = 38)]. By unsupervised hierarchical clustering we were able to define a subgroup of CBF cases (n = 35) characterized by shorter overall survival times (P = .03). While there was n...
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PMID: 17485551
PDF is available here.
PDF is available here.
Haematologica (92)1 2007
Abstract
We investigated a large number of acute myeloid leukemia (AML) samples (n=959) for the presence of the JAK2 V617F mutation. We found a low incidence of the mutation in these AML samples (1%). JAK2 V617F mutations clustered in AML samples with an aberrant karyotype (p<0.05). The incidence of JAK2 V61...
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PMID: 17229652
PDF is available here.
PDF is available here.
Abstract
We analysed gene expression profiles of leukaemic cells by microarray, and selected genes whose expression appeared to be modulated in association with t(8;21) and inv(16). In a pair-wise comparison, 15% of t(8;21)-associated transcripts exhibited high or low expression in inv(16)-AML, and 26% of in...
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PMID: 16989659
PDF is available here.
PDF is available here.
Abstract
To better understand the spectrum of adult acute myeloid leukaemia (AML) associated with core binding factor (CBF) translocations, 370 patients with newly diagnosed CBF-associated AML were analysed. Patients' age ranged from 16-83 years (median 39 years) with a slight male predominance (55%); 53% ha...
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PMID: 16939487
PDF is available here.
PDF is available here.
Abstract
In core binding factors (CBF) acute myeloid leukemia (AML), the disruption of CBFalpha/beta genes impairs normal hematopoietic differentiation and is supposed to cooperate with additional mutations promoting proliferation. The incidence and the prognosis of receptor tyrosine kinase (RTK) c-Kit and F...
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PMID: 16598313
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (20)5 2006
Abstract
By gross examination,mature hard new bone formed at grafted areas at 12 weeks postoperatively in group A, osteotomized ends connected by much callus in group B and less callus in group C at grafted areas. In contrast, bone nonunion formed in group D. X-ray and histological examination showed that th...
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PMID: 16752849
PDF is available here.
PDF is available here.
Abstract
Distinct forms of tyrosine kinase domain (TKD), juxtamembrane domain, exon 8, and internal tandem duplication (ITD) mutations of c-KIT, were observed in about 46% of core binding factor leukemia (CBFL) patients. To evaluate their prognostic significance, 67 adult patients with CBFL were analyzed to...
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PMID: 16384925
PDF is available here.
PDF is available here.
Abstract
Abstract
We screened for the expression of the FIP1L1-PDGFRalpha fusion gene and for mutations in the juxtamembrane and tyrosine kinase domains of PDGFRalpha/beta genes in 22 cases of CBF leukemia with eosinophilia. Among these cases, no FIP1L1-PDGFRalpha fusion gene was found. Although cDNA sequencing also...
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PMID: 16343267
PDF is available here.
PDF is available here.
Abstract
We demonstrate that these complex insertion and deletion mutations lead to constitutive activation of the KIT receptor, which induces factor-independent growth of interleukin-3 (IL-3)-dependent cells. Mutation of the evolutionary conserved amino acid D419 within the extracellular domain was sufficie...
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PMID: 16081693
PDF is available here.
PDF is available here.
Endocrinology (146)9 2005
Abstract
We examined proliferation of cells associated with PTH-induced peritrabecular bone marrow fibrosis in rats as well as the fate of those cells after withdrawal of PTH. Time-course studies established that severe fibrosis was present 7 d after initiation of a continuous sc PTH infusion (40 microg/kg.d...
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PMID: 15947001
PDF is available here.
PDF is available here.
Abstract
We genotyped 150 pediatric AML samples for mutations in KIT (exons 8, 17), NRAS and KRAS (exons 1, 2) and FLT3/ITD. This is the largest cohort of pediatric AML patients reported thus far screened for all four mutations. Of the children with AML, 40% had a mutation in KIT (11.3%), RAS (18%) or FLT3/I...
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PMID: 16015387
PDF is available here.
PDF is available here.
Abstract
I collagen, core-binding factor-1, alkaline phosphatase, and osteonectin; the ability of matrix mineralization and ALP enzymatic activity showed the osteogenic character of the constructs. A significant correlation between the expression of Ets2 and osteopontin mRNA (r = -0.70; p < 0.05) could be sh...
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PMID: 15900611
PDF is available here.
PDF is available here.
Abstract
We analyzed the proproliferative and antiapoptotic potential of 3 KIT exon 8 mutations in interleukin 3 (IL-3)-dependent Ba/F3 cells. All KIT exon 8 mutants induced receptor hyperactivation in response to stem cell factor (SCF) stimulation in terms of proliferation and resistance toward apoptotic ce...
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PMID: 15618474
PDF is available here.
PDF is available here.
Leukemia Research (29)4 2005
Abstract
We did not observe any activity against acute myeloid leukemia (AML) associated with KIT kinase mutations. However, in the patient with extracellular juxtamembrane mutation, Imatinib seems to have some clinical beneficial effect and, most important, is able to abrogate the leukemic subclone carrying...
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PMID: 15725473
PDF is available here.
PDF is available here.
Abstract
Our study demonstrates that EMD stimulates Cbfa1/Runx2 expression and the phosphorylation of Smad1, and that both of these processes can be blocked by noggin. Therefore, the osteogenic activity of EMD may be mediated by BMPlike molecules in EMD....
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PMID: 15974848
PDF is available here.
PDF is available here.
Abstract
We characterised FKBP12 in osteoblasts and investigated the role of FK506 in modulating osteoblast-specific transcription factors, core-binding factor alpha1 (Cbfa1) and osterix gene expression in ROS 17/2.8 cells. RT-PCR, immunolocalisation and Western blotting studies were employed to identify and...
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PMID: 15780950
PDF is available here.
PDF is available here.
Abstract
We applied an adenoviral vector carrying their genes to transduce primary osteoprogenitor cells in vitro and in vivo. Overexpression of the two isoforms induced rapid and marked osteoblast differentiation, with Til-1 being more effective in vitro, by examination of the alkaline phosphatase activity,...
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PMID: 15537653
PDF is available here.
PDF is available here.
Abstract
We report that p204, an interferon-inducible protein that was previously shown to inhibit cell proliferation and promote the differentiation of myoblasts to myotubes, is a novel regulator in the course of osteogenesis. p204 is expressed in embryonic osteoblasts and hypertrophic chondrocytes in the g...
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PMID: 15557274
PDF is available here.
PDF is available here.
Nucleic Acids Research (33)13 2005
Abstract
We report results from molecular dynamics (MD) simulations of RD alone, as a dimer in complexes with DNA and CBFbeta and in a ternary complex with DNA and CBFbeta. Consistent with the experimental findings, in the presence of CBFbeta the estimated free energy of binding of RD to the DNA is more favo...
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PMID: 16049027
PDF is available here.
PDF is available here.
Abstract
We describe the expression pattern of the ctgf gene in the calcifying tissues of normal developing mouse embryos in comparison with that in core binding factor a1 (Cbfa1)-targeted mutant (cbfa1-null) mouse embryos, in which impaired development and growth were characteristically observed in the skel...
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PMID: 15981023
PDF is available here.
PDF is available here.
Der Orthopäde (33)12 2004
Abstract
Cyclic stretching increased cell proliferation. The expression of osteogenic markers was slightly increased by mechanical strain. The cells and matrix were strictly oriented in the stress direction. CONCLUSION: The application of mechanical load might have a beneficial effect on the quality and quan...
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PMID: 15578256
PDF is available here.
PDF is available here.
Laboratory Investigation (84)11 2004
Abstract
We wanted to identify specific target genes of endostatin. For this purpose, the human renal cell carcinoma RC-9 was subcutaneously implanted in nude mice and treated with endostatin. Tumor growth was inhibited by endostatin after 4 days of treatment. Using immunohistochemistry and the hypoxia marke...
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PMID: 15273700
PDF is available here.
PDF is available here.
Haematologica (89)8 2004
Abstract
These results underline that the KIT gene is activated in AML characterized by distinct cytogenetic and molecular genetic patterns and represents the most frequently mutated target in adult CBFL....
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PMID: 15339674
PDF is available here.
PDF is available here.
Abstract
We have described a robust multiplex RT-PCR assay that incorporates experimentally validated control genes that are important for accurate interpretation. The assay is more sensitive than cytogenetics in the detection of CBF AML. Application to large patient cohorts will determine the prognostic sig...
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PMID: 15370133
PDF is available here.
PDF is available here.
Abstract
We monitored the expression of genes involved in calcification upon exposure of human coronary artery endothelial cells (HCAECs) to atherogenic stimuli. Genes studied were: core binding factor alpha-1 (Cbfa1/Runx2), a pivotal transcriptional regulator of osteogenesis; bone morphogenetic protein-2 (B...
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PMID: 15219845
PDF is available here.
PDF is available here.
Abstract
We report that the novel exon that gives rise to these variants (exon 6.1) is located over 100 kb downstream of exon 6 in the mouse, rat and human genomes. Exon 6.1 spans a CpG-rich island, and human/rodent conservation is evident through the coding sequence and the 3' untranslated region (UTR). Rev...
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PMID: 15225881
PDF is available here.
PDF is available here.
Abstract
I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family....
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PMID: 15156173
PDF is available here.
PDF is available here.
Abstract
We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for these proteins in autoimmunity....
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PMID: 15156179
PDF is available here.
PDF is available here.
Abstract
RUNX proteins are evolutionarily well-conserved transcription factors that are involved in essential aspects of the development of metazoan animals ranging from nematodes to humans. Genetic or epigenetic defects in any one of the three RUNX proteins in humans cause severe diseases. Although much is...
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PMID: 15156192
PDF is available here.
PDF is available here.
Abstract
We used a recombinant adenoviral vector carrying the mouse cbfa1/osf2 gene to transduce primary cultured bone marrow stromal cells (MSCs) of BALB/c mice. We found that Ad-cbfa1/osf2-transduced MSCs produced cbfa1/osf2 protein and differentiated into osteoblast-like cells. The transduced MSCs had inc...
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PMID: 14595529
PDF is available here.
PDF is available here.
Abstract
EMD promotes both proliferation and differentiation of MC3T3-E1 cells and indirectly inhibits osteoclastogenesis and osteoclast function by stimulating the expression of OPG....
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PMID: 14970783
PDF is available here.
PDF is available here.
Archives of Oral Biology (49)2 2004
Abstract
These results suggest that Cbfa1 is a master gene controlling the functions of all the skeletal cell lineages by synthesising different functional isoforms. Furthermore, Cbfa1 couples the process of chondrocytes maturation, extracellular matrix mineralisation and degradation, as well as osteoblasts...
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PMID: 14693204
PDF is available here.
PDF is available here.
Cell Biology International (28)10 2004
Abstract
We analyzed the effects of TNF-alpha on the human osteosarcoma cell line Saos2. We used RT-PCR to examine the effects of TNF-alpha on bone sialoprotein (BSP), core binding factor a1 (Cbfa1), osterix, alpha 1 (I) collagen, cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), cathepsin B, cathepsin L and t...
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PMID: 15516323
PDF is available here.
PDF is available here.
Abstract
We examined the effect of magnetic force on differentiation of cultured human osteoblasts. Magnetic microparticles (MPs) were introduced into the cytoplasm of a human osteoblast cell line and the cells were cultured in a magnetic field (MF) in group MP-MF. Three groups of controls were used: cells w...
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PMID: 14575691
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (83)15 2003
Abstract
I collagen in the cultured BMSCs. Histochemical technique was used to examine the expression of alkaline phosphatase (AKP) in the BMSCs. Inversed phase-contrast microscopy and electron microscopy were used to observe the morphology and proliferation of the BMSCs. Induced BMSCs at passage 3 were harv...
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PMID: 12930691
PDF is available here.
PDF is available here.
FASEB Journal (17)11 2003
Abstract
These results suggest that heteromeric NMDA receptor channels may be functionally expressed to regulate mechanisms underlying cellular differentiation rather than proliferation and/or maturation through modulation of expression of CBFA1 in cultured rat calvarial osteoblasts....
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PMID: 12824297
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (205)1-2 2003
Abstract
We cloned 3.0 kb of the human Runx2/Cbfa1 gene 5'-upstream flanking region and created a series of promoter deletions cloned into luciferase-based reporter vectors (Runx2/Cbfa1/Luc). Sequence data revealed six copies of the osteoblastic cis-acting element (OSE2) in the proximal promoter region. In C...
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PMID: 12890574
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)30 2003
Abstract
We examined the effect of Smurf1 on Cbfa1 degradation in osteoblast precursor cells. Smurf1 interacts directly with Cbfa1 and mediates Cbfa1 degradation in a ubiquitin- and proteasome-dependent manner. Because Smurf1 controls the intracellular concentrations of several key molecules in the bone form...
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PMID: 12738770
PDF is available here.
PDF is available here.
Endocrinology (144)6 2003
Abstract
We investigated whether steroid hormones interfere with PTH signaling by modulating PTH-induced RGS-2 expression in osteoblast-like UMR 106-01 cells. PTH (1-34) rapidly and transiently induced expression of RGS-2 mRNA and protein via the cAMP/protein kinase A pathway within 30 min, with maximal prot...
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PMID: 12746312
PDF is available here.
PDF is available here.
Abstract
These results suggest that the odontogenic epithelium differentiated into squamous epithelial cells, which began as ghost cells in the COC, and that this process depended on the dystrophic calcification of differentiated odontogenic epithelial cells, not of osteogenic cells....
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PMID: 12956090
PDF is available here.
PDF is available here.