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Erythroid-Specific DNA-Binding Factors (5):
Recent article
Erythroid-Specific DNA-Binding Factors
Abstract
We used a gene complementation strategy combined with microarray screening to identify miRNAs involved in the formation of erythroid (red blood) cells. Two conserved miRNAs, miR 144 and miR 451, emerged as direct targets of the critical hematopoietic transcription factor GATA-1. In vivo, GATA-1 bind...
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PMID: 18303114
PDF is available here.
PDF is available here.
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Abstract
We postulate that the C allele of rs361072 is a causal variant capable of attenuating insulin resistance in obese children through increased expression of p110beta....
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PMID: 17977952
PDF is available here.
PDF is available here.
Abstract
We report the isolation and detailed study of a newly identified zebrafish ugly duckling (Udu) mutant allele, Udu(sq1). We show that loss-of-function mutation in the udu gene disrupts primitive erythroid cell proliferation and differentiation in a cell-autonomous manner, resulting in red blood cell...
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PMID: 17369489
PDF is available here.
PDF is available here.
Experimental Hematology (35)5 2007
Abstract
These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells: interleukin-3 regulates mainly gene transcription and erythropoietin consistently increases mRNA and protein stability....
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PMID: 17577923
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate a novel interaction between the serine/threonine kinase Akt and members of the hSWI/SNF chromatin remodeling complex. Activation of Akt in HeLa cells resulted in its association with hSWI/SNF subunits: INI1, BAF155 and BAF170, as well as actin. BAF155 became preferentially re...
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PMID: 16568092
PDF is available here.
PDF is available here.
Journal of General Virology (87)Pt 1 2006
Abstract
CCAAT/enhancer-binding protein beta (C/EBPbeta) can function as a repressor or as an activator of human papillomavirus (HPV) gene expression, depending on which cell type the experiments are conducted. In this report, it was shown that within primary human foreskin keratinocyte cells (HFK) the activ...
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PMID: 16361417
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)50 2005
Abstract
We compared the effects of either reducing or ablating Scl using morpholino-modified antisense RNAs. Ablation of Scl resulted in the loss of primitive and definitive hematopoiesis, consistent with its essential role in these processes. Interestingly, in embryos with severely reduced Scl levels, eryt...
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PMID: 16210319
PDF is available here.
PDF is available here.
Abstract
We hypothesized that NO inhibits YY1 activity via S-nitrosation of critical cysteines residues coordinated by Zn2+. Treatment of PC-3 cells with DETA/NONOate inhibited the constitutive DNA-binding activity of YY1 as assessed by EMSA. Further, treatment with DETA/NONOate resulted in S-nitrosation of...
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PMID: 16143308
PDF is available here.
PDF is available here.
Journal of Virology (79)20 2005
Abstract
The initiation and termination of vaccinia virus postreplicative transcription have been reported to require cellular proteins, some of which are believed to be nuclear proteins. Vaccinia virus replicates in the cytoplasmic compartment of the cell, raising questions as to whether vaccinia virus has...
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PMID: 16188987
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that nucleophosmin/B23 plays an important role in the regulation of PCNA through YY1....
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PMID: 16099430
PDF is available here.
PDF is available here.
Abstract
Despite the extraordinary task of packaging mammalian DNA within the constraints of a cell nucleus, individual genes assemble into cell type-specific chromatin structures with high fidelity. This chromatin architecture is a crucial determinant of gene expression signatures that distinguish specific...
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PMID: 15887235
PDF is available here.
PDF is available here.
Abstract
We have previously shown that PU.1 functions as both a transcriptional activator and repressor through complex formation with CBP/p300 and HDAC1/mSin3A/MeCP2, respectively. To determine whether modification of PU.1 is responsible for switching its association between co-activators and co-repressors,...
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PMID: 16098914
PDF is available here.
PDF is available here.
Abstract
We propose that erythrocytes are an ideal instrument for this strategy, because they are present in vast numbers, permeate every organ, and cannot serve as hosts for viral propagation. To test this hypothesis, we generated a transgenic mouse, termed globin transcription factor 1 (GATA1)-coxsackie an...
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PMID: 16123123
PDF is available here.
PDF is available here.
Abstract
We investigated the occurrence of GATA-1 abnormalities in IM patients. CD 34(+) cells were purified from 12 IM patients and 8 controls; erythroblasts and megakaryocytes were then obtained from unilineage cultures of CD 34(+) cells. Purified CD 61(+), GPA(+), and CD 34(+) cells from IM patients conta...
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PMID: 16127162
PDF is available here.
PDF is available here.
Cancer Research (65)17 2005
Abstract
We and others have shown acquired mutations in the X chromosome gene GATA1 in all these cases. The gene or genes on chromosome 21 whose overexpression promote the megakaryoblastic phenotype are presently unknown. We propose that ERG, an Ets transcription factor situated on chromosome 21, is one such...
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PMID: 16140924
PDF is available here.
PDF is available here.
Abstract
We report here that erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt. We found that Akt directly phosphorylates the transcription factor GATA-1 at serine 310 and that...
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PMID: 16107690
PDF is available here.
PDF is available here.
Abstract
We generated mafG::mafF double-mutant mice possessing MafK as the single available small Maf. Induction of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene was significantly impaired in double-mutant mice treated with butylated hydroxyanisole, while other ARE-dependent genes were less affected. Simi...
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PMID: 16135796
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (280)33 2005
Abstract
We report that, upon interleukin-3 stimulation of Ba/F3 cells, the transcription factor GATA-1 is strongly phosphorylated at residue serine 26 by a MAPK-dependent pathway. Phosphorylation of GATA-1 increases GATA-1-mediated transcription of the E4bp4 survival gene without significantly changing the...
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PMID: 15967790
PDF is available here.
PDF is available here.
Biochemical Pharmacology (70)4 2005
Abstract
In the rat, the alpha2B-adrenergic receptor (alpha2B-AR) is encoded by the rat non-glycosylated (RNG) gene and is primarily expressed in the kidney, brain and liver of adult animals. High levels of alpha2B-AR are also found during fetal life in the placenta, liver and blood, where it is borne by cel...
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PMID: 15993847
PDF is available here.
PDF is available here.
Abstract
We first compared the gene expression profile between wild-type and GATA-1-deficient megakaryocytes. Next, we introduced either GATA-1s or a FOG-binding mutant (V205G) into GATA-1-deficient megakaryocytes and assessed the effect on differentiation and gene expression. Whereas GATA-1-deficient megaka...
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PMID: 15860665
PDF is available here.
PDF is available here.
Molecular Cell (19)3 2005
Abstract
We show that H3K9 di- and trimethylation occur in the transcribed region of active genes in mammalian chromatin. This modification is dynamic, as it increases during activation of transcription and is rapidly removed upon gene repression. Heterochromatin Protein 1gamma (HP1gamma), a protein containi...
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PMID: 16061184
PDF is available here.
PDF is available here.
Seminars in Oncology (32)4 2005
Abstract
The primary genetic lesion(s), as well as the biological processes responsible for the typical structural changes of the bone marrow microenvironment in idiopathic myelofibrosis, are still poorly understood, although a central role in disease pathogenesis has been attributed to the clonal proliferat...
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PMID: 16202682
PDF is available here.
PDF is available here.
Abstract
We cloned a Melk-like gene from zebra fish (zMelk). zMelk-like gene was expressed in the brain and lateral mesoderm at 12 hours postfertilization (hpf) and in several tissues of adult fish, including the kidney and spleen, both of which are known to be hematopoietic tissues in zebra fish. Abrogation...
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PMID: 16024803
PDF is available here.
PDF is available here.
Abstract
We examined how these proteins interact functionally in G1E cells, a GATA-1(-) erythroblast line that proliferates in an SCF-dependent fashion and, upon restoration of GATA-1 function, undergoes GATA-1 proliferation arrest and Epo-dependent terminal maturation. We show that SCF-induced cell cycle pr...
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PMID: 16024808
PDF is available here.
PDF is available here.
Abstract
We report the effects of these deletions on chromatin structure in the beta-globin locus of adult erythroblasts. The 234-bp 5'HS3 deletion abolished histone acetylation throughout the beta-globin locus; recruitment of RNA polymerase II (pol II) to the LCR and beta-globin gene promoter was reduced to...
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PMID: 16055715
PDF is available here.
PDF is available here.
Genes to Cells (10)7 2005
Abstract
We set to investigate the regulatory mechanism of the Rb promoter that allows adequate up-regulation in differentiating myoblasts. We report that Rb expression is regulated by the transcription factors GABP, HCF-1 and YY1. Before induction of differentiation, Rb is expressed at a low level and GABP...
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PMID: 15966902
PDF is available here.
PDF is available here.
Abstract
Abstract
We observed that low nuclear YY1 staining is an independent predictor of a shorter time to recurrence (p = 0.012). Based on these results, we hypothesize that YY1 may play a role in prostate cancer development; however, decreased YY1 may give metastatic cells a survival advantage. These results may...
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PMID: 15942652
PDF is available here.
PDF is available here.
Oncology Reports (14)1 2005
Abstract
Vanadium complexes are known to possess potent insulin-mimetic effects, high affinity for several enzymes and anticancer activity, which deserve increasing attention for application to biomedical sciences. Different vanadium complexes have been found to be more effective than the simple vanadium-(IV...
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PMID: 15944761
PDF is available here.
PDF is available here.
EMBO Journal (24)13 2005
Abstract
We show that FOG-1 binds to the NuRD corepressor complex in vitro and in vivo. The interaction is mediated by a small conserved domain at the extreme N-terminus of FOG-1 that is necessary and sufficient for NuRD binding. This domain defines a novel repression module found in diverse transcriptional...
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PMID: 15920470
PDF is available here.
PDF is available here.
EMBO Journal (24)13 2005
Abstract
We describe distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes. Importantly, we show that FOG-1 mediates GATA-1 interactions with the...
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PMID: 15920471
PDF is available here.
PDF is available here.
Abstract
We analyzed cytochrome c release, MtF expression, and gene expression during erythroid differentiation in bone marrow cells from myelodysplastic syndrome (MDS) patients and healthy controls. Whereas none or few cultured erythroid cells from healthy individuals and RA patients expressed MtF, those fr...
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PMID: 15755901
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)26 2005
Abstract
We examined the cooperative effect of Yin Yang 1 (YY1) on AP-2-induced activation of ERBB2 promoter activity. We detected high levels of YY1 transcription factor in mammary cancer cell lines. Notably, we showed that YY1 enhances AP-2alpha transcriptional activation of the ERBB2 promoter through an A...
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PMID: 15870067
PDF is available here.
PDF is available here.
Journal of Molecular Biology (349)5 2005
Abstract
We have previously identified contiguous silencer-enhancer elements located on the 3'-side of the domain. To better characterize the enhancer we performed a systematic functional analysis to define its expression influence range and the ubiquitous and stage-specific transcriptional regulators intera...
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PMID: 15913647
PDF is available here.
PDF is available here.
Abstract
We generated GATA-1 promoter-driven Runx1 transgenic (Tg) mice, which showed a transient mild increase of megakaryocyte marker-positive myeloid cells but no spontaneous leukemia. These mice were then crossed with BXH2 mice, which have a replication-competent retrovirus in the mouse and develop myelo...
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PMID: 15856017
PDF is available here.
PDF is available here.
Journal of Experimental Medicine (201)12 2005
Abstract
Eosinophil lineage-committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow. Purified granulocyte/monocyte progenitors (GMPs) gave rise to eosinophils as well as neutrophils and monocytes at the single cell level. Within the short-term culture of GMPs, the eo...
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PMID: 15955840
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)23 2005
Abstract
We developed in vitro embryonic stem (ES) culture system by using OP9 stromal cells (OP9/ES cell co-culture system), and cultured the mutant (GATA-1.05 and GATA-1-null) and wild type (WT)ES cells, respectively. By using this OP9/ES cell co-culture system, primitive and definitive erythroid cells wer...
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PMID: 15817467
PDF is available here.
PDF is available here.
Abstract
We identified the DnaJ-like heat shock protein 40, HLJ1, and found that the expression of HLJ1 correlates negatively with cancer cell invasion ability. Overexpression of HLJ1 can suppress cancer cell invasion in vitro. We further characterize the putative promoter region and investigate the transcri...
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PMID: 15782117
PDF is available here.
PDF is available here.
Planta Medica (71)6 2005
Abstract
We showed that fagaronine induces a significant hemoglobinization of the human erythroleukemic cell line K562. This hemoglobin synthesis was accompanied by a strong increase of erythroid mRNA expression such as gamma- and alpha-globin, and PBGD, an enzyme of heme synthesis. In addition, the Epo-R tr...
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PMID: 15971117
PDF is available here.
PDF is available here.
Abstract
We have used short interfering RNA (siRNA) to specifically knock down YY1 expression in T2 cells. We wished to assess whether the removal of this negatively acting factor would render these ordinarily non-permissive cells permissive for infection. We show that we can potently inhibit YY1 expression...
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PMID: 16003908
PDF is available here.
PDF is available here.
Abstract
These results indicate that Sp1 and YY1 transactivate the human ATP2C1 promoter via cis-enhancing elements and that incomplete upregulation of ATP2C1 transcription contributes to the keratinocyte-specific pathogenesis of HHD. This is a report describing the regulation of the expression of ATP2C1....
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PMID: 15955096
PDF is available here.
PDF is available here.
Nature Genetics (37)6 2005
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1.
Abstract
We used gene targeting to generate Gata1 alleles that express GATA1s in mice. We show that the dominant action of GATA1s leads to hyperproliferation of a unique, previously unrecognized yolk sac and fetal liver progenitor, which we propose accounts for the transient nature of TMD and the restriction...
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PMID: 15895080
PDF is available here.
PDF is available here.
Abstract
GATA family transcription factors play essential roles in broad developmental settings. GATA-1, one of the hematopoietically expressed members, is required for normal erythroid and megakaryocytic differentiation. Over the past few years, mutations in the gene encoding GATA-1 have been linked to seve...
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PMID: 16158817
PDF is available here.
PDF is available here.
Abstract
We performed chromatin immunoprecipitation analyses, revealing that YY1 only occupies the Grp78 promoter upon ER stress and is mediated in part by the nuclear form of ATF6. We show that YY1 is an essential coactivator of ATF6 and uncover their specific interactive domains. Using small interfering RN...
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PMID: 15899857
PDF is available here.
PDF is available here.
Abstract
We studied platelets from GATA1-deficient mice and from a male patient (S14) with a bleeding diathesis attributed to a single amino acid substitution (R216Q) in the N-terminal GATA1 zinc finger that alters binding to DNA. In both cases there was inhibition of aggregation to collagen and decreased ty...
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PMID: 15701726
PDF is available here.
PDF is available here.
Abstract
We characterized the t(X;21)(p22.3;q22.1) in a patient with myelodysplasia that fuses AML1 in-frame to the novel partner gene FOG2/ZFPM2. The reciprocal gene fusions AML1-FOG2 and FOG2-AML1 are both expressed. AML1-FOG2, which fuses the DNA-binding domain of AML1 to most of FOG2, represses the trans...
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PMID: 15705784
PDF is available here.
PDF is available here.
Abstract
Abstract
We analyzed the fate of YY1 during apoptosis and studied the functional consequences. We observed that this factor is rapidly translocated into the cell nucleus in response to various apoptotic stimuli, including activation of Fas, stimulation by tumor necrosis factor, and staurosporine and etoposid...
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PMID: 15831475
PDF is available here.
PDF is available here.
Abstract
We show that plasma from GATA-1(low) mice contained normal levels of TPO. On the other hand, Mks from TPO-treated wild-type animals (TPO(high) mice), as those from GATA-1(low) animals, had similar morphologic abnormalities and contained low GATA-1. In both animal models, development of myelofibrosis...
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PMID: 15665119
PDF is available here.
PDF is available here.
Abstract
We generated transgenic lines of mice bearing human BACH1 cDNA under the control of the GATA-1 locus hematopoietic regulatory domain. The transgenic mouse lines showed significant thrombocytopenia associated with impaired maturation of the megakaryocytes, and they developed myelofibrosis. The megaka...
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PMID: 15613547
PDF is available here.
PDF is available here.
Abstract
We thus performed cDNA microarray analysis on 40 PV and 12 SE patients. Two independent data sets were obtained: using a two-step training/validation design, a set of 64 genes (class predictors) was determined, which correctly discriminated PV from SE patients. Separately 253 genes were identified t...
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PMID: 15801966
PDF is available here.
PDF is available here.
Cancer Research (65)7 2005
Abstract
We found that carboxyl-terminal Src kinase homologous kinase (CHK) regulated the expression of the chemokine receptor, CXCR4. Northern blot and fluorescence-activated cell-sorting analyses showed that CHK down-regulated CXCR4 mRNA and protein levels, respectively. Mutated CHK, which contains a mutat...
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PMID: 15805285
PDF is available here.
PDF is available here.
Developmental Biology (280)1 2005
Abstract
We have investigated the molecular mechanisms underlying the transition in Epo gene regulation from RXRalpha-dependence to RXRalpha-independence. We find that three independent regulatory components are required for high level Epo expression in the early fetal liver: ligand-activated retinoic acid r...
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PMID: 15766748
PDF is available here.
PDF is available here.
Neuromuscular Disorders (15)4 2005
Abstract
These results suggest that HMBG2, YY1, NCL, and MYOD1 are unlikely to represent the genes responsible for FSHD in these families....
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PMID: 15792872
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)13 2005
Abstract
We have identified additional enhancer binding sites for Cdx factors, for YY1, and for NFI family members. Detailed EMSA studies were used to confirm binding at these sites. This brings the number of confirmed binding sites within the enhancer to thirteen, with five different factors or family of fa...
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PMID: 15677472
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)13 2005
Abstract
We examined the effects of GATA-1 and GATA-2 on cytokine signals. A tamoxifen-inducible form of GATA-1 (GATA-1/ERT) showed a minor inhibitory effect on interleukin-3 (IL-3)-dependent growth of an IL-3-dependent cell line Ba/F3. On the other hand, it drastically inhibited TPO-dependent growth and gp1...
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PMID: 15673499
PDF is available here.
PDF is available here.
Neuroscience Letters (377)2 2005
Abstract
We compared the effects of both excitotoxic and apoptotic insults on the DNA binding profile of multifunctional transcription factor YY1 protein in cultured cerebellar granule neurons. We report that L-glutamate-induced excitotoxic insult but not ionophore A23187 treatment caused the disappearance o...
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PMID: 15740849
PDF is available here.
PDF is available here.
Abstract
GATA proteins are transcription factors that bind GATA DNA elements through Cys4 structural zinc-binding domains and play critical regulatory roles in neurological and urogenital development and the development of cardiac disease. To evaluate GATA proteins as potential targets for lead, spectroscopi...
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PMID: 15771509
PDF is available here.
PDF is available here.
Abstract
We hypothesize that a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression in normal adult erythrocytes. Both the -173 and -175 T to C substitutions may disrupt the comp...
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PMID: 15613485
PDF is available here.
PDF is available here.