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GATA Transcription Factors (6):
Recent article
GATA Transcription Factors
Cell Host & Microbe (9)3 2011
Abstract
We have determined that Gat201 controls the mRNA levels of ∼1100 genes (16% of the genome) and binds the upstream regions of ∼130 genes. Seven Gat201-bound genes encode for putative and known transcription factors--including two previously implicated in virulence--suggesting an extensive regulat...
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PMID: 21402362
PDF is available here.
PDF is available here.
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Abstract
The C. elegans digestive tract (pharynx, intestine, and rectum) contains only approximately 100 cells but develops under the control of the same types of transcription factors (e.g. FoxA and GATA factors) that control digestive tract development in far more complex animals. The GATA-factor dominated...
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PMID: 20570129
PDF is available here.
PDF is available here.
Abstract
We find that male C. elegans worms are much more sensitive than hermaphrodites to oxidative stress and show that the DM domain transcription factor MAB-3 plays a pivotal role in determining this male hypersensitivity. The hypersensitivity to oxidative stress does not depend on the dosage of X chromo...
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PMID: 20498281
PDF is available here.
PDF is available here.
Circulation Research (106)12 2010
Abstract
Abstract
Abstract
Datasets with a high dimensional feature space, advancing statistical methods, and computational efficiency were analyzed to uncover the rules of the circadian rhythms. The aim of the study was to uncover the identity, the dynamic behavior, and the interactions among the components of the circadian...
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PMID: 20865485
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of anthocyanins on the induction of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by TNF-alpha and the possible molecular mechanisms by which anthocyanins differentially regulate ICAM-1 and VCAM-1 expression. Stimulation of cells...
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PMID: 19627149
PDF is available here.
PDF is available here.
Abstract
We and others previously cloned and characterized vertebrate WNT11 orthologs, which are involved in gastrulation, neurulation, cardiogenesis, nephrogenesis, and chondrogenesis during fetal development. WNT11 orthologs activate both canonical and non-canonical WNT signaling cascades depending on the...
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PMID: 19578797
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)30 2009
Abstract
We developed a biological system that allows us to unlink iron-dependent behavior of Php4 protein from its transcriptional regulation by Fep1. Microscopic analyses revealed that a functional GFP-Php4 protein accumulates in the nucleus under conditions of iron starvation. Conversely, in cells undergo...
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PMID: 19502236
PDF is available here.
PDF is available here.
Abstract
We present a modification to the standard protocol, where detachment of follicular cells from the basal membrane of the egg and nuclei isolation precedes formaldehyde-mediated cross-linking. We also discuss application of the modified method for the identification of distinct BmC/EBP and BmGATAbeta...
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PMID: 18368513
PDF is available here.
PDF is available here.
Abstract
We purified a factor from semi-synchronized early embryos that binds to an end-1 cis regulatory region critical for its endoderm-specific expression. Mass spectrometry identified this protein, PLP-1, as a C. elegans orthologue of the vertebrate pur alpha transcription factor. Expression of end-1 is...
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PMID: 19084000
PDF is available here.
PDF is available here.
Abstract
We have identified one GATA123 gene and one GATA456 gene from the genomic sequence of two invertebrate deuterostomes, a cephalochordate (Branchiostoma floridae) and a hemichordate (Saccoglossus kowalevskii). We also have confirmed the presence of six GATA genes in all vertebrate genomes, as well as...
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PMID: 19695090
PDF is available here.
PDF is available here.
Abstract
These results suggest an important role for the direct repeat in determining the cardiac specificity. Furthermore, mice carrying a mutant promoter simultaneously disrupting the direct repeats and overlapping GATA site failed to express the transgene in any tissues tested. Therefore, the direct repea...
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PMID: 18951515
PDF is available here.
PDF is available here.
Abstract
We have previously shown that an upstream enhancer, Eng -8, together with the promoter region, mediates robust endothelial expression yet is inactive in blood. To identify hematopoietic regulatory elements, we used array-based methods to determine chromatin accessibility across the entire locus. Sub...
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PMID: 18805961
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)48 2008
Abstract
We investigated the cis-regulatory control of FEV to begin to identify the upstream transcription factors that restrict FEV expression to 5-HT neurons. We find that sequences extending only 275 bp upstream of the FEV 5' untranslated region are sufficient to direct FEV transgene expression to embryon...
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PMID: 19036967
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)22 2008
Abstract
We define an 11.5 Mb candidate interval for AS on chromosome 8q based on cytogenetic breakpoints in three patients. TRPS1, a gene within this interval, was deleted in a patient with an 8q23 chromosomal rearrangement, while its expression was significantly downregulated in another patient with an inv...
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PMID: 18713754
PDF is available here.
PDF is available here.
Biochemical Journal (416)1 2008
Abstract
A protein displaying significant similarity to mammalian HMGA (high-mobility group A) proteins, but also bearing unique structural features, was isolated from silkmoth (Bombyx mori) follicular cells. This factor, named BmHMGA, exhibits specific binding preference for chorion gene promoter elements a...
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PMID: 18636971
PDF is available here.
PDF is available here.
Abstract
We demonstrate that a single transcription factor is able to regulate distinct core circuitries in two different blastocyst-derived stem cell lines, embryonic stem cells (ESCs) and extraembryonic endoderm (XEN) cells. The transcription factor Sall4 is required for early embryonic development and for...
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PMID: 18804426
PDF is available here.
PDF is available here.
Abstract
Rapid growth is of crucial importance for Adélie penguin chicks reared during the short Antarctic summer. It partly depends on the rapid ontogenesis of fat stores that are virtually null at hatching but then develop considerably (x40) within a month to constitute both an isolative layer against col...
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PMID: 18799630
PDF is available here.
PDF is available here.
Scientific American (299)4 2008
Abstract
Abstract
We report that Decapentaplegic (Dpp; a Drosophila BMP family member) plays a role in blood cell homeostasis and immune responses by regulating a transcription factor cascade. The cascade begins with Dpp repression of Zfh1, continues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminate...
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PMID: 18815369
PDF is available here.
PDF is available here.
Development (135)19 2008
Abstract
We show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate W...
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PMID: 18715946
PDF is available here.
PDF is available here.
Molecular Microbiology (70)1 2008
Abstract
We show that this control is mediated by the GATA factor SreA. During iron-replete conditions, SreA deficiency partially derepressed synthesis of triacetylfusarinine C and uptake of iron resulting in increased cellular accumulation of both iron and ferricrocin. Genome-wide DNA microarray analysis id...
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PMID: 18721228
PDF is available here.
PDF is available here.
Abstract
Effector and regulatory T cells (Tregs) play a fundamental role in the airways in allergic asthma. Here, the role of T cells in the immunopathogenesis of human asthma as well as in animal models of allergic airway inflammation is reviewed. Recent data have shown that Th2 and Th17 eff...
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PMID: 18802339
PDF is available here.
PDF is available here.
Eukaryotic Cell (7)10 2008
Abstract
We examined changes in gene expression of F. fujikuroi wild-type and DeltaareA strains by use of a Fusarium verticillioides microarray representing approximately 9,300 genes. Analysis of the array data revealed sets of genes significantly down- and upregulated in the areA mutant under both N starvat...
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PMID: 18689524
PDF is available here.
PDF is available here.
Abstract
In ROG(-/-) mice T(H)2 cell differentiation, T(H)2 responses, eosinophilic airway inflammation, and AHR were enhanced. In ROG transgenic mice the levels of eosinophilic airway inflammation and AHR were dramatically reduced. Furthermore, adoptive transfer of T(H)2 cells with increased or decreased le...
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PMID: 18620745
PDF is available here.
PDF is available here.
Abstract
We generated a mouse intercross population and carried out a quantitative trait locus (QTL) analysis of 143 female and 124 male F(2) progeny from progenitor strains SM/J and NZB/BlNJ using whole body and vertebral areal BMD (aBMD) as measured by DXA. We found that both whole body and vertebral aBMD...
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PMID: 18442308
PDF is available here.
PDF is available here.
Abstract
We show that SNCA and the heme metabolism genes ALAS2, FECH, and BLVRB form a block of tightly correlated gene expression in 113 samples of human blood, where SNCA naturally abounds (validated P = 1.6 x 10(-11), 1.8 x 10(-10), and 6.6 x 10(-5)). Genetic complementation analysis revealed that these f...
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PMID: 18669654
PDF is available here.
PDF is available here.
Abstract
We used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these...
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PMID: 18662544
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)14 2008
Abstract
We analyzed Trps1 mutant mice (Trps1DeltaGT mice). Analyses of growth plates demonstrated delayed chondrocyte differentiation and accelerated mineralization of perichondrium in Trps1 mutant mice. These abnormalities were accompanied by increased Runx2 and Ihh expression and increased Indian hedgehog...
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PMID: 18424451
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)27 2008
Abstract
We report here that SRE1, a gene encoding a GATA-type protein, bound to promoter sequences of genes involved in siderophore biosynthesis. Sre1 had sequence similarity to the fungal negative regulators of siderophore biosynthesis. Expression of SRE1 was reduced under iron-starving conditions, undersc...
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PMID: 18549241
PDF is available here.
PDF is available here.
Abstract
We use genome-wide transcriptome analysis to characterize the consequence of natural fungal infection in Caenorhabditis elegans. We identify several families of genes encoding putative antimicrobial peptides (AMPs) and proteins that are transcriptionally up-regulated upon infection. Many are located...
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PMID: 18636113
PDF is available here.
PDF is available here.
Journal of Molecular Biology (379)2 2008
Abstract
We investigated the internal promoter of tropomyosin to identify sequences that regulate expression of tmy-1 in the pharynx and intestine. By promoter deletion of tmy-1 reporters as well as by database analyses, a 100-bp fragment that contained binding sequences for a GATA factor, for a chicken CdxA...
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PMID: 18448117
PDF is available here.
PDF is available here.
Plant Physiology (147)2 2008
Abstract
We identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI. The GNC gene encodes a member of the Arabidopsis GATA transcription factor family and has been implicated in the regulation of chlorophyll biosynthesis as well as carbon and nitrogen...
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PMID: 18417639
PDF is available here.
PDF is available here.
EMBO Reports (9)5 2008
Abstract
We show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA dam...
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PMID: 18344972
PDF is available here.
PDF is available here.
Development (135)9 2008
Abstract
We found a mutant (dimC(-)) that is a hypomorphic allele of a GATA family transcription factor (gtaC). gtaC expression is directly regulated by DIF, and GtaC rapidly translocates to the nucleus in response to DIF. gtaC(-) null cells showed some hallmark DIF signalling defects. Surprisingly, other as...
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PMID: 18367552
PDF is available here.
PDF is available here.
Abstract
Autonomous silencing of gamma-globin transcription is an important developmental regulatory mechanism controlling globin gene switching. An adult stage-specific silencer of the (A)gamma-globin gene was identified between -730 and -378 relative to the mRNA start site. A marked copy of the (A)gamma-gl...
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PMID: 18347053
PDF is available here.
PDF is available here.
Abstract
We conclude that GLN3 has a broad role in nitrogen metabolism, partially overlapping, but distinct from that of GAT1, and that its function is important for the ability of C. albicans to survive within the host environment....
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PMID: 17950010
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)4 2008
Abstract
The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory regions of numerous genes. In vertebrates, these motifs are bound by one of six factors (GATA1 to GATA6) that constitute the GATA family of transcriptional regulatory proteins. Although originally considered for...
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PMID: 18174356
PDF is available here.
PDF is available here.
Genes to Cells (13)4 2008
Abstract
We hypothesized a possible functional interaction between these two molecules. Using a chondrogenic cell line (ATDC5), we investigated the association of Gdf5-mediated signaling pathways with Trps1 and the phenotypic changes of ATDC5 cells due to over-expression or suppression of Trps1. Treatment of...
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PMID: 18363966
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)14 2008
Abstract
We conclude that: (i) Tor pathway regulation of Gat1 differs markedly from that of Gln3, (ii) nuclear targeting of Gln3-Myc(13) is alone insufficient for its recruitment to the DAL5 promoter, and (iii) the Tor pathway continues to play an important regulatory role in NCR-sensitive transcription even...
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PMID: 18245087
PDF is available here.
PDF is available here.
Abstract
We show that COUP-TFII acts downstream of hedgehog signaling and is required for the full antiadipogenic effect of this pathway. This effect is mediated in part by interaction with GATA factors. COUP-TFII and GATA2 are physically associated and repress target gene expression in an additive manner. T...
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PMID: 18250317
PDF is available here.
PDF is available here.
Endocrinology (150)2 2008
Abstract
Our findings show that the cis-elements required for Star transcription in the rodent placenta and the ovary are centered in a relatively small proximal region of the promoter. In placental trophoblast giant cells, cAMP is required for activation of the Star promoter, and the cis-elements mediating...
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PMID: 18845640
PDF is available here.
PDF is available here.
Endocrinology (150)2 2008
Abstract
We show that P450c17 is expressed in differentiated mouse parietal and visceral endoderm lineages, in cultured mouse F9 embryonic carcinoma stem cells, in mouse embryonic stem cells, and in cultured mouse P19 stem cells. Bases -110 to -55 (which contain an SF-1 site and two potential GATA sites) of...
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PMID: 18832096
PDF is available here.
PDF is available here.
Abstract
We investigated factors responsible for its transcriptional regulation in vitro and its expression in vivo. Analysis of promoter constructs in the CaCo2 cell line identified a complex element between -422 and -291 critical for promoter activity. This element contained four sites that bound GATA-4, -...
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PMID: 18005670
PDF is available here.
PDF is available here.
FASEB Journal (22)2 2008
Abstract
We conclude that the stress-responsive GSTO-1 plays a key role in counteracting environmental stress....
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PMID: 17901115
PDF is available here.
PDF is available here.
Abstract
We showed that the minimal CLMP promoter was located between nucleotides -550 and -288 relative to the translation start site. Site-directed mutagenic studies showed that three motifs, namely GATA, KLF4, and SRY, within this region functionally co-operated with one another to regulate CLMP gene tran...
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PMID: 17620326
PDF is available here.
PDF is available here.
Journal of Dairy Science (91)1 2008
Abstract
Identification of regulatory elements in 5' regions of chemokine genes is fundamental for understanding chemokine gene expression in response to infection diseases. The CXCR1 receptor is expressed on the surface of neutrophils and interacts primarily with CXCL8 (IL-8), the most potent chemoattractan...
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PMID: 18096965
PDF is available here.
PDF is available here.
Molecular Immunology (45)1 2008
Abstract
We examined Fli1 regulation in a murine B cell line and T cell line and identified several cis-regulatory elements within a 230 bp region that contribute to Fli1 promoter activity. Ets factors Elf1, Tel and Fli1 bind in vitro to this region and increase endogenous Fli1 expression when over-expressed...
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PMID: 17606295
PDF is available here.
PDF is available here.
Human Mutation (29)1 2008
Abstract
We show in luciferase reporter gene assays by a series of chimeric FABP2 promoter constructs in intestinal Caco-2 cells that polymorphism c.-80_-79insT essentially determines different activities of the FABP2 promoter. In accordance, in electrophoretic mobility shift assays (EMSAs), transcriptional...
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PMID: 17960769
PDF is available here.
PDF is available here.
Cardiovascular Pathology (17)1 2008
Abstract
Congenital heart defects (CHDs) affect 1-2% of newborn children and are the leading cause of death in infants under 1 year of age. CHDs represent the single largest class of birth defects and account for 25% of all human congenital abnormalities. Numerous epidemiologic studies have established the h...
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PMID: 18160060
PDF is available here.
PDF is available here.
Abstract
We review the transcription factors that play important roles in the development and maintenance of IFE as evidenced by biochemical and genetic studies....
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PMID: 18197786
PDF is available here.
PDF is available here.
Abstract
During spermatogenesis, intercellular junctions are dynamically remodeled to facilitate the translocation of developing germ cells from the basal to the adluminal compartment of the seminiferous epithelium. In particular, at stage VIII of the seminiferous epithelial cycle, timely restructuring of ce...
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PMID: 18508694
PDF is available here.
PDF is available here.
Abstract
We have identified the complete GATA complement (53 genes) from a diverse sampling of protostome genomes, including six arthropods, three lophotrochozoans, and two nematodes. Reciprocal best hit BLAST analysis suggested orthology of these GATA genes to either the ancestral bilaterian GATA123 or the...
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PMID: 18412965
PDF is available here.
PDF is available here.
Abstract
We have isolated and characterized expression of one FoxA gene (CapI-foxA) and four GATA genes (CapI-gataB1, CapI-gataB2, CapI-gataB3, and CapI-gataA1) from Capitella sp. I. Both gene families are expressed in the developing gut of this polychaete. CapI-foxA, an ortholog of the FoxA subgroup, is exp...
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PMID: 18184360
PDF is available here.
PDF is available here.
Abstract
We found that Trps1 consistently localized to the nuclei of dermal papillae cells and the highly proliferative epithelial cells of mouse, rat and human hair follicles....
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PMID: 18054290
PDF is available here.
PDF is available here.
Abstract
Effector and regulatory T cells (Tregs) play a fundamental role in the airways in allergic asthma. Here, the role of T cells in the immunopathogenesis of human asthma as well as in animal models of allergic airway inflammation is reviewed. Recent data have shown that Th2 and Th17 effector T cells au...
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PMID: 18802339
PDF is available here.
PDF is available here.
Developmental Biology (312)2 2007
Abstract
We show that mice with a disrupted Trps1 gene develop a chondrodysplasia characterized by diminished chondrocyte proliferation and decreased apoptosis in growth plates. Our analyses revealed that Trps1 is a repressor of Stat3 expression, which in turn controls chondrocyte proliferation and survival...
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PMID: 17997399
PDF is available here.
PDF is available here.
Developmental Biology (312)2 2007
Abstract
We show that in zebrafish the gata5 and gata6 genes are redundant for specification of cardiomyocytes. Embryos depleted of these two gene products are heartless. Restoring either gene product is sufficient to rescue cardiomyocyte specification. In contrast, embryos depleted of Gata4 and Gata6, or Ga...
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PMID: 17950269
PDF is available here.
PDF is available here.
Development (134)24 2007
Abstract
We identify here an enhancer in the promoter of ref-1, a C. elegans Notch target, which promotes Notch-dependent expression in mesodermal and endodermal cells. The enhancer contains predicted binding sites for the Notch transcriptional effector LAG-1/CSL that are essential for expression, a non-CSL...
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PMID: 18003741
PDF is available here.
PDF is available here.