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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Immunoglobulin J Recombination Signal Sequence-Binding Protein (0):
Recent article
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
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PMID: 21270765
PDF is available here.
PDF is available here.
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Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
|
PMID: 21270765
PDF is available here.
PDF is available here.
Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
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PMID: 21270765
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
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PMID: 20972443
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
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PMID: 20972443
PDF is available here.
PDF is available here.
Abstract
We demonstrate through the use of chromatin immunoprecipitation (ChIP) assays that the co-ordinated binding of these two factors to the p53 promoter occurs in vivo and serves to regulate p53's activity during the cell cycle....
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PMID: 20446924
PDF is available here.
PDF is available here.
Genes & Development (24)14 2010
Abstract
We report that maintenance of the hair follicle keratinocyte cell fate is defective in mice with mesenchymal deletion of the CSL/RBP-Jkappa gene, the effector of "canonical" Notch signaling. Hair follicle reconstitution assays demonstrate that this can be attributed to an intrinsic defect of dermal...
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PMID: 20634318
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Replacement of Rbpj by Rbpjl in the PTF1 complex drives acinar differentiation by maximizing secretory protein synthesis, stimulating mitochondrial metabolism and cytoplasmic creatine-phosphate energy stores, completing the packaging and secretory apparatus, and maintaining acinar-cell homeostasis....
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PMID: 20398665
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We show that the M2-like tumor-associated macrophages (TAM) have a lower level of Notch pathway activation in mouse tumor models. Forced activation of Notch signaling increased M1 macrophages which produce IL12, no matter whether M1 or M2 inducers were applied. When Notch signaling was blocked, the...
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PMID: 20501839
PDF is available here.
PDF is available here.
Abstract
We show that ORF50 protein, a latent-lytic switch transactivator, activates the transcription of these two early-lytic genes through different mechanisms. Activation of the ORF61 promoter by ORF50 protein is dependent on an intact RBP-Jkappa-binding site within the identified responsive element and...
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PMID: 19969319
PDF is available here.
PDF is available here.
Journal of Virology (84)3 2010
Abstract
For Kaposi's sarcoma-associated herpesvirus (KSHV; also called human herpesvirus 8 [HHV8]), the switch from latency to active lytic replication requires RTA, the product of open reading frame 50 (ORF50). RTA activates transcription from nearly 40 early and delayed-early viral promoters, mainly throu...
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PMID: 19906914
PDF is available here.
PDF is available here.
Abstract
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Abstract
We studied its effect on EBV-carrying B cells. In type I Burkitt lymphoma (BL) cell lines and in the conditional lymphoblastoid cell line (LCL) ER/EB2-5, IL-21 potently activated STAT3 and induced the expression of LMP-1, but not EBNA-2. The IL-21-treated type I Jijoye M13 BL line ceased to prolifer...
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PMID: 20080768
PDF is available here.
PDF is available here.
Molecular Cancer (9)1 2010
Abstract
When DCs were co-inoculated together with tumor cells, while the control DCs repressed tumor growth, the RBP-J deficient DCs had lost tumor repression activity. This was most likely due to that DCs with the conditionally ablated RBP-J were unable to evoke anti-tumor immune responses in the solid tum...
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PMID: 20420708
PDF is available here.
PDF is available here.
Abstract
We describe a signaling cascade activated by the developmental regulator Notch, which inhibits apoptosis triggered by neglect in mammalian cells. In this pathway, the Notch intracellular domain (NIC), which is released after interaction with ligand, converges on the kinase mammalian target of rapamy...
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PMID: 19265851
PDF is available here.
PDF is available here.
Abstract
We hypothesized that lower-dose combination therapy of HDAC inhibitors and lithium chloride could achieve similar growth inhibition to that of the drugs alone. Gastrointestinal and pulmonary carcinoid cells were treated with either VPA or SBHA and lithium chloride for up to 48 hours. Western blot an...
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PMID: 19030935
PDF is available here.
PDF is available here.
Journal of Cell Biology (184)1 2009
Abstract
We investigate the link between the Shh signaling pathway and Hes1, a classical Notch target. We show that Shh-driven stabilization of Hes1 is independent of Notch signaling and requires the Shh effector Gli2. We identify Gli2 as a primary mediator of this response by showing that Gli2 is required f...
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PMID: 19124651
PDF is available here.
PDF is available here.
Abstract
We discuss some of these mechanisms and their relevance for the overall architecture of the Notch pathway. We further highlight the importance of properly terminating Notch activity during cell fate decisions mediated by this pathway....
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PMID: 19247952
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (320)1-2 2009
Abstract
We investigated whether Notch signaling might directly regulate Foxp3 expression. Here, we provide evidence that Notch signaling can modulate the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms. A conserved RBP-J-binding site and N-box sites were identified within the FOXP3 promoter. We...
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PMID: 18777163
PDF is available here.
PDF is available here.
Abstract
We demonstrate that FGF2 signaling through phosphatidylinositol 3 kinase activation inactivates glycogen synthase kinase 3beta (GSK3beta) and leads to the accumulation of beta-catenin in a manner different from that in the Wnt canonical pathway. The nuclear accumulated beta-catenin leads to cell pro...
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PMID: 18852283
PDF is available here.
PDF is available here.
Abstract
We report here that the Ikaros transcription factor plays a crucial role in repressing the transcriptional response to Notch signaling in T-cell development. Using the Notch target gene Hes-1 as a model, we show that Ikaros and RBP-Jkappa, the transcriptional mediator of Notch signaling, compete for...
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PMID: 18852286
PDF is available here.
PDF is available here.
Abstract
We found that Notch and TLR pathways cooperated to activate canonical Notch target genes, including transcriptional repressors Hes1 and Hey1, and to increase production of canonical TLR-induced cytokines TNF, IL-6, and IL-12. Cooperation by these pathways to increase target gene expression was media...
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PMID: 18976936
PDF is available here.
PDF is available here.
Abstract
We show that RTA can activate the expression of the ORF59 which encodes the processivity factor essential for DNA replication during lytic reactivation. We also show that RTA regulates ORF59 promoter through interaction with RBP-Jkappa as well as a cis-acting RTA responsive element within the promot...
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PMID: 18786687
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that Nkx2.5 is a target gene of Notch1 and raised the possibility that Notch1 regulates myocyte commitment in the adult heart. Cardiac progenitor cells (CPCs) in the niches express Notch1 receptor, and the supporting cells exhibit the Notch ligand Jagged1. The nuclear transl...
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PMID: 18832173
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)1 2008
Abstract
We demonstrate that reactivation of Notch signaling causes embryonic stem cell-derived and neonatal ventricular cardiomyocytes to enter the cell cycle. The proliferative response of neonatal ventricular cardiomyocytes declines as they mature, such that late activation of Notch triggers the DNA damag...
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PMID: 18838555
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)1 2008
Abstract
We unmasked functional redundancies and discovered an essential role for AP-2s in the process. In vivo and in vitro, AP-2 deficiency is accompanied by surprisingly minimal changes in basal gene expression but severely perturbed terminal differentiation and suppression of additional transcription fac...
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PMID: 18824566
PDF is available here.
PDF is available here.
Developmental Biology (321)1 2008
Abstract
We employed both gain-of-function and loss-of-function approaches to determine the role of Notch signaling in lens development. Here we analyzed mice containing conditional deletion of the Notch effector Rbpj or overexpression of the activated Notch1 intracellular domain during lens formation. We de...
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PMID: 18588871
PDF is available here.
PDF is available here.
Abstract
The Notch pathway is a short-range signaling mechanism between neighboring cells that results in changes in gene expression. Extracellular interactions between Notch receptors and ligands trigger proteolytic cleavage of the receptor Notch. Following cleavage, the freed intracellular domain of Notch...
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PMID: 18758478
PDF is available here.
PDF is available here.
Abstract
Abstract
The Notch3 gene was identified, at the beginning of 90s, as the third mammalian Notch and was initially reported as being expressed in proliferating neuroepithelium. Since then, increasing evidence has demonstrated a number of structural and functional differences between Notch3 and both Notch1 and...
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PMID: 18758477
PDF is available here.
PDF is available here.
Development (135)16 2008
Abstract
We therefore analyzed conditional pancreas-specific Rbpj and combined Notch1/Notch2 knockout mice using Ptf1a(+/Cre(ex1)) mice crossed with floxed Rbpj or Notch1/Notch2 mice. Mice were analyzed at different embryonic stages for pancreatic exocrine and endocrine development. The absence of Rbpj in pa...
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PMID: 18635610
PDF is available here.
PDF is available here.
Abstract
We demonstrated that N1IC interacted with the c-Myc-regulating proteins alpha-enolase and c-myc promoter binding protein 1 (MBP-1). Both alpha-enolase and MBP-1 suppressed the N1IC-enhanced activity of the c-myc promoter in a CBF1-independent manner. The YY1 response element in front of the P2 c-myc...
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PMID: 18490439
PDF is available here.
PDF is available here.
Abstract
We show that transforming growth factor-alpha (TGF-alpha) stimulated glioma cell line U251 growth and can partly compensate for the inhibitory effect of Notch-signaling inhibitor DAPT. The effect of TGF-alpha on ERK1/2 phosphorylation was prompt and transient and could be inhibited by mitogen-activa...
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PMID: 18636433
PDF is available here.
PDF is available here.
Cardiovascular Research (79)2 2008
Abstract
Treatment of human umbilical vein endothelial cells (HUVECs) with EtOH (1-100 mM, 24 h) dose-dependently increased their network formation on Matrigel (an index of angiogenesis) with a maximum response (2.5- to 3-fold increase) at 25 mM. Ethanol also stimulated the proliferation (by cell count and p...
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PMID: 18448572
PDF is available here.
PDF is available here.
Abstract
We show that keratinocyte-specific deletion of total Notch signaling triggered a severe systemic B-lymphoproliferative disorder, causing death. RBP-j is the DNA binding partner of Notch, but both RBP-j-dependent and independent Notch signaling were necessary for proper epidermal differentiation and...
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PMID: 18507503
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)21 2008
Abstract
We provide a comprehensive thermodynamic, structural, and biochemical analysis of the RAM-CSL interaction for components from both mouse and worm. Our binding data show that RAM and CSL form a high affinity complex in the presence or absence of DNA. Our structural studies reveal a striking distal co...
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PMID: 18381292
PDF is available here.
PDF is available here.
Abstract
We and others have previously identified SHARP as one component of this complex. Here, we show that the corepressor ETO as well as the leukemogenic fusion protein AML1/ETO directly interacts with SHARP, that ETO is part of the endogenous RBP-Jkappa-containing corepressor complex, and that ETO is fou...
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PMID: 18332109
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 9 2008
Abstract
We present evidence to suggest that lipopolysaccharide (LPS) suppresses Notch signaling via the direct modification of Notch by the nitration of tyrosine residues in macrophages. In the RAW264.7 macrophage cell line and in rat primary alveolar macrophages, LPS was found to inhibit Notch1 intracellul...
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PMID: 18411251
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)18 2008
Abstract
We demonstrate here for the first time that M. bovis BCG up-regulates NOTCH1 and activates the NOTCH1 signaling pathway, leading to the expression of SOCS3. We show that perturbing Notch signaling in infected macrophages results in the marked reduction in the expression of SOCS3. Furthermore, enforc...
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PMID: 18332140
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)16 2008
Abstract
We provide evidence that Ikaros directly represses Hes1 in concert with the transcriptional repressor, RBP-Jkappa, allowing for cross-talk between Notch and Ikaros that impacts regulation of CD4 expression. Taken together, these data describe a potential mechanism for Ikaros' function during T cell...
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PMID: 18287091
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 2 2008
Abstract
We modelled the region between the RAM and ANK (ankyrin repeat)-binding regions using polymer statistics. A WLC (wormlike chain) model shows that the most probable sequence separation between the two binding regions is approximately 50 A (1 A=0.1 nm), matching the separation between these two sites...
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PMID: 18363556
PDF is available here.
PDF is available here.
Circulation Research (102)6 2008
Abstract
We show that expression of the constitutive active ICD of human Notch1, Notch2, or Notch4 receptors increase SMA levels. NotchICD also induce expression of the transcriptional repressors HRT1 (Hairy-related transcription factor 1) and HRT2, in a CBF-1-dependent manner. However, unlike the activating...
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PMID: 18239137
PDF is available here.
PDF is available here.
Journal of Molecular Biology (376)1 2008
Abstract
We mapped residues important for the stabilization of this multiprotein-DNA complex using site-directed mutagenesis, determined the affinity of the three-domain form of CSL for its various partners, and investigated sources of cooperativity in complex formation by monitoring the influence of various...
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PMID: 18155729
PDF is available here.
PDF is available here.
Amino Acids (34)2 2008
Abstract
The DNA repair protein Ku acts as a heterodimer of Ku70 and Ku80 that binds to the DNA ends, nicks, or single-to-double-strand transition. It has a crucial role for DNA double-strand-break repair. Either Ku70 or Ku80 itself may have a unique function that is independent of the other Ku subunit. In t...
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PMID: 17031478
PDF is available here.
PDF is available here.
Genes & Development (22)2 2008
Abstract
We demonstrate Ptf1a and Rbpj interact in a complex that is required in vivo for specification of the GABAergic neurons, a function that cannot be substituted by the classical form of the bHLH heterodimer with E-protein or Notch signaling through Rbpj. We show that a mutant form of Ptf1a without the...
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PMID: 18198335
PDF is available here.
PDF is available here.
Abstract
I and IV, and vitronectin without altering the abundance of beta(1) integrin at the cell surface. A study now suggests that this Notch-dependent increase in beta(1) integrin affinity occurs through the activation of the small guanosine triphosphate (GTP)-binding protein, R-Ras. It is proposed that N...
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PMID: 18270166
PDF is available here.
PDF is available here.
Virus Research (131)1 2008
Abstract
We identified an RTA mutant, RTA-K152E, which has a defect in its direct DNA-binding activity. In this report, the effect of the mutant RTA on KSHV activation via RBP-Jkappa protein is examined. We demonstrate that RTA-K152E interacts with RBP-Jkappa physically and the mutant RTA and RBP-Jkappa comp...
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PMID: 17850910
PDF is available here.
PDF is available here.
EMBO Journal (26)24 2007
Abstract
We have found that C-promoter binding factor-1 (CBF-1), a CSL (CBF-1, Su(H) and Lag-1)-type transcription factor and key effector of the Notch signaling pathway, is a remarkably potent and specific inhibitor of the HIV-1 LTR promoter. Knockdown of endogenous CBF-1 using specific small hairpin RNAs e...
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PMID: 18007589
PDF is available here.
PDF is available here.
Genes & Development (21)20 2007
Abstract
We show that early in pancreatic development, active PTF1a requires interaction with RBPJ, the vertebrate Suppressor of Hairless, within a stable trimeric DNA-binding complex (PTF1). Later, as acinar cell development begins, RBPJ is swapped for RBPJL, the constitutively active, pancreas-restricted p...
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PMID: 17938243
PDF is available here.
PDF is available here.
Developmental Dynamics (236)10 2007
Abstract
We have reported the generation of mice with a pancreas-specific knockout of Rbp-j using Pdx.cre mice. Those mice exhibited premature endocrine and ductal differentiation. We now generated mice in which the Rbp-j gene was inactivated in Ptf1a-expressing cells using Ptf1a.cre mice. The timing of the...
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PMID: 17849436
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 19 2007
Abstract
We evaluate whether and how the Notch pathway regulates the cell transition towards an inflammatory or de-differentiated state. Activation of the Notch pathway by the notch ligand Delta1, as well as overexpression of the active form of Notch3, prevents this phenomenon [initiated by interleukin 1beta...
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PMID: 17881497
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)39 2007
Abstract
We show that the intracellular domain of mammalian Notch-1 activates integrins without affecting integrin expression. Integrin activation is dependent on gamma-secretase-mediated intramembranous cleavage of membrane-bound Notch releasing intracellular Notch that activates R-Ras, independent of CSL-t...
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PMID: 17664272
PDF is available here.
PDF is available here.
Cancer Letters (255)1 2007
Abstract
We provide evidence that the inactivation of Notch signaling by zinc is achieved via a PI3K-Akt-dependent, cytoplasmic retention of Notch1-IC and RBP-Jk. Extracellular zinc has been determined to inhibit constitutive active mutants of both Notch1 (DeltaEN1) and Notch1-IC-mediated transcription. Howe...
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PMID: 17513037
PDF is available here.
PDF is available here.
Carcinogenesis (28)9 2007
Abstract
We herein investigated the effect of Notch1 signaling on the expression of YY1 target genes. We found that the N1IC bound to the double-stranded oligonucleotides of YY1-response element to activate luciferase activity of the reporter gene with YY1-response elements through a CBF1-independent manner....
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PMID: 17434929
PDF is available here.
PDF is available here.
Journal of Virology (81)16 2007
Abstract
We propose a model in which Rta transactivation of the promoter is specified by the combination of DNA binding and interactions with several cellular DNA binding proteins including Oct-1....
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PMID: 17537858
PDF is available here.
PDF is available here.
Abstract
We tested the function of the canonical Notch-RBP-J pathway in dendritic cell (DC) development and maintenance in vivo. Genetic inactivation of RBP-J in the bone marrow did not preclude DC lineage commitment but caused the reduction of splenic DC fraction. The inactivation of RBP-J in DCs using a no...
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PMID: 17591855
PDF is available here.
PDF is available here.