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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Kruppel-Like Transcription Factors (2):
Recent article
Kruppel-Like Transcription Factors
Human Molecular Genetics (20)21 2011
Abstract
We previously found that loss-of-function mutations in the transcription factor GLIS2, a putative vertebrate ortholog of Drosophila Ci, cause nephronophthisis type 7 in humans and mice. Kidney tubular cells in Glis2-knockout mice acquire mesenchymal phenotype, but the cellular mechanisms of this tra...
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PMID: 21816948
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We have generated and characterized nonhuman primate iPS cells with the goal of evaluating iPS cell transplantation in a clinically relevant large animal model. We developed stable Phoenix-RD114-based packaging cell lines that produce OCT4, SOX2, c-MYC, and KLF4 (OSCK) expressing gammaretroviral vec...
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PMID: 21058905
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)10 2011
Abstract
Cell Metabolism (13)2 2011
Abstract
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent...
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PMID: 21284980
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Abstract
We have shown that key factors supporting pluripotency-Nanog, Oct4 and Sox2-bind within Xist intron 1 in undifferentiated embryonic stem cells (ESC) to repress Xist transcription. However, the relationship between transcription factors of the pluripotency network and Tsix regulation has remained unc...
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PMID: 21085182
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)11 2010
Abstract
Our findings extend the role of miRNA in the pathogenesis of lupus and provide potential strategies for therapeutic intervention.
Copyright © 2010 by the American College of Rheumatology....
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PMID: 20589685
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
We investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell cycle progression in 91 specimens of human HCCs with immunohistochemistry. These immunostaining results were compared with various clinicopathologic...
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PMID: 20712011
PDF is available here.
PDF is available here.
Abstract
We also demonstrated the upregulation of endogenous Oct4 and Sox2 after successful reprogramming to pluripotency in rHD-iPSCs, which was not expressed in skin fibroblasts. rHD-iPSCs also developed cellular features comparable to Huntington's disease (HD), including the accumulation of mutant hunting...
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PMID: 20936902
PDF is available here.
PDF is available here.
Abstract
We noted chromosomal amplification of Gli2, a downstream effector of Hh signaling, and, more rarely, point mutations in Smo that led to reactivated Hh signaling and restored tumor growth. Analysis of pathway gene expression signatures also, unexpectedly, identified up-regulation of phosphatidylinosi...
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PMID: 20881279
PDF is available here.
PDF is available here.
Abstract
We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the...
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PMID: 20691614
PDF is available here.
PDF is available here.
Nature Genetics (42)9 2010
Abstract
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and t...
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PMID: 20802474
PDF is available here.
PDF is available here.
Abstract
We show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptors required to transduce niche-derived signals. We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity. Aberrant mTORC1 activation in Plzf(-/-)...
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PMID: 20691905
PDF is available here.
PDF is available here.
Experimental Cell Research (316)14 2010
Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages.
Abstract
We demonstrate that murine Klf7 gene expression is required for in vitro differentiation of neuroectodermal and mesodermal cells. Specifically, we show a correlation of Klf7 silencing with down-regulation of the neuronal marker microtubule-associated protein 2 (Map2) and the nerve growth factor (NGF...
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PMID: 20580711
PDF is available here.
PDF is available here.
Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias.
Abstract
We hypothesized that c-Myc, SOX2, and Oct-4 expression would distinguish type II from type I FCDs. In addition, we assayed the expression of progenitor cell proteins forkhead box G1 (FOXG1), Kruppel-like factor 4 (KLF4), Nanog, and SOX3. Differential expression of 7 stem cellproteins and aberrant ph...
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PMID: 20613634
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We showed that PLZF inhibits endothelial cell angiogenesis using a human umbilical vein endothelial cell system. We also focused on characterizing the specific function of the BTB domain of PLZF as a novel apoptotic and anti-angiogenic protein via deletion mapping analysis. The BTB domain directly i...
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PMID: 20236758
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We utilized zebrafish and mouse ES cells to investigate the role of copeb in endoderm specification and hepatogenesis separate from its function in angiogenesis. During zebrafish development, copeb expression is enriched in digestive organs. Morpholino knockdown of copeb blocks expansion of the live...
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PMID: 20430021
PDF is available here.
PDF is available here.
Life Sciences (87)3-4 2010
Abstract
As expected, simvastatin and LSS separately enhanced KLF2, eNOS, and TM mRNA expressions. The combination of simvastatin and LSS resulted in significantly higher mRNA levels of all three genes compared to cells treated with LSS only. The highest KLF2, eNOS, and TM mRNA levels were detected at 10 mic...
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PMID: 20493886
PDF is available here.
PDF is available here.
Abstract
These results provide evidence of a molecular mechanism linking cell-cell contact to cell proliferation and dedifferentiation in RPE cells....
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PMID: 20207963
PDF is available here.
PDF is available here.
Abstract
We report here the molecular characterization of porcine chemerin and its receptors ChemR23 and GPR1, as well as their transcriptional regulation during lipogenesis. Chemerin was mainly expressed in liver, intestine, kidney and adipose tissue, consistent with the expression pattern of GPR1, but not...
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PMID: 20663411
PDF is available here.
PDF is available here.
Journal of Urology (184)1 2010
Abstract
Weak growth suppression by cyclopamine suggests that hedgehog signaling is not involved in bladder cancer cell proliferation but Gli2 expression strongly correlated with invasive behavior. Increased Gli2 expression increased low Gli2 cell invasiveness while Gli inhibition by GANT61 decreased high Gl...
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PMID: 20488474
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Klf4 is essential for squamous epithelial differentiation in vivo and interacts with Klf5 to maintain normal epithelial homeostasis.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
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PMID: 20347813
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
We previously showed that mice null for the progesterone receptor (PGR)-interacting protein Krüppel-like factor (KLF) 9 are subfertile and exhibit reduced uterine progesterone sensitivity. KLF9 expression is high in predecidual stroma, undetectable in decidua, and enhanced in uteri of mice with con...
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PMID: 20410205
PDF is available here.
PDF is available here.
Abstract
Abstract
Together, these results suggest that Vezf1 is involved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition....
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PMID: 20431070
PDF is available here.
PDF is available here.
Cell Stem Cell (7)1 2010
Abstract
We show that the generation of iPSCs from mouse fibroblasts requires a mesenchymal-to-epithelial transition (MET) orchestrated by suppressing pro-EMT signals from the culture medium and activating an epithelial program inside the cells. At the transcriptional level, Sox2/Oct4 suppress the EMT mediat...
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PMID: 20621050
PDF is available here.
PDF is available here.
Abstract
Our results provide the first evidence of a role for KLF3 in muscle gene regulation and reveal an alternate mechanism for transcriptional regulation by SRF via its recruitment to KLF binding sites. Since both factors are expressed in all muscle lineages, SRF may regulate many striated- and smooth-mu...
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PMID: 20404088
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
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PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
|
PMID: 20393151
PDF is available here.
PDF is available here.