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NFATC Transcription Factors (0):
Recent article
NFATC Transcription Factors
Abstract
We hypothesized that early endoplasmic reticulum (ER) stress, which is associated with clinical triggers of PAH including hypoxia, bone morphogenetic protein receptor II mutations, and HIV/herpes simplex virus infections, explains the mitochondrial abnormalities and has a causal role in PAH. We show...
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PMID: 21697531
PDF is available here.
PDF is available here.
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Abstract
We investigated the effect of cyclosporine on HNF4alpha expression and activity and searched for novel HNF4alpha target genes among members of the RAS cascade. Using bioinformatic algorithm and EMSA bandshift assays we identified angiotensin II receptor type 1 (AGTR1), angiotensin I converting enzym...
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PMID: 21298017
PDF is available here.
PDF is available here.
Abstract
We identified a novel Pirh2-interacting protein, AIG1, by yeast two-hybrid screening and confirmed its interaction with p53 both in vitro and in vivo. Quantitative real-time reverse transcription-PCR analysis showed that AIG1 expression levels were reduced in 50 out of 79 (63%) human hepatocellular...
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PMID: 21622095
PDF is available here.
PDF is available here.
Abstract
Osteoclasts are multinucleated cells that have a unique role in bone degradation. Modulation of osteoclast formation and/or its activity is an important approach for the treatment of bone-destructive diseases such as osteoporosis and rheumatoid arthritis. In this study, Gymnasterkore...
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PMID: 20831919
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We identified novel targets of HSF1 in mammalian cells, which suppress the aggregation of polyglutamine (polyQ) protein. Among them, we show that one of the nuclear factor of activated T cells (NFAT) proteins, NFATc2, significantly inhibits polyQ aggregation in cells and is required for HSF1-mediate...
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PMID: 20834230
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)10 2010
Abstract
We have investigated the effect of glycyrol on phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-stimulated IL-2 expression in Jurkat cells.
The enzymatic assay showed glycyrol (IC(50) = 84.6 μM) inhibited calcineurin activity in a dose-dependent manner. Glycyrol, at the non-cytotoxic concen...
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PMID: 20860439
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Bruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-κB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells with greater potency and also showed an ability to up-regulate NFAT transcriptional pathways through...
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PMID: 20944100
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that P. gingivalis induces the MIP-3alpha/CCL20 mRNA in a NF-kappaB-, PLC-, and MAPK-dependent manner....
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PMID: 19710093
PDF is available here.
PDF is available here.
Abstract
We reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce C...
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PMID: 20925194
PDF is available here.
PDF is available here.
Cellular Signalling (22)9 2010
Abstract
We used microarray analyses to examine gene expression profiles in the context of bone marrow-derived macrophages overexpressing a constitutively active form of NFATc1. Herein, we demonstrate that MHC class II transactivator (CIITA) is up-regulated downstream of NFATc1. Overexpression of CIITA in os...
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PMID: 20466061
PDF is available here.
PDF is available here.
Abstract
We targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice. OCL differentiation was drastically decreased in Atf4-/- bone marrow monocyte (BMM) cultures and bones. Coculture of Atf4-/- BMMs with WT OBLs or a high concentration of RANKL failed to res...
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PMID: 20628199
PDF is available here.
PDF is available here.
Abstract
We performed an RNAi-based synthetic lethal screen with imatinib mesylate in CML cells. This screen identified numerous components of a Wnt/Ca(2+)/NFAT signaling pathway. Antagonism of this pathway led to impaired NFAT activity, decreased cytokine production, and enhanced sensitivity to Bcr-Abl inhi...
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PMID: 20609354
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)28 2010
Abstract
These results demonstrate that NFAT plays a role in regulating proinflammatory responses in cultured murine microglia....
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PMID: 20631193
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We investigated the mRNA expression of 12 T-cell markers and the protein expression of CD4, CD25, CD127, FoxP3 after in vitro beta-lactoglobulin stimulation of peripheral blood mononuclear cells from children with persisting CMA (n=16), early recovery (n=20) or no atopy (n=21). Artificial neural net...
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PMID: 20227920
PDF is available here.
PDF is available here.
Abstract
We have generated iPSCs from patients with LEOPARD syndrome (an acronym formed from its main features; that is, lentigines, electrocardiographic abnormalities, ocular hypertelorism, pulmonary valve stenosis, abnormal genitalia, retardation of growth and deafness), an autosomal-dominant developmental...
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PMID: 20535210
PDF is available here.
PDF is available here.
Abstract
We analyzed the proteolytic processing of BAI2 and its activation mechanism. Several cleaved C-terminal fragments of BAI2 were identified in mouse hippocampus. We confirmed that mutation in the GPS domain caused inhibition of the proteolysis of BAI2, which indicated the possibility that BAI2 was cle...
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PMID: 20367554
PDF is available here.
PDF is available here.
Abstract
We study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters. We show that a stochastic rate-limiting step upstream of transcription initiation, but acting at the level of an indi...
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PMID: 20393579
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
We hypothesized that pathological sarcoplasmic reticulum Ca(2+) leak through defective cardiac intracellular Ca(2+) release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca(2+)-dependent hypertrophic signaling. Mice heterozygous for the gain-of-function mut...
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PMID: 20157052
PDF is available here.
PDF is available here.
Abstract
We found that a part of polysaccharides from the stem and leaves of Panax ginseng, termed PGP-SL, could activate CN activity. Subsequently, we investigated whether PGP-SL also has immunological competence on murine spleen lymphocytes. In the present study, we demonstrated that PGP-SL could significa...
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PMID: 20402674
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)6 2010
Abstract
GATA3 siRNA suppressed the expression of GATA3 both in mRNA and protein levels in Hut-78 cells. The binding of NFAT1 to IL-13 promoter was inhibited by GATA3 siRNA in activated T cells, which was followed by the reduction of IL-13 transcription. CONCLUSION: GATA3-NFAT1 complex may play an important...
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PMID: 20368097
PDF is available here.
PDF is available here.
Abstract
We have cloned a novel KRAB-related zinc finger gene, ZNF424, encoding a protein of 555aa. ZNF424 gene consisted of 4 exons and 3 introns, and mapped to chromosome 19p13.3. ZNF424 gene was ubiquitously expressed in human embryo tissues by Northern blot analysis. ZNF424 is conserved across species in...
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PMID: 20356463
PDF is available here.
PDF is available here.
Abstract
These results suggest that EACT may be involved in the inhibition of bone loss by preventing osteoclast formation and may be used to manage bone destruction in inflammatory diseases, such as rheumatoid arthritis....
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PMID: 20195410
PDF is available here.
PDF is available here.
Abstract
We first attempted to investigate the SH3BP2 gene in peripheral giant cell lesion (PGCL). The effect of SH3BP2 gene mutations on the transcription of the downstream genes nuclear factor of activated T cells (NFATc1) and the cytokine tumor necrosis factor-alpha (TNF-alpha) was also investigated toget...
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PMID: 20002873
PDF is available here.
PDF is available here.
Abstract
These results collectively suggested that rotenone demonstrated inhibitory effects on osteoclast differentiation in vitro and suppressed inflammatory bone loss in vivo. Rotenone may therefore serve as a useful drug in the prevention of bone loss....
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PMID: 19900598
PDF is available here.
PDF is available here.
Gastroenterology (138)3 2010
Abstract
Our study uncovers a novel mechanism regulating cell growth and identifies the NFAT/ELK complex as modulators of early stages of mitogen-stimulated proliferation in pancreatic cancer cells.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
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PMID: 19900447
PDF is available here.
PDF is available here.
Abstract
These results identify a glucose-sensitive transcription pathway in vivo, revealing a novel molecular mechanism that may underlie vascular complications of diabetes....
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PMID: 19965778
PDF is available here.
PDF is available here.
Neuroscience Letters (469)3 2010
Abstract
We determined the extent to which serum and cell confluency affect basal and evoked astrocytic NFAT activity in primary cortical astrocyte cultures. Cells were grown to either approximately 50% or >90% confluency, pre-loaded with an NFAT-luciferase reporter construct, and maintained for 16 h in medi...
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PMID: 20026181
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We found that nuclear factor of activated T cells (NFAT) plays an important regulatory role in BKV infection. Luciferase reporter assays and chromatin immunoprecipitation assays demonstrated that NFAT4 bound to the viral promoter and regulated viral transcription and infection. The mutational analys...
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PMID: 19955309
PDF is available here.
PDF is available here.
Molecular Cancer (9) 2010
Abstract
We and others have previously shown that the oncogenic Pim kinases stimulate survival of hematopoietic cells, we now examined their putative role in regulating motility of adherent cancer cells. For this purpose, we inhibited Pim kinase activity using a small molecule compound, 1,10-dihydropyrrolo[2...
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PMID: 20958956
PDF is available here.
PDF is available here.
Abstract
We aimed to elucidate the effects of tonicity during isolation and in vitro expansion on chondrocyte phenotype.
Human articular chondrocytes were isolated and subsequently expanded at control tonicity (280 mOsm) or at moderately elevated, physiological tonicity (380 mOsm). The effects of physiologic...
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PMID: 20492652
PDF is available here.
PDF is available here.
Abstract
We examined the effects of ZSTK474, a novel phosphoinositide 3-kinase (PI3-K)-specific inhibitor, on murine OCs in vitro and in vivo.
The inhibitory effect of ZSTK474 on OC formation was determined and compared with other PI3-K inhibitors by counting tartrate-resistant acid phosphatase (TRAP)-positi...
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PMID: 20482767
PDF is available here.
PDF is available here.
Abstract
Whether tumor progression locus 2 (Tpl2)/cancer Osaka thyroid (Cot) protein kinase participates in osteoclastogenesis from receptor activator of nuclear factor-kappaB ligand (RANKL)-stimulated monocytes/macrophages remains elusive. To clarify this, a selective and potent inhibitor of Tpl2, 1,7-napht...
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PMID: 20045951
PDF is available here.
PDF is available here.
Abstract
We sought first to optimize conditions for a validated cellular model of human Jurkat cells; and then used this model to screen bioactive compounds derived from medicinal plants for inducing T cell anergy in comparison with the effect of well-known T cell anergy inducer, ionomycin. The results showe...
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PMID: 20045933
PDF is available here.
PDF is available here.
BioFactors (36)1 2010
Abstract
In recent years, much progress has been made in understanding the factors that regulate the gene expression program that underlies the induction, proliferation, differentiation, and maturation of osteoblasts. A large and growing number of transcription factors make important contributions to the pre...
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PMID: 20087883
PDF is available here.
PDF is available here.
Abstract
We report here that the c-Rel transcription factor controlled development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB. Although Smad and CREB first bound to Foxp3 enhancers, they later moved to the promoter t...
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PMID: 20064450
PDF is available here.
PDF is available here.
Molecular Immunology (46)13 2009
Abstract
High affinity IgE receptor (FcvarepsilonRI)-induced activation of mast cells results in degranulation and generation of leukotrienes and cytokines. FcvarepsilonRI-induced mast cell activation was analyzed at a single cell basis using a rat basophilic leukemia (RBL-2H3) cell line transfected with a r...
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PMID: 19540596
PDF is available here.
PDF is available here.
Journal of Physiology (587)Pt 15 2009
Abstract
We explored whether 8 weeks of moderate intensity exercise training would lead to a cardiac anti-remodelling effect in an experimental model of heart failure associated with a deactivation of a pathological (calcineurin/NFAT, CaMKII/HDAC) or activation of a physiological (Akt-mTOR) hypertrophy signa...
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PMID: 19505981
PDF is available here.
PDF is available here.
Abstract
We previously reported that VEGF induces DSCR-1s expression in endothelial cells, which in turn negatively feeds back to attenuate endothelial cell activation. Here, in order to characterize the role of the promoter that drives DSCR-1s expression in mediating inducible expression in vivo and to dete...
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PMID: 19620774
PDF is available here.
PDF is available here.
Circulation Research (105)4 2009
Abstract
Green fluorescent protein-tagged NFATc3 was used to determine the cellular location of NFAT in cultured neonatal rat ventricular myocytes (NRVMs) and adult feline ventricular myocytes. Constitutively active (CaMKII-CA) or dominant negative (CaMKII-DN) mutants of cytoplasmic targeted CaMKII(deltac) w...
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PMID: 19608982
PDF is available here.
PDF is available here.
PLoS Pathogens (5)7 2009
Abstract
We demonstrate a novel TLR-independent innate response pathway to T. cruzi. Myd88(-/-)Trif(-/-) mice lacking TLR signaling showed normal T. cruzi-induced Th1 responses and maturation of dendritic cells (DCs), despite high sensitivity to the infection. IFN-gamma was normally induced in T. cruzi-infec...
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PMID: 19609356
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)28 2009
Abstract
We performed an in silico promoter analysis and found a putative NFAT site within the GAP-43 promoter. Using in vitro and in vivo experiments, we demonstrated that NFAT-3 regulates GAP-43, but unexpectedly, does not promote but represses the expression of GAP-43 in neurons and in the developing brai...
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PMID: 19443652
PDF is available here.
PDF is available here.
Circulation Research (105)1 2009
Abstract
European Journal of Pharmacology (614)1-3 2009
Abstract
We examined if hirsutenone suppressed the profiles of atopic dermatitis development in vitro via mimicry of calcineurin inhibitor actions in mouse splenocytes and RBL-2H3 mast cells. Our results showed that hirsutenone effectively inhibited T cell activation by blocking dephosphorylation of nuclear...
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PMID: 19409888
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
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PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
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PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.
FEBS Letters (583)12 2009
Abstract
We constructed 14 non-phosphorylated, 11 phospho-mimetic, and 1 non-acetylated point p53 mutations and compared their transactivation ability in U-87 human glioblastoma cells by the luciferase reporter assay. Despite mutations at the phosphorylation sites, only the p53-K120R and p53-S9E mutants had...
|
PMID: 19416725
PDF is available here.
PDF is available here.