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Nuclear Respiratory Factors (2):
Recent article
Nuclear Respiratory Factors
Abstract
We identified and annotated in the MitoComp2 dataset the orthologs of 68 nuclear genes controlling oxidative phosphorylation in 11 Drosophilidae species and in five non-Drosophilidae insects, and compared them with each other and with their counterparts in three vertebrates (Fugu rubripes, Danio rer...
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PMID: 18315839
PDF is available here.
PDF is available here.
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Abstract
We investigated the role of nuclear respiratory factor-2 (NRF-2) in intragenomic regulation of nuclear COX genes. Vector-mediated short-hairpin RNA interference against NRF-2alpha reduced all 10 COX nuclear subunit mRNAs and mRNAs of other genes involved in mitochondrial function/biogenesis. NRF-2 b...
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PMID: 16516409
PDF is available here.
PDF is available here.
Abstract
We examined age-dependent changes in myocardial bioenergetic enzymes (catalytic activities and transcript levels) and mRNA levels of putative transcriptional regulators of bioenergetic genes. Very old rats (35 months) showed a 22% increase in ventricular mass with no changes in DNA or RNA per gram....
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PMID: 16609700
PDF is available here.
PDF is available here.
Antioxidants and Redox Signaling (8)9-10 2006
Abstract
We used a DNA microarray analysis, with hearts from transgenic mice with cardiac- specific overexpression of Trx1 (Tg-Trx1, n = 4) and nontransgenic controls (n = 4). Expression of a large number of genes is regulated in Tg-Trx1, with a greater number of genes downregulated, versus upregulated, at h...
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PMID: 16987018
PDF is available here.
PDF is available here.
Abstract
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium. In contrast, the dominant-negative m...
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PMID: 15992771
PDF is available here.
PDF is available here.
Abstract
Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE). Interestingly, TBH also induces rat GCLC, but the rat GCLC promoter lack...
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PMID: 15988009
PDF is available here.
PDF is available here.
Biochemistry (Washington) (44)18 2005
Abstract
We report here evidence in support of the role of 17beta-estradiol- (E2-) induced mitochondrial (mt) reactive oxygen species (ROS) as signal-transducing messengers. On the basis of monitoring the oxidation of 2',7'-dichlorofluorescin by spectrofluorometry, flow cytometry, and confocal microscopy, we...
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PMID: 15865435
PDF is available here.
PDF is available here.
Abstract
We report here that mice with somatic inactivation of nrf1 in the liver developed hepatic cancer. Before cancer development, mutant livers exhibited steatosis, apoptosis, necrosis, inflammation, and fibrosis. In addition, hepatocytes lacking Nrf1 showed oxidative stress, and gene expression analysis...
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PMID: 15738389
PDF is available here.
PDF is available here.
Biochemical Journal (386)Pt 2 2005
Abstract
We had previously shown that in mouse brain extracts two of these sites are bound by USF1/USF2 (upstream stimulatory factors 1 and 2) heterodimers and NRF-1 (nuclear respiratory factor-1). We also showed that these sites are involved in the positive regulation of FMR1 transcription in neuronally der...
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PMID: 15479157
PDF is available here.
PDF is available here.
Abstract
We establish that the expression of human TFB1M and TFB2M promoters is governed by nuclear respiratory factors (NRF-1 and NRF-2), key transcription factors implicated in mitochondrial biogenesis. In addition, we show that NRF recognition sites within both TFB promoters are required for maximal trans...
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PMID: 15684387
PDF is available here.
PDF is available here.
Abstract
We characterized the structures and transcriptional regulation of Zfp106 and its human homologue, ZFP106. A TATA-less, CpG island associated promoter (P1), was mapped by 5'-RACE to a region 19 kb upstream of the ZFP106 translation start site. P1 is active throughout development and at low levels in...
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PMID: 15656981
PDF is available here.
PDF is available here.
Biochemical Journal (383)Pt. 3 2004
Abstract
We analysed the activity of the previously cloned promoter region of the human E2F6 gene. DNase I footprinting, gel electrophoreticmobility shift, transient transfection and site-directed mutagenesis experiments allowed the identification of two functional NRF-1/alpha-PAL (nuclear respiratory factor...
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PMID: 15257658
PDF is available here.
PDF is available here.
Journal of Virology (78)20 2004
Abstract
We set out to biochemically purify the binding protein(s) for the 21-bp DNA. We report here the identification of the X gene minimal promoter-binding activity as nuclear respiratory factor 1 (NRF1), a previously known transcription factor that activates the majority of nucleus-encoded mitochondrial...
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PMID: 15452206
PDF is available here.
PDF is available here.
EMBO Journal (23)17 2004
Abstract
We showed that hypertrophy is accompanied by activation of cyclin T/Cdk9, which phosphorylates the C-terminal domain of the large subunit of RNA polymerase II, stimulating transcription elongation and pre-mRNA processing; Cdk9 activity was required for hypertrophy in culture, whereas heart-specific...
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PMID: 15297879
PDF is available here.
PDF is available here.
Abstract
Endurance exercise training induces an increase in the respiratory capacity of muscle, resulting in an increased capacity to generate ATP as well as improved efficiency of muscle contraction. Such adaptations are largely the result of a coordinated genetic response that increases mitochondrial prote...
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PMID: 15294042
PDF is available here.
PDF is available here.
Abstract
We have reported that overexpression of nuclear respiratory factor-1 (NRF-1) and high concentration (50 mM) of glucose increased the promoter activity of the rat Tfam in L6 rat skeletal muscle cells. In this study, we investigated the mechanism of high glucose-induced Tfam transactivation. The addit...
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PMID: 15126285
PDF is available here.
PDF is available here.
Abstract
We used C(2)C(12) cells depleted of mtDNA (rho(-) cells) and fibroblasts from a mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS) patient to examine adaptations of the protein import machinery and transcription factors involved in mitochondrial biogenesis. In rho(-) cell...
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PMID: 14656719
PDF is available here.
PDF is available here.
Abstract
We investigated whether the site-specific methylation would modulate the Tfam promoter-driven transcriptional activity in vitro. The luciferase reporters ligated to Tfam promoter (pGL2-Tfam2378) were in vitro methylated by SssI (CG), HpaII (CCGG), or HhaI (GCGC) methylase and luciferase activities w...
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PMID: 14715254
PDF is available here.
PDF is available here.
Abstract
Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental stimuli, adaptive responses to the redox stress t...
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PMID: 15777020
PDF is available here.
PDF is available here.
Postepy biochemii (50)3 2004
Abstract
Abstract
We have investigated the influence of the PGC-1 related coactivator (PRC) on the high mitochondrial content observed in oncocytoma by quantifying the transcripts of PRC, the nuclear respiratory factor 1 (NRF-1) and the mitochondrial transcription factor A (TFAM), in 30 oncocytic tumors and correspon...
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PMID: 14550271
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1629)1-3 2003
Abstract
These results indicate that the NRF-1 response element in the p115 promoter is important for promoter function, and that it involves the binding of NRF-1. Furthermore, the results suggested that p115 gene transcription is activated by E(2), by insulin, or by both in association with the stimulation...
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PMID: 14522081
PDF is available here.
PDF is available here.
FASEB Journal (17)12 2003
Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity.
Abstract
We generated transgenic mice overexpressing NRF-1 in skeletal muscle. Cytochrome c expression was increased approximately twofold and delta-aminolevulinate synthase was increased approximately 50% in NRF-1 transgenic muscle. The levels of some mitochondrial proteins were increased 50-60%, while othe...
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PMID: 12958173
PDF is available here.
PDF is available here.
Abstract
We report the effect of a 16-week aerobic exercise program (n = 65) or control activity (n = 37) performed by men and women aged 21-87 years on insulin sensitivity and muscle mitochondria. Insulin sensitivity, measured by intravenous glucose tolerance test, decreased with age (r = -0.32) and was rel...
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PMID: 12882902
PDF is available here.
PDF is available here.
Biochemical Journal (373)Pt 3 2003
Abstract
We demonstrated recently that expression of the UDP- N -acetyl-alpha-D-galactosamine: polypeptide N -acetylgalactosaminyltrans-ferase-3 (GalNAc-T3) gene is restricted to epithelial glands [Nomoto, Izumi, Ise, Kato, Takano, Nagatani, Shibao, Ohta, Imamura, Kuwano, Matsuo, Yamada, Itoh and Kohno (1999...
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PMID: 12720548
PDF is available here.
PDF is available here.
Abstract
We analyzed gene expression in skeletal muscle from healthy metabolically characterized nondiabetic (family history negative and positive for DM) and diabetic Mexican-American subjects. We demonstrate that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory fa...
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PMID: 12832613
PDF is available here.
PDF is available here.
Abstract
We show by chimera analysis that Nrf1 is essential for the hepatocyte lineage. Mouse embryonic stem cells lacking Nrf1 developed normally and contributed to most tissues in adult chimeras where Nrf1 is normally expressed. Nrf1-deficient cells contributed to fetal, but not adult, liver cells. Loss of...
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PMID: 12808106
PDF is available here.
PDF is available here.
Abstract
We conclude that activation of the EPRE-signaling pathway, which up-regulates several phase II genes and affects p53 stabilization, may offer resistance to hepatic stellate cells against oxidative damage during hepatic injury. This resistance may be a part of the activation process of the hepatic st...
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PMID: 12729613
PDF is available here.
PDF is available here.
Biochemical Journal (371)Pt 2 2003
Abstract
We report that such a protein can be obtained following its overexpression in bacteria. The pure NBF1+R protein exhibits significant ATPase activity [catalytic-centre activity (turnover number) 6.7 min(-1)] and an apparent affinity for ATP ( K (m), 8.7 microM) higher than reported previously for CFT...
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PMID: 12523935
PDF is available here.
PDF is available here.
FASEB Journal (17)6 2003
Abstract
We are using L6 myotubes. Using this model we have found that raising cytosolic Ca2+ induces an increase in mitochondria. In this study, we tested the hypothesis that raising cytosolic Ca2+ in L6 myotubes induces increased expression of PGC-1, NRF-1, NRF-2, and mtTFA, factors that have been implicat...
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PMID: 12665481
PDF is available here.
PDF is available here.
Abstract
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma...
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PMID: 12574632
PDF is available here.
PDF is available here.
Journal of Physiology (546)Pt 3 2003
Abstract
Endurance exercise training induces mitochondrial biogenesis in skeletal muscle. The peroxisome proliferator activated receptor co-activator 1alpha (PGC-1alpha) has recently been identified as a nuclear factor critical for coordinating the activation of genes required for mitochondrial biogenesis in...
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PMID: 12563009
PDF is available here.
PDF is available here.
Genes & Development (17)2 2003
Abstract
We have evaluated whether the activation of the mitochondrial apoptotic signaling pathway is linked to c-Myc induction of a subset of genes involved in mitochondrial biogenesis. Cytochrome c and other nuclear-encoded mitochondrial genes are regulated by the transcription factor nuclear respiratory f...
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PMID: 12533512
PDF is available here.
PDF is available here.
Reproductive Toxicology (17)4 2003
Abstract
The peripheral benzodiazepine receptor (Bzrp) has been implicated in the control of several processes, including mitochondrial biogenesis and embryo development. The present study examined the impact that specific Bzrp ligands have on oxygen homeostasis in the early mouse embryo. Day 9 embryos at th...
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PMID: 12849846
PDF is available here.
PDF is available here.
FASEB Journal (16)14 2002
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.
Abstract
We tested the hypothesis that increases in PGC-1, NRF-1, and NRF-2 are involved in the initial adaptive response of muscle to exercise. Five daily bouts of swimming induced increases in mitochondrial enzymes and GLUT4 in skeletal muscle in rats. One exercise bout resulted in approximately twofold in...
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PMID: 12468452
PDF is available here.
PDF is available here.
Pediatric Research (52)2 2002
Abstract
I ). HIF-1alpha protein was present in fetal myocardium but dropped below detectable levels at 7 d postnatally. HIF-2alpha protein levels were similar at the four time points. Steady-state mRNA levels of alpha-enolase, lactate dehydrogenase A, and liver phosphofructokinase declined significantly pos...
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PMID: 12149506
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1576)1-2 2002
Abstract
The biogenesis of mitochondria requires the expression of a large number of genes, most of which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13 respiratory subunits necessitating that nuclear regulatory factors play an important role in governing nucleo-mitochond...
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PMID: 12031478
PDF is available here.
PDF is available here.
Abstract
We hypothesized that bleomycin activates oxidative stress response pathways and regulates cellular glutathione (GSH). Bovine pulmonary artery endothelial cells exposed to bleomycin exhibit growth arrest and increased cellular GSH content. gamma-Glutamylcysteine synthetase (gamma-GCS) controls the ke...
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PMID: 12003792
PDF is available here.
PDF is available here.
Abstract
We analysed the temporal and spatial expression pattern of Nrf-1 and Nrf-2 after unilateral excitotoxic lesion of mouse hippocampus. In marked contrast to previous in vitro studies, where upregulation of these transcription factors on the mRNA level was never detected, we found a strong induction of...
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PMID: 12059978
PDF is available here.
PDF is available here.
Molecular Pharmacology (61)5 2002
Abstract
These results implicate albumin precursor protein, phi AP3, and alpha-smooth muscle actin as participants in redox sensing in vSMCs, and suggest that protein complex assembly involves interactions between leucine zipper and zinc finger transcription factors with cytoskeletal proteins....
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PMID: 11961136
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1574)3 2002
Abstract
We have recently isolated an approximately 20 kb genomic fragment of the mouse COX17. Reporter assay experiments have shown that most of the promoter activity was restricted to a 0.85 kb fragment flanking the first exon. Further intensive deletion and detailed mutation analysis suggested that the mi...
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PMID: 11997103
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1574)2 2002
Abstract
Mitochondrial transcription factor A (Tfam) is essential for the initiation of transcription and the replication of mitochondrial DNA (mtDNA). The 5'-upstream region of the rat Tfam gene was isolated from rat genomic DNA by extending the 5' sequence of newly identified Tfam cDNA using PCR-based Geno...
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PMID: 11955630
PDF is available here.
PDF is available here.
Journal of Biomedical Science (9)6 Pt 1 2002
Abstract
We demonstrated that sublethal levels of oxidative stress caused an increase in mitochondrial mass in human lung cells. In this communication, we report our recent findings that the mitochondrial mass in human lung fibroblasts (MRC-5) in a later proliferation stage is significantly increased compare...
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PMID: 12372989
PDF is available here.
PDF is available here.
Anticancer Research (22)4 2002
Abstract
Despite new protocols, non-small cell bronchopulmonary cancers are still difficult to treat by current chemotherapeutic procedures. Thus, it is essential to define new treatment strategies and detect new therapeutic targets. In order to define these new targets, this study applied the "differential...
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PMID: 12174908
PDF is available here.
PDF is available here.
Cancer Letters (174)2 2001
Abstract
This article provides an overview of the mechanisms by which cancer chemopreventive blocking agents increase the expression of detoxication and antioxidant genes. These agents all appear capable of transcriptionally activating a gene battery that includes NAD(P)H:quinone oxidoreductase, aldo-keto re...
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PMID: 11689285
PDF is available here.
PDF is available here.
Nucleic Acids Research (29)24 2001
Abstract
We performed cDNA expression array hybridisation to identify T3-regulated genes and to investigate their expression pattern after various time points in vivo. Radioactively labelled cDNA was prepared from hepatic RNA of hypothyroid and hyperthyroid rats 6, 24 and 48 h after the administration of T3....
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PMID: 11812848
PDF is available here.
PDF is available here.
Diabetes Research and Clinical Practice (54 Suppl 2) 2001
Abstract
We studied on the regulatory mechanism of mtTFA expression and the factors affecting the transcriptional activity of the mtTFA promoter. The promoter of human mtTFA contains 67 CpG dinucleotides. When the plasmids bearing the mtTFA promoter (2378 bp) linked to luciferase were transiently transfected...
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PMID: 11733104
PDF is available here.
PDF is available here.
Abstract
Our data suggest that AMPK may play an important role in muscle adaptations to chronic energy stress and that it promotes mitochondrial biogenesis and expression of respiratory proteins through activation of NRF-1....
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PMID: 11701451
PDF is available here.
PDF is available here.
Molecular Cell (8)5 2001
Abstract
We show here that many cytokines activate the transcriptional PPAR gamma coactivator-1 (PGC-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of PGC-1 protein. Cytokine or lipopolysaccharide (LPS)-induced activation of PGC-1 in cultured muscle cells or muscle in viv...
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PMID: 11741533
PDF is available here.
PDF is available here.
Abstract
These results revealed that the upregulation of mtTFA and mitochondrial biogenesis is preceded by upregulation of NRF-1 and NRF-2, which is consistent with the known molecular events controlling mitochondrial biogenesis in other systems....
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PMID: 11694003
PDF is available here.
PDF is available here.
Abstract
FEBS Letters (501)1 2001
Abstract
The expression of two factors involved in the nuclear-mitochondrial crosstalk, namely the mitochondrial transcription factor A (TFAM) and the nuclear respiratory factor-1 (NRF-1), was studied in human skeletal muscle biopsies of young and aged subjects. Aged subjects presented a 2.6-fold and an 11-f...
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PMID: 11457459
PDF is available here.
PDF is available here.
Abstract
We searched the databases for sequences with similarities to PGC-1. Here, we describe the first characterization of a 177-kDa transcriptional coactivator, designated PGC-1-related coactivator (PRC). PRC is ubiquitously expressed in murine and human tissues and cell lines; but unlike PGC-1, PRC was n...
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PMID: 11340167
PDF is available here.
PDF is available here.
Cancer Research (61)8 2001
Abstract
Northern blotting has shown that mouse small intestine contains relatively large amounts of the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1. Regulation of intestinal antioxidant and detoxication enzymes by Nrf2 has been assessed using a mouse line bea...
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PMID: 11309284
PDF is available here.
PDF is available here.
FEBS Letters (494)3 2001
Abstract
We report that inhibiting mitochondrial protein synthesis causes a modulation in mtDNA gene expression without the concomitant increase in proliferative markers. Further, inhibition results in the production of a previously unidentified light-strand mitochondrial RNA that spans the entire displaceme...
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PMID: 11311238
PDF is available here.
PDF is available here.
BioFactors (15)1 2001
Abstract
The objective of the present study was to characterize the action of Ginkgo biloba extract (EGb761) and its sub-fractions on glutathione homeostasis in a human keratinocyte cell culture model. Cells were incubated with EGb761, its purified flavonoid (quercetin, kaempferol, rutin) or terpenoids (ging...
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PMID: 11673643
PDF is available here.
PDF is available here.
Abstract
We investigated here the in vivo function of NRF-1 in mammals by disrupting the gene in mice. A portion of the NRF-1 gene that encodes the nuclear localization signal and the DNA-binding and dimerization domains was replaced through homologous recombination by a beta-galactosidase-neomycin cassette....
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PMID: 11134350
PDF is available here.
PDF is available here.
Abstract
Although normal megakaryocytic development has been shown to require the presence of functional GATA-1 and NF-E2 transcription factors in vivo, the roles of other members of the GATA binding factors and NF-E2 family during megakaryocytic differentiation are unclear. the present study, the expression...
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PMID: 11286316
PDF is available here.
PDF is available here.
Abstract
We explore these developments in relation to classical physiological views of adaptive thermogenesis....
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PMID: 10766252
PDF is available here.
PDF is available here.
Mammalian Genome (11)2 2000
Abstract
We designed degenerate primers to the conserved DNA-binding domain. The RT-PCR product obtained from mRNA of the mouse muscle cell line C2C12 was used to screen cDNA libraries; a single gene was identified which encodes a predicted 503 amino acid protein. The mouse ewg homolog, termed Nrf1, was mapp...
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PMID: 10656923
PDF is available here.
PDF is available here.