Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Peroxisome Proliferator-Activated Receptors (4):
Recent article
Peroxisome Proliferator-Activated Receptors
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
|
PMID: 21554208
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The monosodium glutamate (MSG) neonatal administration in mice provides a model of obesity with impaired glucose tolerance (IGT) and insulin resistance. However, the inflammatory profile of cytokines produced from fat tissue and its relationship to the metabolic dysfunction induced b...
|
PMID: 21205225
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We utilize a metabolomics approach that detects protein-metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts....
|
PMID: 21283866
PDF is available here.
PDF is available here.
Abstract
Hepatic steatosis is now understood to play an important role in the development of advanced liver disease. Alcoholic and nonalcoholic fatty liver each begin with the accumulation of lipids in the liver. Lipid accumulation in the liver can occur through maladaptations of fatty acid uptake (either th...
|
PMID: 20960377
PDF is available here.
PDF is available here.
Abstract
The metabolic syndrome is characterized by a state of metabolic dysfunction resulting in the development of several chronic diseases that are potentially deadly. These metabolic deregulations are complex and intertwined and it has been observed that many of the mechanisms and pathway...
|
PMID: 20937021
PDF is available here.
PDF is available here.
Abstract
Evidence presented over the past 20 years has shown that long-chain polyunsaturated fatty acids (LCPUFAs), especially the n-3 fatty acids such as eicospentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial for bone health. Some studies in humans indicate that LCPUFAs can increase bone f...
|
PMID: 20600307
PDF is available here.
PDF is available here.
Actas Dermo-Sifiliográficas (101)7 2010
Abstract
The authors describe peroxisome proliferator-activated receptor (PPAR) transcription factors as connectors between the enzymatic mechanisms of the epidermal barrier and the abnormal immune and inflammatory responses that characterize atopic dermatitis and psoriasis. Also described is a new connectio...
|
PMID: 20858385
PDF is available here.
PDF is available here.
Abstract
We screened several classes of immunomodulatory agents possessing the potential to mitigate the effects of influenza virus-induced immunopathology.
Here, we provide preliminary evidence that two classes of drugs, peroxisome proliferator-activated receptor-gamma agonists and AMP-activated protein kin...
|
PMID: 20716159
PDF is available here.
PDF is available here.
Abstract
Our understanding of the pathophysiology of AF has increased dramatically over the past few decades. Recent treatment guidelines have heightened our awareness of the challenges involved in the treatment of AF and provided useful recommendations for its diagnosis and management. Because AF is usually...
|
PMID: 20562374
PDF is available here.
PDF is available here.
Abstract
We recently showed that 1,25-dihydroxyvitamin D3 and some of the investigated PPAR ligands inhibited proliferation of the human melanoma cell line MeWo. In addition to this, our results gave an indication of an interconnection of the PPAR and VDR signaling pathways at the level of cross-regulation o...
|
PMID: 20214982
PDF is available here.
PDF is available here.
Circulation Research (106)10 2010
Abstract
Abstract: Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from...
|
PMID: 20508200
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Macrophages are involved in the immune and the inflammatory response. The deregulation of their physiological properties is associated with several pathologies such as atherosclerosis and some cancers. Cytokines action on this blood lineage modulates p21WAF1/CIP1 expression. It appears that this pro...
|
PMID: 20510146
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We showed previously that dietary provision of whole table grape powder (3% weight:weight) for 18 weeks reduced blood pressure, cardiac hypertrophy, and diastolic dysfunction. The hypothesis tested here is that, in this model, phytochemical provision from whole grape powder impacts cardiac PPAR and...
|
PMID: 20231522
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)3 2010
Abstract
The PPAR gene pathway consists of interrelated genes that encode transcription factors, enzymes, and downstream targets which coordinately act to regulate cellular processes central to glucose and lipid metabolism. The pathway includes the PPAR genes themselves, other class II nuclear hormone recept...
|
PMID: 18998207
PDF is available here.
PDF is available here.
Abstract
Diabetes is associated with a range of metabolic abnormalities including insulin resistance, atherogenic dyslipidemia, hypertension, and inflammation. These factors are likely to underlie the adverse cardiovascular outcome typically observed in diabetic cohorts. The family of peroxis...
|
PMID: 20489419
PDF is available here.
PDF is available here.
Abstract
Vascular inflammatory disorders are often associated with both decreased NO bioavailability and a lack of responsiveness to NO, a consequence of impaired NO biosynthesis, dysregulated l-arginine metabolism, endothelial nitric oxide synthase (eNOS) uncoupling and NO consumption induced by redox react...
|
PMID: 20080062
PDF is available here.
PDF is available here.
Abstract
The PPARs are a family of three ligand-activated nuclear receptors: PPARalpha, PPARbeta/delta and PPARgamma. During the past 20 years, PPARs have been recognized as having important roles in the regulation of glucose and fatty acid metabolism, cell differentiation and immune function. In addition, a...
|
PMID: 20178041
PDF is available here.
PDF is available here.
Abstract
We present data that tocotrienols within palm oil functioned as PPAR modulators. Specifically, both alpha- and gamma-tocotrienol activated PPARalpha, while delta-tocotrienol activated PPARalpha, PPARgamma, and PPARdelta in reporter-based assays. Tocotrienols enhanced the interaction between the puri...
|
PMID: 19866471
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of adiponectin, the adiponectin receptors, and genes involved in the downstream lipid and glucose metabolism in the skeletal muscle of patients with CHF.
Muscle biopsies (vastus lateralis muscle) were obtained from 13 patients with CHF and 10 healthy su...
|
PMID: 20103776
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
Pathways involved in mitochondrial biogenesis associated with myogenic differentiation are poorly defined. Therefore, C(2)C(12) myoblasts were differentiated into multi-nucleated myotubes and parameters/regulators of mitochondrial biogenesis were investigated. Mitochondrial respiration, citrate synt...
|
PMID: 19804813
PDF is available here.
PDF is available here.
Abstract
We investigated the possibility that free fatty acids induce the expression of UCP2 through the peroxisome proliferator-activated receptor pathway, thereby increasing cell apoptosis in adult rat cardiomyocytes. Primary cultured adult rat cardiomyocytes exposed to free fatty acids exhibited a dose-de...
|
PMID: 20010438
PDF is available here.
PDF is available here.
Theriogenology (73)3 2010
Abstract
Downstream effects of prostaglandin-D synthetase (PGDS) in a primary culture of chicken (Gallus gallus) anterior pituitary cells were investigated to study how PGDS regulated laying in hens. Either PGDS downstream metabolite, PGD(2) or PGJ(2), elevated LHB mRNA and LHB protein levels in dose- and ti...
|
PMID: 19954828
PDF is available here.
PDF is available here.
Abstract
PPARdelta activation by PLA-LDL does not influence lipid accumulation in PLA-LDL-treated macrophages. However, it attenuates macrophage inflammatory responses, thus contributing to an anti-inflammatory cell phenotype....
|
PMID: 19948841
PDF is available here.
PDF is available here.
Abstract
Abstract
Molecular Medicine (16)5-6 2010
Abstract
We analyzed the intestinal mucosa proteome alterations using two dimensional difference gel electrophoresis (2D-DIGE) coupled with matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF ms) of CD patients with varying degrees of histological abnormalities defined by...
|
PMID: 20454521
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)14 2010
Abstract
We summarize the most relevant aspects of the structural/functional characterization of these receptors, with a focus on the active role played by biological membranes (in particular lipid rafts) in the modulation of their accessibility and mode of ligand binding. Based on available evidence, we pro...
|
PMID: 20166920
PDF is available here.
PDF is available here.
Abstract
The physiological and pathological role of oxidized polyunsaturated fatty acids (PUFAs) has been extensively studied, whereas those of hydroxy monounsaturated fatty acids (MUFAs) are not well understood. This study demonstrated that 11-hydroxy-(9Z)-octadecenoic acid ((9Z)-11-HOE), which was isolated...
|
PMID: 20460766
PDF is available here.
PDF is available here.
Mediators of Inflammation (2010) 2010
Abstract
Visceral obesity is coupled to a general low-grade chronic inflammatory state characterized by macrophage activation and inflammatory cytokine production, leading to insulin resistance (IR). The balance between proinflammatory M1 and antiinflammatory M2 macrophage phenotypes within visceral adipose...
|
PMID: 20508742
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)14 2010
Abstract
We describe how these effects are relevant under diverse physiological and pathophysiological circumstances, such as lipid metabolism and feeding behaviour, neuroprotection and epilepsy, circadian rhythms, addiction and cognition. A picture is emerging where nuclear receptors are involved in anorexi...
|
PMID: 20166922
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)30 2010
Abstract
Metabolic syndrome is characterized primarily by abdominal obesity, high triglyceride- and low HDL cholesterol levels, elevated blood pressure, and increased fasting glucose levels, which are often associated with coronary heart diseases. Several factors, such as physical inactivity, age, and severa...
|
PMID: 20738247
PDF is available here.
PDF is available here.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (140) 2010
Abstract
Chronic disorders, such as obesity, diabetes, inflammation, non-alcoholic fatty liver disease and atherosclerosis, are related to alterations in lipid and glucose metabolism, in which peroxisome proliferator-activated receptors (PPAR)α, PPARβ/δ and PPARγ are involved. These receptors form a subg...
|
PMID: 20842602
PDF is available here.
PDF is available here.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique (17)3 2010
Abstract
We postulate plays a major role in ethanol neurobehavioral teratogenesis. We propose that many of the prominent adverse effects of chronic prenatal exposure to ethanol on CNS development and function may be prevented or reduced by treatment with peroxisome-proliferated activated receptor (PPAR) agon...
|
PMID: 21063035
PDF is available here.
PDF is available here.
Abstract
Parasitic infections induce a magnitude of host responses. At the opposite ends of the spectrum are those that ensure the host's needs to eliminate the invaders and to minimize damage to its own tissues. This review analyzes how parasites would manipulate immunity by activating the immunosuppressive...
|
PMID: 20169106
PDF is available here.
PDF is available here.
Abstract
Fatty acids binding proteins (FABPs) are involved in uptake, binding, transport and metabolism of fatty acids (FAs). Although FAs are known to stimulate insulin secretion from pancreatic islets when transiently elevated, while contributing to islet loss of function, lipotoxicity and...
|
PMID: 21099311
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (87)12 2009
Abstract
We explored a potential link between a response to I/R and changes in cardiac PPARalpha protein and gene expression in simvastatin-treated normocholesterolaemic rats. After 5 days of treatment with simvastatin (10 mg/kg per day, p.o.), Langendorff-perfused hearts were subjected to 30 min regional is...
|
PMID: 20029539
PDF is available here.
PDF is available here.
Vnitrni lekarstvi (55)12 2009
Abstract
Control angiography was performed in 477 of 565 patients (84.4%) with following restenosis rates in genotype subgroups: CC 29.0% vs GC/GG 22.6% (p = 0.33) in L162V, CC 29.9% vs TC/TT 24.6% (p = 0.24) in C161T and A/A 26.9% vs A/AA + AA/AA 35.0% (p = 0.14) in A(39526)AA polymorphisms. The T allele of...
|
PMID: 20070029
PDF is available here.
PDF is available here.
Abstract
Diets rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) such as alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid are associated with decreased incidence and severity of cardiovascular disease (CVD). At least some of the beneficial effects of these dietary fatty acids are m...
|
PMID: 19852886
PDF is available here.
PDF is available here.
Xenobiotica (39)11 2009
Abstract
A transgenic 'knock-in' mouse model expressing a human UGT1 locus (Tg-UGT1) was recently developed and validated. Although these animals express mouse UGT1A proteins, UGT1A4 is a pseudo-gene in mice. Therefore, Tg-UGT1 mice serve as a 'humanized' UGT1A4 animal model. Lamotrigine (LTG) is primarily m...
|
PMID: 19845433
PDF is available here.
PDF is available here.
Abstract
The expression and signaling of the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor (PPAR) alpha, delta, gamma was investigated in the melanoma cell line MeWo. Using real-time PCR, the mRNA of the nuclear receptors (NR) was detected. The strongest expression was found for the...
|
PMID: 19667161
PDF is available here.
PDF is available here.
Clinical calcium (19)9 2009
Abstract
It is well known that insulin plays an important role in bone metabolism. In addition, resent reports have demonstrated that adipocytokine and peroxisome proliferator-activated receptors (PPARs) , which are involved in insulin resistance, dramatically affect bone metabolism. In particular, Food and...
|
PMID: 19721197
PDF is available here.
PDF is available here.
Critical Care Medicine (37)8 2009
Abstract
Clinical and experimental data indicate that diabetes is protective against the development of ALI/ARDS. The pathways involved are complex and likely include effects of hyperglycemia on the inflammatory response, metabolic abnormalities in diabetes, and the interactions of therapeutic agents given t...
|
PMID: 19531947
PDF is available here.
PDF is available here.
Abstract
Hepatitis C is recognized as a major threat to global public health. The current treatment of patients with chronic hepatitis C is the addition of ribavirin to interferon-based therapy which has limited efficacy, poor tolerability, and significant expense. New treatment options that are more potent...
|
PMID: 19630100
PDF is available here.
PDF is available here.
Abstract
Obesity is one of the major Public Health problems. Obese individuals are more susceptible to develop cardiovascular diseases and type 2 diabetes mellitus. The obesity results from the increase in size and number of the adipocytes. The balance between adipogenesis and adiposity determines the degree...
|
PMID: 19768249
PDF is available here.
PDF is available here.
Brain research (1279) 2009
Abstract
We hypothesized that prophylactic administration of gemfibrozil improves outcome after ischemic stroke. In this study, we measured the impact of gemfibrozil in two permanent middle cerebral artery occlusion (MCAO) models in young adult male mice on normal diet. First, we tested gemfibrozil in a fila...
|
PMID: 19427843
PDF is available here.
PDF is available here.
FEBS Journal (276)12 2009
Abstract
The purpose of this study was to provide a better understanding of the regulatory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells (NFkappaB) in mouse heart. NFkappaB regulates many nuclear genes and has been associated wi...
|
PMID: 19438714
PDF is available here.
PDF is available here.
FEBS Journal (276)12 2009
Abstract
The purpose of this study was to provide a better understanding of the regulatory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells (NFkappaB) in mouse heart. NFkappaB regulates many nuclear genes and has been associated wi...
|
PMID: 19438714
PDF is available here.
PDF is available here.
Abstract
Omega-3 fatty acids (omega3-FA) were shown to attenuate growth and induce apoptosis in a variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast cancer. In addition, recent findings indicate that omega3-FA act synergistically with chemotherapeutic ag...
|
PMID: 19442044
PDF is available here.
PDF is available here.
EMBO Reports (10)4 2009
Abstract
We show that tributyltin (TBT) activates all three RXR-PPAR-alpha, -gamma, -delta heterodimers, primarily through its interaction with RXR. In addition, the 1.9 A resolution structure of the RXR-alpha ligand-binding domain in complex with TBT shows a covalent bond between the tin atom and residue Cy...
|
PMID: 19270714
PDF is available here.
PDF is available here.
Abstract
We and others have provided evidence in support of the hypothesis that labour onset is regulated by specific nuclear regulatory factor (NR) pathways, involving an interplay between transcription factors (TFs) and nuclear hormone receptors, that control the expression of many of the effector pathways...
|
PMID: 19010537
PDF is available here.
PDF is available here.