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Proto-Oncogene Proteins c-rel (0):
Recent article
Proto-Oncogene Proteins c-rel
Journal of Biological Chemistry (285)34 2010
Abstract
We have used a modular approach to determine the crystal structures of the structured domains in the EBF family. The DNA binding domain reveals a striking resemblance to the DNA binding domains of the Rel homology superfamily of transcription factors but contains a unique zinc binding structure, ter...
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PMID: 20592035
PDF is available here.
PDF is available here.
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Journal of Immunology (185)2 2010
Abstract
We first demonstrate that BAFF-R expression is absent from early precursors and is acquired by bone marrow B cells newly expressing the BCR. We next focused on identifying the specific genomic region that controls BAFF-R expression in mature B cells (i.e., the TNFRSF13C promoter). To accomplish this...
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PMID: 20554963
PDF is available here.
PDF is available here.
Abstract
We report here that the c-Rel transcription factor controlled development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB. Although Smad and CREB first bound to Foxp3 enhancers, they later moved to the promoter t...
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PMID: 20064450
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)2 2009
Abstract
We determined whether HMGB1 induces tissue factor (TF) expression in vascular endothelial cells (ECs) and macrophages. Our data showed that HMGB1 stimulated ECs to express TF (but not TF pathway inhibitor) mRNA and protein in a concentration- and time-dependent manner. Blockade of cell surface recep...
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PMID: 19652887
PDF is available here.
PDF is available here.
Abstract
We have discovered that the BAFF-R protein was present in the cell nucleus, in addition to its integral presence in the plasma membrane and cytoplasm, in both normal and neoplastic B cells. BAFF-R interacted with histone H3 and IKK{beta} in the cell nucleus, enhancing histone H3 phosphorylation thro...
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PMID: 19258594
PDF is available here.
PDF is available here.
Pharmacology & Therapeutics (121)1 2009
Abstract
Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders responsible for significant morbidity and mortality worldwide. While the importance of allergic responses in asthma is well known, respiratory viral and bacterial infections and pollutants especially cig...
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PMID: 18950657
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)2 2009
Abstract
We show that in both cortical neurons exposed to oxygen glucose deprivation (OGD) and mice subjected to brain ischaemia, activation of p50/RelA was associated with inhibition of c-Rel/RelA dimer and no change p50/c-Rel. Targeting c-Rel and RelA expression revealed that c-Rel dimers reduced while p50...
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PMID: 19094066
PDF is available here.
PDF is available here.
Abstract
We show that the heightened death of TLR4-activated nfkb1(-/-) B cells is the result of a failure of the Tpl(2)/MEK/ERK pathway to phosphorylate the proapo-ptotic BH3-only protein Bim and target it for degradation. ERK inactivation of Bim after TLR4 stimulation is accompanied by an increase in A1/Bi...
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PMID: 18805964
PDF is available here.
PDF is available here.
Abstract
We describe a novel integrative approach that combines gene expression profiling, promoter sequence analysis, and literature mining to screen candidate regulatory factors in the IFN signal transduction pathway. Application of this method identified the nuclear factor kappaB (NFkappaB) protein, cRel,...
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PMID: 18715197
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)15 2008
Abstract
We performed molecular dynamics simulations of a 20-bp DNA encompassing a cognate kappaB site recognized by the proto-oncogenic 'c-Rel' subfamily of NF-kappaB transcription factors. Simulations of the kappaB DNA in explicit water were extended to microsecond duration, providing a broad, atomically d...
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PMID: 18653524
PDF is available here.
PDF is available here.
Cellular Signalling (20)8 2008
Abstract
We show that all NF-kappaB proteins are imported into the nucleus via a subset of importin alpha isoforms. Our data indicate that the NF-kappaB components of the classical and alternative pathways have somewhat different specifities to importin alpha molecules. Based on the results from binding expe...
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PMID: 18462924
PDF is available here.
PDF is available here.
Journal of Immunology (181)2 2008
Abstract
We describe a novel biphasic regulation of Il2 transcription in naive CD4(+) T cells. Few ( approximately 5%) CD4(+) T cells transcribe Il2 within 6 h of anti-TCR-beta plus anti-CD28 stimulation (early phase). Most naive CD4(+) T cells do not initiate Il2 transcription until after an additional appr...
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PMID: 18606681
PDF is available here.
PDF is available here.
Cancer Research (68)13 2008
Abstract
We report that in normal keratinocytes overexpressing DeltaNp63alpha and in human squamous carcinoma cells, DeltaNp63alpha physically associates with phosphorylated, transcriptionally active nuclear c-Rel, a nuclear factor-kappaB family member, resulting in increased c-Rel nuclear accumulation. This...
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PMID: 18593911
PDF is available here.
PDF is available here.
Journal of Immunology (180)12 2008
Abstract
We have analyzed the role of c-Rel within the innate immune system in the development of lower bowel inflammation, in two well-studied models of murine colitis. We have found that the absence of c-Rel significantly impaired the ability of Helicobacter hepaticus to induce colitis upon infection of RA...
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PMID: 18523276
PDF is available here.
PDF is available here.
Abstract
We here evaluated the protective activity of mGlu5 agonists in dopaminergic SK-N-SH cells exposed to 1-methyl-4-phenylpyridinium (MPP(+)), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causing parkinsonism in experimental animals. MPP(+) produced a concentration-depend...
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PMID: 18094921
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)4 2008
Abstract
Steroids regulate alternative splicing of RUSH/SMARCA3. The full-length, progesterone-dependent alpha-isoform and the 3'-truncated, estrogen-dependent beta-isoform have identical DNA-binding domains, nuclear localization signals, and RING fingers. Transcription of RUSH/SMARCA3 is mediated by a bipar...
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PMID: 18174357
PDF is available here.
PDF is available here.
Journal of Immunology (180)6 2008
Abstract
We demonstrate that human peripheral blood NK cells express nuclear oligomerization domain 2 and respond to MDP. NK cells naturally internalize MDP leading to direct cell activation, including signaling through NFkappaB: characterized by p50/p65 heterodimers at early stimulations times and sustained...
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PMID: 18322218
PDF is available here.
PDF is available here.
Abstract
We used synthetic double-stranded "decoy" deoxyoligonucleotides containing selective NF-kappaB protein dimer binding consensus sequences. Decoys targeting the p65/p50 binding site on the COX-2 promoter decreased SCI-induced cell losses, NF-kappaB p65/p50 DNA-binding activity, and COX-2 and iNOS prot...
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PMID: 17918744
PDF is available here.
PDF is available here.
Cancer Research (68)3 2008
Abstract
Persistent Rel/nuclear factor-kappaB (NF-kappaB) activity is a hallmark of many human cancers, and the Rel proteins are implicated in leukemia/lymphomagenesis but the mechanism is not fully understood. Microarray analysis to identify transformation-impacting genes regulated by NF-kappaB's oncogenic...
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PMID: 18245482
PDF is available here.
PDF is available here.
Learning & Memory (15)7 2008
Abstract
We investigated the activity of one specific member of the NF-kappaB transcription factor family, c-Rel, during memory consolidation. We found that contextual fear conditioning elicited a time-dependent increase in nuclear c-Rel levels in area CA1 and DG of hippocampus. These results suggest that c-...
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PMID: 18626097
PDF is available here.
PDF is available here.
Gene Expression (14)4 2008
Abstract
We have used immune complex kinase assays to identify Ser484 and Ser494 as the primary sites of IKK alpha- and IKK beta-mediated in vitro phosphorylation in the C-terminal transactivation domain of REL. However, in cotransfection studies in A293 cells we have failed to detect IKK beta-mediated phosp...
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PMID: 19110719
PDF is available here.
PDF is available here.
Cancer Research (67)24 2007
Abstract
We show that green tea prevents or reverses loss of the epithelial marker E-cadherin on the surface of DMBA-induced in situ cancers. To investigate the mechanism(s) leading to a less invasive phenotype, the effects of the green tea polyphenol epigallocatechin-3 gallate (EGCG) on mammary tumor cells...
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PMID: 18089804
PDF is available here.
PDF is available here.
Abstract
Our findings provide a better understanding of LPS-induced C/EBPdelta gene expression....
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PMID: 17965828
PDF is available here.
PDF is available here.
Abstract
We show that c-Rel activity in the mammary gland is repressed by estrogen receptor alpha (ERalpha) signaling, and we identify an epigenetic mechanism in breast cancer mediated by activation of what we believe is a novel PKCtheta-Akt pathway that leads to downregulation of ERalpha synthesis and derep...
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PMID: 18037997
PDF is available here.
PDF is available here.
Cancer Research (67)22 2007
Abstract
We performed gene expression profile (GEP) analysis of six AILT, six anaplastic large cell lymphomas (ALCL), 28 PTCL-unspecified (PTCL/U), and 20 samples of normal T lymphocytes (including CD4(+), CD8(+), and activated and resting subpopulations), aiming to (a) assess the relationship of AILT with o...
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PMID: 18006812
PDF is available here.
PDF is available here.
Journal of Immunology (179)10 2007
Abstract
We analyzed mRNA levels in NF-kappaB-deficient macrophages. As reported to occur in dendritic cells, p19 expression was dramatically reduced in c-rel-deficient macrophages. Moreover, we found that p19 expression was halved in rela-deficient macrophages, but it was enhanced in p52-deficient macrophag...
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PMID: 17982049
PDF is available here.
PDF is available here.
Abstract
We investigated the role of c-Maf in regulation of the transcription of the p35 gene, which encodes the chain that is rate limiting in the synthesis of the heterodimeric IL-12. We report that c-Maf is a physiologic modulator of IL-12p35 gene expression and IL-12p70 production. We identify a novel NF...
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PMID: 17892401
PDF is available here.
PDF is available here.
Genome Research (17)9 2007
Abstract
We use the model of the NFKB/Rel-dependent gene regulation in divergent Drosophila species to examine the hypothesis that the functional properties of authentic transcription factor binding sites are under stronger evolutionary constraints than the genomic background. Using molecular modeling we com...
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PMID: 17785540
PDF is available here.
PDF is available here.
Abstract
These results illustrate the fact that expression of Enbocin and Bmgloverin isoform genes is inducible by bacteria and that the effects of bacterial cell wall components on the activation of these peptide genes are not necessarily the same. In addition, selective activation of the Enbocin2, Bmglover...
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PMID: 17827677
PDF is available here.
PDF is available here.
Experimental Cell Research (313)14 2007
Abstract
Cyclooxygenase-2 (COX-2) is an inducible enzyme of the prostaglandin biosynthesis pathway. It is involved in many stress responses, and its activity can produce oxidative damage, suggesting it could participate in senescence. In this study, COX-2 expression is shown to increase during senescence of...
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PMID: 17560572
PDF is available here.
PDF is available here.
Journal of Immunology (179)3 2007
Abstract
We investigated the effects of estrogen (17beta-estradiol) on NF-kappaB in C57BL/6 mice since estrogen is a natural immunomodulator and we have recently reported that estrogen up-regulates several NF-kappaB-regulated proteins (inducible NO synthase, IFN-gamma, and MCP-1). We found that in vivo estro...
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PMID: 17641044
PDF is available here.
PDF is available here.
Journal of Immunology (179)2 2007
Abstract
We analyzed TCR/CD28-stimulated signaling pathways in cytochalasin D-treated T cells to determine the cytoskeletal requirements for T cell activation. Cytochalasin D treatment impaired T cell activation by causing a reduction in TCR/CD28-mediated calcium flux, and blocked activation of two regulator...
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PMID: 17617603
PDF is available here.
PDF is available here.
Journal of Immunology (179)1 2007
Abstract
We found that a catalytically active group V secreted phospholipase A(2) (sPLA(2)-V) was required for COX-2 induction, but the nature of the sPLA(2)-V metabolite involved was not defined. In this study, we identify lysophosphatidylcholine (lysoPC) as the sPLA(2)-V downstream mediator involved in COX...
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PMID: 17579085
PDF is available here.
PDF is available here.
Transplantation (83)12 2007
Abstract
Foxp3+ cells are an integral component of acute rejection of allografts but may be dominated by pathogenic effectors....
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PMID: 17589350
PDF is available here.
PDF is available here.
Journal of Immunology (178)12 2007
Abstract
We show that TLR stimuli also alter BLyS receptor expression, but in contrast to BCR ligation, TLR9 and TLR4 signals, preferentially increase transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI) expression. Although both of these TLRs act through MyD88-dependent mechani...
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PMID: 17548587
PDF is available here.
PDF is available here.
Abstract
We investigated how mutations in c-Rel's cTAD1 and cTAD2 contribute to its oncogenicity and that of v-Rel. Mutations in cTAD2 noticeably increased c-Rel's transforming activity by promoting its nuclear localization and gene-specific transactivation, despite an overall decrease in kappaB site-depende...
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PMID: 17173064
PDF is available here.
PDF is available here.
Journal of Immunology (178)11 2007
Abstract
We investigated NF-kappaB function in regulating type 1 IFN expression in response to Sendai virus and Newcastle disease virus infection. Surprisingly, IFN-beta and IFN-alpha expression was strongly induced following virus infection of mouse embryonic fibroblasts (MEFs) from p50(-/-), RelA/p65(-/-),...
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PMID: 17513724
PDF is available here.
PDF is available here.
Journal of Immunology (178)11 2007
Abstract
We have used expression profiling to identify sets of genes that are affected by either deletion or overexpression of c-Rel in T cells. Very few of these genes exhibit a strong requirement for c-Rel; rather, c-Rel appears to modulate the expression of a large number of genes in these cells. The sets...
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PMID: 17513759
PDF is available here.
PDF is available here.
Abstract
We have identified an identical point mutation in two human B-cell lymphomas (follicular (FL) and mediastinal) that changes serine (Ser)525 (TCA) to proline (Pro) (CCA) within the REL transactivation domain. This mutation was not identified in a similarly sized cohort of healthy individuals. In the...
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PMID: 17072339
PDF is available here.
PDF is available here.
Molecular Immunology (44)11 2007
Abstract
We previously demonstrated that in vivo c-Rel plays a novel regulatory role in that it appears to be in complex with C/EBPbeta when C/EBPbeta is bound to the CRP gene promoter following cytokine stimulation, but is not itself bound to DNA. In this study we found that recombinant c-Rel((1-300)) (trun...
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PMID: 17335903
PDF is available here.
PDF is available here.
Abstract
We analyzed genomic, transcriptional, and protein levels in 20 PMBLs and the PMBL derived cell lines MedB-1 and Karpas1106P. We found gains/amplifications in 75% of the PMBLs by fluorescence in situ hybridization (FISH) and genomic REL overrepresentation in the PMBL lines. Three of the five PMBLs wi...
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PMID: 17243160
PDF is available here.
PDF is available here.
Transplantation (83)4 2007
Abstract
ATGs interfere with basic DC functions, suggesting that DCs are relevant targets for the immunosuppressive action of ATGs in transplantation....
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PMID: 17318082
PDF is available here.
PDF is available here.
Abstract
We describe a dominant role for c-rel involving p38 mitogen-activated protein kinase (p38 MAPK) and calmodulin (CaM) protein in NO-mediated IL-12 p40 inhibition in activated macrophages. Inhibition of NO production by aminoguanidine increased, whereas sodium nitroprusside (SNP; an exogenous NO gener...
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PMID: 17291992
PDF is available here.
PDF is available here.
Hematological Oncology (25)1 2007
Abstract
We performed serial analysis of gene expression (SAGE) and array-based comparative genomic hybridization (aCGH). Comparison of SAGE libraries of cHL cell lines L428 and L1236 with that of germinal centre B cells revealed consistent overexpression of only 14 genes. In contrast, 141 genes were downreg...
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PMID: 17048263
PDF is available here.
PDF is available here.
Journal of Immunology (178)5 2007
Abstract
We established stable posttranscriptional silencing of TFII-I in WEHI-231 immature murine B cells, which undergoes growth arrest and apoptosis either upon anti-IgM or TGF-beta signaling. In this study, we show that TFII-I promotes growth arrest of cells in a signal-dependent manner. Unlike control c...
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PMID: 17312101
PDF is available here.
PDF is available here.
Journal of Immunology (178)5 2007
Abstract
We demonstrate that the absence of PKCtheta resulted in a moderate survival defect in CD4+ T cells and a striking survival defect of CD8+ T lymphocytes. CD8+ T cells lacking the c-Rel, but not the NF-kappaB1/p50, member of the NF-kappaB family of transcription factors displayed a similar impairment...
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PMID: 17312138
PDF is available here.
PDF is available here.
Abstract
We tested whether another NF-kappaB family member, c-Rel, is required for atrophy. Because endogenous inhibitory factor kappaBalpha (IkappaBalpha) was activated (i.e., decreased) at 3 and 7 days of muscle disuse (i.e., hindlimb unloading), we also tested if IkappaBalpha, which binds and retains Rel...
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PMID: 16928772
PDF is available here.
PDF is available here.
Abstract
We recently identified a molecular signature of PMLBCL that is distinct from other forms of DLBCL but shares features with classical Hodgkin lymphoma. This signature includes activation of the nuclear factor kappaB (NFkappaB) signaling pathway, which in part, acts through nuclear translocation of c-...
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PMID: 17197926
PDF is available here.
PDF is available here.
Abstract
We report here, for the first time that a homologue of Rel\NF-kappaB transcription factor, Ab-Rel, was identified and functionally characterized in a gastropod abalone, H. diversicolor supertexta. The full-length Ab-Rel cDNA consists of 1943 bp with an ORF encoding a 584 amino acids protein. Amino a...
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PMID: 16949156
PDF is available here.
PDF is available here.
Journal of Immunology (178)1 2007
Abstract
We report, in this study, that murine dendritic cells deficient in c-Rel, a member of the NF-kappaB family, are severely compromised in their ability to transcribe the p19 gene, one of the two genes that encode the IL-23 protein. The p19 gene promoter contains three putative NF-kappaB binding sites,...
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PMID: 17182554
PDF is available here.
PDF is available here.
Molecular Pharmacology (70)6 2006
Abstract
We evaluated the effect of lipopolysaccharide and interferon-gamma (LPS/IFNgamma) on C-Rel DNA binding in RAW 264.7. LPS/IFNgamma-stimulated C-Rel binding peaked at 4 to 8 h and declined at 24 h. Transfection of cells with a C-Rel small interfering RNA abrogated C-Rel binding at all time points. LPS...
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PMID: 16963620
PDF is available here.
PDF is available here.
Abstract
We used lymphoblastoid cell lines that express LMP1 under the control of a tetracycline-inducible promoter (LCL(tet)). Our analysis revealed that the CD23(lo) phenotype in the pt1-LCL(tet) cells is a direct consequence of diminished CD23 transcription. We demonstrate a marked decrease in c-Rel-conta...
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PMID: 16896156
PDF is available here.
PDF is available here.
Abstract
We analyzed the mechanism of proteasome-mediated NF-kappaB activation in CD and UC. Our studies demonstrate that the subunit composition and the proteolytic function of proteasomes differ between UC and CD. High expression of the immunoproteasome subunits beta1i and beta2i is characteristic of the i...
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PMID: 17124531
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (108)1 2006
Abstract
We demonstrate that KIOM-79, combined extracts obtained from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, inhibits LPS-induced expression of iNOS gene in RAW 264.7 cells. Treatment of RAW 264.7 cells with KIOM-79 inhibited LPS-stimulated nitric oxide produc...
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PMID: 16806764
PDF is available here.
PDF is available here.
Journal of Immunology (177)4 2006
Abstract
We sought to determine whether IKKepsilon and TBK1 could modulate cRel activity via phosphorylation. TBK1 and IKKepsilon directly phosphorylate the C-terminal domain of cRel in vitro and in vivo and regulate nuclear accumulation of cRel, independently of the classical IkappaB/IKK pathway. IkappaBalp...
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PMID: 16888014
PDF is available here.
PDF is available here.
Journal of Immunology (176)11 2006
Abstract
The nonreceptor tyrosine kinase, encoded by the v-Abl oncogene of Abelson murine leukemia virus induces transformation of progenitor B cells. The v-Abl oncogene promotes cell cycle progression and inhibits pre-B cell differentiation. The temperature-sensitive form of Abelson murine leukemia virus of...
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PMID: 16709843
PDF is available here.
PDF is available here.
Abstract
We will try to summarize the current knowledge of distinct DNA damage-induced NF-kappaB signalling pathways....
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PMID: 16410802
PDF is available here.
PDF is available here.
Journal of Neuroscience (26)18 2006
Abstract
We investigated the signaling pathways necessary for DHPG-induced activation of NF-kappaB and found that they included the phosphatidyl inositol 3-kinase, protein kinase C, mitogen-activated protein kinase kinase, and p38-mitogen-activated protein kinase pathways. To determine the functional signifi...
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PMID: 16672661
PDF is available here.
PDF is available here.
International Immunology (18)4 2006
Abstract
It is well established that the nuclear factor-kappaB (NF-kappaB) family of transcription factors participates in the regulation of many aspects of innate and adaptive immunity. The majority of these reports have focused on the role of NF-kappaB in accessory cell and T or B cell function, but less i...
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PMID: 16481345
PDF is available here.
PDF is available here.
Cancer Research (66)5 2006
Abstract
The aberrant expression of the nuclear factor-kappaB (NF-kappaB) c-Rel subunit that occurs in many human breast cancers can play a causal role in tumorigenesis as judged by findings with a mouse mammary tumor virus (MMTV)-c-rel transgenic mouse model, in which 31.6% of mice developed one or more mam...
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PMID: 16510574
PDF is available here.
PDF is available here.