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Receptors, Aryl Hydrocarbon (0):
Recent article
Receptors, Aryl Hydrocarbon
Abstract
A key to understanding the biological function(s) of the aryl hydrocarbon receptor (AHR) - a xenobiotic-activated receptor - is to identify its endogenous ligand(s). The discovery of a tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) as an endogenous, high affinity agonist of AHR filled...
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PMID: 21883026
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We cloned the cDNAs of these genes and examined their expression in untreated tadpoles and in tadpoles exposed to waterborne aryl hydrocarbon receptor agonists, 3,3',4,4',5-pentachlorobiphenyl (PCB126), β-naphthoflavone (βNF), or indigo. We also examined the effects of PCB126 on expression of gene...
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PMID: 20965207
PDF is available here.
PDF is available here.
Abstract
We show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl hydrocarbon receptor. Smoke exposed IL-17RA(-/-) mice failed to induce CCL2 and MMP12 compared to WT mice. Remarkably, in contrast to WT mice, IL-17RA(-/-) mic...
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PMID: 21647421
PDF is available here.
PDF is available here.
Chemosphere (82)3 2011
Abstract
We determine the concentrations of 22 PAHs, including 16 US EPA priority PAHs, in CSSPs generated from a high market-share domestic brand in Taiwan. Five of the 22 PAHs are undetectable. The remaining 17 PAHs constitute about 0.022% of the total mass of CSSPs. Near one fifth of the PAH mass come fro...
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PMID: 20947129
PDF is available here.
PDF is available here.
Abstract
We have reported that human bronchial epithelial cells express AhR, and AhR activation induces mucin production through reactive oxygen species. This review discusses the role of AhR in lung disease, focusing in particular on airway epithelial cells. In addition, although it is not yet clear how the...
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PMID: 21646808
PDF is available here.
PDF is available here.
Abstract
Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to chemical carcinogenesis and other forms of toxicity, whereas disruption of the pathway exacerbates these outcomes. This pathway, w...
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PMID: 20367496
PDF is available here.
PDF is available here.
Abstract
We investigated the interaction between evodiamine and the aryl hydrocarbon receptor (AhR). Molecular modeling results revealed that evodiamine directly interacted with the AhR. Cytosolic receptor binding assay also provided the evidence that evodiamine could interact with the AhR with the K(i) valu...
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PMID: 20888792
PDF is available here.
PDF is available here.
Abstract
This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthal...
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PMID: 20932229
PDF is available here.
PDF is available here.
Abstract
Abstract
We found that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct postulated as a candidate physiological ligand of the aryl hydrocarbon receptor (AhR), induces L1-RTP. Notably, RNA-interference experiments combined with back-transfection of siRNA-resistant cDNAs revealed that the induc...
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PMID: 20852066
PDF is available here.
PDF is available here.
Toxicology (276)2 2010
Abstract
Mechanisms of hepatocyte proliferation triggered by tissue loss are distinguishable from those that promote proliferation in the intact liver in response to mitogens. Previous studies demonstrate that exogenous activation of the aryl hydrocarbon receptor (AhR), a soluble ligand-activated transcripti...
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PMID: 20637255
PDF is available here.
PDF is available here.
Nature Immunology (11)9 2010
Abstract
We show that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), which was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells. After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il...
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PMID: 20676095
PDF is available here.
PDF is available here.
Nature Immunology (11)9 2010
Abstract
We investigated the role of AhR in the differentiation of human induced T(reg) cells (iT(reg) cells). We found that AhR activation promoted the differentiation of CD4(+)Foxp3(-) T cells, which produce IL-10 and control responder T cells through granzyme B. However, activation of AhR in the presence...
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PMID: 20676092
PDF is available here.
PDF is available here.
Aquatic Toxicology (99)2 2010
Abstract
We report effects of TCDD exposure on the morphology of some blood vessels in the head of developing zebrafish. TCDD caused concentration-dependent anatomical rearrangements in the shape of the prosencephalic artery in zebrafish larvae. In contrast, no major vascular defects were recognized in the t...
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PMID: 20554057
PDF is available here.
PDF is available here.
Abstract
We examined AhR protein expression in human placentas from normal (N) and severe preeclamptic (sPE) pregnancies, as well as human fetal tissues from the second trimester of pregnancy, using immunohistochemistry and/or Western blot analysis. In the placentas, the AhR immunoreactivity was present prim...
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PMID: 20354149
PDF is available here.
PDF is available here.
Abstract
The Urdaibai estuary is a UNESCO biosphere reserve impacted by recreational, agricultural and industrial activities. Polycyclic aromatic hydrocarbons (PAHs) are major pollutants in Urdaibai, and their control and the identification of their sources is central on the preservation of the area. Chemica...
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PMID: 20452663
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)2 2010
Abstract
We show that BCRP induction by AHR ligands occurs in human intestinal, liver, and mammary carcinoma cells and in primary colonocytes and hepatocytes. Increased BCRP transporter activity consistent with gene induction was also evident in the Caco2 subclone C2bbe1 cells. Using RNA interference and ect...
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PMID: 20460431
PDF is available here.
PDF is available here.
Abstract
We explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antig...
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PMID: 20559326
PDF is available here.
PDF is available here.
Abstract
We examine the role of these two nuclear factors in the regulation of the expression of human MRP4. HepG2 cells and human hepatocytes were treated with the AhR and Nrf2 activators, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3-MC), or oltipraz and other nuclear receptor agonist...
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PMID: 20395535
PDF is available here.
PDF is available here.
Toxicology and Applied Pharmacology (246)1-2 2010
Abstract
We have investigated the influence of TCDD on functional Rfc1 activity in rat liver. Pre-treatment of rats with TCDD significantly diminished hepatocellular Rfc1 uptake activity in a time- and dose-dependent manner. In further mechanistic studies we demonstrated that this reduction was due to TCDD-d...
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PMID: 20451541
PDF is available here.
PDF is available here.
Toxicology and Applied Pharmacology (246)1-2 2010
Abstract
We hypothesized that AhR activation alters DC differentiation and generates dysfunctional DCs. To test this hypothesis, inflammatory bone marrow-derived DCs (BMDCs) from C57Bl/6 mice were generated in the presence of vehicle or TCDD. TCDD decreased CD11c expression but increased MHC class II, CD86 a...
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PMID: 20350561
PDF is available here.
PDF is available here.
Toxicology (273)1-3 2010
Abstract
Bone geometry and bone biomechanical parameters were affected by TCDD exposure, while bone mineral density parameters were less affected. The trabecular area at proximal tibia and the endocortical circumference at tibial diaphysis were the parameters that showed the highest maximal responses. Signif...
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PMID: 20403408
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of luteolin, a plant-derived flavonoid, on benzo(a)pyrene (B(a)P)-stimulated drug metabolism and transport in human colon carcinoma cells. While luteolin treatment inhibited B(a)P-induced expression and activity of arylhydrocarbon receptor-dependent cytochrome P450 enzymes...
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PMID: 20403331
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that TCDD increases reactive oxygen species (ROS) in endothelial cells by the induction of CYP1A1. A concentration-response to 24h TCDD exposure (10pM-10nM) was performed in confluent primary human aortic endothelial cells (HAECs). Oxidant-sensitive fluorescent probes dihydr...
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PMID: 20171976
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)19 2010
Abstract
We hypothesized that HIF-1alpha activation attenuates BaP-induced AhR-mediated gene expression, which may lead to increased genetic instability and malignant progression. Human lung carcinoma cells (A549) were simultaneously stimulated with CoCl(2), which leads to HIF-1alpha stabilization and varyin...
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PMID: 20228066
PDF is available here.
PDF is available here.
Abstract
Six exonic SNPs were identified; four had been described as previously reported and two seem to be novel. Four of the SNPs identified lead to amino acid changes in the AHR protein and two of the SNPs lead to synonymous substitutions. An additional four SNPs have been reported elsewhere that were not...
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PMID: 20401977
PDF is available here.
PDF is available here.
Aquatic Toxicology (97)3 2010
Abstract
We have previously shown that mRNA of the hepatic CR/20beta-HSD B isoform is increased in rainbow trout caged downstream from a Swedish sewage treatment plant. Here, we report an increase of both the A as well as B form in fish kept downstream from a second sewage treatment plant. The two mRNAs were...
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PMID: 20004983
PDF is available here.
PDF is available here.
Abstract
The TEF model overpredicts effects of AhR ligands at the highest concentration combinations. At lower concentrations, the difference between GCA and TEF approaches depends on the efficacy of the partial agonist. GCA represents a more accurate definition of additivity for mixtures that include partia...
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PMID: 20435555
PDF is available here.
PDF is available here.
Abstract
An AhR reporter assay revealed cumulative levels of AhR activation potential in neat serum, whereas extraction may preclude detection of important non-dioxin-like biological activity. Significant levels of AhR agonist activity in commercial sera and in Faroe Islander sera, compared with that from ex...
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PMID: 20435556
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
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PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
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PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the effects of AhR activation on the circadian clock are mediated by disruption of CLOCK-BMAL1 function and subsequent Per1 gene suppression. Effects of AhR activation on rhythmic Per1 transcripts were examined in livers of mice after treatment with the AhR agonist, TCDD; the mo...
|
PMID: 20106950
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR. Structure-activity studies further indicate that the carboxylic acid group is required for significant agonist activity. KA is capab...
|
PMID: 20106948
PDF is available here.
PDF is available here.