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Receptors, Retinoic Acid (1):
Recent article
Receptors, Retinoic Acid
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
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PMID: 21554208
PDF is available here.
PDF is available here.
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Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
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PMID: 21270765
PDF is available here.
PDF is available here.
Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
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PMID: 21270765
PDF is available here.
PDF is available here.
Kidney International (79)10 2011
Abstract
We conditionally deleted Rbpj, a transcription factor required for canonical Notch signaling, in nephrogenic progenitors (NPs) of the metanephric mesenchyme. The retinoic acid receptor-β2 (Rarb2) promoter efficiently directed Cre-recombinase (Cre) activity to these progenitors. Conditional knockout...
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PMID: 21270765
PDF is available here.
PDF is available here.
Abstract
We were referred a difficult diagnostic case of acute promyelocytic leukemia with no pathogenic X-RARA fusion identified by routine metaphase cytogenetics or interphase fluorescence in situ hybridization (FISH). The case patient was enrolled in an institutional review board-approved protocol, with c...
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PMID: 21505136
PDF is available here.
PDF is available here.
Brain research (1382) 2011
Abstract
We studied the mRNA expression patterns of 6 RA receptors in the postnatal rat cerebral cortex and white matter at 1, 3, 7, 10, 14, 21, 28, and 35days. We found that RARβ, RXRα and RXRβ mRNA levels gradually increased during postnatal development. RARα presented a nearly unimodal trend, but RAR...
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PMID: 21241670
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We first reported that ATRA-induced myeloid leukemia differentiation was accompanied with the increased level of ubiquitin-protein conjugates and the upregulation of proteasome activity. To explore the functional role of the activated proteasome in retinoic acid (RA) signaling, the effects of protea...
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PMID: 20945414
PDF is available here.
PDF is available here.
FASEB Journal (24)11 2010
Abstract
We determined that the N-terminal domain (NTD) also plays a role through its phosphorylation, and we isolated vinexinβ, a cytoskeleton protein with three SH3 domains, as a new partner of the RARγ NTD. Here we deciphered the mechanism of the interaction and its role in RARγ-mediated transcription....
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PMID: 20634350
PDF is available here.
PDF is available here.
Abstract
Screening of a total of 86 crude drugs for retinoid X receptor (RXR) ligands demonstrated that the methanol extract of the bark of Magnolia obovata markedly activated the transcriptional activity of RXRalpha in luciferase reporter assays. Thereafter, honokiol (1) was isolated as a constituent able t...
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PMID: 20695472
PDF is available here.
PDF is available here.
Abstract
We interrogated the folding landscape of a model beta-rich protein, cellular retinoic acid-binding protein I (CRABP I), in the presence of an inert crowding agent (Ficoll 70). Urea titrations revealed a crowding-induced change in the water-accessible polar amide surface of its denatured state, based...
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PMID: 20662522
PDF is available here.
PDF is available here.
Journal of Nutrition (140)8 2010
Abstract
We have previously shown that all-trans retinoic acid (atRA), a bioactive metabolite of vitamin A, significantly augmented DC MMP-9 mRNA and protein production. We investigated the mechanisms by which atRA increased MMP-9 activity in vitro. Mouse myeloid DC cultured with atRA demonstrated increased...
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PMID: 20534877
PDF is available here.
PDF is available here.
Abstract
Vitamin A (VA) is essential for embryonic development and the retinoic acid receptors (RARs) are crucial in mediating the diverse actions of VA in embryogenesis. However, the association between RARs and teratogenicity on skeleton growth and development of vitamin A deficiency (VAD) is not clear. In...
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PMID: 19616926
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)21 2010
Abstract
One hundred seven patients were included, 55 in the P/PC group and 52 in the RA/PC group. RR for RA/PC was 55.8% (95% CI, 46.6% to 64.9%) and for P/PC, 25.4% (95% CI, 21.3 to 29.5%; P = .001). The RA/PC group had a longer median PFS (8.9 v 6.0 months; P = .008). Multivariate analysis of PFS showed s...
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PMID: 20547984
PDF is available here.
PDF is available here.
Abstract
Mantle cell lymphoma (MCL) is characterized by translocation t(11;14)(q13;q32), aggressive clinical behaviour, and poor patient outcomes following conventional chemotherapy. New treatment approaches are needed that target novel biological pathways. All trans retinoic acid (ATRA) is a...
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PMID: 20507312
PDF is available here.
PDF is available here.
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Abstract
We show that the basal repressive activity of RAR is conferred by an extended beta-strand that forms an antiparallel beta-sheet with specific corepressor residues. Agonist binding induces a beta-strand-to-alpha-helix transition that allows for helix H11 formation, which in turn provokes corepressor...
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PMID: 20543827
PDF is available here.
PDF is available here.
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Abstract
We show that the basal repressive activity of RAR is conferred by an extended beta-strand that forms an antiparallel beta-sheet with specific corepressor residues. Agonist binding induces a beta-strand-to-alpha-helix transition that allows for helix H11 formation, which in turn provokes corepressor...
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PMID: 20543827
PDF is available here.
PDF is available here.
Abstract
Abstract
We show here that ablation of Rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling. While abnormal serotonin signalin...
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PMID: 20620876
PDF is available here.
PDF is available here.
Abstract
We hypothesized that specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. A total of 50 uniparous mouse mammary tumor virus (MMTV)-neu...
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PMID: 20453882
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)25 2010
Abstract
We tested whether RA and its receptors may regulate CB(1)R expression in cultured mouse hepatocytes. Incubation of hepatocytes with RA or RA receptor (RAR) agonists increased CB(1)R mRNA and protein, the most efficacious being the RARgamma agonist CD437 and the pan-RAR agonist TTNPB. The endocannabi...
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PMID: 20410309
PDF is available here.
PDF is available here.
Abstract
We compared genomic breakpoints at the PML and RARA loci in 23 patients with therapy-related acute promyelocytic leukemia (t-APL) and 25 de novo APL cases.Eighteen of 23 t-APL cases received the topoisomerase II poison mitoxantrone for their primary disorder. DNA breaks were clustered in a previousl...
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PMID: 20544846
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)24 2010
Abstract
We have determined that both this 5' nucleotide overhang, as well as mismatches within the dsRNA (as found in some arenavirus genomes), clearly reduce the ability of these model dsRNAs to induce interferon upon transfection into cells. The presence of this unpaired 5' ppp-nucleotide is thus another...
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PMID: 20400512
PDF is available here.
PDF is available here.
Abstract
These results suggest that RA is required for the regeneration of the gut. A gene encoding the RA receptor (Pm-RAR) and its target gene, TRAMP, were expressed in and around the regenerating gut. Pm-RAR-specific and TRAMP-specific double-stranded RNA molecules inhibited the regeneration of the gut, i...
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PMID: 20507359
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)12 2010
Abstract
We investigated the effect of a high-fat diet (HFD) on (1) PUFA status in the plasma and brain, and (2) the expression of RA and fatty acid NR (RARbeta, RXRbetagamma and PPARdelta), and synaptic plasticity genes (GAP-43 and RC3), in young male Wistar rats. In the striatum of rats given a HFD for 8 w...
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PMID: 20102671
PDF is available here.
PDF is available here.
Abstract
We suggest that alternative splicing of PML/RARalpha transcripts might be involved in NMD and each isoform should be quantified to further understand the pathogenesis of APL, stratify the risk of relapse, and monitor minimal residual disease....
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PMID: 19863682
PDF is available here.
PDF is available here.
Archives of Dermatology (146)6 2010
Abstract
Abstract
The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements (VDREs). A modified yeast one-hybrid screen was utilized to search for partner proteins capable of ass...
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PMID: 20420906
PDF is available here.
PDF is available here.
Abstract
Although hereditary or acquired defects in hepatobiliary transporter systems cause or predispose to cholestasis, adaptive bile acid transporter changes can counteract cholestasis by reducing hepatocellular and systemic concentrations of retained cholephiles. An important level in the regulation of a...
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PMID: 20422498
PDF is available here.
PDF is available here.
Abstract
We utilized the ubiquitin ligase activity of cellular inhibitor of apoptosis protein 1 (cIAP1), which is activated by methyl bestatin (MeBS, 2). We speculated that formation of an artificial (nonphysiological) complex of cIAP1 and a target protein would be induced by a hybrid molecule consisting of...
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PMID: 20369832
PDF is available here.
PDF is available here.
Abstract
We show that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARalpha and PML. Arsenic binding induces PML oligomerization, which increases its interaction with the small ubiquitin-like protein modifier (SUMO)-conjugating enzyme UBC9, resulting in en...
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PMID: 20378816
PDF is available here.
PDF is available here.
Reproduction (139)4 2010
Abstract
We demonstrate that a disulfide isomerase glucose-regulated protein 58 (GRp58) participates in the nuclear import and degradation of RARA in Sertoli cells. GRp58 interacted with RARA in the presence of all-trans retinoic acid (ATRA) ligand and, as a complex, it was translocated from the cytoplasm to...
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PMID: 20130111
PDF is available here.
PDF is available here.
Induction of uncoupling protein-1 in mouse embryonic fibroblast-derived adipocytes by retinoic acid.
Abstract
We investigated the capacity of retinoic acid (RA), the carboxylic acid form of vitamin A and a known positive regulator of UCP1 gene transcription in brown adipocytes, to stimulate UCP1 expression in adipocytes differentiated in culture from primary mouse embryonic fibroblasts (MEFs), which are com...
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PMID: 19834471
PDF is available here.
PDF is available here.
Abstract
This study demonstrates a novel method by which multiple separate plasmids can be stably integrated into the genome using single antibiotic resistance for selection. This method was used to integrate three different cardiac-specific promoters driving different fluorophores into murine embryonic stem...
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PMID: 20357978
PDF is available here.
PDF is available here.
médecine/sciences (26)4 2010
Abstract
Molecular Endocrinology (24)4 2010
Abstract
We sought to identify new pathways regulated by C-peptide of relevance to the pathophysiology of diabetic nephropathy. Microarray analysis was performed to identify genes regulated by either C-peptide and/or TGF-beta1 in a human proximal tubular cell line, HK-2. Expression of retinoic acid receptor...
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PMID: 20197308
PDF is available here.
PDF is available here.
Developmental Cell (18)3 2010
Abstract
We found that as the initial SHF population incorporates into the outflow tract, it is replenished from the surrounding progenitor territory. In retinoic acid (RA) receptor mutant mice, this latter process fails, and the outflow tract is shortened and misaligned as a result. As an additional consequ...
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PMID: 20230754
PDF is available here.
PDF is available here.
Abstract
We hereby present a case of APL, morphologically distinct from the hypergranular APL; however, the flow cytometry revealed a characteristic phenotype showing dim CD45, bright CD13, bright CD33 and dim CD117 positivity. These were negative for CD34, HLA-DR, B-lymphoid and T-lymphoid lineage markers....
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PMID: 21045428
PDF is available here.
PDF is available here.
Molecular Cancer (9) 2010
Abstract
We investigated the molecular mechanism responsible for BPDE-suppressed expression of retinoic acid receptor-beta2 (RAR-beta2) in esophageal cancer cells. We treated esophageal cancer cells with BPDE before performing methylation-specific polymerase chain reaction (MSP) to find that BPDE induced met...
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PMID: 20426865
PDF is available here.
PDF is available here.
Abstract
Palladium-catalyzed cross-coupling reactions of a 2-substituted 3-iodobenzo[b]furans and stannanyl ester afforded the stereoselective production of 9Z-retinoic acid ester analogs in good yields. These esters were then converted to the corresponding acids via basic hydrolysis in excellent yields, and...
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PMID: 20190455
PDF is available here.
PDF is available here.
Pathobiology (77)1 2010
Abstract
We showed that suppressing the expression of RORalpha by the siRNA inhibited the expression of both bone sialoprotein and dentin matrix protein 1. It was discovered coincidentally that the inhibitory effect of RORalpha resulted in failure of mineralization and bone nodule formation during the course...
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PMID: 20185965
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
Five SNP variants in RARbeta were detected in Chinese subjects with high myopia, none of them were associated significantly with high myopia. Further studies are needed to identify which genes are responsible for high myopia....
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PMID: 20508731
PDF is available here.
PDF is available here.
Molecular Medicine (16)1-2 2010
Abstract
Our study highlights the implication of MGMT and RARbeta methylation in the aggressive phenotype of primary glioblastomas. The association of MGMT methylation with clinical outcome indicates its potential prognostic value....
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PMID: 19809523
PDF is available here.
PDF is available here.
Abstract
We describe an optical method for measuring the concentrations of RA in biological samples. This method uses cellular retinoic acid-binding protein I (CRABP-I), a protein that binds RA with high affinity and specificity, as a "read-out" for its ligand. Replacing (28)Leu of CRABP-I with a Cys residue...
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PMID: 20552429
PDF is available here.
PDF is available here.
Abstract
We have used chromatin immunoprecipitation to map 354 RA receptor (RAR) binding loci in MEFs, most of which were similarly occupied by the RAR alpha and RAR gamma receptors. Only a subset of the genes associated with these loci are regulated by RA, among which are several critical components of the...
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PMID: 19884340
PDF is available here.
PDF is available here.
Abstract
Abstract
We combined rapid subtractive hybridization and microarray analysis in a hierarchical manner to select genes that are putatively reactivated by the demethylating agent 5-aza-2'-deoxycytidine (5Aza-dC) in HNSCC cell lines (FaDu, UM-SCC-14A, UM-SCC-17A, UM-SCC-38A). This combined analysis identified 7...
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PMID: 20019841
PDF is available here.
PDF is available here.
Abstract
Cancer Biology & Therapy (8)23 2009
Abstract
In this study, a comparative quantitative methylation profiling of inflammatory breast cancer (IBC) and non-IBC was set up for the identification of tumor-specific methylation patterns. Methylation ratios of six genes (DAPK, TWIST, HIN-1, RASSF1A, RARbeta2 and APC) were measured in b...
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PMID: 19829046
PDF is available here.
PDF is available here.
Journal of Immunology (183)8 2009
Abstract
We show that IL-27 had surprisingly little effect on committed Th17 cells, despite its expression of a functional IL-27R. Contrary to de novo differentiation of Th17 cells, IL-27 did not suppress expression of retinoid-related orphan receptor (ROR)gammat or RORalpha in committed Th17 cells. Consiste...
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PMID: 19786534
PDF is available here.
PDF is available here.
Journal of Experimental Medicine (206)10 2009
Abstract
We identify the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) as a key negative regulator of human and mouse Th17 differentiation. PPAR gamma activation in CD4(+) T cells selectively suppressed Th17 differentiation, but not differentiation into Th1, Th2, or regulator...
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PMID: 19737866
PDF is available here.
PDF is available here.
Nature Immunology (10)10 2009
Abstract
We show that a T(H)-17 population differentiates in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-beta (TGF-beta). Like previously described T(H)-17 cells, the T(H)-17 cells that developed in the thymus expressed the transcr...
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PMID: 19734905
PDF is available here.
PDF is available here.
Abstract
We identified the specific RAR egonists in sewage treatment plants (STPs) and receiving rivers using an RAR yeast two-hybrid bioassay. Water samples were extracted by solid-phase extract cartridges, which were successively eluted by hexane, ethyl acetate, and methanol for bioassay. Among the three f...
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PMID: 19764225
PDF is available here.
PDF is available here.
Abstract
Six subjects had STAT3 mutations affecting the DNA binding, Src homology 2, and transactivation domains, including 3 novel ones. Mutation-positive but not mutation-negative subjects with HIES exhibited reduced phosphorylation of STAT3 in response to cytokine stimulation, whereas pSTAT1 activation wa...
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PMID: 19577286
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that compounds 7 and 9 are potentially useful agents that warrant further preclinical development for treatment of prostate cancer....
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PMID: 19375825
PDF is available here.
PDF is available here.
Abstract
Both naturally occurring and transforming growth factor-beta-induced Tregs can be converted into Th17 cells in the presence of inflammatory cytokines. Transforming growth factor-beta upregulates the Treg transcription factor, forkhead box P3, as well as the Th17 transcription factor, retinoic acid r...
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PMID: 19448538
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (328)1-2 2009
Abstract
We investigated the expression of genes and transcription factors associated with steroidogenesis during the luteinization of granulosa cells isolated from bovine small follicles. Granulosa cells produced progesterone when cultivated in a culture medium including serum and attached to the substrate...
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PMID: 19288253
PDF is available here.
PDF is available here.
Abstract
We examined the function of RARalpha2 in MM. Reverse transcription-polymerase chain reaction (RT-PCR) revealed ubiquitous RARalpha1 expression in MM cells, but RARalpha2 was expressed in 26 (32%) of 80 newly diagnosed patients and 10 (28%) of 36 MM cell lines. Patients with RARalpha2 expression had...
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PMID: 19458357
PDF is available here.
PDF is available here.
Journal of Immunology (183)1 2009
Abstract
In contrast to CD4 T cells, CD8 T cells inherently differentiate into IFN-gamma-producing effectors. Accordingly, while generation of IFN-gamma-producing Th1 CD4 T cells was profoundly impaired in mice deficient for both type-I IFN and IL-12 signaling in response to infection with Listeria monocytog...
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PMID: 19542449
PDF is available here.
PDF is available here.
Abstract
We have previously shown that expression of the retinoic acid receptor alpha (RARalpha) is upregulated in activated rat HSCs at a posttranscriptional level and that these RARalpha proteins showed a speckled distribution in the cytosol, despite their possession of a nuclear localization signal (NLS)....
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PMID: 19332432
PDF is available here.
PDF is available here.
Abstract
We investigated the role of chemerin, a recently discovered, relatively selective chemoattractant for macrophages, in the recruitment of macrophage precursors to the fetal intestine. Chemerin mRNA/protein expression was measured in jejunoileal tissue from 10- to 24-wk human fetuses, neonates operate...
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PMID: 19443732
PDF is available here.
PDF is available here.