Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, Steroid (6):
Recent article
Receptors, Steroid
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
|
PMID: 21554208
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Endocrinology (207)3 2010
Abstract
We report that systemic deletion of PXR results in marked osteopenia with mechanical fragility in female mice as young as 4 months old. Bone mineral density (BMD) of PXR knockout (PXRKO) mice was significantly decreased compared with the BMD of wild-type (WT) mice. Micro-computed tomography analysis...
|
PMID: 20876238
PDF is available here.
PDF is available here.
Experimental Cell Research (316)19 2010
Abstract
We characterize here ORP11, a member of the oxysterol-binding protein family. ORP11 is present at highest levels in human ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Immunohistochemistry demonstrates abundant ORP11 in the epithelial cells of kidney tubules, testicular tubules,...
|
PMID: 20599956
PDF is available here.
PDF is available here.
Abstract
Steroid hormone receptors (SHR) are crucial regulators of disease and the basis for clinical intervention in cancers. Recent evidence confirms that microRNAs (miRNAs) impact the pathobiology of hormone-regulated malignancies. Therefore, elucidating miRNA regulation of SHR expression and modulation o...
|
PMID: 20739888
PDF is available here.
PDF is available here.
Abstract
We have, therefore, analysed the association of six single nucleotide polymorphisms (SNPs) within the three genes belonging to the NR4A orphan nuclear receptor family, NR4A1 (rs2603751, rs2701124), NR4A2 (rs12803, rs834835) and NR4A3 (rs1131339, rs1405209), with the degree of smoking in a sample of...
|
PMID: 20659174
PDF is available here.
PDF is available here.
Current Biology (20)20 2010
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.
Abstract
We analyze here the in vivo function of DOR by studying flies mutant for Drosophila DOR (dDOR).
We show that dDOR is a novel coactivator of ecdysone receptor (EcR) that is needed during metamorphosis. dDOR binds EcR and is required for maximal EcR transcriptional activity. In the absence of dDOR, f...
|
PMID: 20888228
PDF is available here.
PDF is available here.
Abstract
Our study showed that vincristine, tamoxifen, vinblastine, docetaxel, cyclophosphamide, flutamide, ifosfamide and paclitaxel activate PXR-mediated Pgp induction, and were additionally shown to affect the intracellular accumulation of the Pgp probe rhodamine 123. Moreover, PXR activation was also sho...
|
PMID: 20041327
PDF is available here.
PDF is available here.
Abstract
Endosulfan is an organochlorine pesticide commonly used in agriculture. Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expr...
|
PMID: 20361990
PDF is available here.
PDF is available here.
British Journal of Cancer (102)12 2010
Abstract
Using histochemistry analysis, we found that PXR expressions were lost or greatly diminished in many colon tumours. Ectopic expression of human PXR through stable transfection of PXR into colon cancer cell line HT29 significantly inhibited cell proliferation as determined by cell proliferation assay...
|
PMID: 20531417
PDF is available here.
PDF is available here.
An ortholog of the ecdysone receptor protein (EcR) from the parasitic nematode Haemonchus contortus.
Abstract
We report the cloning of cDNA encoding an EcR ortholog (HcEcR) from H. contortus mRNA expressed during L3. Phylogenetically, this and the putative EcR from Brugia malayi form a separate branch between arthropod EcRs and liver X receptors. Two isoforms of HcEcR differ in the inclusion/omission of a 3...
|
PMID: 20226216
PDF is available here.
PDF is available here.
Abstract
We have identified a D. immitis nuclear receptor, DiEcR that shows strong sequence similarity to the insect EcR and shares many of its biochemical properties, including ligand-dependent activation of transcription. However, unlike most insect EcRs, DiEcR requires a ligand-activated RXR partner to ex...
|
PMID: 20170689
PDF is available here.
PDF is available here.
Abstract
It appears that the selected genetic markers explain variability in CsA exposure insufficiently to be of clinical relevance. Therefore, therapeutic drug monitoring is still required to optimize CsA exposure after administration of individualized doses based on body weight and, as this study suggests...
|
PMID: 20354687
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)6 2010
Abstract
We not only explore the functions of the heat-shock protein 90 (Hsp90) molecular chaperone machine for the intracellular transport of SHRs, but also for the regulation of their nuclear mobility, for their recycling and for the regulation of their transcriptional output....
|
PMID: 20006655
PDF is available here.
PDF is available here.
Abstract
In the present study, the genotype frequencies of some SNPs related to mirtazapine metabolism in Spaniards were analyzed and showed that our study population is representative of HapMap European population. The results obtained could be analyzed with pharmacokinetic parameters of mirtazapine to eluc...
|
PMID: 20218903
PDF is available here.
PDF is available here.
Modern Pathology (23)5 2010
Abstract
Our study showed that apocrine breast carcinomas are molecularly diverse group of carcinomas. Strictly defined pure apocrine carcinomas are either HER-2-overexpressing breast carcinomas or triple-negative breast carcinomas, whereas apocrine-like carcinomas predominantly belong to the luminal phenoty...
|
PMID: 20208479
PDF is available here.
PDF is available here.
Abstract
We propose a research agenda focusing on the identification of new receptoral structures and the identification of mechanisms of actions at physiological steroid concentrations. Additionally, efforts for the propagation of translational studies, which should finally lead to clinical benefit in the a...
|
PMID: 20194525
PDF is available here.
PDF is available here.
Hypertension Research (33)5 2010
Abstract
We found that the three single-nucleotide polymorphisms (SNPs) with the smallest P-values were located in the fifth intronic region of the oxysterol-binding protein-like 10 (OSBPL10) gene. In this study, we examined the association between polymorphisms in the OSBPL10 gene and risk factors for the m...
|
PMID: 20224571
PDF is available here.
PDF is available here.
Abstract
Although hereditary or acquired defects in hepatobiliary transporter systems cause or predispose to cholestasis, adaptive bile acid transporter changes can counteract cholestasis by reducing hepatocellular and systemic concentrations of retained cholephiles. An important level in the regulation of a...
|
PMID: 20422498
PDF is available here.
PDF is available here.
Anticancer Research (30)5 2010
Abstract
Gd was expressed in invasive lobular and ductal breast cancer and its expression was significantly reduced upon dedifferentiation. A non significant increase in Gd staining intensity was noted upon axillary lymph node involvement steroid receptor positivity. CONCLUSION: These results indicate that G...
|
PMID: 20592348
PDF is available here.
PDF is available here.
Abstract
This study demonstrates a novel method by which multiple separate plasmids can be stably integrated into the genome using single antibiotic resistance for selection. This method was used to integrate three different cardiac-specific promoters driving different fluorophores into murine embryonic stem...
|
PMID: 20357978
PDF is available here.
PDF is available here.
Abstract
Human papillomavirus (HPV) virus-like particle (VLP) vaccines are highly effective at preventing viral infections and the development of precancerous lesions through the induction of high-titer neutralizing antibodies and strong cell-mediated immune responses. Women taking combined o...
|
PMID: 20130130
PDF is available here.
PDF is available here.
Reproductive Sciences (17)4 2010
Abstract
We investigated the messenger RNA (mRNA) expression of the genes of reproductive steroid hormone receptors (estrogen receptors alpha [ERalpha] and beta [ERbeta], G protein-coupled receptor 30 [GPR30], and progesterone receptor [PR]) in EP tissue and autologous normal appearing endometrium (R) Within...
|
PMID: 20228382
PDF is available here.
PDF is available here.
Molecular Endocrinology (24)4 2010
Abstract
Because of their central importance in gene regulation and mediating the actions of many hormones, the nuclear receptors (NRs) have long been recognized as very important biological and pharmaceutical targets. Of all the surfaces available on a given NR, the singular site for regulation of receptor...
|
PMID: 19933380
PDF is available here.
PDF is available here.
Abstract
Our findings show that organic PM(2.5) consist of toxic as well as bioactive components that can regulate the secretion of cytokines in BEAS-2B, which could modulate inflammatory response in the lung. Trace element analyses confirmed the presence of metals in organic extracts highlighting the relati...
|
PMID: 20026096
PDF is available here.
PDF is available here.
Abstract
The SAR of PXR transactivation by 3-(benzimidazol-2-yl)-pyridine-2-one based ATP competitive inhibitors of Insulin-like Growth Factor 1 Receptor kinase (IGF-1R) is discussed. Compounds without PXR transactivation, with in vivo antitumor activity, reduced protein binding and improved oral exposure ar...
|
PMID: 20153189
PDF is available here.
PDF is available here.
Biochemical Society transactions (38)Pt 1 2010
Abstract
We will focus on the influence of SUMO (small ubiquitin-related modifier) and ubiquitin modifications on the function of transcription factors involved in adrenal cortex formation, steroidogenesis and the hormonal response....
|
PMID: 20074035
PDF is available here.
PDF is available here.
Toxicological Sciences (113)2 2010
Abstract
I enzyme induction, and decreased in vivo total thyroxine (T4) suggest adverse effects on thyroid hormone homeostasis. Current research tested the hypothesis that triclosan decreases circulating T4 via upregulation of hepatic catabolism and transport. Weanling female Long-Evans rats received triclos...
|
PMID: 19910387
PDF is available here.
PDF is available here.
Abstract
We showed that the GMPS/USP7 complex cooperates with the Polycomb silencing system through removal of the active ubiquitin mark from histone H2B (H2Bub). Here, we explored the interplay between GMPS and USP7 further and assessed their role in hormone-regulated gene expression. Genetic analysis estab...
|
PMID: 19995917
PDF is available here.
PDF is available here.
Laboratory Investigation (90)2 2010
Abstract
The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification. Recent studies show that PXR is important in abrogating intestinal tissue damage. This study examin...
|
PMID: 19997066
PDF is available here.
PDF is available here.
Abstract
Our aim was to assess the effect of two isomers of conjugated linoleic acids (CLA), cis-9,trans-11-CLA (c9,t11-CLA) and trans-10,cis-12-CLA (t10,c12-CLA), on glucose metabolism and hepatic expression of NR4A receptors, key transcription factors regulating gluconeogenesis. ApoE-deficient mice were fe...
|
PMID: 20036857
PDF is available here.
PDF is available here.
Abstract
Synergism between gemfibrozil and CDD 3540, drugs used to elevate mouse serum HDL cholesterol and apoprotein A1, is modeled using nonlinear response surface techniques. This approach employs a common simple pharmacological model to describe the dose-response function. Its parameters are modeled as f...
|
PMID: 20036888
PDF is available here.
PDF is available here.
Abstract
We show that ecdysone signaling plays an important role in the early development and functioning of Malpighian tubules. Disruption of ecdysone receptor function, using targeted expression of dominant negative ecdysone receptor in stellate cells, results in disruption of organization of Malpighian tu...
|
PMID: 20209436
PDF is available here.
PDF is available here.
Abstract
We observed that the multimarker composed of rs2461823/A-rs7643645/G was significantly associated with disease severity (P<6.9 x 10(-5), beta: 0.45). In addition, the rs7643645/G variant was significantly associated with ALT level (P<0.026), a surrogate marker of severe liver injury. Finally, in uni...
|
PMID: 19940802
PDF is available here.
PDF is available here.
Abstract
Our aim was to assess the effect of two isomers of conjugated linoleic acids (CLA), cis-9,trans-11-CLA (c9,t11-CLA) and trans-10,cis-12-CLA (t10,c12-CLA), on glucose metabolism and hepatic expression of NR4A receptors, key transcription factors regulating gluconeogenesis. ApoE-deficient mice were fe...
|
PMID: 20036857
PDF is available here.
PDF is available here.
Development (137)1 2010
Abstract
We turn to embryonic development to address these two issues. We show that mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade similar to that seen in mid-prepupae, directing maximal expression of E74A and E75A during late embryogen...
|
PMID: 20023167
PDF is available here.
PDF is available here.
Abstract
We show that mice lacking Pxr are resistant to LCA-mediated hepatotoxicity. This unexpected phenotype is found in association with enhanced urinary BA excretion and elevated basal expression of drug metabolism enzymes and the hepatic sulfate donor synthesis enzyme Papss2 in Pxr(-/-) mice. By subsequ...
|
PMID: 19797606
PDF is available here.
PDF is available here.
Abstract
150 of the patients (56.7%) presented stage I disease, and only 39 (14.7%) stage IV. 151 (57%) of the patients had no regional lymph nodes metastasis and 252 (94.9%) were free of metastatic disease when they first presented for diagnosis. Almost 43% of all tumors were poorly differentiated. In the m...
|
PMID: 20509292
PDF is available here.
PDF is available here.
Abstract
We present a comprehensive analysis focused on prediction of 115 steroids for ligand binding activity towards human PXR. Six crystal structures were used as templates for docking and ligand-based modeling approaches (two-, three-, four- and five-dimensional analyses). The best success at external pr...
|
PMID: 20011107
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
Steroid hormones act in the central and peripheral nervous systems to regulate a variety of functions, including development, cell proliferation, cognition and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the nuclear receptor su...
|
PMID: 19541426
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
We will discuss how coregulators influence gene transcription and repression, the role of chromatin-binding factors in the regulation of gene transcription, and their potential impact on brain development....
|
PMID: 19545950
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
We report that the inhibition of SRC-1 expression blocks the activating effects of exogenous testosterone on male sexual behaviors and increases the volume of the median preoptic area. Other coactivators are likely to be involved in the modulation in vivo of steroid receptor activity and it seems th...
|
PMID: 19524371
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (8)21 2009
Abstract
The molecular regulation of growth and progression of hormone refractory breast and prostate cancers remains challenging. The Division of Cancer Biology, NCI organized a small "think tank" style workshop and invited scientists in relevant areas to assess the state of science on the b...
|
PMID: 19783900
PDF is available here.
PDF is available here.
Bulletin du cancer (96)10 2009
Abstract
We conducted a retrospective study among all patients with metastatic breast cancer seen by three senior breast oncologists during a 4-month period. We evaluated correlation of CA15-3 level at the time of metastatic relapse with ER, PgR and Her2 expressions, tumor type, size and nodal status at init...
|
PMID: 19696005
PDF is available here.
PDF is available here.
Abstract
A series of 3-pyridinyl-tropane analogues based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. From the SAR study and our lead optimization efforts, compound 10 was found to possess potent oral antitussive activity in the caps...
|
PMID: 19678644
PDF is available here.
PDF is available here.
Abstract
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such...
|
PMID: 19688601
PDF is available here.
PDF is available here.
Abstract
We review the mechanisms of PXR-mediated repression of CYP expression.
We discuss the clinical implications of CYP repression and the role of signal cross-talks, including protein-protein interactions and phosphorylation of PXR and coregulators, in inhibiting PXR and repressing CYP e...
|
PMID: 19505191
PDF is available here.
PDF is available here.
Pharmaceutical Research (26)8 2009
Abstract
We propose the development of PXR antagonists through chemical, genetic and molecular modeling approaches. Based on this review it will be clear that antagonists of PXR and PXR-like pathways will have widespread utility in PXR biology and therapeutics....
|
PMID: 19415465
PDF is available here.
PDF is available here.
Abstract
Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP-induced hepatotoxicity, mice humanized for PXR...
|
PMID: 19460945
PDF is available here.
PDF is available here.
Abstract
Abstract
We provide a brief summary of oocyte maturation, focusing primarily on steroid-triggered meiotic progression in frogs and mice. Furthermore, we present new studies that implicate classical steroid receptors rather than alternative non-classical membrane steroid receptors as the primary regulators of...
|
PMID: 19071151
PDF is available here.
PDF is available here.
Abstract
Abstract
Membrane receptors are often modulated by steroids and it is necessary to distinguish the effects of steroids at these receptors from effects occurring at nuclear receptors. Additionally, it may also be mechanistically important to distinguish between direct effects caused by binding of steroids to...
|
PMID: 19103212
PDF is available here.
PDF is available here.
Toxicological Sciences (110)1 2009
Abstract
Alpha-naphthyl isothiocyanate (ANIT) is a hepatotoxicant that produces acute intrahepatic cholestasis in rodents. Farnesoid X receptor (FXR) and pregnane X receptor (PXR) are two major bile acid sensors in liver. The purpose of this study was to characterize the regulation of hepatic transporters by...
|
PMID: 19407337
PDF is available here.
PDF is available here.
Chemmedchem (4)7 2009
Abstract
PPARgamma agonist DIM-Ph-4-CF(3), a template for RXRalpha agonist (E)-3-[5-di(1-methyl-1H-indol-3-yl)methyl-2-thienyl] acrylic acid: DIM-Ph-CF(3) is reported to inhibit cancer growth independent of PPARgamma and to interact with NR4A1. As both receptors dimerize with RXR, and natural...
|
PMID: 19378296
PDF is available here.
PDF is available here.
Abstract
We show that a gene encoding a member of the CES2 subtype of liver- and intestine-enriched CES enzymes, called Ces6, is induced after treatment with pregnenolone 16alpha-carbonitrile in a PXR-dependent manner in duodenum and liver in mice. Treatment of mice with the CAR activator 1,4-bis[2-(3,5-dich...
|
PMID: 19359405
PDF is available here.
PDF is available here.
Endocrinology (150)7 2009
Abstract
We demonstrate that activation of the PKC pathway, by phorbol 12-myristate 13-acetate (PMA), was capable of potentiating dibutyryl cAMP [(Bu)(2)cAMP]-stimulated StAR expression, StAR phosphorylation, and progesterone synthesis in both mouse Leydig (MA-10) and granulosa (KK-1) tumor cells. The steroi...
|
PMID: 19282384
PDF is available here.
PDF is available here.
Abstract
We show here that ORP2 also binds 22(R)-hydroxycholesterol [22(R)OHC], 7-ketocholesterol, and cholesterol, with 22(R)OHC being the highest affinity ligand of ORP2 (K(d) 1.4 x 10(-8) M). We report the localization of ORP2 on cytoplasmic lipid droplets (LDs) and its function in neutral lipid metabolis...
|
PMID: 19224871
PDF is available here.
PDF is available here.
Life Sciences (85)1-2 2009
Abstract
We hypothesized that this effect could be associated with the altered expression of steroid receptors and their coregulators in the testes. The present study describes the effect of perinatal exposure of rats to BPA on the expression profile of testicular steroid receptor coregulators in the F(1) ge...
|
PMID: 19379760
PDF is available here.
PDF is available here.
Life Sciences (85)1-2 2009
Abstract
We hypothesized that this effect could be associated with the altered expression of steroid receptors and their coregulators in the testes. The present study describes the effect of perinatal exposure of rats to BPA on the expression profile of testicular steroid receptor coregulators in the F(1) ge...
|
PMID: 19379760
PDF is available here.
PDF is available here.
Life Sciences (85)1-2 2009
Abstract
We hypothesized that this effect could be associated with the altered expression of steroid receptors and their coregulators in the testes. The present study describes the effect of perinatal exposure of rats to BPA on the expression profile of testicular steroid receptor coregulators in the F(1) ge...
|
PMID: 19379760
PDF is available here.
PDF is available here.