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Receptors, Thyroid Hormone (2):
Recent article
Receptors, Thyroid Hormone
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
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PMID: 21554208
PDF is available here.
PDF is available here.
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Discovery medicine (11)59 2011
Abstract
Integrin αvβ3 is a heterodimeric structural protein of the plasma membrane that bears a cell surface receptor for thyroid hormone. The functions of this receptor are distinct from those of the classical nuclear receptor (TR) for thyroid hormone. The integrin is expressed primarily...
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PMID: 21524387
PDF is available here.
PDF is available here.
Abstract
We have, therefore, analysed the association of six single nucleotide polymorphisms (SNPs) within the three genes belonging to the NR4A orphan nuclear receptor family, NR4A1 (rs2603751, rs2701124), NR4A2 (rs12803, rs834835) and NR4A3 (rs1131339, rs1405209), with the degree of smoking in a sample of...
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PMID: 20659174
PDF is available here.
PDF is available here.
Cell Research (20)5 2010
Abstract
We demonstrated that liganded TR activated LAT transcription, but repressed infected cell protein no. 0 (ICP0) transcription in the presence of LAT TRE. Chromatin immunoprecipitation (ChIP) assays showed that TRs were recruited to LAT TREs independently of T(3) and hyperacetylated H4 was associated...
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PMID: 20386570
PDF is available here.
PDF is available here.
Abstract
Molecular Endocrinology (24)4 2010
Abstract
Because of their central importance in gene regulation and mediating the actions of many hormones, the nuclear receptors (NRs) have long been recognized as very important biological and pharmaceutical targets. Of all the surfaces available on a given NR, the singular site for regulation of receptor...
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PMID: 19933380
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)1 2010
Abstract
We performed serial deletions of the promoter and chromatin immunoprecipitation assays. The T(3) response element on the spondin 2 promoter was localized in the -1104/-1034 or -984/-925 regions. To explore the effect of spondin 2 on cellular function, spondin 2 knockdown cell lines were established...
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PMID: 19903741
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
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PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
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PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
Thyroid hormone exerts a large number of influences on the cardiovascular system. Increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. Furthermore, thyroid hormone has ma...
|
PMID: 19125327
PDF is available here.
PDF is available here.
Heart Failure Reviews (15)2 2010
Abstract
This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect...
|
PMID: 19096930
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
We summarize the consequences of thyroid hormone deficiency for brain development with special focus on the cerebellum, an important target of thyroid action. In addition, we discuss the role of iodothyronine deiodinases and thyroid hormone transporters in regulating local thyroid hormone concentrat...
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PMID: 19765631
PDF is available here.
PDF is available here.
Abstract
Our aim was to assess the effect of two isomers of conjugated linoleic acids (CLA), cis-9,trans-11-CLA (c9,t11-CLA) and trans-10,cis-12-CLA (t10,c12-CLA), on glucose metabolism and hepatic expression of NR4A receptors, key transcription factors regulating gluconeogenesis. ApoE-deficient mice were fe...
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PMID: 20036857
PDF is available here.
PDF is available here.
Neuroendocrinology (91)1 2010
Abstract
In primary cultures of fetal hypothalamic cells, TRH mRNA levels rapidly diminished with 10 nM T(3) while they increased by 1 mM 8Br-cAMP (+/- T(3)). Site-4 was protected from DNase I digestion with nuclear extracts from T(3)-incubated cells but not from controls or from those incubated with 8Br-cAM...
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PMID: 19602869
PDF is available here.
PDF is available here.
Abstract
Our aim was to assess the effect of two isomers of conjugated linoleic acids (CLA), cis-9,trans-11-CLA (c9,t11-CLA) and trans-10,cis-12-CLA (t10,c12-CLA), on glucose metabolism and hepatic expression of NR4A receptors, key transcription factors regulating gluconeogenesis. ApoE-deficient mice were fe...
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PMID: 20036857
PDF is available here.
PDF is available here.
Abstract
Such results emphasize the need of determining T3 levels, before the introduction of antiestrogenic forms of treatment in breast cancer patients....
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PMID: 19942988
PDF is available here.
PDF is available here.
Journal of Experimental Medicine (206)10 2009
Abstract
We identify the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) as a key negative regulator of human and mouse Th17 differentiation. PPAR gamma activation in CD4(+) T cells selectively suppressed Th17 differentiation, but not differentiation into Th1, Th2, or regulator...
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PMID: 19737866
PDF is available here.
PDF is available here.
Nature Immunology (10)10 2009
Abstract
We show that a T(H)-17 population differentiates in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-beta (TGF-beta). Like previously described T(H)-17 cells, the T(H)-17 cells that developed in the thymus expressed the transcr...
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PMID: 19734905
PDF is available here.
PDF is available here.
Abstract
Differentiated thyroid cancers are the predominant malignancies of the thyroid. Due to advances in the understanding of the activation of the cell proliferation pathway at a molecular level, multiple genetic alterations have been linked to the development of thyroid carcinogenesis. A...
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PMID: 19594419
PDF is available here.
PDF is available here.
Endocrine Research (34)1 2009
Abstract
Introduction. In CV-1 cells, shuttling from cytoplasm to nucleus of the nuclear thyroid hormone receptor-β1 (TRβ1, TR) is shown in this report to be regulated by extracellular thyroid hormone at a hormone receptor on cell surface integrin αv3. Methods. The receptor was introduced into cells as a G...
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PMID: 19557589
PDF is available here.
PDF is available here.
Abstract
Six subjects had STAT3 mutations affecting the DNA binding, Src homology 2, and transactivation domains, including 3 novel ones. Mutation-positive but not mutation-negative subjects with HIES exhibited reduced phosphorylation of STAT3 in response to cytokine stimulation, whereas pSTAT1 activation wa...
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PMID: 19577286
PDF is available here.
PDF is available here.
Abstract
Both naturally occurring and transforming growth factor-beta-induced Tregs can be converted into Th17 cells in the presence of inflammatory cytokines. Transforming growth factor-beta upregulates the Treg transcription factor, forkhead box P3, as well as the Th17 transcription factor, retinoic acid r...
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PMID: 19448538
PDF is available here.
PDF is available here.
Abstract
RNA splicing is an essential, precisely regulated process that occurs after gene transcription and before mRNA translation, in which introns may be removed and exons, retained. Variability in splicing patterns is a major source of protein diversity from the genome and function to generate a tremendo...
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PMID: 19893912
PDF is available here.
PDF is available here.
Molecular Endocrinology (23)8 2009
Abstract
We report here that the majority of these RCCC TR mutants tested are defective for transcriptional activation and behave as dominant-negative inhibitors of wild-type receptor function. Although several of the dominant-negative RCCC TR mutants are impaired for hormone binding, all fail to release fro...
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PMID: 19407221
PDF is available here.
PDF is available here.
Abstract
We have previously reported the discovery and preliminary structure activity relationships of a series of beta-aminoketones that disrupt the binding of coactivators to TR. However, the most active compounds had moderate inhibitory potency and relatively high cytotoxicity, resulting in narrow therape...
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PMID: 19469546
PDF is available here.
PDF is available here.
Journal of Immunology (183)1 2009
Abstract
In contrast to CD4 T cells, CD8 T cells inherently differentiate into IFN-gamma-producing effectors. Accordingly, while generation of IFN-gamma-producing Th1 CD4 T cells was profoundly impaired in mice deficient for both type-I IFN and IL-12 signaling in response to infection with Listeria monocytog...
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PMID: 19542449
PDF is available here.
PDF is available here.
Abstract
We show that Batf is required for the differentiation of IL17-producing T helper (T(H)17) cells. T(H)17 cells comprise a CD4(+) T-cell subset that coordinates inflammatory responses in host defence but is pathogenic in autoimmunity. Batf(-/-) mice have normal T(H)1 and T(H)2 differentiation, but sho...
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PMID: 19578362
PDF is available here.
PDF is available here.
Abstract
The intracellular actions of thyroid hormones in brain are determined by a complex of factors, including circulating concentrations of thyroid hormones, availability of free hormone, activity of thyroid hormone transporters and deiodinase enzymes, and activity of thyroid hormone receptors. Individua...
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PMID: 19387348
PDF is available here.
PDF is available here.
Endocrinology (150)7 2009
Abstract
We reported a novel mutation of thyroid hormone receptor (TR)-beta, F455S, in a patient with pituitary resistance to thyroid hormone (RTH), who showed impaired release of nuclear receptor corepressor and abnormal histone deacetylation. In the present study, we further analyzed the histone modificati...
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PMID: 19299458
PDF is available here.
PDF is available here.
Cerebellum (8)2 2009
Abstract
Thyroid hormone plays a crucial role in the development and functional maintenance of the central nervous system including the cerebellum. To study the molecular mechanisms of thyroid hormone action, various animal models have been used. These are classified: (1) congenital hypothyroid animals due t...
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PMID: 19130164
PDF is available here.
PDF is available here.
FEBS Journal (276)12 2009
Abstract
The purpose of this study was to provide a better understanding of the regulatory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells (NFkappaB) in mouse heart. NFkappaB regulates many nuclear genes and has been associated wi...
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PMID: 19438714
PDF is available here.
PDF is available here.
FEBS Journal (276)12 2009
Abstract
The purpose of this study was to provide a better understanding of the regulatory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells (NFkappaB) in mouse heart. NFkappaB regulates many nuclear genes and has been associated wi...
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PMID: 19438714
PDF is available here.
PDF is available here.
Abstract
Childhood thyroid hormone (T3) is essential for the normal development of endochondral and intramembranous bone and plays an important role in the linear growth and maintenance of bone mass. In adult, T3 stimulates osteoclastic bone resorption mediated primarily by TR alpha and local conversion by d...
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PMID: 19432125
PDF is available here.
PDF is available here.
Developmental Biology (328)2 2009
Abstract
These results demonstrate that TH controls the remodeling of beta-cells through cell-cell interaction with dedifferentiating acinar cells and a cell autonomous program that temporarily shuts off the insulin gene....
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PMID: 19389350
PDF is available here.
PDF is available here.
Journal of Immunology (182)9 2009
Abstract
We have previously shown that the IL-1 receptor associated kinase 1 (IRAK-1) selectively activates STAT3 and inactivates NFAT. Physiological studies have shown that IRAK-1(-/-) mice are protected from developing various inflammatory diseases, including experimental autoimmune encephalomyelitis and a...
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PMID: 19380824
PDF is available here.
PDF is available here.
Melanoma Research (19)2 2009
Abstract
We hypothesized that common germline variants in the STX17 gene might be associated with a predisposition to human CMM or might interact with other melanoma risk genes. We genotyped 26 tagging single nucleotide polymorphisms (SNPs) across the STX17 gene region in an Australian sample of 1560 melanom...
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PMID: 19209086
PDF is available here.
PDF is available here.
Abstract
In vitro differentiated T(H)17 cells differ from Treg and other T(H) cells in their potency to induce IL-6 and IL-1beta expression in primary bronchial epithelial cells. TGF-beta, IL-1beta, IL-6, and IL-23 are necessary during T(H)17 cell differentiation to acquire these functions, including IL-17 p...
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PMID: 19178935
PDF is available here.
PDF is available here.
Abstract
We examined whether various phytochemicals have agonistic and/or antagonistic activity against six human nuclear receptors (ERalpha, ERbeta, androgen receptor (AR), glucocorticoid receptor (GR), thyroid hormone receptor alpha(1) (TRalpha(1)) and TRbeta(1)) by in vitro reporter gene assays using Chin...
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PMID: 19182375
PDF is available here.
PDF is available here.
Hepatology (49)2 2009
Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, with a prevalence ranging from 10% to 30%. The use of thyroid hormone receptor (TR) agonists for the treatment of NAFLD has not been considered viable because thyroid hormones increase free fatty acid...
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PMID: 19072834
PDF is available here.
PDF is available here.
Hepatology (49)2 2009
Abstract
Abstract
We and others have shown that PPARgamma recruits the nuclear corepressors NCoR and silencing mediator for retinoid and thyroid hormone receptors (SMRT) to modulate adipogenesis. While the synthetic ligands for PPARgamma, the thiazolidinediones (TZD), are widely used in the treatment of type 2 diabet...
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PMID: 19165156
PDF is available here.
PDF is available here.
BMC Medical Genetics (10)1 2009
Abstract
All five SNPs were in Hardy-Weinberg equilibrium (p >or= 0.7, all). The minor alleles of three SNPs, i.e., rs1526267, rs12686676, and rs10819699, consistently tended to associate with higher insulin release as derived from plasma insulin at 30 min(OGTT), AUCC C-peptide-to-AUC Gluc ratio and the AUC...
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PMID: 19682370
PDF is available here.
PDF is available here.
Journal of Pathology (217)1 2009
Abstract
We performed an expression microarray analysis of EMC tumours expressing the EWSR1/NR4A3 fusion protein, comparing their expression profiles to those of other sarcoma types. We thereby identified a set of genes significantly overexpressed in EMC relative to other sarcomas, including PPARG and NDRG2....
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PMID: 18855877
PDF is available here.
PDF is available here.
Nature Immunology (10)1 2009
Abstract
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
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PMID: 19088733
PDF is available here.
PDF is available here.
Nature Immunology (10)1 2009
Abstract
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
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PMID: 19088733
PDF is available here.
PDF is available here.
Nature Immunology (10)1 2009
Abstract
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
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PMID: 19088733
PDF is available here.
PDF is available here.
Abstract
We learn more about the mechanisms of transcriptional repression, the importance of repression by nuclear receptors in development and disease has become clear. The protein encoded by the mammalian Hairless (Hr) gene was shown to be a corepressor by virtue of its functional similarity to the well-es...
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PMID: 20087431
PDF is available here.
PDF is available here.
Clinical Endocrinology (70)1 2009
Abstract
Amiodarone and dronedarone are two clinically important benzofuran derivatives. Amiodarone has been used widely for treating resistant tachyarrhythmias in the past three decades. However amiodarone and its main metabolically active metabolite desethylamiodarone can adversely affect many organs, incl...
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PMID: 18727707
PDF is available here.
PDF is available here.
Gastroenterology (136)1 2009
Abstract
We have identified a crucial role of RORgamma-expressing Th17 cells in chronic intestinal inflammation. RORgamma controls IL-17A and IL-17F production, and these cytokines have a redundant but highly pathogenic role in gut inflammation. Reagents that target RORgamma or a combination of anti-IL-17A a...
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PMID: 18992745
PDF is available here.
PDF is available here.
Abstract
We demonstrate that these effects of IL-21 on Th17 differentiation are completely dependent on IFN regulatory factor 4 (IRF4). After culturing in the presence of IL-21 plus TGFbeta, IRF4-deficient (Irf4(-/-)) Th cells showed a profound intrinsic defect in IL-17 production and in the autocrine IL-21...
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PMID: 19088203
PDF is available here.
PDF is available here.