Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
COUP Transcription Factor II (0):
Recent article
COUP Transcription Factor II
Genetika (Moskva) (46)10 2010
Abstract
The Tsix regulatory region was examined in vole Microtus rossiaemeridionalis. The minimal promoter region, three potential enhancer regulatory elements and one transcription suppressor element were identified. The enhancer regions contained potential binding sites of transcription activators, while...
|
PMID: 21254563
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Biological Chemistry (285)30 2010
Abstract
We define the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex. Whereas the N-terminal 1-91-amino acid region of the protein is required and sufficient for binding to the Arp1 rod, additional determinants contain...
|
PMID: 20463029
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
We produced tissue recombinants using uteri from neonatal PR knockout (ko) mice and wild-type (wt) mice containing PR in S and/or E or lacking PR altogether using a tissue recombinant methodology and assessed their response to P4. In tissue recombinants containing wt-S (wt-S + wt-E and wt-S + ko-E),...
|
PMID: 19372202
PDF is available here.
PDF is available here.
Oncology Reports (21)1 2009
Abstract
We investigated the presence of COUP-TFII in human colorectal cancer tissues and adjacent normal tissues from 95 primary colorectal cancer patients by immunohistochemistry. The correlation between the expression of COUP-TFII and clinicopathologic features was investigated. The 3-year disease-free su...
|
PMID: 19082449
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)50 2008
Abstract
We showed that, although CGE and lateral ganglionic eminence (LGE) express almost the same marker molecules, LGE cells do not migrate caudally when transplanted into the CGE, suggesting that LGE cells are intrinsically different from CGE cells. We therefore compared the transcriptomes of the CGE, MG...
|
PMID: 19074032
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)45 2008
Abstract
We have cloned and localized the promoter region of the human PED/PEA-15 gene within the first 230 bp of the 5(R)-flanking region. A cis-acting regulatory element located between -320 and -335 bps upstream the PED/PEA-15 gene transcriptional start site (+1) is recognized by both the hepatocyte nucle...
|
PMID: 18765665
PDF is available here.
PDF is available here.
Abstract
We showed this previously by deleting COUP-TFII from pancreatic beta cells in heterozygous mutant mice, which led to abnormal insulin secretion. Here, we report that COUP-TFII expression is reduced in the pancreas and liver of mice refed with a carbohydrate-rich diet and in the pancreas and liver of...
|
PMID: 18765640
PDF is available here.
PDF is available here.
Rinsho Ketsueki (49)10 2008
Abstract
Abstract
We report the ligand-free 1.48 A crystal structure of the human COUP-TFII ligand-binding domain. The structure reveals an autorepressed conformation of the receptor, where helix alpha10 is bent into the ligand-binding pocket and the activation function-2 helix is folded into the cofactor binding sit...
|
PMID: 18798693
PDF is available here.
PDF is available here.
Nature Neuroscience (11)9 2008
Abstract
We found that chicken ovalbumin upstream promoter-transcription factor I and II (Coup-tfI and Coup-tfII, also known as Nr2f1 and Nr2f2) are required for the temporal specification of neural stem/progenitor cells (NSPCs), including their acquisition of gliogenic competence, as demonstrated by their r...
|
PMID: 19160499
PDF is available here.
PDF is available here.
FEBS Letters (582)19 2008
Abstract
We aimed to investigate whether hMSCs could also differentiate into a specific arterial or venous ECs. hMSCs were induced to differentiate into ECs using vascular endothelial growth factor (VEGF). Low VEGF concentration (50 ng/ml) upregulated the venous marker gene EphB4, however high concentration...
|
PMID: 18671974
PDF is available here.
PDF is available here.
Abstract
We demonstrate specific HNF4alpha activation of a reporter plasmid containing the COUP-TFII gene promoter region in transfected pancreatic beta cells. The stable association of the endogenous HNF4alpha with a region of the COUP-TFII gene promoter that contains a direct repeat 1 (DR-1) binding site w...
|
PMID: 18474611
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (314)1-2 2008
Abstract
We analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid production in theca cells. Theca cells begin to display an elongated...
|
PMID: 18409030
PDF is available here.
PDF is available here.
Abstract
We show that COUP-TFII acts downstream of hedgehog signaling and is required for the full antiadipogenic effect of this pathway. This effect is mediated in part by interaction with GATA factors. COUP-TFII and GATA2 are physically associated and repress target gene expression in an additive manner. T...
|
PMID: 18250317
PDF is available here.
PDF is available here.
Cancer Research (68)2 2008
Abstract
We identified a novel, atypical direct repeat (DR) element consisting of a consensus half-site (AGGTCA) at -125/-119 and a degenerated DR half-site (ATGTTA) at -99/-94 as sufficient and necessary for vegf-D transcription. The vegf-D DR element is bound and activated by the orphan receptors hepatocyt...
|
PMID: 18199540
PDF is available here.
PDF is available here.
Abstract
We knocked out COUP-TFII gene in a time-specific manner by using a tamoxifen inducible Cre recombinase. The ablation of COUP-TFII during pre-pubertal stages of male development results in infertility, hypogonadism and spermatogenetic arrest. Homozygous adult male mutants are defective in testosteron...
|
PMID: 18818749
PDF is available here.
PDF is available here.
Abstract
The regulation of renin gene expression is thought to be fundamental to regulation of the total renin-angiotensin system. The human renin gene contains a direct repeat (DR) motif AGGGGTCAC-AGGGCCA in the proximal region (-259/-245 bp), which contains similar sequence for nuclear receptor superfamily...
|
PMID: 17455195
PDF is available here.
PDF is available here.
EMBO Reports (8)10 2007
Abstract
How arterial and venous fates are established is largely unknown. In the past, circulatory dynamics were thought to be the exclusive cause of arteries and veins being structurally and functionally distinct; however, growing evidence indicates that an orderly progression of molecular signals controls...
|
PMID: 17906673
PDF is available here.
PDF is available here.
PLoS Genetics (3)6 2007
Abstract
We have identified a novel genetic pathway in which BMP2 lies downstream of COUP-TFII. Epithelial progesterone-induced Indian hedgehog regulates stromal COUP-TFII, which in turn controls BMP2 to allow decidualization to manifest in vivo. Interestingly, enhanced epithelial estrogen activity, which im...
|
PMID: 17590085
PDF is available here.
PDF is available here.
Abstract
We examine key findings that are likely to form the basis for future research in this field. Specific topics include a short overview of normal and abnormal diaphragm development, a discussion of syndromic forms of CDH, a detailed review of chromosomal regions recurrently altered in CDH, a descripti...
|
PMID: 17436238
PDF is available here.
PDF is available here.
Abstract
We used the cre/loxP system to conditionally inactivate COUP-TFII in the ovary and uterus. Homozygous adult female mutants with specific inactivation of the Coup-tfII gene in uterine stromal and smooth muscle cells have severely impaired placental formation, leading to miscarriage at days 10-12 of p...
|
PMID: 17404209
PDF is available here.
PDF is available here.
Developmental Dynamics (236)3 2007
Abstract
We employed immunohistochemistry to investigate the expression pattern of 18 NRs in the cerebellum. Ten receptors were demonstrated to be expressed in the postnatal day 21 (P21) cerebellum. Among them, five receptors (COUP-TFI, COUP-TFII, RORalpha, ERbeta, and ERRgamma) were expressed at all stages...
|
PMID: 17205580
PDF is available here.
PDF is available here.
Abstract
By quantitative PCR we demonstrated a positive correlation of Coup-TFII and Ucp3 mRNA expression in skeletal muscle and brown adipose tissue in response to food deprivation and cold exposure, respectively. In reporter gene assays Coup-TFII enhanced transactivation of the Ucp3 promoter conveyed by My...
|
PMID: 17204145
PDF is available here.
PDF is available here.
Experimental Cell Research (313)1 2007
Abstract
We show that hypoxia is an inducer of Notch signaling. Hypoxic conditions lead to induction of the Notch ligand Dll4 and the Notch target genes Hey1 and Hey2 in various cell lines. Promoter analysis revealed that Hey1, Hey2 and Dll4 are induced by HIF-1alpha and Notch activation. Hypoxia-induced Not...
|
PMID: 17045587
PDF is available here.
PDF is available here.
Molecular Endocrinology (20)12 2006
Abstract
We examined the expression patterns of a subset of nuclear receptors in which specific antibodies are available for profiling using immunohistochemistry. As a prototype for our analysis, we investigated the expression patterns of chicken ovalbumin upstream promoter transcription factor (COUP-TF) -I...
|
PMID: 16973757
PDF is available here.
PDF is available here.
Abstract
We have compared the anatomical characteristics of diaphragm defects in the well-described nitrofen model with the pathogenesis of CDH in vitamin A-deficient rats and wt1 null-mutant mice, representing teratogen-induced, dietary and genetic models of CDH, respectively. Our histological investigation...
|
PMID: 17071579
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)43 2006
Abstract
Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2), also known as Bcl11b, is a transcriptional repressor that functions by direct, sequence-specific DNA binding activity or by recruitment to the promoter template by interaction with COUP-TF family member...
|
PMID: 16950772
PDF is available here.
PDF is available here.
Cancer Research (66)20 2006
Abstract
We tested the hypothesis that reduced COUP-TFI and COUP-TFII correlate with TAM resistance. We report for the first time that COUP-TFII, but not COUP-TFI, is reduced in three antiestrogen/TAM-R cell lines derived from TAM-sensitive (TAM-S) MCF-7 human breast cancer cells and in MDA-MB-231 cells comp...
|
PMID: 17047084
PDF is available here.
PDF is available here.
Abstract
We review this work and discuss how activation of the MAPK signaling cascade could stimulate an arterial fate....
|
PMID: 17018851
PDF is available here.
PDF is available here.
Orvosi Hetilap (147)35 2006
Abstract
It can be concluded that the level of homocysteine in patients suffering from various CV diseases is high in Hungary. This may have a prognostic value, and shows that reduction of homocysteine level in these patients may be beneficial....
|
PMID: 17051744
PDF is available here.
PDF is available here.
Experimental Gerontology (41)9 2006
Abstract
Our results show that in male senescent rats (1) the decrease of HNF4alpha is not consistent with the continuous secretion of GH, and (2) the suppression of CYP3A2 expression is not dependent to the HNF4alpha binding activity....
|
PMID: 16891075
PDF is available here.
PDF is available here.
Abstract
We report that the human hepatic lipase gene (LIPC) promoter is regulated by hepatocyte nuclear factor 4alpha (HNF4alpha), peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), apolipoprotein A-I regulatory protein-1 (ARP-1), and hepatocyte nuclear factor 1alpha (HNF1alph...
|
PMID: 16603721
PDF is available here.
PDF is available here.
Journal of Molecular Biology (359)4 2006
Abstract
We used single particle analysis to obtain a two-dimensional averaged image of dynactin isolated from chick embryo brains and visualized by negative stain electron microscopy (EM). Each individual image, consisting of the shoulder/sidearm and the rod, closely resembled the previously published quick...
|
PMID: 16697405
PDF is available here.
PDF is available here.
Abstract
We show that tissue-specific null mutants of COUP-TFII exhibit Bochdalek-type CDH, the most common form of CDH. COUP-TFII, a member of orphan nuclear receptors, is expressed in regions critical for the formation of the diaphragm during embryonic development. Ablation of COUP-TFII in the foregut mese...
|
PMID: 16251273
PDF is available here.
PDF is available here.
Journal of Cell Science (118)Pt 17 2005
Abstract
We demonstrate that ARFRP1 is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of Arl1 and GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. Furthermore, we show that, in concert wi...
|
PMID: 16129887
PDF is available here.
PDF is available here.
Abstract
We systemically examined the temporal and spatial expression of COUP-TFI and COUP-TFII transcripts and, for the first time, their protein during development and functional maturation of the cochlea. Both COUP-TFI and COUP-TFII were expressed early in the developing otic vesicle. COUP-TFI expression...
|
PMID: 15907456
PDF is available here.
PDF is available here.
Abstract
We systemically examined the temporal and spatial expression of COUP-TFI and COUP-TFII transcripts and, for the first time, their protein during development and functional maturation of the cochlea. Both COUP-TFI and COUP-TFII were expressed early in the developing otic vesicle. COUP-TFI expression...
|
PMID: 15907456
PDF is available here.
PDF is available here.
Abstract
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been implicated in the control of blood glucose by its potent effect on expression and signaling of various nuclear receptors. To understand the role of COUP-TFII in glucose homeostasis, conditional COUP-TFII-deficient mice...
|
PMID: 15855320
PDF is available here.
PDF is available here.
Abstract
We show that COUP-TFII (also known as Nr2f2), a member of the orphan nuclear receptor superfamily, is specifically expressed in venous but not arterial endothelium. Ablation of COUP-TFII in endothelial cells enables veins to acquire arterial characteristics, including the expression of arterial mark...
|
PMID: 15875024
PDF is available here.
PDF is available here.
Development (132)9 2005
Abstract
We found COUP-TFII is expressed in the mesenchyme and the epithelium of the developing stomach. Conditional ablation of floxed COUP-TFII by Nkx3-2Cre recombinase in the gastric mesenchyme results in dysmorphogenesis of the developing stomach manifested by major patterning defects in posteriorization...
|
PMID: 15829524
PDF is available here.
PDF is available here.
Journal of Dairy Science (88)4 2005
Abstract
These results together suggest that, at the molecular level, decreased expression of GHR 1A mRNA in the liver of dairy cows at parturition may involve increased expression of HNF-4gamma mRNA and that, at the systemic level, decreased expression of GHR 1A mRNA is not a direct result of the end of pre...
|
PMID: 15778305
PDF is available here.
PDF is available here.
Mammalian Genome (16)2 2005
Abstract
We employed a comparative genomic approach. Initial comparisons between humans and mice of the 3470-kb gene-poor region surrounding COUP-TFII revealed 2023 conserved noncoding elements. To prioritize a subset of these elements for functional studies, we performed further genomic comparisons with the...
|
PMID: 15859353
PDF is available here.
PDF is available here.
Neuroendocrinology (82)5-6 2005
Abstract
We cloned COUP-TFII and EAR-2 cDNAs from an anterior pituitary cDNA library. Subsequently, we raised and characterized specific antibodies to the N-terminal domain of both nuclear receptors. We next examined their cellular and subcellular distribution in the pituitary gland and determined their regu...
|
PMID: 16721029
PDF is available here.
PDF is available here.
Molecular Endocrinology (19)1 2005
Abstract
We have examined whether chicken ovalbumin upstream promoter-transcription factor (COUP-TF), a member of the orphan nuclear receptor family of transcription factors, is involved in this transcriptional regulation. We analyzed COUP-TF and StAR mRNA and protein levels in bovine adrenal glomerulosa cel...
|
PMID: 15375188
PDF is available here.
PDF is available here.
Development (131)24 2004
Abstract
We have first identified a novel dorsal-to-ventral migratory route, in which cells migrate from the interganglionic sulcus, located in the basal telencephalon between the lateral and medial ganglionic eminences, towards the pre-optic area and anterior hypothalamus in the diencephalon. Next, with the...
|
PMID: 15548577
PDF is available here.
PDF is available here.
Abstract
We bypassed the early embryonic lethality of the COUP-TFII mutant by using two methods. First, embryonic chimera analysis has revealed an obligatory role for COUP-TFII in limb bud outgrowth since mutant cells are unable to contribute to the distally growing limb mesenchyme. Second, we used a conditi...
|
PMID: 15572686
PDF is available here.
PDF is available here.
Cancer Letters (214)1 2004
Abstract
I footprint analysis and proved to involve the E-box motif of hTERT promoter. Luciferase reporter assays indicated that COUP-TFII could suppress the transcription of hTERT promoter, and the inhibition to some extent could be reversed by co-transfection of c-myc. Stable introduction of COUP-TFII into...
|
PMID: 15331176
PDF is available here.
PDF is available here.
Abstract
We mapped six putative cis-elements in the promoter region of the human renin gene with nuclear proteins from human chorionic cells and human renal cortex by DNase I protection assay (footprint A-F). Each footprint contains Ets motif like site (A), HOXñPBX recognition sequence (B), unknown sequence...
|
PMID: 15368359
PDF is available here.
PDF is available here.
Abstract
COUP-TFII could firmly bind to the downstream E-box and the other two binding sites in hTERT promoter. Luciferase reporter assay indicated COUP-TFII could suppress hTERT promoter activity and stable introduction of COUP-TFII into HeLa cells also decreased both endogenous hTERT transcription and telo...
|
PMID: 15506639
PDF is available here.
PDF is available here.
Cancer Research (64)15 2004
Abstract
We demonstrate here that noninvasive human lung cancer cells become invasive when COUP-TFII was expressed. The expression of extracellular matrix degrading proteinases, such as matrix metalloproteinase 2 and urokinase-type plasminogen activator, was up-regulated in these cells. This finding was conf...
|
PMID: 15289311
PDF is available here.
PDF is available here.
Abstract
We recently found that GR physically interacts with the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), which plays a critical role in the metabolism of glucose, cholesterol, and xenobiotics, as well as in the development of the central nervous system in fetus. GR stimulates...
|
PMID: 15265774
PDF is available here.
PDF is available here.
Abstract
We previously found that the region between nucleotide -218 and nucleotide -151 (relative to the major transcription start site) of the bovine GHR 1A promoter contained a binding site between -196 and -178 for the liver-enriched transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha) and...
|
PMID: 15171724
PDF is available here.
PDF is available here.
Molecular Endocrinology (18)4 2004
Abstract
We found the chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan nuclear receptor that plays important roles in glucose, cholesterol, and xenobiotic metabolism, as a partner of GR. In an in vitro glutathione-S-transferase pull-down assay, COUP-TFII interacted via its D...
|
PMID: 14739255
PDF is available here.
PDF is available here.
Mechanisms of Ageing and Development (125)10-11 2004
Abstract
We have sought to determine whether Ets-1 is a potential regulator of COUP-TFII gene expression. For this purpose, we performed transient transfection experiments using a luciferase reporter construct containing the mouse COUP-TFII promoter. We found that the COUP-TFII promoter activity is indeed re...
|
PMID: 15541767
PDF is available here.
PDF is available here.
Molecular Pharmacology (64)3 2003
Abstract
We studied how troglitazone, an antidiabetic drug that selectively activates peroxisome proliferator-activated receptor gamma (PPARgamma), affected the expression of several of these genes. A single-day troglitazone administration (100 mg/kg/day) did not significantly alter plasma free fatty acids o...
|
PMID: 12920214
PDF is available here.
PDF is available here.
Abstract
We tested the ability of Arp11 to interact with conventional actin and found it could coassemble. Like Arp1, cytosolic Arp11 is found only in dynactin, suggesting that Arp11 and free cytosolic actin do not interact significantly. Recombinant Arp11 and Arp1 were demonstrated to interact by coprecipit...
|
PMID: 12857853
PDF is available here.
PDF is available here.
Abstract
These results indicated that DAX-1 and COUP-TFII may play a role in the modulation of Ad4BP/SF-1-dependent transcription of steroidogenic enzymes in different cell types and follicular stages in normal cycling human ovaries....
|
PMID: 12843196
PDF is available here.
PDF is available here.
Abstract
We then screened for COUP-TFI-interacting proteins from a cortisol-producing adenoma cDNA library using a yeast two-hybrid system and identified a novel RING finger-containing protein which can function as a coregulator for COUP-TFI. Notably, COUP-TFI activated rather than repressed several target g...
|
PMID: 12943735
PDF is available here.
PDF is available here.
Abstract
We have previously determined that the regulatory factor, upstream stimulatory factor 2 (USF2), can stimulate transcription of the ATPA gene through the cis-acting regulatory element 1 in the upstream promoter of this gene. In this study, we used the yeast one-hybrid screening method to identify ano...
|
PMID: 12614160
PDF is available here.
PDF is available here.
Abstract
We used chromatin immunoprecipitation (ChIP) assay in order to determine in vivo whether these proteins regulate class I transcription by affecting chromatin. The ChIP assay revealed that there is lack of chromatin histone acetylation in the region of the class I enhancer in Ad12-transformed cells....
|
PMID: 12620799
PDF is available here.
PDF is available here.