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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Repressor Proteins (2):
Recent article
Repressor Proteins
Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
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PMID: 22014525
PDF is available here.
PDF is available here.
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Cancer Genetics (204)8 2011
Abstract
We report the case of a 57-year-old man, who was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t(3;9)(p13;p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1) and paired box gene 5 (PAX5). The PAX5...
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PMID: 21962897
PDF is available here.
PDF is available here.
PLoS Genetics (7)7 2011
Abstract
We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. Specifically, we performed genome-wide in vivo ChIP-chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targ...
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PMID: 21765815
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We investigate how chromatin structure is modified following UV irradiation to facilitate DNA repair in yeast. Using a combination of chromatin immunoprecipitation to measure histone acetylation levels, histone acetylase occupancy in chromatin, MNase digestion, or restriction enzyme endonuclease acc...
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PMID: 21698136
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that Tet1 is specifically expressed in murine embryonic stem (ES) cells and is required for ES cell maintenance. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich...
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PMID: 21451524
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Today the treatment of inherited diseases holds a major field in gene therapy, and gamma -retroviral vectors are often the preferred tool for stable introduction of the therapeutic gene(s) into the host cell genome. In many cases, the newly introduced gene has to be constitutively expressed, since e...
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PMID: 19110630
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We report that BMI1 contains a functional recognition motif for the F box protein βTrCP, which regulates ubiquitination and proteasome-mediated degradation of various proteins. We show that overexpression of wild-type βTrCP but not the ΔF mutant of it promotes BMI1 ubiquitination and degradation,...
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PMID: 21430439
PDF is available here.
PDF is available here.
Medical Hypotheses (76)4 2011
Abstract
We propose a novel hypothesis that early proteins E6 and E7 of HPV attenuate ischemia-reperfusion injury by inhibiting apoptosis and inactivating p53 and pRb. It is possible that the two oncoproteins can be used to protect organ function from ischemia-reperfusion injury in special clinical condition...
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PMID: 21277688
PDF is available here.
PDF is available here.
Medical Hypotheses (76)4 2011
Abstract
We propose a novel hypothesis that early proteins E6 and E7 of HPV attenuate ischemia-reperfusion injury by inhibiting apoptosis and inactivating p53 and pRb. It is possible that the two oncoproteins can be used to protect organ function from ischemia-reperfusion injury in special clinical condition...
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PMID: 21277688
PDF is available here.
PDF is available here.
Medical Hypotheses (76)4 2011
Abstract
We propose a novel hypothesis that early proteins E6 and E7 of HPV attenuate ischemia-reperfusion injury by inhibiting apoptosis and inactivating p53 and pRb. It is possible that the two oncoproteins can be used to protect organ function from ischemia-reperfusion injury in special clinical condition...
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PMID: 21277688
PDF is available here.
PDF is available here.
Abstract
We identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human P...
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PMID: 21376232
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)10 2011
Abstract
Abstract
We determined the methylation status of all 110 CpG sites within the viral epigenome in advanced stage III/IV HPV-16-associated head and neck cancers. We found that the viral genome was hypomethylated in the majority of head and neck cancers, in particular within the viral regulatory region, long co...
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PMID: 21292634
PDF is available here.
PDF is available here.
Abstract
We reported that a human microRNA, hsa-miR-138, could inhibit the adipogenic differentiation of hAD-MSCs. Our results showed that miR-138 was significantly down-regulated during adipogenic differentiation. Overexpression of miR-138 in hAD-MSCs could effectively reduce lipid droplets accumulation, in...
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PMID: 20486779
PDF is available here.
PDF is available here.
Abstract
We could show that OSID contacts a second pleiotropic corepressor, Ssn6 (=Cyc8), which together with Tup1 is also able to recruit HDACs. Interestingly, mutations sin3 and ssn6 turned out as synthetically lethal. Our analysis further revealed that OSID not only binds to PAH1 but also interacts with t...
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PMID: 21104417
PDF is available here.
PDF is available here.
Abstract
We employed SILAM (Stable Isotope Labeling in Mammals) combined with mass spectrometry to quantify the proteome between mammalian tissues. Using (15)N labeled rat tissue, we quantified 3742 phosphorylated peptides in nuclear extracts from liver and brain tissue. Analysis of the phosphorylation sites...
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PMID: 21283754
PDF is available here.
PDF is available here.
Abstract
We attempted to identify PR-Set7-interacting proteins reasoning that these proteins would provide important insights into the role of PR-Set7 in transcriptional regulation. Using an unbiased yeast two-hybrid approach, we discovered that PR-Set7 interacts with the UBC9 E2 SUMO conjugating enzyme. Thi...
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PMID: 21829513
PDF is available here.
PDF is available here.
Abstract
We explored the global transcriptional regulation by CovR in S. mutans. Comparison of the transcriptome profiles of the wild-type strain UA159 with its isogenic covR deleted strain IBS10 indicated that at least 128 genes (∼6.5% of the genome) were differentially regulated. Among these genes, 69 we...
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PMID: 21655290
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
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PMID: 21466690
PDF is available here.
PDF is available here.
Abstract
We found that expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382, a KZNF with tumor suppressor activity. ChIP of MAGE I (-) HEK293T cells showed KAP1 and H3me3K9 are normally bound to the ID1 gene, a target of ZNF382, but that binding is greatly reduc...
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PMID: 21876767
PDF is available here.
PDF is available here.
Abstract
The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self-proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor...
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PMID: 21603204
PDF is available here.
PDF is available here.
Abstract
We show that a strain carrying a deletion of cre-1 has increased cellulolytic activity and increased expression of cellulolytic genes during growth on crystalline cellulose (Avicel). Constitutive expression of cre-1 complements the phenotype of a N. crassa Δcre-1 strain grown on Avicel, and also re...
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PMID: 21980519
PDF is available here.
PDF is available here.
Abstract
We revisited the topic of gene-dependent cell death in yeast to determine the prevalence of yeast genes with the capacity to contribute to cell-autonomous death. We developed a rigorous strategy by allowing sufficient time for gene-dependent events to occur, but insufficient time to evolve new popul...
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PMID: 21814286
PDF is available here.
PDF is available here.
Abstract
We demonstrate using co-immunoprecipitation approaches that Ccr4-Not subunits interact with Hmt1, the budding yeast ortholog of PRMT1. Furthermore, using genetic and biochemical approaches, we demonstrate that Ccr4-Not physically and functionally interacts with the heterogenous nuclear ribonucleopro...
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PMID: 21464899
PDF is available here.
PDF is available here.
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
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PMID: 21197711
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We demonstrate for the first time that curcumin treatment suppresses cervical cancer cell growth in a three-dimensional raft culture system. Curcumin also inhibits tumorigenic characteristics as shown by decreases in both clonogenic potential and cell motility. Additionally, our findings show that c...
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PMID: 21061268
PDF is available here.
PDF is available here.
Abstract
We found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and p73 were induced to stabilize in association with a significant reduction of MDM2 and Itch, suggesting that, in addition to Itch, MDM2 cou...
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PMID: 21093410
PDF is available here.
PDF is available here.
Biochemical Journal (433)2 2010
Abstract
We report the crystal structures of c-Rph1 in apo form and in complex with Ni²(+) and α-KG [2-oxoglutarate (α-ketoglutarate)]. The structure of c-Rph1 is composed of a JmjN (Jumonji N) domain, a long β-hairpin, a mixed structural motif and a JmjC domain. The α-KG cofactor forms hydrogen-bonding...
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PMID: 21067515
PDF is available here.
PDF is available here.
Abstract
We used immunohistochemistry to evaluate the expression of Oct4 (also known as Oct3 or POU5F1), a transcription factor expressed in primordial germ cells and embryonic stem cells, along with that of PAX6, a transcription factor contributing to neurogenesis, and CD56, a known marker for tumors of neu...
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PMID: 21107090
PDF is available here.
PDF is available here.
Abstract
We summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology....
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PMID: 21091425
PDF is available here.
PDF is available here.
Abstract
We studied the influences of dietary LC-PUFAs in dams (C57BL/6 and C3H/He) on the eye morphogenesis and organogenesis of their pups. Intriguingly, fetuses and newborn mice from C57BL/6 dams fed an LC-PUFA (particularly ARA)-enriched diet displayed a much higher incidence of eye abnormalities such as...
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PMID: 20951676
PDF is available here.
PDF is available here.
Abstract
We isolated a SET domain-containing gene from the zebrafish (Danio rerio). The gene has the highest sequence similarity to human NSD2, also known as Wolf-Hirschhorn syndrome candidate 1 or WHSC1, and therefore, was named DrWhsc1. DrWhsc1 mRNA is expressed in various tissues with the highest level in...
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PMID: 20946879
PDF is available here.
PDF is available here.
Abstract
We have previously reported that MMTR (MAT1-mediated transcriptional repressor) is a co-repressor that inhibits TFIIH-mediated transcriptional activity via interaction with MAT1 (Kang et al., 2007). Since MAT1 is a member of the CAK kinase complex that is crucial for cell cycle progression and that...
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PMID: 20920467
PDF is available here.
PDF is available here.
Abstract
We identified an FDA-approved drug, pyrvinium, as a potent inhibitor of Wnt signaling (EC(50) of ∼10 nM). We show pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. CK1α...
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PMID: 20890287
PDF is available here.
PDF is available here.
Abstract
Serum response factor (SRF) is a widely expressed protein that plays a key role in the regulation of smooth muscle differentiation, proliferation, migration, and apoptosis. It is generally accepted that one mechanism by which SRF regulates these diverse functions is through pathway-specific cofactor...
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PMID: 20739623
PDF is available here.
PDF is available here.
Abstract
We present a microarray-based survey of the methylation status of CpG islands (CGIs) in 45 human atherosclerotic arteries and 16 controls. Data from 10,367 CGIs revealed that a subset (151 or 1.4%) of these was hypermethylated in control arteries. The vast majority (142 or 94%) of this CGI subset wa...
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PMID: 20878091
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)11 2010
Abstract
Our findings extend the role of miRNA in the pathogenesis of lupus and provide potential strategies for therapeutic intervention.
Copyright © 2010 by the American College of Rheumatology....
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PMID: 20589685
PDF is available here.
PDF is available here.
Fungal Genetics and Biology (47)11 2010
Abstract
We show that RCO-1 and RCM-1, the Neurospora homologs of the components of the yeast Tup1-Ssn6 repressor complex, participate in photoadaptation. Mutation in either rco-1 or rcm-1 result in high and sustained accumulation of mRNAs for con-10 and other light-regulated genes after long exposures to li...
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PMID: 20709620
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
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PMID: 20972443
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
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PMID: 20972443
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We report the crystal structure of Schizosaccharomyces pombe Cut9 (Cdc16/Apc6) in complex with Hcn1 (Cdc26), showing that Cdc16/Cut9 is a contiguous TPR superhelix of 14 TPR units. A C-terminal block of TPR motifs interacts with Hcn1, whereas an N-terminal TPR block mediates Cdc16/Cut9 self-associat...
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PMID: 20924356
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We provide evidence that CtsR activity during heat stress is mediated by intrinsic heat sensing through a glycine-rich loop, probably in all Gram-positive species. Moreover, a function for the recently identified arginine kinase McsB is confirmed, however, not for initial inactivation and dissociati...
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PMID: 20852588
PDF is available here.
PDF is available here.
Journal of Experimental Medicine (207)11 2010
Abstract
We review the latest models for how changes in chromatin methylation can modulate ES cell fate, focusing on two major repressive pathways, Polycomb group (PcG) repressive complexes and promoter DNA methylation....
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PMID: 20975044
PDF is available here.
PDF is available here.
Abstract
We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with damaged DNA, many of which are involved in DNA repair or nucleolar function. We show that polycomb group members are recruited by poly(ADP ribose) p...
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PMID: 20937877
PDF is available here.
PDF is available here.
Abstract
We show, by targeting a conditional knockout of Rnf12 to oocytes where RLIM accumulates to high levels, that the maternal transmission of the mutant X chromosome (Δm) leads to lethality in female embryos as a result of defective imprinted XCI. We provide evidence that in Δm female embryos the in...
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PMID: 20962847
PDF is available here.
PDF is available here.
Abstract
We use a method called discrete chemical master equation (dCME) to compute directly the full steady-state probability landscape of the lysogeny maintenance network in phage lambda from its CME. Results show that wild-type phage lambda can maintain a constant level of repressor over a wide range of r...
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PMID: 20937911
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We followed two different approaches. In the first, we deleted the last eight amino acids of Hxk2 and replaced Ser³⁰⁴ with phenylalanine to generate Hxk2(wca). Analysis of this mutant demonstrated that these domains play an essential role in the catalytic activity of yeast Hxk2, but has no effe...
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PMID: 20815814
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We revealed that Bmi-1 regulates the expression of p16 by binding directly to the Bmi-1-responding element (BRE) within the p16 promoter. The BRE resided at bp -821 to -732 upstream of the p16 ATG codon. BRE alone was sufficient to allow Bmi-1-mediated regulation of the CMV promoter. Bmi-1 typically...
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PMID: 20551323
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)42 2010
Abstract
We have found that the N terminus of PIASy is not required for SUMO modification in vitro but is essential for mitotic SUMOylation in Xenopus egg extracts. We demonstrate that swapping the N terminus of PIASy protein with the corresponding region of other PIAS family members abolishes chromosomal bi...
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PMID: 20696768
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
The Tsix regulatory region was examined in vole Microtus rossiaemeridionalis. The minimal promoter region, three potential enhancer regulatory elements and one transcription suppressor element were identified. The enhancer regions contained potential binding sites of transcription activators, while...
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PMID: 21254563
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
Interaction of transcription factor CTCF with the minimal promoter of Xist gene was investigated in intraspecific hybrids ofcommon voles. CTCF was shown to bind with the minimal promoter region in vivo. However, the experiments of the delay in gel resulted in the absence of interaction between the C...
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PMID: 21254564
PDF is available here.
PDF is available here.
Abstract
We characterize the role of fibronectin, a high-molecular weight extracellular matrix glycoprotein secreted by tumor cells, in controlling glioma progression and in mediating immunosuppression. Fibronectin binds to membrane-spanning integrin receptors and plays an important role in cell signaling, i...
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PMID: 20927322
PDF is available here.
PDF is available here.
Cell Research (20)10 2010
Abstract
We reported that Dvl also functions in the nucleus by stabilizing the β-catenin/TCFs transcriptional complex. Here we describe that Dvl may function as a repressor of NF-κB. Our data show that Dvl directly binds to p65 and their interaction occurs in the nucleus. Dvl expression inhibits p65-mediat...
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PMID: 20628365
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
We scrutinized the 2 genetic polymorphisms in exons of DNMT1 that may influence the activity of DNMT1. Our research subjects consisted of 305 patients with IDC and 314 age-matched healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Data...
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PMID: 20920981
PDF is available here.
PDF is available here.
Cell Cycle (9)19 2010
Abstract
We show that in the mRNA degradation mutant Kllsm4Δ1, histone mRNAs are induced early in the S-phase and maintained at high level all along the entire cell cycle due to a delay in the exit from S-phase and/or entry into M-phase. The overexpression of the HIR1 gene (Histone transcriptional repressor...
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PMID: 20935467
PDF is available here.
PDF is available here.
Abstract
We show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. Silencing of Pcif1 increased Pdx1 protein levels in cultured mouse β cells, and Pcif1 heterozygosity normalized Pdx1 protein levels in Pdx1(+/-) mouse islets, thereby increasing expression of key Pdx1 transcriptional ta...
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PMID: 20811152
PDF is available here.
PDF is available here.
Abstract
We show here that this plasticity of olfactory behavior is dependent on population density and that this regulation is mediated by pheromonal signaling. We show that a peptide, suppressor of NEP-2 (SNET-1), negatively regulates olfactory plasticity and that its expression is down-regulated by the ph...
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PMID: 20929849
PDF is available here.
PDF is available here.
Human Molecular Genetics (19)18 2010
Abstract
We report the identification of the Krüppel-like ZF protein, ZNF224, as a novel human WT1-associating protein and demonstrate that ZNF224 and its isoform ZNF255 show a specific pattern of interaction with the WT1 splicing variants WT1(-KTS) and WT1(+KTS). These interactions occur in different subce...
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PMID: 20591825
PDF is available here.
PDF is available here.
Abstract
Journal of Dairy Science (93)9 2010
Abstract
We determined the mRNA and protein expression of DNMT1 in Jurkat T-leukemia cells, after incubation with Lfcin B, by real-time quantitative reverse transcription PCR and Western blot analysis. The results of real-time quantitative reverse transcription PCR showed that DNMT1 expression in Jurkat T-le...
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PMID: 20723665
PDF is available here.
PDF is available here.