Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Repressor Proteins (2):
Recent article
Repressor Proteins
Eukaryotic Cell (9)9 2010
Abstract
We employed the same strategy to analyze the role of Rfg1p in filamentation and virulence. Studies using a tet-RFG1 strain revealed that RFG1 overexpression does not inhibit hypha formation in vitro or in the mouse model of hematogenously disseminated candidiasis. Interestingly, RFG1 overexpression...
|
PMID: 20656914
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Eukaryotic Cell (9)9 2010
Abstract
We have previously observed that constitutive expression of UME6, which encodes a filament-specific transcriptional regulator, is sufficient to direct hyphal growth in the absence of filament-inducing conditions. Here we show that HGC1, encoding a cyclin-related protein necessary for hyphal growth u...
|
PMID: 20656912
PDF is available here.
PDF is available here.
Abstract
It has been proven that MTA2 was expressed in many tumor cell lines and was correlated with tumor invasion and metastasis. The aim of this study is to investigate the expression of MTA2 protein in non-small cell lung cancer (NSCLC) and to explore the relationship between the expression of MTA2 and t...
|
PMID: 20704817
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We analyzed zebrafish embryos null for cohesin subunit rad21 using microarrays to determine global effects of cohesin on gene expression during embryogenesis. This identified Rad21-associated gene networks that included myca (zebrafish c-myc), p53 and mdm2. In zebrafish, cohesin binds to the transcr...
|
PMID: 20553708
PDF is available here.
PDF is available here.
Genes & Development (24)16 2010
Abstract
We show that a single transcription factor, Foxp1, can control the balance of cardiomyocyte proliferation during development by targeting different pathways in the endocardium and myocardium. Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to re...
|
PMID: 20713518
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
The CDX2 transcription factor is known to play a crucial role in inhibiting proliferation, promoting differentiation and the expression of intestinal specific genes in intestinal cells. The overall effect of CDX2 in intestinal cells has previously been investigated in conditional knock-out mice, rev...
|
PMID: 20551321
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We compared a DNA search of multidomain proteins with a search of isolated domains. Furthermore, we studied how manipulating the binding affinity of a single domain to DNA can affect the overall DNA search of the multidomain protein. Tethering the two domains via a flexible linker increases their af...
|
PMID: 20713004
PDF is available here.
PDF is available here.
Abstract
We investigated MTA1 expression and its prognostic value for NSCLC.
NSCLC surgical tissue samples were taken from 100 patients with NSCLC who had been followed up for more than 2 years. The expression of MTA1 protein was evaluated by immunohistochemistry, and the correlations between the expression...
|
PMID: 20661085
PDF is available here.
PDF is available here.
Abstract
In Escherichia coli, the lsr operon is composed of six genes lsrACDBFG which regulate uptake and modification of the signalling molecule AI-2. LsrR is a repressor of the lsr operon and itself, which can bind phospho-AI-2 and be released from the promoter region of the operon and thus activate gene e...
|
PMID: 20693666
PDF is available here.
PDF is available here.
Abstract
I and decrease in collagenase (MMP-1) was observed with 75/25% ratio of 590/870 nm. The addition of increasing proportions of IR wavelengths causes alteration in gene expression profile. The ratios of the wavelengths caused variation in magnitude of expression.
Cell metabolism and gene expression ca...
|
PMID: 20662030
PDF is available here.
PDF is available here.
Abstract
KLF8 possibly involved in regulating the cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer cells. Blocking the KLF8 channel might be a potential therapeutic strategy for RCC....
|
PMID: 20182889
PDF is available here.
PDF is available here.
Abstract
WIF-1 silencing as a result of its promoter hypermethylation may be a frequent event in HCC....
|
PMID: 20119713
PDF is available here.
PDF is available here.
Abstract
We attempted to identify profiles of proteins with altered expression levels in rats following unilateral stereotaxic injection of 6-hydroxydopamine into the SNc. Protein expression profiles of these proteins in the substantia nigra and the striatum were made using two-dimensional gel electrophoresi...
|
PMID: 20403401
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
Human papillomavirus type 16 (HPV-16) genotype variants have been the subject of several investigations, but study participants have rarely been sampled more than once. In this study, among a cohort of human immunodeficiency virus (HIV)-infected adults, HPV-16 variants were investigated in samples c...
|
PMID: 20392894
PDF is available here.
PDF is available here.
Abstract
Abstract
Notch signalling is of fundamental importance to various processes during embryonic development and in adults. The possible role of Hey1, an important Notch signalling component, in odontoblast differentiation was evaluated in this study. Primary cultured dental pulp cells, derived from upper inciso...
|
PMID: 20666749
PDF is available here.
PDF is available here.
Abstract
We identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA inte...
|
PMID: 20689760
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We also analyzed WIF-1 and SFRPs promoter methylations in 46 mesothelioma tissues, 8 mesothelioma cell lines by methylation-specific polymerase chain reaction (MSP). WIF-1 promoter methylation was observed in 34 of 46 mesothelioma tissues (73.9%) and in all 8 mesothelioma cell lines. SFRP1, 2 and 4...
|
PMID: 20596629
PDF is available here.
PDF is available here.
Abstract
Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order organization of genomes is functionally important for gene regulation and control of gene expression programs. Defe...
|
PMID: 20591991
PDF is available here.
PDF is available here.
Abstract
We confirm that a previously identified polymorphism (rs2295490/Q84R) in exon 2 of the pseudokinase-encoding gene tribbles 3 (TRB3) is associated with an increased risk for T2DM in 2 populations of people of mixed European descent. Carriers of the 84R allele had substantially reduced plasma levels o...
|
PMID: 20592469
PDF is available here.
PDF is available here.
Cancer Research (70)14 2010
Abstract
We examined the biological functions of DEPDC1 and defined a potential therapeutic strategy to target this molecule. Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 interacted and colocalized with zinc finger transcription factor ZNF224, a known transcriptional repressor. Inhibiti...
|
PMID: 20587513
PDF is available here.
PDF is available here.
Cell Cycle (9)14 2010
Abstract
We show that hypoxia induces downregulation of MAD2 expression, independently of MAD2 promoter methylation. We also show no evidence of MAD2 promoter methylation in breast and prostate cancer cells or in breast cancer clinical material. While our findings provide no evidence for MAD2 promoter methyl...
|
PMID: 20676051
PDF is available here.
PDF is available here.
Cell Cycle (9)14 2010
Abstract
We propose that these feedback regulators help to flexibly adjust and adapt HIF activated responses to the fluctuating oxygen concentrations within tumors during acute and chronic hypoxia and to curtail the tumor-suppressing components of the HIF pathway. Moreover, feedback regulation of HIF induces...
|
PMID: 20603601
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We show that MLK3 mediates its effects via the pseudokinase TRB3, a mammalian homolog of Drosophila Tribbles. TRB3 expression strongly coincided with conformational change and mitochondrial translocation of BAX. Mechanistically, MLK3 directly interacted with and stabilized TRB3, resulting in inhibit...
|
PMID: 20421299
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We found that serum induction of some SRF target genes is preferentially regulated by MKL1/2, whereas others are redundantly activated by both TCFs and MKL1/2. Yet ELK1 can also repress transcription. Binding of ELK1 and MKL1 to SRF has been found to be mutually exclusive in vitro, suggesting that E...
|
PMID: 20466732
PDF is available here.
PDF is available here.