Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
SOX Transcription Factors (7):
Recent article
SOX Transcription Factors
Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias.
Abstract
We hypothesized that c-Myc, SOX2, and Oct-4 expression would distinguish type II from type I FCDs. In addition, we assayed the expression of progenitor cell proteins forkhead box G1 (FOXG1), Kruppel-like factor 4 (KLF4), Nanog, and SOX3. Differential expression of 7 stem cellproteins and aberrant ph...
|
PMID: 20613634
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The groundbreaking discovery about arterial and venous expression of ephrinB2 and EphB4, respectively, in early embryonic development has led to a new paradigm for vascular research, providing compelling evidence that arterial and venous endothelial cells are established by genetic mechanisms before...
|
PMID: 20238301
PDF is available here.
PDF is available here.
médecine/sciences (26)4 2010
Abstract
OCT4 encoded by pou5f1 is one of the most ancient and early transcription factors identified in the embryo. It has been longwise recognized as a gatekeeper for pluripotency of embryonic stem (ES) cell. Uncovered twenty years ago, its fame was built up from its key role in maintaining embryonic stem...
|
PMID: 20412747
PDF is available here.
PDF is available here.
Abstract
We used the classic example of the duplicated zebrafish sox11a and -b loci to test the duplication, degeneration, complementation (DDC) model of genome evolution through whole genome duplication. While recent reports have demonstrated sub-partitioning of regulatory sequences in duplicated regions, a...
|
PMID: 20039180
PDF is available here.
PDF is available here.
BMC Biology (8)1 2010
Abstract
We hypothesised that there are parallels between dedifferentiation or reprogramming of somatic cells to induced pluripotent stem cells and the natural process of dedifferentiation during epimorphic regeneration. We analysed expression levels of the most commonly used pluripotency associated factors...
|
PMID: 20089153
PDF is available here.
PDF is available here.
Abstract
We define a gene regulatory network for Hoxa2, responsible for temporal and spatial expression in hindbrain development. Hoxa2 plays an important role in regulating the regional identity of rhombomere 2 (r2) and is the only Hox gene expressed in this segment. In this study, we found that a Hoxa2 cis...
|
PMID: 19104046
PDF is available here.
PDF is available here.
Genetika (Moskva) (44)11 2008
Abstract
We found evidence of gene duplication. In the phylogenetic tree, two paralogs of Sox1 1b (Sox1 1b1 and Sox1 1b2) fit within the clade of Sox11, especially in the Sox 1b subfamily, not in the Sox1 1a subfamily. Three Sox1 sequences (Soxl-1, Soxl-2 and Sox1-3) which shared the same amino acid sequence...
|
PMID: 19137736
PDF is available here.
PDF is available here.
Abstract
We show that Castor and Seven-Up, members of this temporal series, regulate key events in many different neuroblast lineages during late neurogenesis. First, they schedule a switch in the cell size and identity of neurons involving the targets Chinmo and Broad Complex. Second, they regulate the time...
|
PMID: 18510932
PDF is available here.
PDF is available here.
Zoological Science (25)3 2008
Abstract
We showed that the Sox15 gene is highly expressed in the trophoblast giant cells of the mouse placenta. To elucidate the molecular mechanisms of the tissue-dependent transcription of the gene, we isolated approximately 2.2 kb of the 5'-flanking sequence upstream of the transcription initiation site...
|
PMID: 18393569
PDF is available here.
PDF is available here.
Current Biology (18)4 2008
Live analysis of endodermal layer formation identifies random walk as a novel gastrulation movement.
Abstract
We demonstrate that in contrast to mesoderm, internalized endodermal cells display a nonoriented/noncoordinated movement fit by a random walk that rapidly disperses them over the yolk surface. Transplantation experiments reveal that this behaviour is largely cell autonomous, induced by TGF-beta/Noda...
|
PMID: 18291651
PDF is available here.
PDF is available here.
Abstract
Based on overall domain structures and HMG box sequences, the Acropora Sox genes considered here clearly fall into four of the five major Sox classes. AmSoxC is expressed in the ectoderm during development, in cells whose morphology is consistent with their assignment as sensory neurons. The express...
|
PMID: 19014479
PDF is available here.
PDF is available here.
Abstract
We describe the cloning of the X. laevis orthologs of the SoxB2 family of transcription factors, sox14 and sox21. In situ hybridization revealed that sox14 expression is restricted to the hypothalamus, dorsal thalamus, the optic tectum, a region of the somatic motornucleus in the midbrain and hindbr...
|
PMID: 18956331
PDF is available here.
PDF is available here.
Endokrynologia Polska (59)6 2008
Abstract
Intersexual disorders, the causes of which are frequently difficult to diagnose, usually result from the disruption of sex determination and gonadal development or from impairment in function of endocrine organs such as gonads and adrenal glands. Thus consideration of etiopatogenesis of intersexuali...
|
PMID: 19347816
PDF is available here.
PDF is available here.
Molecules and Cells (24)3 2007
Abstract
We established stable NT2/D1 cell lines overexpressing SOX15 (SOX15-NT2/D1), and a modified 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the SOX15-NT2/D1 cells exhibited significantly slower growth than the controls. Flow cytometry analysis revealed that an i...
|
PMID: 18182846
PDF is available here.
PDF is available here.
EMBO Journal (26)7 2007
Abstract
We have previously shown that the Foxk1 gene, a member of the forkhead/winged helix family of transcription factors, is expressed in myogenic progenitor cells in adult skeletal muscle. In the present study, we utilize transgenic technology and demonstrate that the 4.6 kb upstream fragment of the Fox...
|
PMID: 17363903
PDF is available here.
PDF is available here.
Developmental Biology (300)2 2006
Abstract
We focused on Fgf signaling, downstream of Nodal signaling, during endoderm induction. We found that activation of Fgf signaling decreases the number of cas-expressing endodermal cells. Conversely, inhibition of this signaling increases the number of endodermal cells without affecting the expression...
|
PMID: 17026981
PDF is available here.
PDF is available here.
Developmental Biology (299)2 2006
Abstract
We show that SoxN expression persists in a subset of neurons and glial cells of the ventral nerve cord at embryonic stages 15/16. In an attempt to address SoxN function in late stages of CNS development, we have used a chromatin immunoprecipitation approach to isolate genomic regions bound in vivo b...
|
PMID: 16979619
PDF is available here.
PDF is available here.
Differentiation (74)5 2006
Abstract
We report that Sox15 transcripts were much more abundant in mouse placenta than in the fetus, the yolk sac, or several adult tissues. In situ hybridization analysis of the mouse E8.0 conceptus indicated that Sox15 mRNA was predominantly expressed in the trophoblast giant cells of the placenta. We al...
|
PMID: 16759287
PDF is available here.
PDF is available here.
Development (133)11 2006
Abstract
We have analysed how the FGF and BMP pathways interact with Nodal signalling during the process of endoderm formation. We found that activation of the FGF/ERK pathway disrupts endoderm formation in the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the an...
|
PMID: 16672336
PDF is available here.
PDF is available here.
Development (133)5 2006
Abstract
We have developed a novel cell transplantation technique, using the ability of the SOX32 transcription factor to confer endodermal identity, to selectively target reagents to (or exclude them from) the endodermal germ layer of the zebrafish. We show that RA synthesized in the anterior paraxial mesod...
|
PMID: 16452093
PDF is available here.
PDF is available here.
Abstract
We disrupted the Sox15 by homologous recombination in mice. Sox15-deficient mice were born at expected ratios, were healthy and fertile, and displayed normal long-term survival rates. Histological analysis revealed the normal ultrastructure of myofibers and the presence of comparable amounts of sate...
|
PMID: 15367664
PDF is available here.
PDF is available here.
Current Biology (14)1 2004
Abstract
We rescued zygotic spg(m793) mutants by injecting pou5f1 mRNA at the one-cell stage and raised them into fertile homozygous spg(m793) adults that mate to produce maternal-zygotic spg (MZspg) mutant embryos. Although neurectoderm, mesoderm, and germ cells develop in MZspg mutants, gastrulation is del...
|
PMID: 14711414
PDF is available here.
PDF is available here.
Abstract
We have isolated a novel protein in Drosophila, SoxNeuro Co-Factor (SNCF). The expression of the SNCF gene was detected during early embryogenesis at the blastoderm stages, and stopped just at the beginning of gastrulation. In transfected cells, the protein localised to nuclei, and strongly accumula...
|
PMID: 14597169
PDF is available here.
PDF is available here.
Nature Neuroscience (6)11 2003
Abstract
Abstract
The mammalian sex determining region on the Y chromosome, SRY, is the founding member of the SOX gene family. SOX genes share a common DNA-binding motif termed the HMG box and have diverse roles in vertebrate embryonic development and tissue differentiation. Sox15 expression was analysed during mous...
|
PMID: 12915303
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1628)2 2003
Abstract
We isolated and sequenced a novel Sox cDNA from African clawed frog (Xenopus laevis). The Sox gene was named xSox33. xSox33 was revealed to encode 244 amino acids. Reverse transcription-polymerase chain reaction (RT-PCR) showed that xSox33 was expressed at very low levels in some frog tissues includ...
|
PMID: 12890561
PDF is available here.
PDF is available here.
Development (129)21 2002
Abstract
We show that Mezzo, a novel paired-like homeobox protein, may be this missing transcription factor. The homeobox of Mezzo is mostly related to the homeodomain of the Mix-like and Mixer homeoproteins, but Mezzo is distinct from Bon/Mixer, the product of the bonnie and clyde gene. Like bon/mixer, mezz...
|
PMID: 12397099
PDF is available here.
PDF is available here.
Nature Cell Biology (4)10 2002
Abstract
We show that spt and oep genetically interact and are together essential for the formation of cardiac and somitic mesoderm. These two mesodermal defects are dependent on different effectors of Nodal signalling; cardiac mesoderm formation involves the mix-like transcription factor Bonnie and Clyde (B...
|
PMID: 12360294
PDF is available here.
PDF is available here.
Development (129)19 2002
Abstract
We explore here the function of endoderm in this process. By genetic ablation and reintroduction of endoderm in zebrafish, we show that it is required for the development of chondrogenic neural crest cells, including their identity, survival and differentiation into arch cartilages. Using a genetic...
|
PMID: 12223404
PDF is available here.
PDF is available here.
Mechanisms of Development (118)1-2 2002
Abstract
We have used dorsalized swirl (bmp2b) and ventralized chordino (chordin) zebrafish mutants to investigate the effects of dorsoventral signalling on endoderm patterning and on the differentiation and positioning of its derivatives. Alterations of dorsoventral Bmp signalling do not perturb the inducti...
|
PMID: 12351167
PDF is available here.
PDF is available here.
Development (129)18 2002
Abstract
We describe the CNS phenotype of a null mutation in the Drosophila SoxNeuro gene and provide the first direct evidence for both redundant and differential Sox function during CNS development in DROSOPHILA: In the lateral neuroectoderm, where SoxNeuro is uniquely expressed, SoxNeuro mutants show a lo...
|
PMID: 12183374
PDF is available here.
PDF is available here.
Development (129)18 2002
Abstract
We demonstrate that SoxNeuro is essential for the formation of the neural progenitor cells in central nervous system. We show that loss of function mutations of SoxNeuro are associated with a spatially restricted hypoplasia: neuroblast formation is severely affected in the lateral and intermediate r...
|
PMID: 12183372
PDF is available here.
PDF is available here.
Development (129)5 2002
Abstract
We show that the Sox-domain-containing gene Dichaete/fish-hook also plays a crucial role to pattern the neuroectoderm along the DV axis. Dichaete is expressed in the medial and intermediate columns of the neuroectoderm, and mutant analysis indicates that Dichaete regulates cell fate and neuroblast f...
|
PMID: 11874912
PDF is available here.
PDF is available here.
Development (129)2 2002
Abstract
We first show that the timing and dose of Nodal activation are crucial for endoderm formation and the endoderm versus mesoderm fate choice, because sustained Nodal signalling is required to ensure endoderm formation but transient signalling is sufficient for mesoderm formation. In zebrafish, downstr...
|
PMID: 11807021
PDF is available here.
PDF is available here.
Mechanisms of Development (109)2 2001
Abstract
We report the embryonic and larval expression pattern of four previously uncharacterized Sox genes, through antibody staining and in situ hybridization experiments....
|
PMID: 11731252
PDF is available here.
PDF is available here.
Abstract
We named the putative egg receptor EROS. This is the first evidence for an egg/sperm recognition system in insects. The mechanism is similar to those known from higher animals.
Copyright 2001 Wiley-Liss, Inc....
|
PMID: 11553926
PDF is available here.
PDF is available here.
Development (128)20 2001
Abstract
We show that marginal cells become committed to endoderm at the onset of gastrulation and that commitment to endoderm can be reached by intracellular activation of the Nodal pathway induced by expression of an activated form of the taram-A receptor, Tar*. In a manner similar to endoderm progenitors,...
|
PMID: 11641218
PDF is available here.
PDF is available here.
Mechanisms of Development (107)1-2 2001
Abstract
We have identified a novel sox gene, 226D7, which is important in zebrafish endoderm development. 226D7 was isolated by an in situ hybridization screening for genes expressed in the yolk syncytial layer (YSL) at the blastula stage. 226D7 is expressed mainly in the YSL at this stage and, during gastr...
|
PMID: 11520661
PDF is available here.
PDF is available here.
Genes & Development (15)12 2001
Abstract
We isolated an HMG box-containing gene, 10J3, which is expressed in the endoderm. The cas phenotype is rescued by overexpression of 10J3 and can be mimicked by 10J3-directed morpholinos. Furthermore, we identified a mutation within 10J3 coding sequence that cosegregates with the cas phenotype, clear...
|
PMID: 11410529
PDF is available here.
PDF is available here.
Genes & Development (15)12 2001
Abstract
We show that cas encodes a novel member of the Sox family of transcription factors. Initial cas expression appears in the dorsal yolk syncytial layer (YSL) in the early blastula, and is independent of Nodal signaling. In contrast, endodermal expression of cas, which begins in the late blastula, is r...
|
PMID: 11410530
PDF is available here.
PDF is available here.
Mechanisms of Development (100)1 2001
Abstract
We have identified a novel Sox gene in zebrafish (Danio rerio), Sox31, closely related to mammalian group B Sox genes. The gene is maternally expressed. Zygotic transcription starts at gastrulation, in the presumptive neuroectoderm. Later, expression is restricted to the developing central nervous s...
|
PMID: 11118886
PDF is available here.
PDF is available here.
FEBS Letters (481)2 2000
Abstract
We have identified a novel SoxLZ/Sox6 binding protein, termed Solt, which we obtained independently using both a far-Western blot and a yeast two-hybrid screen. Like SoxLZ/Sox6 mRNA, Solt mRNA was exclusively expressed in the testis in mouse. Solt contains an unusual leucine zipper, which bound to t...
|
PMID: 10996314
PDF is available here.
PDF is available here.
Journal of Neuroscience (20)12 2000
Abstract
We show here that Fish-hook (Fish), a Sox HMG domain protein, and Drifter (Dfr), a POU domain protein, act in concert with Single-minded to control midline gene expression. single-minded, fish-hook, and drifter are all expressed in developing midline cells, and both loss- and gain-of-function assays...
|
PMID: 10844029
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (275)21 2000
Abstract
We report the isolation and characterization of mouse Sox15 that was uncovered during a screen for high mobility group box containing transcription factors that are expressed at different levels during skeletal muscle differentiation. Sox15 cDNAs were found at a much higher frequency in myoblasts pr...
|
PMID: 10821863
PDF is available here.
PDF is available here.
The Drosophila dominant wing mutation Dichaete results from ectopic expression of a Sox-domain gene.
Abstract
We show that the wing phenotype results from ectopic expression of the Sox-domain gene Dichaete. Ectopic expression of the Sox gene results in an increase in cell death in the proximal region of the wing imaginal disc and leads to alterations in the normal expression of wingless. Since ectopic expre...
|
PMID: 10852492
PDF is available here.
PDF is available here.
Mechanisms of Development (93)1-2 2000
Abstract
We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous syste...
|
PMID: 10781960
PDF is available here.
PDF is available here.
Developmental Biology (220)2 2000
Abstract
We characterized the organization of the Dichaete gene using a combination of regulatory mutant alleles and reporter gene constructs. Dichaete expression is tightly controlled during embryonic development by a complex of regulatory elements distributed over 25 kb downstream and 3 kb upstream of the...
|
PMID: 10753518
PDF is available here.
PDF is available here.
Developmental Biology (217)1 2000
Abstract
We examined potential functional roles of fish in postembryonic developmental processes, including those involved in adult appendage development. We show here that Fish protein is expressed in discrete patterns in the larval eye-antennal and leg imaginal discs, the central nervous system, the hindgu...
|
PMID: 10625538
PDF is available here.
PDF is available here.
Mechanisms of Development (89)1-2 1999
Abstract
We have cloned three sox genes in zebrafish (Danio rerio), one related to human and chicken SOX21, and two related to mammalian and chicken Sox-11. Zebrafish sox21, sox11A and sox11B transcripts are accumulated in the egg, are present in all cells until gastrulation and become restricted later to th...
|
PMID: 10559493
PDF is available here.
PDF is available here.
Abstract
We characterized a region of the mouse genome disrupted by integration of a gene trap (GT) vector in ES cells. On 5' rapid amplification of cDNA ends analysis of the fusion transcripts containing the GT vector, we identified the eukaryotic protein synthesis initiation factor 4A1 gene (Eif4a1) as a p...
|
PMID: 10524236
PDF is available here.
PDF is available here.
Development (125)20 1998
Abstract
We find defects in the differentiation of midline glia and concomitant axonal defects in Dichaete mutants that are rescued by driving Dichaete expression in the midline. Since Dichaete is required for the correct specification or differentiation of midline glia, we have used the ventral midline as a...
|
PMID: 9735360
PDF is available here.
PDF is available here.
Abstract
We investigate the gene regulatory functions of Drosophila Fish-hook (Fish), a high mobility group (HMG) Sox protein that is essential for embryonic segmentation. We show that the Fish HMG domain binds to the vertebrate Sox protein consensus DNA binding sites, AACAAT and AACAAAG, and that this bindi...
|
PMID: 9622621
PDF is available here.
PDF is available here.
Abstract
We have isolated a cDNA clone for a new member of Sox genes, termed rtSox23, from a rainbow trout ovary cDNA library. rtSox23 mRNA was notably expressed in ovary and brain. rtSox23 contains a leucine zipper in addition to an SRY-type HMG box. Although the recombinant HMG box region protein of rtSox2...
|
PMID: 9524264
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1396)2 1998
Abstract
We have isolated and sequenced an hSOX20 cDNA from a cell line of human embryonic carcinoma. This cDNA contains an open reading frame (ORF) encoding 233 amino acids. The protein encompasses an SRY-type HMG box exhibiting strong homologies to those of mouse Sox15 and Sox16. Various adult and fetal ti...
|
PMID: 9540826
PDF is available here.
PDF is available here.
Cytogenetics and Cell Genetics (81)3-4 1998
Abstract
Development (122)11 1996
Abstract
We describe the isolation and analysis of the Drosophila fish-hook (fish) gene, which encodes a novel member of the SOX subgroup of High Mobility Group (HMG) domain proteins that exhibit similarity to the mammalian testis determining factor, SRY. The fish gene is initially expressed in a pair-rule-l...
|
PMID: 8951062
PDF is available here.
PDF is available here.
Development (122)11 1996
Abstract
We have cloned and characterised a member of the High Mobility Group superfamily of genes from Drosophila, Sox70D, which is closely related to the mammalian testis determining gene SRY. Sox70D corresponds to the dominant wing mutation Dichaete. Homozygous deletions of the Sox70D gene and recessive l...
|
PMID: 8951082
PDF is available here.
PDF is available here.
Cytogenetics and Cell Genetics (72)2-3 1996
Abstract
We have identified a HMG box-like sequence motif on six contiguous cosmids, which cross-hybridize to a SOX9 cDNA probe. A data base search revealed a high similarity of the deduced amino acid sequence to the human SOX12 and the murine Sox16 HMG domains. The cosmids were assigned to chromosome 17p13...
|
PMID: 8978787
PDF is available here.
PDF is available here.
Abstract
SRY-related cDNA encoding a protein with a high-mobility-group (HMG) box and a leucine zipper motif, which was designated SOX-LZ, was isolated from a rainbow trout testis cDNA library. Comparison of this cDNA with the mouse homologous cDNA isolated from a testis cDNA library exhibits an overall amin...
|
PMID: 7791783
PDF is available here.
PDF is available here.